CA2126132A1 - Synthese de peptide sur chitosane - Google Patents

Synthese de peptide sur chitosane

Info

Publication number
CA2126132A1
CA2126132A1 CA002126132A CA2126132A CA2126132A1 CA 2126132 A1 CA2126132 A1 CA 2126132A1 CA 002126132 A CA002126132 A CA 002126132A CA 2126132 A CA2126132 A CA 2126132A CA 2126132 A1 CA2126132 A1 CA 2126132A1
Authority
CA
Canada
Prior art keywords
peptide
chitosan
groups
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002126132A
Other languages
English (en)
Inventor
Witold Neugebauer
Gordon E. Willick
Ryszard Brzezinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002126132A priority Critical patent/CA2126132A1/fr
Publication of CA2126132A1 publication Critical patent/CA2126132A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
CA002126132A 1994-06-17 1994-06-17 Synthese de peptide sur chitosane Abandoned CA2126132A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002126132A CA2126132A1 (fr) 1994-06-17 1994-06-17 Synthese de peptide sur chitosane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002126132A CA2126132A1 (fr) 1994-06-17 1994-06-17 Synthese de peptide sur chitosane

Publications (1)

Publication Number Publication Date
CA2126132A1 true CA2126132A1 (fr) 1995-12-18

Family

ID=4153835

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002126132A Abandoned CA2126132A1 (fr) 1994-06-17 1994-06-17 Synthese de peptide sur chitosane

Country Status (1)

Country Link
CA (1) CA2126132A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023594A1 (fr) * 1998-10-22 2000-04-27 The General Hospital Corporation PEPTIDES ET DERIVES PEPTIDIQUES BIOACTIFS DE L'HORMONE PARATHYROIDE (PTH) ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE (PTHrP)
US7169567B1 (en) 1998-12-31 2007-01-30 The General Hospital Corporation Screening assay utilizing the PTH receptor
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
US7910544B2 (en) 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
US8119780B2 (en) 2006-06-02 2012-02-21 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
CN101747451B (zh) * 2008-12-03 2012-02-22 中国科学院大连化学物理研究所 一种靶向粘附壳聚糖材料及其应用
US8143374B2 (en) 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
WO2012101612A1 (fr) * 2011-01-30 2012-08-02 The National Institute for Biotechnology in the Negev Ltd. Procédés de synthèse peptidique en phase solide de fmoc sur support biodégradable et utilisations desdits procédés
US8568737B2 (en) 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
US8568736B2 (en) 1999-09-29 2013-10-29 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US8603977B2 (en) 2001-07-23 2013-12-10 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
WO2015126269A1 (fr) 2014-02-19 2015-08-27 Instytut Biochemii I Biofizyki Polskiej Akademii Nauk Procédé de synthèse d'un dérivé de biopolymère, dérivé de biopolymère et son utilisation
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495662B1 (en) 1998-10-22 2002-12-17 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
US7153951B2 (en) 1998-10-22 2006-12-26 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
US7985835B2 (en) 1998-10-22 2011-07-26 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
WO2000023594A1 (fr) * 1998-10-22 2000-04-27 The General Hospital Corporation PEPTIDES ET DERIVES PEPTIDIQUES BIOACTIFS DE L'HORMONE PARATHYROIDE (PTH) ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE (PTHrP)
US7169567B1 (en) 1998-12-31 2007-01-30 The General Hospital Corporation Screening assay utilizing the PTH receptor
US8568736B2 (en) 1999-09-29 2013-10-29 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US8603977B2 (en) 2001-07-23 2013-12-10 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
US7910544B2 (en) 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
US9029351B2 (en) 2006-06-02 2015-05-12 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US8658775B2 (en) 2006-06-02 2014-02-25 Shenda Baker Chitosan-derivative compounds and methods of controlling microbial populations
US8119780B2 (en) 2006-06-02 2012-02-21 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US9732164B2 (en) 2006-06-02 2017-08-15 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US10494451B2 (en) 2006-06-02 2019-12-03 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US8143374B2 (en) 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US8568737B2 (en) 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
US9057727B2 (en) 2007-08-01 2015-06-16 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
CN101747451B (zh) * 2008-12-03 2012-02-22 中国科学院大连化学物理研究所 一种靶向粘附壳聚糖材料及其应用
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
WO2012101612A1 (fr) * 2011-01-30 2012-08-02 The National Institute for Biotechnology in the Negev Ltd. Procédés de synthèse peptidique en phase solide de fmoc sur support biodégradable et utilisations desdits procédés
WO2015126269A1 (fr) 2014-02-19 2015-08-27 Instytut Biochemii I Biofizyki Polskiej Akademii Nauk Procédé de synthèse d'un dérivé de biopolymère, dérivé de biopolymère et son utilisation

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Legal Events

Date Code Title Description
FZDE Discontinued