DE69807523D1 - Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten - Google Patents

Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten

Info

Publication number
DE69807523D1
DE69807523D1 DE69807523T DE69807523T DE69807523D1 DE 69807523 D1 DE69807523 D1 DE 69807523D1 DE 69807523 T DE69807523 T DE 69807523T DE 69807523 T DE69807523 T DE 69807523T DE 69807523 D1 DE69807523 D1 DE 69807523D1
Authority
DE
Germany
Prior art keywords
beta
adrenore
carboxyl
substituted
receptor agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69807523T
Other languages
English (en)
Other versions
DE69807523T2 (de
Inventor
D Connell
G Lease
Jeremy Baryza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69807523D1 publication Critical patent/DE69807523D1/de
Publication of DE69807523T2 publication Critical patent/DE69807523T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Detergent Compositions (AREA)
  • Pyrrole Compounds (AREA)
DE69807523T 1997-12-19 1998-12-16 Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten Expired - Fee Related DE69807523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99462097A 1997-12-19 1997-12-19
PCT/US1998/026735 WO1999032476A1 (en) 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

Publications (2)

Publication Number Publication Date
DE69807523D1 true DE69807523D1 (de) 2002-10-02
DE69807523T2 DE69807523T2 (de) 2003-01-09

Family

ID=25540853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69807523T Expired - Fee Related DE69807523T2 (de) 1997-12-19 1998-12-16 Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten

Country Status (24)

Country Link
EP (1) EP1040106B1 (de)
JP (1) JP2001526282A (de)
KR (1) KR20010033188A (de)
CN (1) CN1284952A (de)
AT (1) ATE222901T1 (de)
AU (1) AU749097B2 (de)
BG (1) BG104593A (de)
BR (1) BR9814302A (de)
CA (1) CA2316971A1 (de)
DE (1) DE69807523T2 (de)
DK (1) DK1040106T3 (de)
ES (1) ES2183434T3 (de)
HU (1) HUP0004565A3 (de)
ID (1) ID26524A (de)
IL (1) IL136689A0 (de)
NO (1) NO20003083L (de)
NZ (1) NZ505200A (de)
PL (1) PL341229A1 (de)
PT (1) PT1040106E (de)
RU (1) RU2223269C2 (de)
SK (1) SK9362000A3 (de)
TR (1) TR200001927T2 (de)
UA (1) UA62993C2 (de)
WO (1) WO1999032476A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
US20040265991A1 (en) * 2001-10-17 2004-12-30 Naoaki Taoka Process for preparation of (s)-alpha-halomethylpyridine-methanol derivatives
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2597616A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
EP1803716B1 (de) * 2005-12-28 2012-07-25 Acino Pharma AG Ein Verfahren zur Herstellung von racemischem Nebivolol
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
ATE154935T1 (de) * 1993-06-14 1997-07-15 Pfizer Zweite amine als antidiabetische mittel und für die behandlung von fettleibigkeit
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (de) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclische Beta-3 adrenergische Angonisten

Also Published As

Publication number Publication date
HUP0004565A3 (en) 2002-12-28
WO1999032476A1 (en) 1999-07-01
BG104593A (en) 2001-09-28
DE69807523T2 (de) 2003-01-09
SK9362000A3 (en) 2001-09-11
ES2183434T3 (es) 2003-03-16
DK1040106T3 (da) 2002-12-02
NO20003083D0 (no) 2000-06-15
PT1040106E (pt) 2002-11-29
NO20003083L (no) 2000-08-15
UA62993C2 (en) 2004-01-15
RU2223269C2 (ru) 2004-02-10
AU1830099A (en) 1999-07-12
AU749097B2 (en) 2002-06-20
EP1040106B1 (de) 2002-08-28
ATE222901T1 (de) 2002-09-15
CN1284952A (zh) 2001-02-21
NZ505200A (en) 2002-09-27
EP1040106A1 (de) 2000-10-04
IL136689A0 (en) 2001-06-14
KR20010033188A (ko) 2001-04-25
CA2316971A1 (en) 1999-07-01
TR200001927T2 (tr) 2001-06-21
HUP0004565A2 (hu) 2001-08-28
ID26524A (id) 2001-01-11
PL341229A1 (en) 2001-03-26
BR9814302A (pt) 2000-10-10
JP2001526282A (ja) 2001-12-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee