DE69928002D1 - Verfahren zur herstellung von mycophenolatestern - Google Patents

Verfahren zur herstellung von mycophenolatestern

Info

Publication number
DE69928002D1
DE69928002D1 DE69928002T DE69928002T DE69928002D1 DE 69928002 D1 DE69928002 D1 DE 69928002D1 DE 69928002 T DE69928002 T DE 69928002T DE 69928002 T DE69928002 T DE 69928002T DE 69928002 D1 DE69928002 D1 DE 69928002D1
Authority
DE
Germany
Prior art keywords
mycophenolate
production
mycophenolic acid
mofetil
mycophenolate esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928002T
Other languages
English (en)
Other versions
DE69928002T2 (de
Inventor
Anindya Sircar
Anand Khedkar
Madhav Kulkarni
Shrikumar Suryanarayan
Madhavan Sridharan
Poorpanapranja Acharaya
Ganesh Samvasivam
Ramakrishnan Melarkode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocon Ltd
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Application granted granted Critical
Publication of DE69928002D1 publication Critical patent/DE69928002D1/de
Publication of DE69928002T2 publication Critical patent/DE69928002T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69928002T 1998-12-09 1999-12-09 Verfahren zur herstellung von mycophenolatestern Expired - Lifetime DE69928002T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
INMA275498 1998-12-09
IN2754MA1998 IN188985B (de) 1998-12-09 1998-12-09
PCT/IN1999/000070 WO2000034503A2 (en) 1998-12-09 1999-12-09 Methods of producing esters of mycophenolate

Publications (2)

Publication Number Publication Date
DE69928002D1 true DE69928002D1 (de) 2005-12-01
DE69928002T2 DE69928002T2 (de) 2006-07-27

Family

ID=11096895

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928002T Expired - Lifetime DE69928002T2 (de) 1998-12-09 1999-12-09 Verfahren zur herstellung von mycophenolatestern

Country Status (10)

Country Link
US (1) US6709846B1 (de)
EP (1) EP1137795B1 (de)
AT (1) ATE307892T1 (de)
AU (1) AU3073200A (de)
CA (1) CA2354554C (de)
DE (1) DE69928002T2 (de)
DK (1) DK1137795T3 (de)
ES (1) ES2252995T3 (de)
IN (1) IN188985B (de)
WO (1) WO2000034503A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042393A1 (en) * 2001-11-16 2003-05-22 Biocon Limited Enzymatic preparation of mycophenolate mofetil
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
ES2308226T3 (es) * 2003-09-11 2008-12-01 Sandoz Ag Proceso para la produccion de micofenolato mofetil.
WO2005105768A2 (en) * 2004-04-26 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolic acid and ester derivatives thereof
WO2005105769A2 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg - Mycophenolate mofetil impurity
CA2573781A1 (en) * 2004-07-20 2006-02-02 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Processes for preparation of crystalline mycophenolate sodium
ITMI20041703A1 (it) * 2004-09-03 2004-12-03 Poli Ind Chimica Spa Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN1328272C (zh) * 2005-08-22 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产霉酚酸莫啡酯的方法
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753935A (en) 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
DK0724581T3 (da) 1993-09-15 1999-08-02 Syntex Inc Krystallinsk vandfri mycophenolatmofetil og intravenøs formulering deraf

Also Published As

Publication number Publication date
WO2000034503A2 (en) 2000-06-15
CA2354554A1 (en) 2000-06-15
CA2354554C (en) 2010-05-25
DK1137795T3 (da) 2006-03-20
WO2000034503A3 (en) 2000-08-17
US6709846B1 (en) 2004-03-23
ES2252995T3 (es) 2006-05-16
AU3073200A (en) 2000-06-26
EP1137795A2 (de) 2001-10-04
DE69928002T2 (de) 2006-07-27
EP1137795B1 (de) 2005-10-26
ATE307892T1 (de) 2005-11-15
IN188985B (de) 2002-11-30

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