DK1102592T3 - Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser - Google Patents
Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelserInfo
- Publication number
- DK1102592T3 DK1102592T3 DK99933882T DK99933882T DK1102592T3 DK 1102592 T3 DK1102592 T3 DK 1102592T3 DK 99933882 T DK99933882 T DK 99933882T DK 99933882 T DK99933882 T DK 99933882T DK 1102592 T3 DK1102592 T3 DK 1102592T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- zero
- moiety
- alkyls
- polymeric
- Prior art date
Links
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title 2
- 150000001491 aromatic compounds Chemical class 0.000 title 1
- 229960000956 coumarin Drugs 0.000 title 1
- 235000001671 coumarin Nutrition 0.000 title 1
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 2
- -1 C3-8 Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- JXASPPWQHFOWPL-UHFFFAOYSA-N Tamarixin Natural products C1=C(O)C(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 JXASPPWQHFOWPL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 239000003574 free electron Substances 0.000 abstract 1
- 125000004405 heteroalkoxy group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/114,860 US6214330B1 (en) | 1998-07-13 | 1998-07-13 | Coumarin and related aromatic-based polymeric prodrugs |
| PCT/US1999/015652 WO2000002568A1 (en) | 1998-07-13 | 1999-07-12 | Coumarin and related aromatic-based polymeric prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1102592T3 true DK1102592T3 (da) | 2004-08-16 |
Family
ID=22357836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99933882T DK1102592T3 (da) | 1998-07-13 | 1999-07-12 | Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6214330B1 (enExample) |
| EP (1) | EP1102592B1 (enExample) |
| JP (1) | JP4999226B2 (enExample) |
| AT (1) | ATE266424T1 (enExample) |
| AU (1) | AU4983999A (enExample) |
| CA (1) | CA2336663C (enExample) |
| DE (1) | DE69917281T2 (enExample) |
| DK (1) | DK1102592T3 (enExample) |
| WO (1) | WO2000002568A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1863510A (zh) | 2003-08-13 | 2006-11-15 | 比奥孔有限公司 | 用于治疗剂的微－粒子脂肪酸盐固体剂量制剂 |
| WO2005047245A2 (en) * | 2003-11-14 | 2005-05-26 | Wisconsin Alumni Research Foundation | Fluorescence assays with improved blocking groups |
| EP1734988A4 (en) * | 2004-03-01 | 2009-08-05 | Enzon Pharmaceuticals Inc | INTERFERON BETA-polymer |
| JP2007533750A (ja) * | 2004-04-21 | 2007-11-22 | アルザ コーポレイション | 緩和なチオール分解条件下で遊離可能なポリマー結合体 |
| AU2005238015A1 (en) * | 2004-04-21 | 2005-11-10 | Alza Corporation | Polymer conjugate releasable under mild thiolytic conditions |
| US8367065B2 (en) * | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| AU2007296056B2 (en) * | 2006-09-15 | 2012-09-13 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| US20090017004A1 (en) * | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery systems containing an aromatic allylic acid |
| CN101939023B (zh) | 2007-10-16 | 2016-08-03 | 百康有限公司 | 可经口给药的固体药物组合物及其方法 |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| KR102645430B1 (ko) | 2013-10-15 | 2024-03-11 | 씨젠 인크. | 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| CN108367043A (zh) | 2015-12-04 | 2018-08-03 | 西雅图基因公司 | 季铵化的微管溶素化合物的缀合物 |
| KR20180134351A (ko) | 2016-03-25 | 2018-12-18 | 시애틀 지네틱스, 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| JPH09504033A (ja) * | 1993-10-20 | 1997-04-22 | エンゾン，インコーポレーテッド | ２’−及び／又は７−置換タキソイド類 |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| EP0751144B1 (en) | 1995-06-27 | 2004-10-06 | Pharmachemie B.V. | Novel anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy |
| JPH1087815A (ja) * | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
| CA2264227A1 (en) | 1996-09-27 | 1998-04-02 | Raymond A. Firestone | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
-
1998
- 1998-07-13 US US09/114,860 patent/US6214330B1/en not_active Expired - Lifetime
-
1999
- 1999-07-12 CA CA002336663A patent/CA2336663C/en not_active Expired - Fee Related
- 1999-07-12 EP EP99933882A patent/EP1102592B1/en not_active Expired - Lifetime
- 1999-07-12 WO PCT/US1999/015652 patent/WO2000002568A1/en not_active Ceased
- 1999-07-12 AT AT99933882T patent/ATE266424T1/de not_active IP Right Cessation
- 1999-07-12 AU AU49839/99A patent/AU4983999A/en not_active Abandoned
- 1999-07-12 DK DK99933882T patent/DK1102592T3/da active
- 1999-07-12 JP JP2000558827A patent/JP4999226B2/ja not_active Expired - Fee Related
- 1999-07-12 DE DE69917281T patent/DE69917281T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2336663C (en) | 2009-10-20 |
| DE69917281T2 (de) | 2005-06-30 |
| AU4983999A (en) | 2000-02-01 |
| US6214330B1 (en) | 2001-04-10 |
| EP1102592B1 (en) | 2004-05-12 |
| EP1102592A1 (en) | 2001-05-30 |
| DE69917281D1 (de) | 2004-06-17 |
| EP1102592A4 (en) | 2001-12-19 |
| ATE266424T1 (de) | 2004-05-15 |
| JP4999226B2 (ja) | 2012-08-15 |
| CA2336663A1 (en) | 2000-01-20 |
| WO2000002568A1 (en) | 2000-01-20 |
| JP2002520288A (ja) | 2002-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1102592T3 (da) | Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser | |
| AU2021299A (en) | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents | |
| TW377370B (en) | Waterborne fluoropolymer solutions for treating hard surfaces | |
| BR9813480A (pt) | Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza- | |
| ES2062395T3 (es) | Nuevos compuestos de bencimidazol y su uso. | |
| DE60015606D1 (de) | Zusammensetzungen, enthaltend aminische antioxidantien auf basis von n-(4-anilinophenyl)amiden | |
| DE60031577D1 (de) | Hemmer der zelladhäsion | |
| ES445075A1 (es) | Un procedimiento para la preparacion de nuevos acidos fenoxi-alquil-carboxilicos. | |
| KR927003520A (ko) | 펩티딜(peptidyl) 유도체 | |
| NO20005714D0 (no) | Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem | |
| EP0709373A4 (en) | NEW PYRROLIDINE DERIVATIVE | |
| NZ505968A (en) | Sulfonylamino derivatives which inhibit matrix- degrading metallproteinases | |
| GB2303851A (en) | Pharmaceutical diketopiperazine compounds | |
| ATE439147T1 (de) | Prodrugs von krebsmitteln mit substituierten aromatischen säuren | |
| DK340081A (da) | Polyesteramider og deres anvendelse til kloebning af organiske og uorganiske substrater | |
| AR037342A1 (es) | Sulfonamidas ciclicas, inhibidores del factor xa de la coagulacion | |
| DK623486A (da) | Guanidinobenzoesyreesterderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne | |
| CO5060509A1 (es) | 2-aminopiridinas que contienen sustituyentes de anillos condensados | |
| NO20052598L (no) | Nye 2,3-dihydro-4(1H)-pyridonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem. | |
| DK0420803T3 (da) | Benzo-1,2,3-thiadiazol-derivater og deres anvendelse til beskyttelse af planter mod sygdomme | |
| EP0399953A3 (en) | Piperidine-triazine compounds for use as stabilizers for organic materials | |
| ES2156099T1 (es) | Metodo para tratar sustratos metalicos usando polieteres derivados de mannich. | |
| DE60008362D1 (en) | 3-bicycloaryl-2-aminomethyl bicycloalkane als serotoniner reuptake inhibitor | |
| DE60221250D1 (de) | Bis(5-aryl-2-pyridyl)derivate | |
| LU72450A1 (enExample) |