DE60022642D1 - Identifizierung von liganden für "orphan"-rezeptoren unter verwendung von massenspektrometrie - Google Patents

Identifizierung von liganden für "orphan"-rezeptoren unter verwendung von massenspektrometrie

Info

Publication number
DE60022642D1
DE60022642D1 DE60022642T DE60022642T DE60022642D1 DE 60022642 D1 DE60022642 D1 DE 60022642D1 DE 60022642 T DE60022642 T DE 60022642T DE 60022642 T DE60022642 T DE 60022642T DE 60022642 D1 DE60022642 D1 DE 60022642D1
Authority
DE
Germany
Prior art keywords
receptors
mass spectrometry
ligands
orphanic
identification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60022642T
Other languages
English (en)
Inventor
Der Greef Jan Van
Hubertus Irth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KIADIS B.V., GRONINGEN, NL
Original Assignee
SCREEN TEC BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCREEN TEC BV filed Critical SCREEN TEC BV
Application granted granted Critical
Publication of DE60022642D1 publication Critical patent/DE60022642D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G01N2030/8435—Preparation of the fraction to be distributed adding modificating material for chemical reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE60022642T 1999-04-26 2000-04-26 Identifizierung von liganden für "orphan"-rezeptoren unter verwendung von massenspektrometrie Expired - Lifetime DE60022642D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201301A EP1048950A1 (de) 1999-04-26 1999-04-26 Identifizierung von Liganden für "Orphan"-Rezeptoren unter Verwendung von gekoppelten Massenspektrometrisch- und Durchfluss-Trennungstechniken
PCT/NL2000/000268 WO2000065353A1 (en) 1999-04-26 2000-04-26 Identification of ligands for orphan receptors using mass spectrometry

Publications (1)

Publication Number Publication Date
DE60022642D1 true DE60022642D1 (de) 2005-10-20

Family

ID=8240148

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022642T Expired - Lifetime DE60022642D1 (de) 1999-04-26 2000-04-26 Identifizierung von liganden für "orphan"-rezeptoren unter verwendung von massenspektrometrie

Country Status (6)

Country Link
EP (2) EP1048950A1 (de)
JP (1) JP2002543387A (de)
AT (1) ATE304710T1 (de)
AU (1) AU4624200A (de)
DE (1) DE60022642D1 (de)
WO (1) WO2000065353A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
JP2007510935A (ja) 2003-11-07 2007-04-26 プリンストン・バイオケミカルズ・インコーポレーテッド 多次元電気泳動装置
US8030092B2 (en) 2003-11-07 2011-10-04 Princeton Biochemicals, Inc. Controlled electrophoresis method
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037777A1 (en) * 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
DE69627333T2 (de) * 1995-06-26 2004-02-12 PerSeptive Biosystems, Inc., Framingham Automatisierte, kontinuierliche mehrdimensionale hochgeschwindigkeitsmolekularselektion und -analyse
WO1997043301A2 (en) * 1996-05-10 1997-11-20 Novartis Ag Identification of members of combinatorial libraries by mass spectrometry
WO1998056028A1 (en) * 1997-06-03 1998-12-10 Arqule, Inc. An automated, high throughput method for screening a plurality of compounds using mass spectrometry

Also Published As

Publication number Publication date
ATE304710T1 (de) 2005-09-15
WO2000065353A1 (en) 2000-11-02
EP1175617A1 (de) 2002-01-30
EP1048950A1 (de) 2000-11-02
EP1175617B1 (de) 2005-09-14
AU4624200A (en) 2000-11-10
JP2002543387A (ja) 2002-12-17

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: KIADIS B.V., GRONINGEN, NL

8332 No legal effect for de