DK1137795T3 - Fremgangsmåder til fremstilling af estere af mycophenolat - Google Patents

Fremgangsmåder til fremstilling af estere af mycophenolat

Info

Publication number
DK1137795T3
DK1137795T3 DK99964770T DK99964770T DK1137795T3 DK 1137795 T3 DK1137795 T3 DK 1137795T3 DK 99964770 T DK99964770 T DK 99964770T DK 99964770 T DK99964770 T DK 99964770T DK 1137795 T3 DK1137795 T3 DK 1137795T3
Authority
DK
Denmark
Prior art keywords
mycophenolate
methods
esters
preparation
mycophenolic acid
Prior art date
Application number
DK99964770T
Other languages
English (en)
Inventor
Anindya Sircar
Anand Khedkar
Madhav Kulkarni
Shrikumar Suryanarayan
Madhavan Sridharan
Poorpanapranja Acharaya
Ganesh Samvasivam
Ramakrishnan Melarkode
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Application granted granted Critical
Publication of DK1137795T3 publication Critical patent/DK1137795T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK99964770T 1998-12-09 1999-12-09 Fremgangsmåder til fremstilling af estere af mycophenolat DK1137795T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2754MA1998 IN188985B (da) 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
DK1137795T3 true DK1137795T3 (da) 2006-03-20

Family

ID=11096895

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964770T DK1137795T3 (da) 1998-12-09 1999-12-09 Fremgangsmåder til fremstilling af estere af mycophenolat

Country Status (10)

Country Link
US (1) US6709846B1 (da)
EP (1) EP1137795B1 (da)
AT (1) ATE307892T1 (da)
AU (1) AU3073200A (da)
CA (1) CA2354554C (da)
DE (1) DE69928002T2 (da)
DK (1) DK1137795T3 (da)
ES (1) ES2252995T3 (da)
IN (1) IN188985B (da)
WO (1) WO2000034503A2 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042393A1 (en) * 2001-11-16 2003-05-22 Biocon Limited Enzymatic preparation of mycophenolate mofetil
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
EP1667987B1 (en) * 2003-09-11 2008-07-23 Sandoz AG Process for the production of mycophenolate mofetil
US7683188B2 (en) 2004-04-26 2010-03-23 TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság Process for preparation of mycophenolic acid and ester derivatives thereof
CA2555454C (en) * 2004-04-27 2009-12-15 Sandor Molnar Mycophenolate mofetil impurity
CN101014584A (zh) * 2004-07-20 2007-08-08 特瓦药厂私人有限公司 结晶霉酚酸钠的制备方法
ITMI20041703A1 (it) * 2004-09-03 2004-12-03 Poli Ind Chimica Spa Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN1328272C (zh) * 2005-08-22 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产霉酚酸莫啡酯的方法
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753935A (en) 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US5247083A (en) 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
CZ292423B6 (cs) * 1993-09-15 2003-09-17 Syntex (U.S.A.) Inc. Krystalický, bezvodý mykofenolát mofetilu a intravenózní prostředek, ve kterém je obsažen

Also Published As

Publication number Publication date
IN188985B (da) 2002-11-30
US6709846B1 (en) 2004-03-23
CA2354554A1 (en) 2000-06-15
AU3073200A (en) 2000-06-26
ES2252995T3 (es) 2006-05-16
WO2000034503A3 (en) 2000-08-17
WO2000034503A2 (en) 2000-06-15
CA2354554C (en) 2010-05-25
ATE307892T1 (de) 2005-11-15
EP1137795B1 (en) 2005-10-26
DE69928002D1 (de) 2005-12-01
EP1137795A2 (en) 2001-10-04
DE69928002T2 (de) 2006-07-27

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