AU772176B2 - Bioactive peptides - Google Patents
Bioactive peptides Download PDFInfo
- Publication number
- AU772176B2 AU772176B2 AU55267/99A AU5526799A AU772176B2 AU 772176 B2 AU772176 B2 AU 772176B2 AU 55267/99 A AU55267/99 A AU 55267/99A AU 5526799 A AU5526799 A AU 5526799A AU 772176 B2 AU772176 B2 AU 772176B2
- Authority
- AU
- Australia
- Prior art keywords
- peptide
- lfb
- peptides
- amino acid
- pmc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
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- 102000040430 polynucleotide Human genes 0.000 description 1
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- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
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- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 230000036303 septic shock Effects 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- JMHCCAYJTTWMCX-QWPJCUCISA-M sodium;(2s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate;pentahydrate Chemical compound O.O.O.O.O.[Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 JMHCCAYJTTWMCX-QWPJCUCISA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- ZNVGYHOBTCWGTO-UHFFFAOYSA-N solutin Natural products Cc1cc(O)cc2OC(C)(O)C(=O)c12 ZNVGYHOBTCWGTO-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
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- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
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- 230000009385 viral infection Effects 0.000 description 1
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- 238000010626 work up procedure Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9818938.4A GB9818938D0 (en) | 1998-08-28 | 1998-08-28 | Bioactive peptides |
| GB9818938 | 1998-08-28 | ||
| PCT/GB1999/002850 WO2000012541A2 (en) | 1998-08-28 | 1999-08-31 | Cytotoxic peptides modified by bulky or lipophilic moieties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5526799A AU5526799A (en) | 2000-03-21 |
| AU772176B2 true AU772176B2 (en) | 2004-04-08 |
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| AU55267/99A Ceased AU772176B2 (en) | 1998-08-28 | 1999-08-31 | Bioactive peptides |
| AU55268/99A Abandoned AU5526899A (en) | 1998-08-28 | 1999-08-31 | Bioactive peptides |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU55268/99A Abandoned AU5526899A (en) | 1998-08-28 | 1999-08-31 | Bioactive peptides |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6890902B2 (https=) |
| EP (2) | EP1109831B1 (https=) |
| JP (1) | JP5475937B2 (https=) |
| AT (2) | ATE495192T1 (https=) |
| AU (2) | AU772176B2 (https=) |
| CA (2) | CA2341037C (https=) |
| DE (1) | DE69943130D1 (https=) |
| DK (1) | DK1109831T3 (https=) |
| ES (1) | ES2359616T3 (https=) |
| GB (1) | GB9818938D0 (https=) |
| NO (1) | NO333073B1 (https=) |
| WO (2) | WO2000012542A2 (https=) |
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| GB9818938D0 (en) | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
| GB0605685D0 (en) * | 2006-03-21 | 2006-05-03 | Lytix Biopharma As | Inhibition of tumour growth |
| US8283315B2 (en) | 1998-08-28 | 2012-10-09 | Lytix Biopharma As | Inhibition of tumour growth |
| US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| GB0005702D0 (en) * | 2000-03-09 | 2000-05-03 | Alpharma As | Method |
| GB0005703D0 (en) | 2000-03-09 | 2000-05-03 | Alpharma As | Compounds |
| KR20020080731A (ko) * | 2001-04-17 | 2002-10-26 | 주식회사 이지바이오 시스템 | 락토페리신 유전자 및 이를 도입한 락토페리신 발현용형질전환체 |
| KR100454595B1 (ko) | 2001-11-30 | 2004-10-28 | 주식회사 이지바이오 시스템 | 락토페리신 유전자 및 이를 도입한 형질전환 대장균 |
| SE0200598D0 (sv) * | 2002-02-27 | 2002-02-27 | A & Science Invest Ab | Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences |
| AU2003239393A1 (en) | 2002-05-10 | 2003-11-11 | Agennix Incorporated | Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| US7541139B2 (en) * | 2002-06-28 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins |
| NO20031818D0 (no) * | 2003-04-23 | 2003-04-23 | Uni I Tromsoe | Fremgangsmåte av bioaktiv peptid forberedelse |
| WO2005046571A2 (en) * | 2003-06-06 | 2005-05-26 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| KR100773259B1 (ko) | 2004-03-19 | 2007-11-05 | 모리나가 뉴교 가부시키가이샤 | 암치료를 위한 약제 |
| CA2571168A1 (en) * | 2004-06-17 | 2006-01-26 | Mannkind Corporation | Mhc i-binding ssx-241-49 variants |
| US8034762B2 (en) * | 2004-09-02 | 2011-10-11 | Cognosci, Inc. | Treatment of subarachnoid hemorrhage with Apo E analogs |
| WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
| NZ555134A (en) * | 2004-11-19 | 2010-07-30 | Fonterra Co Operative Group | Methods of immune or haematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer |
| DE102005051366A1 (de) * | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
| WO2007055578A1 (en) * | 2005-11-11 | 2007-05-18 | Leids Universitair Medisch Centrum | Cyclic antimicrobial peptides derived from lactoferrin |
| ATE501169T1 (de) | 2005-12-30 | 2011-03-15 | Evonik Roehm Gmbh | Lactoferrin-peptide, geeignet als in die zelle eindringende peptide |
| ES2321358B1 (es) * | 2006-04-05 | 2010-03-05 | Consejo Susperior De Investigaciones Cientificas | Uso de peptidos derivados de la lactoferrina para preparar formulaciones inhibidoras de la enzima conversora de angiotensina i. |
| JP2009535027A (ja) * | 2006-04-27 | 2009-10-01 | シンガポール ヘルス サービシーズ ピーティーイー リミテッド | 抗菌ペプチド |
| AU2007272272B2 (en) | 2006-07-10 | 2012-04-12 | Pba3 Biomed Gmbh | Antimicrobial peptides |
| GB0821616D0 (en) | 2008-11-26 | 2008-12-31 | Lytix Biopharma As | Compounds |
| EP2754450A1 (en) * | 2013-01-11 | 2014-07-16 | Österreichische Akademie der Wissenschaften | Lactoferricin derived peptides |
| GB201401877D0 (en) | 2014-02-04 | 2014-03-19 | Univ Tromsoe | Peptides |
| JPWO2016056665A1 (ja) * | 2014-10-08 | 2017-08-10 | 学校法人慶應義塾 | 白血球の細胞外トラップ形成の阻害剤 |
| ITUB20153058A1 (it) * | 2015-08-11 | 2017-02-11 | Farmagens Health Care S R L Roma | ?frammento di lattoferrina per uso come agente antibatterico ed antivirale? |
| WO2017223098A1 (en) * | 2016-06-21 | 2017-12-28 | The Curators Of The University Of Missouri | Bis-amino acid based compound and use thereof |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| CA3071836A1 (en) | 2017-08-04 | 2019-02-07 | Bioventures, Llc | Linear lipopeptide paenipeptins and methods of using the same |
| US11236138B2 (en) * | 2020-01-14 | 2022-02-01 | Renorigin Innovation Institute Co., Ltd. | Peptide, method and composition for melanin polymerization and hair darkening |
| CN115073352A (zh) * | 2022-06-28 | 2022-09-20 | 吉尔多肽生物制药(大连市)有限公司 | 一种2,5,7-三叔丁基色氨酸的合成方法 |
| CN119859181B (zh) * | 2024-12-19 | 2025-10-17 | 合肥工业大学 | 牛乳铁蛋白多肽及其应用 |
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| WO1993024138A1 (en) * | 1992-06-01 | 1993-12-09 | Magainin Pharmaceuticals, Inc. | Biologically active peptides having n-terminal substitutions |
| WO1996040770A2 (en) * | 1995-06-07 | 1996-12-19 | Periodontix, Inc. | Anti-fungal d-amino acid histatin-based peptides |
| WO1998040091A1 (en) * | 1997-03-13 | 1998-09-17 | The Research Foundation Of State University Of New York | Microbicidal peptides and methods of use |
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| US5141581A (en) * | 1972-10-08 | 1992-08-25 | Markham Harold A | Implants with a cover which resists formation of firm spherical encapsulation |
| US4476116A (en) * | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
| US5073542A (en) | 1989-06-07 | 1991-12-17 | Magainin Sciences Inc. | CPF peptide compositions and their use in inhibiting growth of target cells or a virus |
| DK167813B1 (da) * | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| US5141851A (en) | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| JP2818056B2 (ja) * | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
| DE69220397T2 (de) * | 1991-03-13 | 1997-10-02 | Morinaga Milk Industry Co Ltd | Antimikrobielles Peptid und antimikrobieller Wirkstoff |
| JPH06511234A (ja) * | 1991-06-12 | 1994-12-15 | マゲイニン ファーマス−ティカルズ，インコーポレーテッド | Ｃ末端置換を有する生物活性ペプチド組成物および治療法 |
| US5547939A (en) * | 1991-06-14 | 1996-08-20 | The Regents Of The University Of California | Broad spectrum antimicrobial compounds and methods of use |
| US5631228A (en) * | 1991-11-01 | 1997-05-20 | Periodontix, Inc. | Anti-fungal and anti-bacterial histatin-based peptides |
| EP0629347B1 (en) | 1992-01-23 | 1997-07-02 | Morinaga Milk Industry Co., Ltd. | Antibacterial agent and treatment of article therewith |
| JPH07509128A (ja) * | 1992-07-13 | 1995-10-12 | バイオネブラスカ・インコーポレーテッド | 組換型ポリペプチドの修飾方法 |
| US5593866A (en) | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
| AU5743194A (en) | 1992-12-03 | 1994-06-22 | Magainin Pharmaceuticals, Inc. | Treatment of dermatological malignancies with biologically active peptides |
| JP3312946B2 (ja) * | 1993-03-04 | 2002-08-12 | 雪印乳業株式会社 | ウイルス感染・増殖抑制剤 |
| US5789542A (en) * | 1994-04-22 | 1998-08-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Amphipathic peptides |
| WO1998006425A1 (en) * | 1996-08-12 | 1998-02-19 | A+ Science Invest Ab | Treatment and prevention of infections, inflammations and/or tumours with lactoferrin and/or lactoferricin |
| KR20000029948A (ko) * | 1996-08-14 | 2000-05-25 | 한스 루돌프 하우스;헨리테 브룬너;베아트리체 귄터 | 식물병원성진균에대해억제활성을갖는펩타이드 |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| GB9818938D0 (en) | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
-
1998
- 1998-08-28 GB GBGB9818938.4A patent/GB9818938D0/en not_active Ceased
-
1999
- 1999-08-31 AU AU55267/99A patent/AU772176B2/en not_active Ceased
- 1999-08-31 AT AT99941773T patent/ATE495192T1/de active
- 1999-08-31 DE DE69943130T patent/DE69943130D1/de not_active Expired - Lifetime
- 1999-08-31 EP EP99941773A patent/EP1109831B1/en not_active Expired - Lifetime
- 1999-08-31 CA CA2341037A patent/CA2341037C/en not_active Expired - Fee Related
- 1999-08-31 WO PCT/GB1999/002851 patent/WO2000012542A2/en not_active Ceased
- 1999-08-31 ES ES99941773T patent/ES2359616T3/es not_active Expired - Lifetime
- 1999-08-31 WO PCT/GB1999/002850 patent/WO2000012541A2/en not_active Ceased
- 1999-08-31 JP JP2000567559A patent/JP5475937B2/ja not_active Expired - Fee Related
- 1999-08-31 EP EP99941774A patent/EP1109827B1/en not_active Expired - Lifetime
- 1999-08-31 AT AT99941774T patent/ATE513847T1/de not_active IP Right Cessation
- 1999-08-31 DK DK99941773.6T patent/DK1109831T3/da active
- 1999-08-31 CA CA002340326A patent/CA2340326A1/en not_active Abandoned
- 1999-08-31 AU AU55268/99A patent/AU5526899A/en not_active Abandoned
-
2001
- 2001-02-27 NO NO20010995A patent/NO333073B1/no not_active IP Right Cessation
- 2001-02-27 US US09/798,869 patent/US6890902B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/798,026 patent/US7439228B2/en not_active Expired - Fee Related
-
2008
- 2008-07-02 US US12/217,160 patent/US8143211B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024138A1 (en) * | 1992-06-01 | 1993-12-09 | Magainin Pharmaceuticals, Inc. | Biologically active peptides having n-terminal substitutions |
| WO1996040770A2 (en) * | 1995-06-07 | 1996-12-19 | Periodontix, Inc. | Anti-fungal d-amino acid histatin-based peptides |
| WO1998040091A1 (en) * | 1997-03-13 | 1998-09-17 | The Research Foundation Of State University Of New York | Microbicidal peptides and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| DK1109831T3 (da) | 2011-04-18 |
| US7439228B2 (en) | 2008-10-21 |
| US6890902B2 (en) | 2005-05-10 |
| CA2341037A1 (en) | 2000-03-09 |
| JP2002523517A (ja) | 2002-07-30 |
| NO20010995D0 (no) | 2001-02-27 |
| ATE513847T1 (de) | 2011-07-15 |
| AU5526899A (en) | 2000-03-21 |
| JP5475937B2 (ja) | 2014-04-16 |
| ES2359616T3 (es) | 2011-05-25 |
| WO2000012541A2 (en) | 2000-03-09 |
| DE69943130D1 (de) | 2011-02-24 |
| US20030148936A1 (en) | 2003-08-07 |
| AU5526799A (en) | 2000-03-21 |
| US20030022821A1 (en) | 2003-01-30 |
| EP1109831A2 (en) | 2001-06-27 |
| CA2340326A1 (en) | 2000-03-09 |
| GB9818938D0 (en) | 1998-10-21 |
| EP1109831B1 (en) | 2011-01-12 |
| WO2000012542A3 (en) | 2000-06-29 |
| CA2341037C (en) | 2013-11-05 |
| NO333073B1 (no) | 2013-02-25 |
| WO2000012542A2 (en) | 2000-03-09 |
| NO20010995L (no) | 2001-04-27 |
| EP1109827B1 (en) | 2011-06-22 |
| WO2000012541A3 (en) | 2000-06-08 |
| ATE495192T1 (de) | 2011-01-15 |
| US20080287346A1 (en) | 2008-11-20 |
| EP1109827A2 (en) | 2001-06-27 |
| US8143211B2 (en) | 2012-03-27 |
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| FGA | Letters patent sealed or granted (standard patent) |