DE69917281D1 - Coumarin und damit verwandte aromatische polymere prodrugs - Google Patents

Coumarin und damit verwandte aromatische polymere prodrugs

Info

Publication number
DE69917281D1
DE69917281D1 DE69917281T DE69917281T DE69917281D1 DE 69917281 D1 DE69917281 D1 DE 69917281D1 DE 69917281 T DE69917281 T DE 69917281T DE 69917281 T DE69917281 T DE 69917281T DE 69917281 D1 DE69917281 D1 DE 69917281D1
Authority
DE
Germany
Prior art keywords
substituted
prodrugs
zero
moiety
alkyls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69917281T
Other languages
English (en)
Other versions
DE69917281T2 (de
Inventor
B Greenwald
H Choe
Annapurna Pendri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of DE69917281D1 publication Critical patent/DE69917281D1/de
Application granted granted Critical
Publication of DE69917281T2 publication Critical patent/DE69917281T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69917281T 1998-07-13 1999-07-12 Coumarin und damit verwandte aromatische polymere prodrugs Expired - Lifetime DE69917281T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/114,860 US6214330B1 (en) 1998-07-13 1998-07-13 Coumarin and related aromatic-based polymeric prodrugs
US114860 1998-07-13
PCT/US1999/015652 WO2000002568A1 (en) 1998-07-13 1999-07-12 Coumarin and related aromatic-based polymeric prodrugs

Publications (2)

Publication Number Publication Date
DE69917281D1 true DE69917281D1 (de) 2004-06-17
DE69917281T2 DE69917281T2 (de) 2005-06-30

Family

ID=22357836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69917281T Expired - Lifetime DE69917281T2 (de) 1998-07-13 1999-07-12 Coumarin und damit verwandte aromatische polymere prodrugs

Country Status (9)

Country Link
US (1) US6214330B1 (de)
EP (1) EP1102592B1 (de)
JP (1) JP4999226B2 (de)
AT (1) ATE266424T1 (de)
AU (1) AU4983999A (de)
CA (1) CA2336663C (de)
DE (1) DE69917281T2 (de)
DK (1) DK1102592T3 (de)
WO (1) WO2000002568A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1660047E (pt) 2003-08-13 2014-02-27 Biocon Ltd Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos
US7534902B2 (en) * 2003-11-14 2009-05-19 Wisconsin Alumni Research Foundation Fluorescence assays with improved sensitivity
US20090214472A1 (en) * 2004-03-01 2009-08-27 Enzon Pharmaceuticals Inc. Interferon-beta polymer conjugates
US20050265925A1 (en) * 2004-04-21 2005-12-01 Samuel Zalipsky Releasable linkage and compositions containing same
JP2007533750A (ja) * 2004-04-21 2007-11-22 アルザ コーポレイション 緩和なチオール分解条件下で遊離可能なポリマー結合体
RU2009114154A (ru) * 2006-09-15 2010-10-20 Энзон Фармасьютикалз, Инк. (Us) Полимерные пролекарства с направленной доставкой, содержащие полифункциональные линкеры
US8367065B2 (en) * 2006-09-15 2013-02-05 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2009009716A1 (en) * 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery systems containing an aromatic allylic acid
EP2203181B1 (de) 2007-10-16 2018-02-14 Biocon Limited Oral zu verabreichende feste pharmazeutische zusammensetzung und verfahren dafür
US20100227327A1 (en) * 2008-08-08 2010-09-09 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
US20100036110A1 (en) * 2008-08-08 2010-02-11 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
KR20240034882A (ko) 2013-10-15 2024-03-14 씨젠 인크. 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커
EP4074328A1 (de) 2015-12-04 2022-10-19 Seagen Inc. Intermediate von konjugaten quaternierter tubulysinverbindungen
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
EP3433278A4 (de) 2016-03-25 2019-11-06 Seattle Genetics, Inc. Verfahren zur herstellung von pegylierten wirkstoff-linkern und zwischenprodukten davon
US11730822B2 (en) 2017-03-24 2023-08-22 Seagen Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
FR2676058B1 (fr) 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
US5622986A (en) * 1993-10-20 1997-04-22 Enzon, Inc. 2'-and/or 7-substituted taxanes
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
DE69533615T2 (de) 1995-06-27 2005-10-13 Pharmachemie B.V. Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie
JPH1087815A (ja) * 1996-08-22 1998-04-07 Enzon Inc ポリアルキレンオキシドカルボン酸の改良製造方法
EP0961619A4 (de) 1996-09-27 2001-09-26 Bristol Myers Squibb Co Hydrolisierbare prodrugs zur verabreichung von wirkstoffen gegen krebs an metastatische zellen

Also Published As

Publication number Publication date
ATE266424T1 (de) 2004-05-15
AU4983999A (en) 2000-02-01
EP1102592A1 (de) 2001-05-30
EP1102592A4 (de) 2001-12-19
WO2000002568A1 (en) 2000-01-20
JP2002520288A (ja) 2002-07-09
EP1102592B1 (de) 2004-05-12
CA2336663C (en) 2009-10-20
DK1102592T3 (da) 2004-08-16
JP4999226B2 (ja) 2012-08-15
US6214330B1 (en) 2001-04-10
DE69917281T2 (de) 2005-06-30
CA2336663A1 (en) 2000-01-20

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