DK1040106T3 - Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister - Google Patents

Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister

Info

Publication number
DK1040106T3
DK1040106T3 DK98963240T DK98963240T DK1040106T3 DK 1040106 T3 DK1040106 T3 DK 1040106T3 DK 98963240 T DK98963240 T DK 98963240T DK 98963240 T DK98963240 T DK 98963240T DK 1040106 T3 DK1040106 T3 DK 1040106T3
Authority
DK
Denmark
Prior art keywords
beta
carboxyl
chroman derivatives
adrenoreceptor agonists
substituted chroman
Prior art date
Application number
DK98963240T
Other languages
Danish (da)
English (en)
Inventor
Timothy G Lease
Jeremy Baryza
Richard D Connell
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK1040106T3 publication Critical patent/DK1040106T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK98963240T 1997-12-19 1998-12-16 Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister DK1040106T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99462097A 1997-12-19 1997-12-19
PCT/US1998/026735 WO1999032476A1 (fr) 1997-12-19 1998-12-16 Derives de chromanne a substitution carboxyle, utiles comme agonistes de l'adrenorecepteur beta-3

Publications (1)

Publication Number Publication Date
DK1040106T3 true DK1040106T3 (da) 2002-12-02

Family

ID=25540853

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963240T DK1040106T3 (da) 1997-12-19 1998-12-16 Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister

Country Status (24)

Country Link
EP (1) EP1040106B1 (fr)
JP (1) JP2001526282A (fr)
KR (1) KR20010033188A (fr)
CN (1) CN1284952A (fr)
AT (1) ATE222901T1 (fr)
AU (1) AU749097B2 (fr)
BG (1) BG104593A (fr)
BR (1) BR9814302A (fr)
CA (1) CA2316971A1 (fr)
DE (1) DE69807523T2 (fr)
DK (1) DK1040106T3 (fr)
ES (1) ES2183434T3 (fr)
HU (1) HUP0004565A3 (fr)
ID (1) ID26524A (fr)
IL (1) IL136689A0 (fr)
NO (1) NO20003083L (fr)
NZ (1) NZ505200A (fr)
PL (1) PL341229A1 (fr)
PT (1) PT1040106E (fr)
RU (1) RU2223269C2 (fr)
SK (1) SK9362000A3 (fr)
TR (1) TR200001927T2 (fr)
UA (1) UA62993C2 (fr)
WO (1) WO1999032476A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
JPWO2003033468A1 (ja) * 2001-10-17 2005-02-03 株式会社カネカ （Ｓ）−α−ハロメチルピリジンメタノール誘導体の製造方法
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
JP2008530229A (ja) 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
US7560575B2 (en) 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (fr) * 2005-12-28 2012-07-25 Acino Pharma AG Un procédé pour la préparation de nebivolol racémique
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (fr) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derives du 2,2'-imino-bis-ethanol
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
PL312005A1 (en) * 1993-06-14 1996-04-01 Pfizer Binary amines as antidiabetic and antiobesitic agents
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (fr) * 1996-04-09 1997-10-15 Pfizer Inc. Des agonistes bèta-3 adrénergiques hétérocycliques

Also Published As

Publication number Publication date
NO20003083L (no) 2000-08-15
HUP0004565A2 (hu) 2001-08-28
AU1830099A (en) 1999-07-12
DE69807523T2 (de) 2003-01-09
PT1040106E (pt) 2002-11-29
HUP0004565A3 (en) 2002-12-28
TR200001927T2 (tr) 2001-06-21
ID26524A (id) 2001-01-11
NO20003083D0 (no) 2000-06-15
AU749097B2 (en) 2002-06-20
BR9814302A (pt) 2000-10-10
EP1040106B1 (fr) 2002-08-28
JP2001526282A (ja) 2001-12-18
ATE222901T1 (de) 2002-09-15
IL136689A0 (en) 2001-06-14
BG104593A (en) 2001-09-28
RU2223269C2 (ru) 2004-02-10
PL341229A1 (en) 2001-03-26
NZ505200A (en) 2002-09-27
KR20010033188A (ko) 2001-04-25
UA62993C2 (en) 2004-01-15
EP1040106A1 (fr) 2000-10-04
DE69807523D1 (de) 2002-10-02
CN1284952A (zh) 2001-02-21
ES2183434T3 (es) 2003-03-16
CA2316971A1 (fr) 1999-07-01
WO1999032476A1 (fr) 1999-07-01
SK9362000A3 (en) 2001-09-11

Similar Documents

Publication Publication Date Title
TR200000927T2 (tr) Prostaglandin agonistleri ve kemik bozukluklarının tedavisi
YU7797A (sh) Kombinovana terapija za osteoporozu
BR9804437A (pt) Compostos para a osteoporose
CO4910163A1 (es) Prevencion de la perdida y restauracion de la masa osea por determinados agonistas de prostaglandinas
TR200100267T2 (tr) İkameli anilid bileşimleri ve yöntemler.
PA8459901A1 (es) Derivados de resorcinol
ES2184127T3 (es) Derivados de sulfamato anticonvulsivos utiles para el tratamiento de la obesidad.
BR9811099A (pt) Inibidores de urocinase
DE69840603D1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
AP9801269A0 (en) Prostaglandin agonists.
DE69531682D1 (de) Sterolderivate für die regulierung der meiose
DK1040106T3 (da) Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister
CY1105482T1 (el) Χρηση της αζιθρομυκινης στην τοπικη αγωγη οφθαλμικων μολυνσεων
DK1105114T3 (da) Nimesulidholdige topiske farmaceutiske sammensætninger
ES2156642T3 (es) Composicion que comprende un derivado de acido cinamico y un polimero poliaminado.
WO2002048134A3 (fr) Agonistes adrenorecepteurs beta-3 de derives chroman aminomethyl bi-substitues
SE9801494D0 (sv) Novel use
ATE402933T1 (de) Neue sulfonamid-substituierte chroman-derivate verwendbar als beta 3 adrenorezeptor agonisten
BR9913649A (pt) Rede anelar wdm
BR0007183A (pt) Isonipectoamidas para o tratamento de distúrbios mediados por integrina
AR013749A1 (es) Tratamiento de retinopatia diabetica
ES2127759T3 (es) Composiciones de detergentes.
BR9902081A (pt) Combinação de dofetilida e um bloqueador dos canais de cálcio
SI1040106T1 (en) Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
ECSP982554A (es) Agonistas de prostaglandinas