ATE357658T1 - Verfahren zum screening von tgf-beta inhibierenden substanzen - Google Patents
Verfahren zum screening von tgf-beta inhibierenden substanzenInfo
- Publication number
- ATE357658T1 ATE357658T1 AT98950354T AT98950354T ATE357658T1 AT E357658 T1 ATE357658 T1 AT E357658T1 AT 98950354 T AT98950354 T AT 98950354T AT 98950354 T AT98950354 T AT 98950354T AT E357658 T1 ATE357658 T1 AT E357658T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibiting substances
- polypeptide
- screening
- tgf
- beta
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
- 101000674731 Homo sapiens TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Proteins 0.000 abstract 3
- 102100026888 Mitogen-activated protein kinase kinase kinase 7 Human genes 0.000 abstract 3
- 102100021228 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Human genes 0.000 abstract 3
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29018897 | 1997-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357658T1 true ATE357658T1 (de) | 2007-04-15 |
Family
ID=17752897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98950354T ATE357658T1 (de) | 1997-10-22 | 1998-10-22 | Verfahren zum screening von tgf-beta inhibierenden substanzen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6451617B1 (de) |
| EP (1) | EP1043586B1 (de) |
| JP (1) | JP3480941B2 (de) |
| KR (1) | KR20010031325A (de) |
| AT (1) | ATE357658T1 (de) |
| AU (1) | AU752461B2 (de) |
| CA (1) | CA2306778A1 (de) |
| DE (1) | DE69837399T2 (de) |
| WO (1) | WO1999021010A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989244B1 (en) | 1998-10-21 | 2006-01-24 | Chugai Seiyaku Kabushiki Kaisha | Method for screening compounds inhibiting signal transduction through inflammatory cytokines |
| WO2003037255A2 (en) * | 2001-10-31 | 2003-05-08 | Millennium Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of hematological disorders using 16319 |
| US6784525B2 (en) * | 2002-10-29 | 2004-08-31 | Micron Technology, Inc. | Semiconductor component having multi layered leadframe |
| US7078485B2 (en) * | 2002-12-05 | 2006-07-18 | Yantai Medgenn Ltd. | N-terminal modified recombinant human endostatin and its production |
| GB0306071D0 (en) * | 2003-03-17 | 2003-04-23 | Novartis Ag | Organic compounds |
| JPWO2005105144A1 (ja) * | 2004-04-30 | 2007-09-13 | 協和醗酵工業株式会社 | 潜在型ＴＧＦ−βの活性化抑制剤 |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| AU2015325055B2 (en) | 2014-10-01 | 2021-02-25 | Eagle Biologics, Inc. | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5318890A (en) | 1991-05-06 | 1994-06-07 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
| US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
| JP3907247B2 (ja) * | 1996-04-24 | 2007-04-18 | 中外製薬株式会社 | Ｔａｂ１蛋白質及びそれをコードするｄｎａ |
| EP0803571B1 (de) * | 1996-04-24 | 2004-11-24 | Chugai Seiyaku Kabushiki Kaisha | TAB1 Protein und dafür kodierende DNA |
| US5837838A (en) * | 1997-03-14 | 1998-11-17 | The Burnham Institute | Bax inhibitor proteins |
-
1998
- 1998-10-22 AT AT98950354T patent/ATE357658T1/de not_active IP Right Cessation
- 1998-10-22 DE DE69837399T patent/DE69837399T2/de not_active Expired - Lifetime
- 1998-10-22 EP EP98950354A patent/EP1043586B1/de not_active Expired - Lifetime
- 1998-10-22 JP JP52371599A patent/JP3480941B2/ja not_active Expired - Lifetime
- 1998-10-22 KR KR1020007004319A patent/KR20010031325A/ko not_active Ceased
- 1998-10-22 CA CA002306778A patent/CA2306778A1/en not_active Abandoned
- 1998-10-22 US US09/529,279 patent/US6451617B1/en not_active Expired - Fee Related
- 1998-10-22 WO PCT/JP1998/004796 patent/WO1999021010A1/ja not_active Ceased
- 1998-10-22 AU AU96468/98A patent/AU752461B2/en not_active Ceased
-
2002
- 2002-06-03 US US10/158,895 patent/US6551840B2/en not_active Expired - Fee Related
-
2003
- 2003-03-11 US US10/384,743 patent/US20030162228A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1043586A4 (de) | 2004-07-28 |
| AU9646898A (en) | 1999-05-10 |
| CA2306778A1 (en) | 1999-04-29 |
| EP1043586B1 (de) | 2007-03-21 |
| US20020155624A1 (en) | 2002-10-24 |
| US6451617B1 (en) | 2002-09-17 |
| JP3480941B2 (ja) | 2003-12-22 |
| AU752461B2 (en) | 2002-09-19 |
| DE69837399T2 (de) | 2007-12-20 |
| US20030162228A1 (en) | 2003-08-28 |
| DE69837399D1 (de) | 2007-05-03 |
| WO1999021010A1 (en) | 1999-04-29 |
| KR20010031325A (ko) | 2001-04-16 |
| EP1043586A1 (de) | 2000-10-11 |
| US6551840B2 (en) | 2003-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |