JP4999226B2 - クマリン及び関連芳香族系ポリマープロドラッグ - Google Patents
クマリン及び関連芳香族系ポリマープロドラッグ Download PDFInfo
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- JP4999226B2 JP4999226B2 JP2000558827A JP2000558827A JP4999226B2 JP 4999226 B2 JP4999226 B2 JP 4999226B2 JP 2000558827 A JP2000558827 A JP 2000558827A JP 2000558827 A JP2000558827 A JP 2000558827A JP 4999226 B2 JP4999226 B2 JP 4999226B2
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- aryl
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| US7534902B2 (en) * | 2003-11-14 | 2009-05-19 | Wisconsin Alumni Research Foundation | Fluorescence assays with improved sensitivity |
| US20090214472A1 (en) * | 2004-03-01 | 2009-08-27 | Enzon Pharmaceuticals Inc. | Interferon-beta polymer conjugates |
| JP2007533750A (ja) * | 2004-04-21 | 2007-11-22 | アルザ コーポレイション | 緩和なチオール分解条件下で遊離可能なポリマー結合体 |
| MXPA06012144A (es) * | 2004-04-21 | 2007-01-31 | Alza Corp | Conjugado polimerico liberable bajo condiciones tioliticas suaves. |
| US8367065B2 (en) * | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| JP2010503708A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | 多官能性リンカーを含む標的化ポリマープロドラッグ |
| CA2693645A1 (en) * | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery systems containing an aromatic allylic acid |
| BRPI0818004B8 (pt) | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| JP6747971B2 (ja) | 2013-10-15 | 2020-08-26 | シアトル ジェネティックス， インコーポレイテッド | 改善されたリガンド−薬物コンジュゲート薬物動態のためのｐｅｇ化薬物−リンカー |
| US11229708B2 (en) | 2015-12-04 | 2022-01-25 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
| CN110430901B (zh) | 2017-03-24 | 2024-08-16 | 西雅图基因公司 | 制备葡糖苷酸药物-接头及其中间体的方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1087815A (ja) * | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| EP0727992A4 (en) * | 1993-10-20 | 2001-01-31 | Enzon Inc | SUBSTITUTED TAXOID SUBSTANCES IN 2 'AND / OR 7' POSITION |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| ES2227536T3 (es) | 1995-06-27 | 2005-04-01 | Pharmachemie B.V. | Nuevos profarmacos de antraciclina, procedimiento de preparacion asi como su uso en quimioterapia selectiva. |
| EP0961619A4 (en) | 1996-09-27 | 2001-09-26 | Bristol Myers Squibb Co | HYDROLYSABLE DRUGS FOR THE RELEASE OF ANTI-CANCER DRUGS IN METASTATIC CELLS |
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- 1999-07-12 DK DK99933882T patent/DK1102592T3/da active
- 1999-07-12 DE DE69917281T patent/DE69917281T2/de not_active Expired - Lifetime
- 1999-07-12 AT AT99933882T patent/ATE266424T1/de not_active IP Right Cessation
- 1999-07-12 JP JP2000558827A patent/JP4999226B2/ja not_active Expired - Fee Related
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- 1999-07-12 EP EP99933882A patent/EP1102592B1/en not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH1087815A (ja) * | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002520288A (ja) | 2002-07-09 |
| AU4983999A (en) | 2000-02-01 |
| EP1102592A1 (en) | 2001-05-30 |
| WO2000002568A1 (en) | 2000-01-20 |
| CA2336663C (en) | 2009-10-20 |
| CA2336663A1 (en) | 2000-01-20 |
| US6214330B1 (en) | 2001-04-10 |
| ATE266424T1 (de) | 2004-05-15 |
| DE69917281D1 (de) | 2004-06-17 |
| DE69917281T2 (de) | 2005-06-30 |
| DK1102592T3 (da) | 2004-08-16 |
| EP1102592A4 (en) | 2001-12-19 |
| EP1102592B1 (en) | 2004-05-12 |
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