DK1078081T3 - Fremgangsmåde til fremstilling af heterologe polypeptider i trichothecen deficiente filamentöse svampe mutantceller - Google Patents
Fremgangsmåde til fremstilling af heterologe polypeptider i trichothecen deficiente filamentöse svampe mutantcellerInfo
- Publication number
- DK1078081T3 DK1078081T3 DK99925717T DK99925717T DK1078081T3 DK 1078081 T3 DK1078081 T3 DK 1078081T3 DK 99925717 T DK99925717 T DK 99925717T DK 99925717 T DK99925717 T DK 99925717T DK 1078081 T3 DK1078081 T3 DK 1078081T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- filamentous fungal
- mutant
- cells
- trichothecene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
- C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03006—Trichodiene synthase (4.2.3.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8221798A | 1998-05-20 | 1998-05-20 | |
PCT/US1999/011223 WO1999060137A2 (en) | 1998-05-20 | 1999-05-20 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1078081T3 true DK1078081T3 (da) | 2008-08-04 |
Family
ID=22169802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99925717T DK1078081T3 (da) | 1998-05-20 | 1999-05-20 | Fremgangsmåde til fremstilling af heterologe polypeptider i trichothecen deficiente filamentöse svampe mutantceller |
Country Status (9)
Country | Link |
---|---|
US (3) | US6180366B1 (de) |
EP (1) | EP1078081B1 (de) |
JP (2) | JP2002515253A (de) |
CN (2) | CN1190495C (de) |
AT (1) | ATE395424T1 (de) |
AU (1) | AU4195099A (de) |
DE (1) | DE69938722D1 (de) |
DK (1) | DK1078081T3 (de) |
WO (1) | WO1999060137A2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060305A (en) * | 1994-06-30 | 2000-05-09 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system |
AU760408B2 (en) * | 1998-04-27 | 2003-05-15 | Surmodics, Inc. | Bioactive agent release coating |
DE69938722D1 (de) * | 1998-05-20 | 2008-06-26 | Novozymes Inc | Verfahren zur herstellung von heterologen polypeptiden in trichothecene mangelmutanten filamentlösen pilzen |
FR2826978B1 (fr) * | 2001-07-06 | 2004-09-17 | Agronomique Inst Nat Rech | Procede de determination de la capacite de fusarium a produire des toxines trichotecenes |
AU2003231028A1 (en) * | 2002-04-22 | 2003-11-03 | Novozymes Biotech, Inc. | Methods for increasing homologous recombination of a nucleic acid sequence |
EP1539926A1 (de) * | 2002-08-30 | 2005-06-15 | Puratos Naamloze Vennootschap | Transformations- und expressionssystem für myrothecium sp. |
ATE439432T1 (de) | 2002-08-30 | 2009-08-15 | Novozymes Inc | Verfahren zur herstellung von säugetier-trypsinen |
CN100480391C (zh) | 2002-11-18 | 2009-04-22 | 诺维信股份有限公司 | 用于在真菌细胞中表达基因的启动子变体 |
EP2010559A1 (de) * | 2006-04-25 | 2009-01-07 | DSM IP Assets B.V. | Produktion von verbindungen in einem rekombinanten wirt |
KR20090017608A (ko) * | 2006-05-18 | 2009-02-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 상부 가열수단이 상대적으로 작은 수평 토스트 장치 |
CN102227502B (zh) | 2008-09-30 | 2016-01-13 | 诺维信股份有限公司 | 在镶片镰孢的酶缺陷突变体中产生多肽的方法 |
US20100316764A1 (en) * | 2009-06-10 | 2010-12-16 | Engrain, LLC | Flour supplement compositions and methods for preparing wheat flour |
CN102695787A (zh) * | 2009-08-05 | 2012-09-26 | 诺维信公司 | 用于从木素纤维素原料产生trichodiene的丝状真菌和方法 |
MX350399B (es) | 2009-12-18 | 2017-09-06 | Novozymes Inc | Metodos para producir polipeptidos en mutantes de trichoderma deficientes en proteasa. |
CN108588060B (zh) * | 2017-03-07 | 2020-12-01 | 武汉康复得生物科技股份有限公司 | 一种用丝状真菌宿主细胞表达的重组草酸脱羧酶 |
JP2021078354A (ja) * | 2018-03-08 | 2021-05-27 | 有限会社アルティザイム・インターナショナル | フラビンアデニンジヌクレオチドグルコース脱水素酵素とシトクロム分子との融合タンパク質 |
CN112522231B (zh) * | 2020-12-14 | 2023-03-14 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种酰基转移酶及其编码基因和应用 |
WO2023088791A1 (en) | 2021-11-22 | 2023-05-25 | Basf Se | Paenibacillus strains producing low amounts of dab comprising compounds. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8904762D0 (en) * | 1989-03-02 | 1989-04-12 | Glaxo Group Ltd | Biological process |
EP0777737B1 (de) * | 1994-06-30 | 2005-05-04 | Novozymes Biotech, Inc. | Nicht-toxisches, nicht-toxigenes, nicht-pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren |
US5594119A (en) * | 1994-09-20 | 1997-01-14 | Novo Nordisk A/S | Gene encoding carboxypeptidase of aspergillus niger |
TW555853B (en) * | 1996-03-11 | 2003-10-01 | Meiji Seika Kaisha | Recombinant beta-fructofuranosidase, its gene and preparation |
DE69938722D1 (de) * | 1998-05-20 | 2008-06-26 | Novozymes Inc | Verfahren zur herstellung von heterologen polypeptiden in trichothecene mangelmutanten filamentlösen pilzen |
US6383781B1 (en) * | 1998-12-23 | 2002-05-07 | Novozymes A/S | Methods for producing polypeptides in aspergillus mutant cells |
-
1999
- 1999-05-20 DE DE69938722T patent/DE69938722D1/de not_active Expired - Lifetime
- 1999-05-20 US US09/316,080 patent/US6180366B1/en not_active Expired - Lifetime
- 1999-05-20 JP JP2000549743A patent/JP2002515253A/ja active Pending
- 1999-05-20 EP EP99925717A patent/EP1078081B1/de not_active Expired - Lifetime
- 1999-05-20 CN CNB998081124A patent/CN1190495C/zh not_active Expired - Fee Related
- 1999-05-20 AT AT99925717T patent/ATE395424T1/de not_active IP Right Cessation
- 1999-05-20 AU AU41950/99A patent/AU4195099A/en not_active Abandoned
- 1999-05-20 CN CNB031588026A patent/CN1231579C/zh not_active Expired - Fee Related
- 1999-05-20 DK DK99925717T patent/DK1078081T3/da active
- 1999-05-20 WO PCT/US1999/011223 patent/WO1999060137A2/en active Application Filing
-
2005
- 2005-03-31 US US11/095,491 patent/US7332341B2/en not_active Expired - Fee Related
-
2008
- 2008-01-31 US US12/023,417 patent/US20080213901A1/en not_active Abandoned
-
2009
- 2009-08-19 JP JP2009190191A patent/JP2009291207A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1309711A (zh) | 2001-08-22 |
CN1190495C (zh) | 2005-02-23 |
EP1078081A2 (de) | 2001-02-28 |
CN1231579C (zh) | 2005-12-14 |
US20050181480A1 (en) | 2005-08-18 |
US20080213901A1 (en) | 2008-09-04 |
WO1999060137A2 (en) | 1999-11-25 |
EP1078081B1 (de) | 2008-05-14 |
JP2009291207A (ja) | 2009-12-17 |
DE69938722D1 (de) | 2008-06-26 |
AU4195099A (en) | 1999-12-06 |
JP2002515253A (ja) | 2002-05-28 |
WO1999060137A3 (en) | 2000-05-18 |
US7332341B2 (en) | 2008-02-19 |
CN1500882A (zh) | 2004-06-02 |
US6180366B1 (en) | 2001-01-30 |
ATE395424T1 (de) | 2008-05-15 |
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