DK1027372T3 - Metoder, kits og sammensætninger vedrörende lineære ledemærker - Google Patents

Metoder, kits og sammensætninger vedrörende lineære ledemærker

Info

Publication number
DK1027372T3
DK1027372T3 DK98953983T DK98953983T DK1027372T3 DK 1027372 T3 DK1027372 T3 DK 1027372T3 DK 98953983 T DK98953983 T DK 98953983T DK 98953983 T DK98953983 T DK 98953983T DK 1027372 T3 DK1027372 T3 DK 1027372T3
Authority
DK
Denmark
Prior art keywords
kits
methods
probe
target sequence
linear
Prior art date
Application number
DK98953983T
Other languages
Danish (da)
English (en)
Inventor
Brian D Gildea
James M Coull
Jens J Hyldig-Nielsen
Mark J Fiandaca
Original Assignee
Boston Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Probes Inc filed Critical Boston Probes Inc
Application granted granted Critical
Publication of DK1027372T3 publication Critical patent/DK1027372T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Radio Relay Systems (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Packages (AREA)
  • Sealing Material Composition (AREA)
  • Polymerisation Methods In General (AREA)
DK98953983T 1997-10-27 1998-10-27 Metoder, kits og sammensætninger vedrörende lineære ledemærker DK1027372T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6328397P 1997-10-27 1997-10-27
US09/179,162 US6485901B1 (en) 1997-10-27 1998-10-26 Methods, kits and compositions pertaining to linear beacons
PCT/US1998/022630 WO1999021881A1 (en) 1997-10-27 1998-10-27 Methods, kits and compositions pertaining to linear beacons
EP98953983A EP1027372B1 (en) 1997-10-27 1998-10-27 Methods, kits and compositions pertaining to linear beacons

Publications (1)

Publication Number Publication Date
DK1027372T3 true DK1027372T3 (da) 2005-05-09

Family

ID=26743242

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98953983T DK1027372T3 (da) 1997-10-27 1998-10-27 Metoder, kits og sammensætninger vedrörende lineære ledemærker

Country Status (9)

Country Link
US (5) US6485901B1 (https=)
EP (2) EP1484337B1 (https=)
JP (2) JP4372341B2 (https=)
AT (2) ATE286066T1 (https=)
AU (1) AU1121499A (https=)
DE (2) DE69828432T2 (https=)
DK (1) DK1027372T3 (https=)
ES (1) ES2235375T3 (https=)
WO (1) WO1999021881A1 (https=)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485901B1 (en) * 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
WO1999055916A1 (en) 1998-04-29 1999-11-04 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
GB9815933D0 (en) 1998-07-23 1998-09-23 Secr Defence Detection method
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6692965B1 (en) * 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
US6579680B2 (en) 2000-02-28 2003-06-17 Corning Incorporated Method for label-free detection of hybridized DNA targets
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
CA2383939C (en) * 2000-06-27 2009-12-01 National Institute Of Advanced Industrial Science And Technology Novel nucleic acid probes, method for determining nucleic acids by using the probes, and method for analyzing data obtained by the method
ATE432994T1 (de) 2000-09-26 2009-06-15 Boston Probes Inc Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
EP1356113B1 (en) 2000-12-15 2012-07-18 Life Technologies Corporation Methods for determining organisms
CN100523216C (zh) * 2001-03-02 2009-08-05 匹兹堡大学 Pcr方法
AU2007200335B2 (en) * 2001-03-09 2009-01-22 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
EP1412517B1 (en) 2001-03-09 2006-11-29 Boston Probes, Inc. Methods, kits and compositions of combination oligomers
ATE527376T1 (de) 2001-05-18 2011-10-15 Boston Probes Inc Pna-sonden, sondensätze, verfahren und kits im zusammenhang mit dem nachweis von candida
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
EP1432826B1 (en) 2001-09-24 2012-12-12 Life Technologies Corporation Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
CA2462505A1 (en) * 2001-10-25 2003-05-15 Gorilla Genomics, Inc. Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons
WO2003080857A2 (en) * 2002-03-21 2003-10-02 Boston Probes,Inc. Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
EP1509624A2 (en) * 2002-05-31 2005-03-02 Secretary, Department Of Atomic Energy Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands
US20040137469A1 (en) 2002-09-08 2004-07-15 Casale Ralph A Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
AU2003275018B2 (en) * 2002-09-20 2009-10-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
US8323897B2 (en) 2002-12-04 2012-12-04 Applied Biosystems, Llc Multiplex amplification of polynucleotides
DE602004030114D1 (de) * 2003-05-20 2010-12-30 Investigen Inc System zum nachweis von polynukleotiden
EP1649066A4 (en) * 2003-07-11 2006-10-11 Surromed Inc MULTIPLEX ASSAY BASED ON MOLECULAR TAGS FOR THE DETECTION OF PATHOGENS
WO2005012571A1 (ja) * 2003-07-30 2005-02-10 The Circle For The Promotion Of Science And Engineering 部分二重鎖型核酸分子
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
WO2005028629A2 (en) * 2003-09-19 2005-03-31 Applera Corporation Whole genome expression analysis system
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
WO2005052193A2 (en) * 2003-11-19 2005-06-09 Applera Corporation Methods for determining the degradation state or concentration of nucleic acids
EP1689764B1 (en) * 2003-11-19 2013-01-02 AlleLogic Biosciences Corporation Oligonucleotides labeled with a plurality of fluorophores
KR20130082179A (ko) * 2004-02-18 2013-07-18 크로모셀 코포레이션 신호 프로브를 이용하는 방법 및 물질
WO2005085475A1 (en) 2004-03-01 2005-09-15 Applera Corporation Methods, compositions and kits for use in polynucleotide amplification
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
WO2006034387A1 (en) 2004-09-21 2006-03-30 Applera Corporation TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (miRNAs)
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
JP2008541698A (ja) * 2005-05-03 2008-11-27 アンサンブル ディスカバリー コーポレイション 核酸検出のためのターンオーバープローブおよびその使用
JP2008545659A (ja) 2005-05-20 2008-12-18 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド オリゴヌクレオチドを標識する化合物及び方法
JP5479731B2 (ja) 2005-06-02 2014-04-23 アドヴァンディーエックス，インコーポレイテッド 微生物を解析するためのペプチド核酸プローブ
WO2007106690A2 (en) 2006-03-15 2007-09-20 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
US8133984B2 (en) 2006-03-16 2012-03-13 Pentabase Aps Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids
US20080038783A1 (en) * 2006-06-29 2008-02-14 Applera Corporation Compositions and Methods Pertaining to Guanylation of PNA Oligomers
EP3305915B1 (en) 2006-08-01 2022-01-26 Applied Biosystems, LLC Detection of analytes and nucleic acids
EP2104734A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US9534255B2 (en) * 2008-12-17 2017-01-03 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
EP3249053A1 (en) 2009-03-27 2017-11-29 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
WO2010135692A2 (en) 2009-05-22 2010-11-25 Asuragen, Inc. Mirna biomarkers of prostate disease
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
EP2462515A4 (en) 2009-08-05 2015-08-12 Life Technologies Corp METHODS OF ANALYZING FIXING TEST DATA NEARBY
EP2470897A4 (en) 2009-08-28 2013-05-29 Asuragen Inc MICRO-RNA BIOMARKERS OF PULMONARY DISEASE
BR112012018394B8 (pt) * 2009-12-21 2021-07-27 Seegene Inc método para detecção de uma sequência de ácido nucleico alvo e kit para detecção de uma sequência de ácido nucleico alvo
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
EP2558971B1 (en) 2010-04-11 2021-02-17 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
US20110287425A1 (en) * 2010-05-14 2011-11-24 Kromatid, Inc. Assays to Detect Small-Scale Mutations in Individual Cells
EP2582850B1 (en) 2010-06-21 2016-11-09 Life Technologies Corporation Compositions, kits, and methods for synthesis and/or detection of nucleic acids
DK3109326T3 (da) 2010-06-21 2022-02-14 Life Technologies Corp Sammensætning og fremgangsmåde til nukleinsyresyntese og amplifikation under anvendelse af rt
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
AU2011319755B2 (en) 2010-10-27 2017-02-23 President And Fellows Of Harvard College Compositions of toehold primer duplexes and methods of use
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
US20130304390A1 (en) 2010-11-16 2013-11-14 Life Technologies Corporation Systems and Methods for the Analysis of Proximity Binding Assay Data
CN107326073A (zh) 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
EP3567121B1 (en) 2011-01-17 2023-08-30 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
CN103459598B (zh) 2011-02-03 2016-08-10 米尔纳医疗股份有限公司 Mir-124的合成模拟物
EP2694526A4 (en) * 2011-04-01 2015-04-22 Advandx Inc MOLECULAR GRAM STAINING
US20140170653A1 (en) 2011-04-15 2014-06-19 Life Technologies Corporation Chemical ligation
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
FI3461807T3 (fi) 2011-06-08 2023-09-07 Life Technologies Corp Uudenlaisten detergenttien suunnittelu ja kehitys pcr-järjestelmissä käyttöä varten
BR112013033488B8 (pt) 2011-06-27 2022-11-22 Eisai R&D Man Co Ltd Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit
HK1199066A1 (en) 2011-08-18 2015-06-19 Nestec S.A. Compositions and methods for detecting allelic variants
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130179086A1 (en) 2011-11-29 2013-07-11 Life Technologies Corporation Systems and methods for the determination of a copy number of a genomic sequence
US9127317B2 (en) 2012-03-02 2015-09-08 Winthrop-University Hospital Method for using probe based PCR detection to measure the levels of circulating demethylated β cell derived DNA as a measure of β cell loss in diabetes
KR20210072137A (ko) 2012-06-14 2021-06-16 라이프 테크놀로지스 코포레이션 폴리머라제 연쇄 반응 (pcr)을 위한 신규 조성물, 방법 및 키트
WO2014059011A1 (en) 2012-10-09 2014-04-17 Advandx, Inc. Devices, compositions and methods pertaining to microscopic analysis of microorganisms and other analytes of interest
WO2014071322A1 (en) 2012-11-02 2014-05-08 Life Technologies Corporation Small RNA Capture, Detection and Quantification
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
US11254977B2 (en) 2013-03-12 2022-02-22 Life Technologies Corporation Universal reporter-based genotyping methods and materials
WO2014144121A2 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Classification and actionability indices for lung cancer
US20150080239A1 (en) 2013-09-13 2015-03-19 Life Technologies Corporation Classification and Actionability Indices for Cancer
WO2014165710A2 (en) 2013-04-05 2014-10-09 Life Technologies Corporation Gene fusions
JP5928906B2 (ja) * 2013-08-27 2016-06-01 横河電機株式会社 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置
EP3539944A1 (en) 2013-10-25 2019-09-18 Life Technologies Corporation Novel compounds for use in pcr systems and applications thereof
CN106414764B (zh) * 2013-11-22 2020-10-30 欧雷恩诊断公司 通过基于链侵入的扩增的核酸检测
AU2014375224A1 (en) 2014-01-05 2016-07-28 Biomirna Holdings Ltd Lung cancer determinations using miRNA ratios
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
EP3122901B1 (en) 2014-03-27 2018-08-15 Life Technologies Corporation Gene fusions and gene variants associated with cancer
WO2015152446A1 (en) * 2014-04-04 2015-10-08 Panagene Inc. Melting curve analysis using PNA probe, Method and Kit for analyzing Nucleotide Polymorphism using melting curve analysis
WO2016027162A2 (en) 2014-08-19 2016-02-25 Tataa Biocenter Ab Methods and compositions for nucleic acid detection
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
WO2016092045A1 (en) 2014-12-11 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting medically refractory acute severe colitis
ES2891085T3 (es) 2015-01-30 2022-01-26 Harvard College Obtención de imágenes sin microscopio
WO2016177774A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Method of quantifying mirnas using normalization
CN116949140A (zh) 2016-02-17 2023-10-27 哈佛学院院长及董事 分子编程工具
WO2017177025A1 (en) 2016-04-06 2017-10-12 Life Technologies Corporation Compositions, methods, and kits for synthesis and detection of nucleic acids
EP3472349A1 (en) 2016-06-16 2019-04-24 Life Technologies Corporation Novel compositions, methods and kits for microorganism detection
CN118207299A (zh) 2016-08-26 2024-06-18 生命技术公司 核酸提取和扩增对照及其使用方法
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
EP3568492B1 (en) 2017-01-10 2025-01-01 President and Fellows of Harvard College Multiplexed signal amplification
CN111527216A (zh) 2017-11-13 2020-08-11 生命技术公司 用于尿路微生物检测的组合物、方法和试剂盒
CN111630179B (zh) 2018-01-26 2024-07-19 哈佛学院院长及董事 邻近检测方法和组合物
CN112602153A (zh) 2018-08-30 2021-04-02 生命科技股份有限公司 用于对pcr测定进行基因分型的机器学习系统
JP7254165B2 (ja) 2018-08-31 2023-04-07 ライフ テクノロジーズ コーポレーション アレイベースのｐｃｒのための画像を駆使した品質管理
EP3719144A1 (en) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p as an universal endogenous control for exosome cargo normalization
EP3999664A1 (en) 2019-07-19 2022-05-25 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
WO2022020731A2 (en) 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
CA3186955A1 (en) 2020-07-23 2022-01-27 Scott Benson Energy transfer dye conjugates for use in biological assays
US11649441B2 (en) 2020-10-07 2023-05-16 Abclonal Science, Inc. Taq DNA polymerase mutants for probe qPCR
EP4294833A2 (en) 2021-02-22 2023-12-27 Cotropia, Joseph Corona virus antigens and epitopes and proteins that bind thereto
US20240156945A1 (en) 2021-03-18 2024-05-16 Joseph COTROPIA Human immunodeficiency virus (hiv) antigens and epitopes and proteins that bind thereto
US20250084250A1 (en) 2021-07-21 2025-03-13 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation
US20250092261A1 (en) 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation
IL311066A (en) 2021-08-30 2024-04-01 Galderma Holding SA Treatments for atopic dermatitis
WO2023039525A1 (en) 2021-09-10 2023-03-16 Life Technologies Corporation Master mix compositions, kits, and methods
EP4426854A1 (en) 2021-11-02 2024-09-11 Life Technologies Corporation Compositions and methods for reducing master mix contamination
WO2025007089A1 (en) 2023-06-30 2025-01-02 Life Technologies Corporation Compositions, methods and kits for nucleic acids synthesis and amplification
WO2025151807A1 (en) 2024-01-11 2025-07-17 Life Technologies Corporation Crude lysate sample extraction for digital pcr
WO2025175212A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Methods for rapid extraction-free genotyping
WO2025175243A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Amplification and data collection protocol for rapid genotyping
WO2025188713A1 (en) 2024-03-05 2025-09-12 Cotropia Joseph Feline leukemia virus antigens and epitopes and proteins that bind thereto

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5641631A (en) 1983-01-10 1997-06-24 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4666862A (en) 1984-08-14 1987-05-19 Ortho Diagnostic Systems Inc. Fluorescent energy transfer with phycobiliproteins
FR2572180B1 (fr) * 1984-10-24 1987-03-20 Eric Marteau D Autry Procede et appareil de reparation d'echantillons a des fins d'analyse
US4822733A (en) 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4725537A (en) 1985-09-19 1988-02-16 Allied Corporation Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4725538A (en) * 1985-10-25 1988-02-16 The Beth Israel Hospital Association Method of assaying the presence of cancer cells
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5635347A (en) 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
EP0537270B1 (en) 1990-07-02 1998-09-09 The Regents Of The University Of California Detection of analytes using fluorescent energy transfer
US5439793A (en) 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5237515A (en) 1991-04-10 1993-08-17 University Of Utah Research Foundation Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
CA2073630C (en) 1991-08-30 2007-12-11 Atsushi Ohshima Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
ATE193558T1 (de) 1991-11-15 2000-06-15 Igen Int Inc Schnelle bestimmungsverfahren für amplifikationsprodukte
US5348853A (en) 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
DE69326967T2 (de) 1992-01-17 2000-06-15 Lakowicz, Joseph R. Phasenmodulationsenergieübertragungsfluoroimmunassay
CA2129105A1 (en) 1992-02-12 1993-08-19 Michael J. Conrad Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
ES2082256T3 (es) 1992-03-23 1996-03-16 Hoffmann La Roche Metodo de deteccion del adn.
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US5849544A (en) 1992-07-24 1998-12-15 University Of Australia Amplification and detection process
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
EP0601889A2 (en) 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
GB9311386D0 (en) 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
ATE218893T1 (de) * 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
CA2105364A1 (en) 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
JP4071277B2 (ja) 1993-11-12 2008-04-02 ピーエイチアールアイ・プロパティーズ・インコーポレーテッド 核酸検出用ハイブリダイゼーションプローブ、共通ステム、方法およびキット
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US6169169B1 (en) 1994-05-19 2001-01-02 Dako A/S PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5629178A (en) 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
US5675517A (en) 1995-04-25 1997-10-07 Systemix Fluorescence spectral overlap compensation for high speed flow cytometry systems
EP0826066B1 (en) 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
US5879885A (en) 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
WO1997007235A2 (en) 1995-08-14 1997-02-27 Abbott Laboratories All-in-one nucleic acid amplification assay
US5770365A (en) 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
WO1997014026A2 (en) 1995-10-12 1997-04-17 Dako A/S Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule
DE69637194T2 (de) 1995-11-16 2008-04-30 Dako Denmark A/S In situ-hybridisation zum nachweis von spezifischen nukleinsäuresequenzen in eukaryontischen proben
US5888733A (en) 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
AU710425B2 (en) 1995-12-18 1999-09-23 Washington University Method for nucleic acid analysis using fluorescence resonance energy transfer
US5723294A (en) 1996-03-05 1998-03-03 Gull Laboratories Methods for detection and discrimination of multiple analytes using fluorescent technology
EP0892808B1 (en) * 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
WO1998010096A1 (en) 1996-04-12 1998-03-12 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
US5780233A (en) 1996-06-06 1998-07-14 Wisconsin Alumni Research Foundation Artificial mismatch hybridization
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5827660A (en) 1996-08-09 1998-10-27 University Of Massachusetts Caged fluorochrome-labeled probes and subtraction of autoflourescence background
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5853992A (en) 1996-10-04 1998-12-29 The Regents Of The University Of California Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
DE19782089T1 (de) 1996-10-29 1999-12-23 Univ Nebraska At Lincoln Linco Verfahren zum Nachweisen von Punktmutationen in DNA unter Verwendung von Fluoreszenzenergieübergang
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6451530B1 (en) 1996-12-13 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent nucleotide analog hairpin formation for detection of nucleic acid hybridization
US5837466A (en) 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
US6025133A (en) 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US5804386A (en) 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
EP0968309B1 (en) 1997-02-24 2004-10-13 Georgia Tech Research Corporation Method for determining a nucleic acid
US5846729A (en) 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
US6485901B1 (en) * 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
ATE478090T1 (de) 1997-10-27 2010-09-15 Boston Probes Inc SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes

Also Published As

Publication number Publication date
DE69828432D1 (de) 2005-02-03
JP4372341B2 (ja) 2009-11-25
US7422852B2 (en) 2008-09-09
EP1484337A2 (en) 2004-12-08
US20110250596A1 (en) 2011-10-13
US20070178471A1 (en) 2007-08-02
EP1484337B1 (en) 2010-12-08
EP1027372B1 (en) 2004-12-29
US7892741B2 (en) 2011-02-22
ATE490978T1 (de) 2010-12-15
US6485901B1 (en) 2002-11-26
EP1027372A1 (en) 2000-08-16
JP2009082137A (ja) 2009-04-23
ES2235375T3 (es) 2005-07-01
DE69828432T2 (de) 2006-01-12
DE69842040D1 (de) 2011-01-20
US6649349B2 (en) 2003-11-18
US20020064772A1 (en) 2002-05-30
ATE286066T1 (de) 2005-01-15
JP2003526597A (ja) 2003-09-09
AU1121499A (en) 1999-05-17
EP1484337A3 (en) 2005-06-29
WO1999021881A1 (en) 1999-05-06
US20090136941A1 (en) 2009-05-28

Similar Documents

Publication Publication Date Title
DK1027372T3 (da) Metoder, kits og sammensætninger vedrörende lineære ledemærker
AU1366299A (en) Methods, kits and compositions pertaining to pna molecular beacons
DK0613502T3 (da) Fremgangsmåde og reagenser til detektering af bakterier i cerebrospinalvæske
EP1012232A4 (en) GENETICALLY TARGETED MODIFIED REDUCED VIRULENCE BACTERIA ON TUMORS
AU5338399A (en) Detection of contaminants using self-contained devices employing target materialbinding dyes
FI900602A0 (fi) Bestaemning.
FI963989L (fi) Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon
TR199901667T2 (xx) 3-Heterosiklil-ikame edilmi� benzoil t�revleri
DK0630971T3 (da) Fremgangsmåde, reagenser og kits til påvisning af Neisseria Gonorrhoeae
EP1383914A4 (en) IMPROVED METHOD FOR DETECTING ATP
PT702090E (pt) Co-amplificacao de acidos nucleicos alvo utilizando agentes de exclusao de volume na composicao da reaccao, kit de teste e respectivo dispositivo de teste
ATE114051T1 (de) Verfahren zum nachweis von endotoxin.
NO20015096L (no) Måling og bruk av molekul¶re interaksjoner
CY1110307T1 (el) Πολυνουκλεοτιδια για την ενισχυση και ανιχνευση του χλαμυδιου του τραχωματος και της ναϊσσεριας της γονορροιας
DE69737628D1 (de) Nukleinsäureprimer und -sonden zur detektion onkogener humaner papillomaviren
DE69900465D1 (de) Ein screeningverfahren, basierend auf fluoreszenzpolarisation
KR960007789A (ko) 단백질 c/단백질 s시스템의 장해를 검출하기 위한 방법
DK1179183T3 (da) Fremgangsmåde til identifikation af præneoplastiske og/eller neoplastiske tilstande hos pattedyr
CY1105025T1 (el) Αναλυση λεπτινης βασιζομενη στην ανιχνευση εκφρασης ang-2
BR0213997A (pt) Métodos de detecção e identificação de bactérias entéricas
ATE466284T1 (de) Bakterientestverfahren mit bindung einer intrazellularer enzyme
DE59402498D1 (de) Flache einstückige Messsaite mit zwei Knoten zur Weg- oder Kraftmessung
ATE466884T1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
AT384488B (de) Kuevette zur messung von dampf- bzw. gasspektren
BR0115689A (pt) Análise de expressão de inibidor de diferenciação de ácidos nucléicos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata