DK1040106T3 - Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister - Google Patents

Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister

Info

Publication number
DK1040106T3
DK1040106T3 DK98963240T DK98963240T DK1040106T3 DK 1040106 T3 DK1040106 T3 DK 1040106T3 DK 98963240 T DK98963240 T DK 98963240T DK 98963240 T DK98963240 T DK 98963240T DK 1040106 T3 DK1040106 T3 DK 1040106T3
Authority
DK
Denmark
Prior art keywords
beta
carboxyl
chroman derivatives
adrenoreceptor agonists
substituted chroman
Prior art date
Application number
DK98963240T
Other languages
Danish (da)
English (en)
Inventor
Timothy G Lease
Jeremy Baryza
Richard D Connell
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK1040106T3 publication Critical patent/DK1040106T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98963240T 1997-12-19 1998-12-16 Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister DK1040106T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99462097A 1997-12-19 1997-12-19
PCT/US1998/026735 WO1999032476A1 (en) 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

Publications (1)

Publication Number Publication Date
DK1040106T3 true DK1040106T3 (da) 2002-12-02

Family

ID=25540853

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963240T DK1040106T3 (da) 1997-12-19 1998-12-16 Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister

Country Status (24)

Country Link
EP (1) EP1040106B1 (de)
JP (1) JP2001526282A (de)
KR (1) KR20010033188A (de)
CN (1) CN1284952A (de)
AT (1) ATE222901T1 (de)
AU (1) AU749097B2 (de)
BG (1) BG104593A (de)
BR (1) BR9814302A (de)
CA (1) CA2316971A1 (de)
DE (1) DE69807523T2 (de)
DK (1) DK1040106T3 (de)
ES (1) ES2183434T3 (de)
HU (1) HUP0004565A3 (de)
ID (1) ID26524A (de)
IL (1) IL136689A0 (de)
NO (1) NO20003083L (de)
NZ (1) NZ505200A (de)
PL (1) PL341229A1 (de)
PT (1) PT1040106E (de)
RU (1) RU2223269C2 (de)
SK (1) SK9362000A3 (de)
TR (1) TR200001927T2 (de)
UA (1) UA62993C2 (de)
WO (1) WO1999032476A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035605A1 (es) * 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
US20040265991A1 (en) * 2001-10-17 2004-12-30 Naoaki Taoka Process for preparation of (s)-alpha-halomethylpyridine-methanol derivatives
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AU2006214233A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (de) * 2005-12-28 2012-07-25 Acino Pharma AG Ein Verfahren zur Herstellung von racemischem Nebivolol
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
ES2104383T3 (es) * 1993-06-14 1997-10-01 Pfizer Aminas secundarias como agentes antidiabeticos y antiobesidad.
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (de) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclische Beta-3 adrenergische Angonisten

Also Published As

Publication number Publication date
IL136689A0 (en) 2001-06-14
NO20003083L (no) 2000-08-15
BR9814302A (pt) 2000-10-10
HUP0004565A3 (en) 2002-12-28
DE69807523T2 (de) 2003-01-09
ID26524A (id) 2001-01-11
CN1284952A (zh) 2001-02-21
ATE222901T1 (de) 2002-09-15
PT1040106E (pt) 2002-11-29
SK9362000A3 (en) 2001-09-11
NZ505200A (en) 2002-09-27
WO1999032476A1 (en) 1999-07-01
EP1040106B1 (de) 2002-08-28
TR200001927T2 (tr) 2001-06-21
JP2001526282A (ja) 2001-12-18
KR20010033188A (ko) 2001-04-25
ES2183434T3 (es) 2003-03-16
RU2223269C2 (ru) 2004-02-10
EP1040106A1 (de) 2000-10-04
BG104593A (en) 2001-09-28
HUP0004565A2 (hu) 2001-08-28
AU1830099A (en) 1999-07-12
DE69807523D1 (de) 2002-10-02
CA2316971A1 (en) 1999-07-01
UA62993C2 (en) 2004-01-15
AU749097B2 (en) 2002-06-20
PL341229A1 (en) 2001-03-26
NO20003083D0 (no) 2000-06-15

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