DK1141237T3 - PTH-receptor og screeningsassay der anvender denne - Google Patents
PTH-receptor og screeningsassay der anvender denneInfo
- Publication number
- DK1141237T3 DK1141237T3 DK98965037T DK98965037T DK1141237T3 DK 1141237 T3 DK1141237 T3 DK 1141237T3 DK 98965037 T DK98965037 T DK 98965037T DK 98965037 T DK98965037 T DK 98965037T DK 1141237 T3 DK1141237 T3 DK 1141237T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor
- pth receptor
- screening assay
- pth
- ligand binding
- Prior art date
Links
- 238000007423 screening assay Methods 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 4
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 108020001756 ligand binding domains Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/027862 WO2000040698A1 (fr) | 1998-12-31 | 1998-12-31 | Recepteur pth et test de criblage l'utilisant |
| EP98965037A EP1141237B1 (fr) | 1998-12-31 | 1998-12-31 | Recepteur pth et test de criblage l'utilisant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1141237T3 true DK1141237T3 (da) | 2006-02-13 |
Family
ID=22268582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98965037T DK1141237T3 (da) | 1998-12-31 | 1998-12-31 | PTH-receptor og screeningsassay der anvender denne |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7169567B1 (fr) |
| EP (2) | EP1141237B1 (fr) |
| JP (1) | JP2002534081A (fr) |
| AT (1) | ATE308609T1 (fr) |
| AU (1) | AU2023499A (fr) |
| DE (1) | DE69832206T2 (fr) |
| DK (1) | DK1141237T3 (fr) |
| ES (1) | ES2251793T3 (fr) |
| WO (1) | WO2000040698A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023594A1 (fr) * | 1998-10-22 | 2000-04-27 | The General Hospital Corporation | PEPTIDES ET DERIVES PEPTIDIQUES BIOACTIFS DE L'HORMONE PARATHYROIDE (PTH) ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE (PTHrP) |
| JP4486258B2 (ja) | 1998-11-25 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | ヒト副甲状腺ホルモンの改変、調製および使用 |
| ATE308609T1 (de) | 1998-12-31 | 2005-11-15 | Gen Hospital Corp | Pth rezeptor und testverfahren unter verwendung desselben |
| WO2001023521A2 (fr) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Derives polypeptidiques de l'hormone parathyroidienne (pth) |
| WO2003009804A2 (fr) | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Analogues d'hormone parathyroide (pth) a contrainte conformationnelle |
| WO2004093902A1 (fr) * | 2003-03-19 | 2004-11-04 | The General Hospital Corporation | Hormones parathyroidiennes contraintes de maniere conformationnelle avec des stabilisateurs en helice $g(a) |
| US7910544B2 (en) * | 2003-07-17 | 2011-03-22 | The General Hospital Corporation | Conformationally constrained parthyroid hormone (PTH) analogs |
| JP2009545320A (ja) * | 2006-08-04 | 2009-12-24 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン（ｐｔｈ）のポリペプチド誘導体 |
| EP1961765A1 (fr) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Peptides PTH tronqués à formation cyclique |
| US20090023655A1 (en) * | 2007-04-02 | 2009-01-22 | Louis Luttrell | Biased Ligands for Receptors Such as the PTH Receptor |
| CN101784281B (zh) | 2007-08-01 | 2014-07-02 | 总医院有限公司 | 确定g蛋白偶联受体激动剂的方法 |
| WO2009155283A2 (fr) * | 2008-06-17 | 2009-12-23 | Duke University | Dosage radiomarqué de la cyclopamine destiné au récepteur smoothened |
| WO2010051473A2 (fr) * | 2008-10-31 | 2010-05-06 | The Uab Research Foundation | Identification d'agonistes et d'antagonistes de l'hormone parathyroïdienne |
| EP2411038B1 (fr) | 2009-03-27 | 2016-12-28 | Van Andel Research Institute | Peptides de l'hormone parathyroïdienne et peptides de la protéine apparentée à l'hormone parathyroïdienne ainsi que des procédés d'utilisation |
| US9492508B2 (en) | 2010-05-13 | 2016-11-15 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| CN105986001B (zh) * | 2015-02-12 | 2019-12-03 | 上海交通大学 | 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法 |
| WO2019178462A1 (fr) | 2018-03-16 | 2019-09-19 | The General Hospital Corporation | Conjugués polypeptes-hormone parathyroïde et leurs procédés d'utilisation |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| EP0232262A4 (fr) | 1985-08-15 | 1989-09-19 | Stauffer Chemical Co | Microorganisme producteur de tryptophane. |
| US5217896A (en) | 1988-12-30 | 1993-06-08 | Oncogene Science, Inc. | Monoclonal antibodies recognizing parathyroid hormone-like protein |
| WO1991005050A1 (fr) | 1989-09-29 | 1991-04-18 | Her Majesty In Right Of Canada As Represented By The National Research Council Of Canada | Synthese de l'hormone parathyroïde humaine mature |
| ATE169030T1 (de) | 1990-06-28 | 1998-08-15 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung |
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| JPH0532696A (ja) | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| WO1992017602A1 (fr) | 1991-04-05 | 1992-10-15 | The General Hospital Corporation Office Of Technology Affairs | Recepteur d'hormone parathyroidienne et adn codant ce recepteur |
| US5434246A (en) | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| CA2126132A1 (fr) | 1994-06-17 | 1995-12-18 | Witold Neugebauer | Synthese de peptide sur chitosane |
| US5556940A (en) | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| CA2178894A1 (fr) | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Derives de la parathormone et leur utilisation |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| RU2203286C2 (ru) | 1996-08-02 | 2003-04-27 | Нэшнл Рисерч Каунсил ов Кэнэда | Аналоги паратиреоидного гормона для лечения остеопороза |
| WO1999018945A1 (fr) | 1997-10-14 | 1999-04-22 | Eli Lilly And Company | Procede de recalcification et de conservation osseuses |
| WO2000023594A1 (fr) | 1998-10-22 | 2000-04-27 | The General Hospital Corporation | PEPTIDES ET DERIVES PEPTIDIQUES BIOACTIFS DE L'HORMONE PARATHYROIDE (PTH) ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE (PTHrP) |
| JP4486258B2 (ja) | 1998-11-25 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | ヒト副甲状腺ホルモンの改変、調製および使用 |
| ATE384743T1 (de) | 1998-11-25 | 2008-02-15 | Gen Hospital Corp | Aminoterminal modifizierte parathyroidhormon (pth) analoge |
| WO2000032771A1 (fr) | 1998-11-30 | 2000-06-08 | The General Hospital Corporation | Recepteurs de pth1r et de pth3r, procedes s'y rapportant et utilisation |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| ATE308609T1 (de) | 1998-12-31 | 2005-11-15 | Gen Hospital Corp | Pth rezeptor und testverfahren unter verwendung desselben |
| WO2000039278A2 (fr) | 1998-12-31 | 2000-07-06 | The General Hospital Corporation | Peptides conjugues a domaine fonctionnel pth, leurs derives et nouvelles molecules ligand-recepteur |
| DE60040678D1 (en) | 1999-09-29 | 2008-12-11 | Gen Hospital Corp | Parathyroid hormon (pth) polypeptidderivate |
| US7022815B1 (en) * | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
| WO2001023521A2 (fr) | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Derives polypeptidiques de l'hormone parathyroidienne (pth) |
| WO2003009804A2 (fr) | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Analogues d'hormone parathyroide (pth) a contrainte conformationnelle |
| WO2004067021A1 (fr) | 2003-01-24 | 2004-08-12 | Gardella Thomas J | Analogues de parathormone (pth) a contrainte conformationnelle avec ponts lactame |
| WO2004093902A1 (fr) | 2003-03-19 | 2004-11-04 | The General Hospital Corporation | Hormones parathyroidiennes contraintes de maniere conformationnelle avec des stabilisateurs en helice $g(a) |
| US7910544B2 (en) | 2003-07-17 | 2011-03-22 | The General Hospital Corporation | Conformationally constrained parthyroid hormone (PTH) analogs |
-
1998
- 1998-12-31 AT AT98965037T patent/ATE308609T1/de not_active IP Right Cessation
- 1998-12-31 EP EP98965037A patent/EP1141237B1/fr not_active Expired - Lifetime
- 1998-12-31 JP JP2000592396A patent/JP2002534081A/ja not_active Ceased
- 1998-12-31 US US09/869,565 patent/US7169567B1/en not_active Expired - Fee Related
- 1998-12-31 DE DE69832206T patent/DE69832206T2/de not_active Expired - Fee Related
- 1998-12-31 AU AU20234/99A patent/AU2023499A/en not_active Abandoned
- 1998-12-31 EP EP05018345A patent/EP1612263A1/fr not_active Withdrawn
- 1998-12-31 ES ES98965037T patent/ES2251793T3/es not_active Expired - Lifetime
- 1998-12-31 WO PCT/US1998/027862 patent/WO2000040698A1/fr not_active Ceased
- 1998-12-31 DK DK98965037T patent/DK1141237T3/da active
-
2006
- 2006-12-22 US US11/644,002 patent/US20070117969A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000040698A1 (fr) | 2000-07-13 |
| EP1141237B1 (fr) | 2005-11-02 |
| EP1612263A1 (fr) | 2006-01-04 |
| AU2023499A (en) | 2000-07-24 |
| EP1141237A4 (fr) | 2003-03-19 |
| US20070117969A1 (en) | 2007-05-24 |
| ES2251793T3 (es) | 2006-05-01 |
| EP1141237A1 (fr) | 2001-10-10 |
| US7169567B1 (en) | 2007-01-30 |
| DE69832206T2 (de) | 2006-08-03 |
| ATE308609T1 (de) | 2005-11-15 |
| JP2002534081A (ja) | 2002-10-15 |
| DE69832206D1 (de) | 2005-12-08 |
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