DK1109831T3 - Cytotoksiske peptider modificeret ved store eller lipofile dele - Google Patents

Cytotoksiske peptider modificeret ved store eller lipofile dele

Info

Publication number
DK1109831T3
DK1109831T3 DK99941773.6T DK99941773T DK1109831T3 DK 1109831 T3 DK1109831 T3 DK 1109831T3 DK 99941773 T DK99941773 T DK 99941773T DK 1109831 T3 DK1109831 T3 DK 1109831T3
Authority
DK
Denmark
Prior art keywords
lipophilic moieties
peptides modified
cytotoxic peptides
well
cytotoxic
Prior art date
Application number
DK99941773.6T
Other languages
Danish (da)
English (en)
Inventor
John Sigurd Svendsen
Oeystein Rekdal
Baldur Sveinbjoernsson
Lars Vorland
Original Assignee
Lytix Biopharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lytix Biopharma As filed Critical Lytix Biopharma As
Application granted granted Critical
Publication of DK1109831T3 publication Critical patent/DK1109831T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK99941773.6T 1998-08-28 1999-08-31 Cytotoksiske peptider modificeret ved store eller lipofile dele DK1109831T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9818938.4A GB9818938D0 (en) 1998-08-28 1998-08-28 Bioactive peptides
PCT/GB1999/002850 WO2000012541A2 (en) 1998-08-28 1999-08-31 Cytotoxic peptides modified by bulky or lipophilic moieties

Publications (1)

Publication Number Publication Date
DK1109831T3 true DK1109831T3 (da) 2011-04-18

Family

ID=10838089

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99941773.6T DK1109831T3 (da) 1998-08-28 1999-08-31 Cytotoksiske peptider modificeret ved store eller lipofile dele

Country Status (12)

Country Link
US (3) US6890902B2 (https=)
EP (2) EP1109827B1 (https=)
JP (1) JP5475937B2 (https=)
AT (2) ATE513847T1 (https=)
AU (2) AU5526899A (https=)
CA (2) CA2340326A1 (https=)
DE (1) DE69943130D1 (https=)
DK (1) DK1109831T3 (https=)
ES (1) ES2359616T3 (https=)
GB (1) GB9818938D0 (https=)
NO (1) NO333073B1 (https=)
WO (2) WO2000012541A2 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0605685D0 (en) * 2006-03-21 2006-05-03 Lytix Biopharma As Inhibition of tumour growth
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
GB0005702D0 (en) * 2000-03-09 2000-05-03 Alpharma As Method
GB0005703D0 (en) 2000-03-09 2000-05-03 Alpharma As Compounds
KR20020080731A (ko) * 2001-04-17 2002-10-26 주식회사 이지바이오 시스템 락토페리신 유전자 및 이를 도입한 락토페리신 발현용형질전환체
KR100454595B1 (ko) * 2001-11-30 2004-10-28 주식회사 이지바이오 시스템 락토페리신 유전자 및 이를 도입한 형질전환 대장균
SE0200598D0 (sv) * 2002-02-27 2002-02-27 A & Science Invest Ab Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences
CN100467059C (zh) 2002-05-10 2009-03-11 阿根尼克斯有限公司 乳铁蛋白在治疗恶性肿瘤疾病中的用途
CA2490290A1 (en) * 2002-06-28 2004-01-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins
NO20031818D0 (no) * 2003-04-23 2003-04-23 Uni I Tromsoe Fremgangsmåte av bioaktiv peptid forberedelse
US8105615B2 (en) * 2003-06-06 2012-01-31 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
CA2533753C (en) * 2004-03-19 2012-10-16 Morinaga Milk Industry Co., Ltd. Drug for cancer therapy
US8202841B2 (en) * 2004-06-17 2012-06-19 Mannkind Corporation SSX-2 peptide analogs
US8034762B2 (en) * 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
WO2006054908A1 (en) * 2004-11-19 2006-05-26 Fonterra Corporate Research And Development Limited Methods of immune or haematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
WO2007055578A1 (en) * 2005-11-11 2007-05-18 Leids Universitair Medisch Centrum Cyclic antimicrobial peptides derived from lactoferrin
PL1966240T6 (pl) 2005-12-30 2012-05-31 Evonik Roehm Gmbh Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkę
ES2321358B1 (es) * 2006-04-05 2010-03-05 Consejo Susperior De Investigaciones Cientificas Uso de peptidos derivados de la lactoferrina para preparar formulaciones inhibidoras de la enzima conversora de angiotensina i.
JP2009535027A (ja) * 2006-04-27 2009-10-01 シンガポール ヘルス サービシーズ ピーティーイー リミテッド 抗菌ペプチド
US7960339B2 (en) 2006-07-10 2011-06-14 Österreichische Akademie der Wissenschaften Antimicrobial peptides
GB0821616D0 (en) 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
EP2754450A1 (en) * 2013-01-11 2014-07-16 Österreichische Akademie der Wissenschaften Lactoferricin derived peptides
GB201401877D0 (en) 2014-02-04 2014-03-19 Univ Tromsoe Peptides
CN106794218A (zh) * 2014-10-08 2017-05-31 学校法人庆应义塾 白细胞的细胞外诱捕网形成抑制剂
ITUB20153058A1 (it) * 2015-08-11 2017-02-11 Farmagens Health Care S R L Roma ?frammento di lattoferrina per uso come agente antibatterico ed antivirale?
US11213512B2 (en) 2016-06-21 2022-01-04 The Curators Of The University Of Missouri Bis-amino acid based compound and use thereof
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US11364275B2 (en) 2017-08-04 2022-06-21 Bioventures, Llc Linear lipopeptide paenipeptins and methods of using the same
US11236138B2 (en) * 2020-01-14 2022-02-01 Renorigin Innovation Institute Co., Ltd. Peptide, method and composition for melanin polymerization and hair darkening
CN115073352A (zh) * 2022-06-28 2022-09-20 吉尔多肽生物制药(大连市)有限公司 一种2,5,7-三叔丁基色氨酸的合成方法
CN121086066A (zh) * 2024-12-19 2025-12-09 合肥工业大学 牛乳铁蛋白多肽及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141581A (en) * 1972-10-08 1992-08-25 Markham Harold A Implants with a cover which resists formation of firm spherical encapsulation
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
DK167813B1 (da) 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
NZ241936A (en) * 1991-03-13 1994-03-25 Morinaga Milk Industry Co Ltd Antimicrobial peptide and its use in an antimicrobial composition
CA2111214A1 (en) * 1991-06-12 1992-12-23 W. Lee Maloy Composition and treatment with biologically active peptides having c-terminal substitutions
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US5631228A (en) * 1991-11-01 1997-05-20 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
DK0629347T3 (da) 1992-01-23 1998-02-16 Morinaga Milk Industry Co Ltd Antibakterielt middel og behandling af genstande dermed
EP0644769A4 (en) * 1992-06-01 1995-08-09 Magainin Pharma BIOLOGICALLY ACTIVE PEPTIDES WITH N-TERMINAL SUBSTITUTIONS.
AU673190B2 (en) * 1992-07-13 1996-10-31 Bionebraska, Inc. Method for modification of recombinant polypeptides
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
WO1994012206A1 (en) 1992-12-03 1994-06-09 Magainin Pharmaceuticals, Inc. Treatment of dermatological malignancies with biologically active peptides
JP3312946B2 (ja) * 1993-03-04 2002-08-12 雪印乳業株式会社 ウイルス感染・増殖抑制剤
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
WO1998006425A1 (en) * 1996-08-12 1998-02-19 A+ Science Invest Ab Treatment and prevention of infections, inflammations and/or tumours with lactoferrin and/or lactoferricin
CA2262429A1 (en) * 1996-08-14 1998-02-19 Novartis Ag Peptide with inhibitory activity towards plant pathogenic fungi
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
WO1998040091A1 (en) * 1997-03-13 1998-09-17 The Research Foundation Of State University Of New York Microbicidal peptides and methods of use
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides

Also Published As

Publication number Publication date
JP5475937B2 (ja) 2014-04-16
EP1109831A2 (en) 2001-06-27
US20080287346A1 (en) 2008-11-20
US20030148936A1 (en) 2003-08-07
ATE495192T1 (de) 2011-01-15
NO20010995D0 (no) 2001-02-27
EP1109831B1 (en) 2011-01-12
JP2002523517A (ja) 2002-07-30
WO2000012541A2 (en) 2000-03-09
NO20010995L (no) 2001-04-27
WO2000012541A3 (en) 2000-06-08
US7439228B2 (en) 2008-10-21
AU772176B2 (en) 2004-04-08
CA2340326A1 (en) 2000-03-09
NO333073B1 (no) 2013-02-25
WO2000012542A3 (en) 2000-06-29
ATE513847T1 (de) 2011-07-15
EP1109827B1 (en) 2011-06-22
GB9818938D0 (en) 1998-10-21
AU5526899A (en) 2000-03-21
DE69943130D1 (de) 2011-02-24
ES2359616T3 (es) 2011-05-25
US6890902B2 (en) 2005-05-10
EP1109827A2 (en) 2001-06-27
CA2341037A1 (en) 2000-03-09
AU5526799A (en) 2000-03-21
CA2341037C (en) 2013-11-05
US8143211B2 (en) 2012-03-27
US20030022821A1 (en) 2003-01-30
WO2000012542A2 (en) 2000-03-09

Similar Documents

Publication Publication Date Title
DK1109831T3 (da) Cytotoksiske peptider modificeret ved store eller lipofile dele
PT1086124E (pt) Ciclosporinas novas
MY121908A (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them.
HUP0004310A3 (en) Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents
BR9807076B1 (pt) "uso de acetato de glatirâmero para a fabricação de medicamento para o tratamento de esclerose múltipla e composição farmacêutica"
DK0528312T3 (da) Cykliske peptider og anvendelse deraf
HUP0102579A2 (hu) Antiangiogén hatású peptid gyógyszervegyületek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
DE69709407D1 (de) Zytotoxischer aminozucker und verwandte zuckerderivate von indolopyrrolocarbazolen
BR0300709A (pt) Sal de perindopril e as composições farmacêuticas contendo o mesmo
DE69900756D1 (de) Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung
DK1313440T3 (da) Dentalprodukter indeholdende knoglevækstforögende peptider
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
KR950032165A (ko) 토코페롤 유도체
FR2741076B1 (fr) Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
MXPA01011955A (es) Aminoacidos policiclicos, fusionados, como agentes farmaceuticos.
FR2766489B1 (fr) Derives de streptogramines, leur preparation et les compositions qui les contiennent
TR200002652T2 (tr) Bir tetrapeptidin hazırlanması için işlem
ATE283276T1 (de) Deoxyhypusin reagenz und peptide
AR018328A1 (es) Forma cristalina de la 1s-[1 alfa(2s*,3r*), 9 alfa-]-6,10-dioxo-n-(2-etoxi-5-oxo-tetrahidro-3-furanil)-9-[[(1-isoquinolil)carbonil]amino]octahidro-6-h-piridazino[1,2-a][1,2] diazepina-1-carboxamida, su procedimiento de preparacion , su aplicacion en la preparacion de un medicamento, y las composicio
SE9704835D0 (sv) New compound
TH27915B (th) การปรับปรุงความสามารถที่จะทนทานได้ของกรด(สูตร)- อะมิโนที่ออกฤทธิ์ทางเภสัชกรรม