DE69917281T2 - Coumarin und damit verwandte aromatische polymere prodrugs - Google Patents
Coumarin und damit verwandte aromatische polymere prodrugs Download PDFInfo
- Publication number
- DE69917281T2 DE69917281T2 DE69917281T DE69917281T DE69917281T2 DE 69917281 T2 DE69917281 T2 DE 69917281T2 DE 69917281 T DE69917281 T DE 69917281T DE 69917281 T DE69917281 T DE 69917281T DE 69917281 T2 DE69917281 T2 DE 69917281T2
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- Germany
- Prior art keywords
- substituted
- group
- alkyl
- compound according
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229920000642 polymer Polymers 0.000 title claims abstract description 56
- 239000000651 prodrug Substances 0.000 title claims abstract description 46
- 229940002612 prodrug Drugs 0.000 title claims abstract description 46
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title description 20
- 229960000956 coumarin Drugs 0.000 title description 10
- 235000001671 coumarin Nutrition 0.000 title description 10
- -1 C3-8 Chemical group 0.000 claims abstract description 45
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 39
- 150000001412 amines Chemical class 0.000 claims abstract description 26
- 125000003118 aryl group Chemical group 0.000 claims abstract description 26
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims abstract description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 24
- 239000001257 hydrogen Substances 0.000 claims abstract description 22
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- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 18
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 16
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract description 14
- 125000002252 acyl group Chemical group 0.000 claims abstract description 12
- 125000004181 carboxyalkyl group Chemical group 0.000 claims abstract description 12
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract description 10
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- 125000000623 heterocyclic group Chemical class 0.000 claims abstract description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US114860 | 1998-07-13 | ||
| US09/114,860 US6214330B1 (en) | 1998-07-13 | 1998-07-13 | Coumarin and related aromatic-based polymeric prodrugs |
| PCT/US1999/015652 WO2000002568A1 (en) | 1998-07-13 | 1999-07-12 | Coumarin and related aromatic-based polymeric prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69917281D1 DE69917281D1 (de) | 2004-06-17 |
| DE69917281T2 true DE69917281T2 (de) | 2005-06-30 |
Family
ID=22357836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69917281T Expired - Lifetime DE69917281T2 (de) | 1998-07-13 | 1999-07-12 | Coumarin und damit verwandte aromatische polymere prodrugs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6214330B1 (enExample) |
| EP (1) | EP1102592B1 (enExample) |
| JP (1) | JP4999226B2 (enExample) |
| AT (1) | ATE266424T1 (enExample) |
| AU (1) | AU4983999A (enExample) |
| CA (1) | CA2336663C (enExample) |
| DE (1) | DE69917281T2 (enExample) |
| DK (1) | DK1102592T3 (enExample) |
| WO (1) | WO2000002568A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005016312A1 (en) | 2003-08-13 | 2005-02-24 | Nobex Corporation | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
| US7534902B2 (en) * | 2003-11-14 | 2009-05-19 | Wisconsin Alumni Research Foundation | Fluorescence assays with improved sensitivity |
| CA2556339A1 (en) * | 2004-03-01 | 2005-09-15 | David Ray Filpula | Interferon-beta polymer conjugates |
| JP2007533750A (ja) * | 2004-04-21 | 2007-11-22 | アルザ コーポレイション | 緩和なチオール分解条件下で遊離可能なポリマー結合体 |
| US20050265925A1 (en) * | 2004-04-21 | 2005-12-01 | Samuel Zalipsky | Releasable linkage and compositions containing same |
| CN101541332A (zh) * | 2006-09-15 | 2009-09-23 | 安佐制药股份有限公司 | 含多官能连接基的靶向聚合物前药 |
| US8367065B2 (en) * | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| WO2009009716A1 (en) * | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery systems containing an aromatic allylic acid |
| KR101234540B1 (ko) | 2007-10-16 | 2013-02-19 | 바이오콘 리미티드 | 경구 투여가능한 고형 약제학적 조성물 및 그 제조방법 |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| BR112016007622A2 (pt) | 2013-10-15 | 2018-01-23 | Seattle Genetics, Inc. | composto, composição farmacêutica, conjugado de ligante-droga, e, método para tratar câncer |
| SG11201804268RA (en) | 2015-12-04 | 2018-06-28 | Seattle Genetics Inc | Conjugates of quaternized tubulysin compounds |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| BR112018069273A2 (pt) | 2016-03-25 | 2019-01-22 | Seattle Genetics Inc | métodos para preparação de um composto e para tratamento de um indivíduo com uma malignidade hematológica, composto, composição, e, intermediário ligante de fármaco ou composto ligante de fármaco |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| US5622986A (en) * | 1993-10-20 | 1997-04-22 | Enzon, Inc. | 2'-and/or 7-substituted taxanes |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| ATE278700T1 (de) | 1995-06-27 | 2004-10-15 | Pharmachemie Bv | Anthracyclin prodrugs, verfahren zu deren herstellung und deren verwendung in der selektiven chemotherapie |
| JPH1087815A (ja) * | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
| AU739028B2 (en) | 1996-09-27 | 2001-10-04 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
-
1998
- 1998-07-13 US US09/114,860 patent/US6214330B1/en not_active Expired - Lifetime
-
1999
- 1999-07-12 AU AU49839/99A patent/AU4983999A/en not_active Abandoned
- 1999-07-12 EP EP99933882A patent/EP1102592B1/en not_active Expired - Lifetime
- 1999-07-12 CA CA002336663A patent/CA2336663C/en not_active Expired - Fee Related
- 1999-07-12 AT AT99933882T patent/ATE266424T1/de not_active IP Right Cessation
- 1999-07-12 JP JP2000558827A patent/JP4999226B2/ja not_active Expired - Fee Related
- 1999-07-12 WO PCT/US1999/015652 patent/WO2000002568A1/en not_active Ceased
- 1999-07-12 DE DE69917281T patent/DE69917281T2/de not_active Expired - Lifetime
- 1999-07-12 DK DK99933882T patent/DK1102592T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| US6214330B1 (en) | 2001-04-10 |
| DK1102592T3 (da) | 2004-08-16 |
| CA2336663A1 (en) | 2000-01-20 |
| EP1102592A4 (en) | 2001-12-19 |
| CA2336663C (en) | 2009-10-20 |
| DE69917281D1 (de) | 2004-06-17 |
| EP1102592A1 (en) | 2001-05-30 |
| JP2002520288A (ja) | 2002-07-09 |
| AU4983999A (en) | 2000-02-01 |
| JP4999226B2 (ja) | 2012-08-15 |
| EP1102592B1 (en) | 2004-05-12 |
| WO2000002568A1 (en) | 2000-01-20 |
| ATE266424T1 (de) | 2004-05-15 |
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