DK1039908T3 - Præparat med indhold af en molekylær dispersion med forøget biotilgængelighed - Google Patents

Præparat med indhold af en molekylær dispersion med forøget biotilgængelighed

Info

Publication number
DK1039908T3
DK1039908T3 DK98963031T DK98963031T DK1039908T3 DK 1039908 T3 DK1039908 T3 DK 1039908T3 DK 98963031 T DK98963031 T DK 98963031T DK 98963031 T DK98963031 T DK 98963031T DK 1039908 T3 DK1039908 T3 DK 1039908T3
Authority
DK
Denmark
Prior art keywords
preparation containing
increased bioavailability
molecular dispersion
dispersion
molecular
Prior art date
Application number
DK98963031T
Other languages
Danish (da)
English (en)
Inventor
Surendra A Sangekar
Ping I Lee
Amin A Nomeir
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1039908T3 publication Critical patent/DK1039908T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98963031T 1997-12-22 1998-12-17 Præparat med indhold af en molekylær dispersion med forøget biotilgængelighed DK1039908T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99716897A 1997-12-22 1997-12-22
PCT/US1998/026218 WO1999032118A1 (en) 1997-12-22 1998-12-17 Molecular dispersion composition with enhanced bioavailability

Publications (1)

Publication Number Publication Date
DK1039908T3 true DK1039908T3 (da) 2004-05-03

Family

ID=25543717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963031T DK1039908T3 (da) 1997-12-22 1998-12-17 Præparat med indhold af en molekylær dispersion med forøget biotilgængelighed

Country Status (28)

Country Link
EP (1) EP1039908B1 (hu)
JP (2) JP2001526227A (hu)
KR (1) KR100597331B1 (hu)
CN (1) CN1116039C (hu)
AR (1) AR017436A1 (hu)
AT (1) ATE260105T1 (hu)
AU (1) AU761994C (hu)
BR (1) BR9813728A (hu)
CA (1) CA2315685C (hu)
CO (1) CO4970793A1 (hu)
CZ (1) CZ295956B6 (hu)
DE (1) DE69821984T2 (hu)
DK (1) DK1039908T3 (hu)
ES (1) ES2214757T3 (hu)
HK (1) HK1027040A1 (hu)
HU (1) HU229052B1 (hu)
ID (1) ID28304A (hu)
IL (1) IL136460A0 (hu)
MY (1) MY126580A (hu)
NO (1) NO327383B1 (hu)
NZ (1) NZ504834A (hu)
PE (1) PE20000012A1 (hu)
PL (1) PL192423B1 (hu)
PT (1) PT1039908E (hu)
SK (1) SK285662B6 (hu)
TW (1) TW527196B (hu)
WO (1) WO1999032118A1 (hu)
ZA (1) ZA9811592B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6316462B1 (en) * 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
ES2333645T3 (es) 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
MXPA04008536A (es) * 2002-03-04 2005-09-08 Teva Pharma Forma de dosificacion de liberacion controlada.
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
WO2008136394A1 (ja) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. ラクタム化合物の製造方法及びその製造中間体
US8835635B2 (en) * 2012-06-05 2014-09-16 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546577B2 (de) * 1975-10-17 1981-04-02 Sandoz-Patent-GmbH, 7850 Lörrach Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden
EP0214092A1 (en) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
WO1993011749A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company A process for the preparation of a solid dispersion
JPH0848632A (ja) * 1994-08-08 1996-02-20 Kanebo Ltd エトポシドを含有する固形組成物および固形製剤
KR100295224B1 (ko) * 1995-12-22 2001-09-17 둘락 노먼 씨. G-단백질기능의억제및증식성질환의치료에유용한트리사이클릭아미드
EP0954288B1 (en) * 1996-06-28 2004-08-11 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability

Also Published As

Publication number Publication date
AR017436A1 (es) 2001-09-05
CA2315685A1 (en) 1999-07-01
CA2315685C (en) 2008-02-05
EP1039908A1 (en) 2000-10-04
ATE260105T1 (de) 2004-03-15
AU761994C (en) 2004-01-08
NZ504834A (en) 2001-12-21
JP2010059212A (ja) 2010-03-18
ID28304A (id) 2001-05-10
WO1999032118A1 (en) 1999-07-01
MY126580A (en) 2006-10-31
DE69821984D1 (de) 2004-04-01
CN1116039C (zh) 2003-07-30
KR20010033397A (ko) 2001-04-25
DE69821984T2 (de) 2004-12-30
SK285662B6 (sk) 2007-05-03
AU1814399A (en) 1999-07-12
PL192423B1 (pl) 2006-10-31
TW527196B (en) 2003-04-11
HU229052B1 (en) 2013-07-29
CN1282245A (zh) 2001-01-31
NO20003235D0 (no) 2000-06-21
HUP0100850A2 (hu) 2001-10-28
CO4970793A1 (es) 2000-11-07
SK8962000A3 (en) 2001-07-10
ZA9811592B (en) 1999-06-17
JP2001526227A (ja) 2001-12-18
PE20000012A1 (es) 2000-01-18
CZ295956B6 (cs) 2005-12-14
IL136460A0 (en) 2001-06-14
AU761994B2 (en) 2003-06-12
HK1027040A1 (en) 2001-01-05
NO20003235L (no) 2000-07-27
KR100597331B1 (ko) 2006-07-10
BR9813728A (pt) 2000-10-10
CZ20002304A3 (cs) 2001-04-11
EP1039908B1 (en) 2004-02-25
HUP0100850A3 (en) 2002-12-28
PT1039908E (pt) 2004-06-30
NO327383B1 (no) 2009-06-22
PL341344A1 (en) 2001-04-09
ES2214757T3 (es) 2004-09-16

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