DK0997145T3 - Fremgangsmåde til at identificere forbindelser til inhibering af neoplastiske læsioner - Google Patents

Fremgangsmåde til at identificere forbindelser til inhibering af neoplastiske læsioner

Info

Publication number
DK0997145T3
DK0997145T3 DK99308129T DK99308129T DK0997145T3 DK 0997145 T3 DK0997145 T3 DK 0997145T3 DK 99308129 T DK99308129 T DK 99308129T DK 99308129 T DK99308129 T DK 99308129T DK 0997145 T3 DK0997145 T3 DK 0997145T3
Authority
DK
Denmark
Prior art keywords
compound
activity
determining
pde
cox
Prior art date
Application number
DK99308129T
Other languages
Danish (da)
English (en)
Inventor
Li Liu
Bing Zhu
Joseph W Thompson
Rifat Pamukeu
Gary A Piazza
Li Han
Original Assignee
Cell Pathways Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/173,375 external-priority patent/US6200771B1/en
Priority claimed from US09/366,003 external-priority patent/US6130053A/en
Priority claimed from US09/414,628 external-priority patent/US20020009764A1/en
Application filed by Cell Pathways Inc filed Critical Cell Pathways Inc
Application granted granted Critical
Publication of DK0997145T3 publication Critical patent/DK0997145T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK99308129T 1998-10-15 1999-10-14 Fremgangsmåde til at identificere forbindelser til inhibering af neoplastiske læsioner DK0997145T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/173,375 US6200771B1 (en) 1998-10-15 1998-10-15 Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
US09/366,003 US6130053A (en) 1999-08-03 1999-08-03 Method for selecting compounds for inhibition of neoplastic lesions
US09/414,628 US20020009764A1 (en) 1999-10-08 1999-10-08 Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds

Publications (1)

Publication Number Publication Date
DK0997145T3 true DK0997145T3 (da) 2002-07-29

Family

ID=27390268

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99308129T DK0997145T3 (da) 1998-10-15 1999-10-14 Fremgangsmåde til at identificere forbindelser til inhibering af neoplastiske læsioner

Country Status (13)

Country Link
EP (2) EP0997145B1 (zh)
JP (1) JP2000186047A (zh)
CN (1) CN100389829C (zh)
AT (1) ATE214920T1 (zh)
AU (1) AU770308B2 (zh)
CA (1) CA2284853A1 (zh)
DE (1) DE69901082T2 (zh)
DK (1) DK0997145T3 (zh)
ES (1) ES2174573T3 (zh)
IL (1) IL132366A0 (zh)
NO (2) NO994995L (zh)
TR (1) TR199902578A2 (zh)
TW (1) TWI239837B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002531826A (ja) * 1998-11-25 2002-09-24 セル パスウェイズ インコーポレイテッド 新形成診断法
US6569638B1 (en) * 2000-03-03 2003-05-27 Cell Pathways, Inc Method for screening compounds for the treatment of neoplasia
KR20080027400A (ko) * 2000-08-21 2008-03-26 아스트라제네카 아베 퀴나졸린 유도체
WO2004044234A1 (en) * 2002-11-13 2004-05-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 2a (pde2a)
US9408405B2 (en) 2003-10-03 2016-08-09 Veijlen N.V. Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals
EP1690852A1 (en) * 2003-12-01 2006-08-16 Reverse Proteomics Research Institute Co., Ltd Novel target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto
JP5219135B2 (ja) * 2008-07-25 2013-06-26 独立行政法人産業技術総合研究所 炎症性疾患モデル動物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69202721T2 (de) * 1991-03-08 1995-10-12 Fgn Inc Substituierte Indenylverbindungen.
US5776962A (en) * 1994-08-03 1998-07-07 Cell Pathways, Inc. Lactone compounds for treating patient with precancerous lesions
US5696159A (en) * 1994-08-03 1997-12-09 Cell Pathways, Inc. Lactone compounds for treating patients with precancerous lesions
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
ES2245465T3 (es) * 1996-09-18 2006-01-01 Applied Genetics Incorporated Dermatics Dioles de compuestos de norborneno y norbornano para el tratamiento de trastornos de la pigmentacion, enfermedades neurodegenerativas o enfermedades proliferativas de la piel.
CA2238283C (en) * 1997-05-30 2002-08-20 Cell Pathways, Inc. Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
US5922595A (en) * 1997-12-09 1999-07-13 Incyte Pharmaceuticals, Inc. Cyclic GMP phosphodiesterase
TR200001687T2 (tr) * 1997-12-12 2000-10-23 Cell Pathways, Inc. Neopleasyo için N-benzil-3-indenilasetamid türevleri.

Also Published As

Publication number Publication date
NO994995L (no) 2000-04-17
AU770308B2 (en) 2004-02-19
NO994995D0 (no) 1999-10-14
CN100389829C (zh) 2008-05-28
IL132366A0 (en) 2001-03-19
TR199902578A3 (tr) 2000-06-21
EP1161943A2 (en) 2001-12-12
DE69901082D1 (de) 2002-05-02
TR199902578A2 (xx) 2000-06-21
DE69901082T2 (de) 2002-08-29
ATE214920T1 (de) 2002-04-15
TWI239837B (en) 2005-09-21
JP2000186047A (ja) 2000-07-04
NO20062682L (no) 2000-04-17
EP0997145B1 (en) 2002-03-27
CN1255379A (zh) 2000-06-07
CA2284853A1 (en) 2000-04-15
EP0997145A1 (en) 2000-05-03
EP1161943A3 (en) 2003-12-10
AU5401099A (en) 2000-04-20
ES2174573T3 (es) 2002-11-01

Similar Documents

Publication Publication Date Title
NO20062682L (no) Farmasoytiske blandinger inneholdende forbindelser for inhibering av neoplastiske lesjoner
UA83243C2 (ru) Соединения, которые ингибируют натриезависимый переносчик глюкозы
FI971489A0 (fi) Uusia bentsoksatsoleja
ATE307119T1 (de) Bicyclische protein-farnesyl-transferase inhibitoren
BR0211750A (pt) Agente antiviral
ATE217865T1 (de) Verbindungen zur hemmung von phosphodiesrerase iv
DK1233958T3 (da) Hæmmere af histondeacetylase
BR0317183A (pt) Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno
YU76401A (sh) 1-amino triazolo(4,3-a)hinazolin-5-oni i/ili - 5-tioni koji inhibiraju fosfodiesteraze iv
DK0881300T3 (da) Metode til at identificere forbindelser til inhibition af neoplastiske læsioner
DE69823648D1 (de) 1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)
EA200300716A1 (ru) Гетероциклилалкилиндольные или -азаиндольные соединения в качестве лиганд 5-гидрокситриптамина-6
WO2003030886A3 (en) Allylamides useful in the treatment of alzheimer's disease
HUP0102615A2 (hu) 2-(2-Klór-fenil)-3,4-dihidro-2H-pirrol-származékok
ATE326964T1 (de) Aminosäurederivate zur behandlung der alzheimer- krankheit
DE60018186D1 (de) Arzneimittel zur vorbeugung / behandlung / inhibierung des fortschritts für einfache oder preproliferative retinopathie
NO308829B1 (no) Anvendelse av forbindelsen finasterid for fremstilling av et preparat for behandling av kronisk prostatitt hos menn
ATE267194T1 (de) Medikamente geeignet zur behandlung von proliferativen erkrankungen
NZ512546A (en) Use of actylcholine esterase inhibitors to treat delirium
DK1077694T3 (da) Arylnitron-terapeutika til behandling af inflammatorisk tarmsygdom
ES2185154T3 (es) Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
MXPA04000139A (es) Uso de compuestos biciclo para tratar enfermedad de alzheimer.
DE60135157D1 (de) Fab i und hemmung von apicomplexan-parasiten
ECSP993189A (es) Nuevos inhibidores de la enzima impdh
ECSP972122A (es) Nuevos derivados de quino leina y procedimientos para su preparacion