DK1137795T3 - Fremgangsmåder til fremstilling af estere af mycophenolat - Google Patents
Fremgangsmåder til fremstilling af estere af mycophenolatInfo
- Publication number
- DK1137795T3 DK1137795T3 DK99964770T DK99964770T DK1137795T3 DK 1137795 T3 DK1137795 T3 DK 1137795T3 DK 99964770 T DK99964770 T DK 99964770T DK 99964770 T DK99964770 T DK 99964770T DK 1137795 T3 DK1137795 T3 DK 1137795T3
- Authority
- DK
- Denmark
- Prior art keywords
- mycophenolate
- methods
- esters
- preparation
- mycophenolic acid
- Prior art date
Links
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract 4
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229940014456 mycophenolate Drugs 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- KKFDCBRMNNSAAW-UHFFFAOYSA-N 2-(morpholin-4-yl)ethanol Chemical compound OCCN1CCOCC1 KKFDCBRMNNSAAW-UHFFFAOYSA-N 0.000 abstract 2
- 229960000951 mycophenolic acid Drugs 0.000 abstract 2
- WNWVKZTYMQWFHE-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound [CH2]CN1CCOCC1 WNWVKZTYMQWFHE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229950007856 mofetil Drugs 0.000 abstract 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 abstract 1
- 229960004866 mycophenolate mofetil Drugs 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2754MA1998 IN188985B (cs) | 1998-12-09 | 1998-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1137795T3 true DK1137795T3 (da) | 2006-03-20 |
Family
ID=11096895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99964770T DK1137795T3 (da) | 1998-12-09 | 1999-12-09 | Fremgangsmåder til fremstilling af estere af mycophenolat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6709846B1 (cs) |
| EP (1) | EP1137795B1 (cs) |
| AT (1) | ATE307892T1 (cs) |
| AU (1) | AU3073200A (cs) |
| CA (1) | CA2354554C (cs) |
| DE (1) | DE69928002T2 (cs) |
| DK (1) | DK1137795T3 (cs) |
| ES (1) | ES2252995T3 (cs) |
| IN (1) | IN188985B (cs) |
| WO (1) | WO2000034503A2 (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003042393A1 (en) * | 2001-11-16 | 2003-05-22 | Biocon Limited | Enzymatic preparation of mycophenolate mofetil |
| TWI221414B (en) * | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
| EP1667987B1 (en) * | 2003-09-11 | 2008-07-23 | Sandoz AG | Process for the production of mycophenolate mofetil |
| EP1740564A2 (en) | 2004-04-26 | 2007-01-10 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
| JP2007534697A (ja) * | 2004-04-27 | 2007-11-29 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ミコフェノール酸モフェチルおよび他のミコフェノール酸エステルの調製方法 |
| JP2008506784A (ja) * | 2004-07-20 | 2008-03-06 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 結晶形ミコフェノール酸・ナトリウム |
| ITMI20041703A1 (it) * | 2004-09-03 | 2004-12-03 | Poli Ind Chimica Spa | Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica |
| US20080281111A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| CN1328272C (zh) * | 2005-08-22 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产霉酚酸莫啡酯的方法 |
| CN100402516C (zh) * | 2005-10-18 | 2008-07-16 | 深圳市东阳光实业发展有限公司 | 一种霉酚酸莫啡酯的制备方法 |
| US20080188653A1 (en) | 2007-02-04 | 2008-08-07 | Formosa Laboratories, Inc. | Process for Preparation of Mycophenolate Mofetil |
| CN100484930C (zh) * | 2007-03-16 | 2009-05-06 | 重庆大新药业股份有限公司 | 一种吗替麦考酚酯的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US5247083A (en) | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
| RO118075B1 (ro) | 1993-09-15 | 2003-01-30 | Syntex Inc | Sare de micofenolat de mofetil, compozitie farmaceutica care o contine si formulare intravenoasa |
-
1998
- 1998-12-09 IN IN2754MA1998 patent/IN188985B/en unknown
-
1999
- 1999-12-09 DK DK99964770T patent/DK1137795T3/da active
- 1999-12-09 AT AT99964770T patent/ATE307892T1/de not_active IP Right Cessation
- 1999-12-09 CA CA2354554A patent/CA2354554C/en not_active Expired - Fee Related
- 1999-12-09 ES ES99964770T patent/ES2252995T3/es not_active Expired - Lifetime
- 1999-12-09 WO PCT/IN1999/000070 patent/WO2000034503A2/en active IP Right Grant
- 1999-12-09 EP EP99964770A patent/EP1137795B1/en not_active Expired - Lifetime
- 1999-12-09 US US09/857,579 patent/US6709846B1/en not_active Expired - Fee Related
- 1999-12-09 DE DE69928002T patent/DE69928002T2/de not_active Expired - Lifetime
- 1999-12-09 AU AU30732/00A patent/AU3073200A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69928002T2 (de) | 2006-07-27 |
| EP1137795B1 (en) | 2005-10-26 |
| CA2354554A1 (en) | 2000-06-15 |
| WO2000034503A2 (en) | 2000-06-15 |
| EP1137795A2 (en) | 2001-10-04 |
| ATE307892T1 (de) | 2005-11-15 |
| US6709846B1 (en) | 2004-03-23 |
| AU3073200A (en) | 2000-06-26 |
| WO2000034503A3 (en) | 2000-08-17 |
| IN188985B (cs) | 2002-11-30 |
| ES2252995T3 (es) | 2006-05-16 |
| CA2354554C (en) | 2010-05-25 |
| DE69928002D1 (de) | 2005-12-01 |
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