DK0978284T3 - Anvendelse af 15-keto-prostaglandin-E-forbindelser som endothelinantagonister - Google Patents
Anvendelse af 15-keto-prostaglandin-E-forbindelser som endothelinantagonisterInfo
- Publication number
- DK0978284T3 DK0978284T3 DK98953058T DK98953058T DK0978284T3 DK 0978284 T3 DK0978284 T3 DK 0978284T3 DK 98953058 T DK98953058 T DK 98953058T DK 98953058 T DK98953058 T DK 98953058T DK 0978284 T3 DK0978284 T3 DK 0978284T3
- Authority
- DK
- Denmark
- Prior art keywords
- keto
- prostaglandin
- compounds
- endothelin antagonists
- endothelin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32783297 | 1997-11-28 | ||
PCT/JP1998/005143 WO1999027934A1 (fr) | 1997-11-28 | 1998-11-16 | Antagoniste d'endotheline |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0978284T3 true DK0978284T3 (da) | 2008-10-27 |
Family
ID=18203488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98953058T DK0978284T3 (da) | 1997-11-28 | 1998-11-16 | Anvendelse af 15-keto-prostaglandin-E-forbindelser som endothelinantagonister |
Country Status (17)
Country | Link |
---|---|
US (1) | US6197821B1 (zh) |
EP (1) | EP0978284B1 (zh) |
JP (1) | JP4319256B2 (zh) |
KR (1) | KR100648868B1 (zh) |
CN (1) | CN1206997C (zh) |
AT (1) | ATE401894T1 (zh) |
AU (1) | AU739343B2 (zh) |
CA (1) | CA2279267C (zh) |
DE (1) | DE69839767D1 (zh) |
DK (1) | DK0978284T3 (zh) |
ES (1) | ES2310013T3 (zh) |
HK (1) | HK1025521A1 (zh) |
NO (1) | NO328460B1 (zh) |
NZ (1) | NZ336960A (zh) |
PT (1) | PT978284E (zh) |
TW (1) | TW592701B (zh) |
WO (1) | WO1999027934A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04002006A (es) | 2001-08-31 | 2004-06-07 | Sucampo Ag | Analogos de prostagladina como abridor del canal de cloruro. |
TWI331920B (en) * | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
CN1753680B (zh) * | 2002-12-27 | 2010-12-08 | 苏坎波公司 | 用于治疗腹部不适的前列腺素衍生物 |
AR043161A1 (es) * | 2003-02-14 | 2005-07-20 | Sucampo Pharmaceuticals Inc | Composicion oftalmica para tratar hipertension ocular y glaucoma |
ES2375082T3 (es) * | 2005-01-27 | 2012-02-24 | Sucampo Ag | Composición para el tratamiento de trastornos del sistema nervioso central. |
JP5213448B2 (ja) * | 2005-03-04 | 2013-06-19 | スキャンポ・アーゲー | 末梢血管疾患の処置のための方法および組成物 |
CN102391237B (zh) * | 2006-02-07 | 2014-07-16 | 株式会社·R-技术上野 | 用于制备前列腺素衍生物的方法 |
JP5377970B2 (ja) * | 2006-02-28 | 2013-12-25 | スキャンポ・アーゲー | 慢性閉塞性肺疾患を処置するための方法および組成物 |
US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
US20080207759A1 (en) * | 2007-02-27 | 2008-08-28 | Sucampo Ag | Method for protecting mitochondria |
US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
CN102050808B (zh) * | 2009-11-02 | 2014-03-12 | 上海天伟生物制药有限公司 | 一种前列腺素中间体的制备方法 |
EP2516412A4 (en) * | 2009-12-18 | 2013-05-29 | Apotex Pharmachem Inc | PROCESS FOR CLEANING LUBIPROSTON |
CN104557845B (zh) * | 2015-01-13 | 2020-12-22 | 齐鲁制药有限公司 | 一种鲁比前列酮化合物的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853951A (en) | 1971-07-14 | 1974-12-10 | American Cyanamid Co | Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone |
US4018811A (en) | 1972-02-11 | 1977-04-19 | American Cyanamid Company | 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof |
US3981868A (en) | 1973-05-31 | 1976-09-21 | American Cyanamid Company | Derivatives of 9-oxo-13-trans-prostenoic acid amides |
CA1323364C (en) * | 1987-01-28 | 1993-10-19 | Ryuzo Ueno | Prostaglandins e and anti ulcer agents containing same |
JP2597649B2 (ja) * | 1988-05-11 | 1997-04-09 | 株式会社上野製薬応用研究所 | 気管・気管支拡張剤 |
US5362751A (en) | 1988-05-11 | 1994-11-08 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Tracheobronchodilator using 16-substituted PGEs |
EP0343904B1 (en) | 1988-05-23 | 1993-04-28 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Hypersphyxia causing composition |
JPH0232031A (ja) * | 1988-07-22 | 1990-02-01 | Nippon Steel Chem Co Ltd | イソプロピル化p‐ターフェニル類の製造法 |
CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
CA2030344C (en) * | 1989-11-22 | 2000-04-18 | Ryuji Ueno | Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds |
CA2030345C (en) * | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
CA2030346C (en) * | 1989-11-22 | 2000-04-11 | Ryuji Ueno | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds |
TW249226B (zh) | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
EP0455448B1 (en) * | 1990-05-01 | 1998-12-09 | R-Tech Ueno Ltd. | Treatment of pancreatic disease with 15-keto-prostaglandin E compounds |
CA2046069C (en) | 1990-07-10 | 2002-04-09 | Ryuji Ueno | Treatment of inflammatory diseases with 15-keto-prostaglandin compounds |
EP0503887B1 (en) * | 1991-03-14 | 1996-08-28 | R-Tech Ueno Ltd. | Promotion of wound-healing with 15-keto-prostaglandin compounds |
DK0857718T3 (da) | 1996-06-10 | 2002-12-16 | Sucampo Ag | Endothelinantagonist |
JPH107574A (ja) | 1996-06-17 | 1998-01-13 | R Tec Ueno:Kk | エンドセリン拮抗剤 |
-
1998
- 1998-11-16 PT PT98953058T patent/PT978284E/pt unknown
- 1998-11-16 AT AT98953058T patent/ATE401894T1/de active
- 1998-11-16 CN CNB988035863A patent/CN1206997C/zh not_active Expired - Fee Related
- 1998-11-16 WO PCT/JP1998/005143 patent/WO1999027934A1/ja active IP Right Grant
- 1998-11-16 JP JP53056099A patent/JP4319256B2/ja not_active Expired - Fee Related
- 1998-11-16 DE DE69839767T patent/DE69839767D1/de not_active Expired - Lifetime
- 1998-11-16 DK DK98953058T patent/DK0978284T3/da active
- 1998-11-16 KR KR1019997006752A patent/KR100648868B1/ko not_active IP Right Cessation
- 1998-11-16 ES ES98953058T patent/ES2310013T3/es not_active Expired - Lifetime
- 1998-11-16 NZ NZ336960A patent/NZ336960A/en not_active IP Right Cessation
- 1998-11-16 US US09/355,270 patent/US6197821B1/en not_active Expired - Lifetime
- 1998-11-16 CA CA002279267A patent/CA2279267C/en not_active Expired - Fee Related
- 1998-11-16 EP EP98953058A patent/EP0978284B1/en not_active Expired - Lifetime
- 1998-11-16 AU AU10537/99A patent/AU739343B2/en not_active Ceased
- 1998-11-17 TW TW087118975A patent/TW592701B/zh not_active IP Right Cessation
-
1999
- 1999-07-27 NO NO19993647A patent/NO328460B1/no not_active IP Right Cessation
-
2000
- 2000-08-08 HK HK00104940.3A patent/HK1025521A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1025521A1 (en) | 2000-11-17 |
ES2310013T3 (es) | 2008-12-16 |
ATE401894T1 (de) | 2008-08-15 |
NO993647L (no) | 1999-09-27 |
AU1053799A (en) | 1999-06-16 |
KR20000070508A (ko) | 2000-11-25 |
AU739343B2 (en) | 2001-10-11 |
CN1206997C (zh) | 2005-06-22 |
EP0978284A1 (en) | 2000-02-09 |
JP4319256B2 (ja) | 2009-08-26 |
CA2279267C (en) | 2010-01-12 |
KR100648868B1 (ko) | 2006-11-24 |
CA2279267A1 (en) | 1999-06-10 |
PT978284E (pt) | 2008-10-07 |
NO328460B1 (no) | 2010-02-22 |
NZ336960A (en) | 2001-02-23 |
EP0978284B1 (en) | 2008-07-23 |
TW592701B (en) | 2004-06-21 |
US6197821B1 (en) | 2001-03-06 |
DE69839767D1 (de) | 2008-09-04 |
NO993647D0 (no) | 1999-07-27 |
EP0978284A4 (en) | 2001-07-18 |
CN1251040A (zh) | 2000-04-19 |
WO1999027934A1 (fr) | 1999-06-10 |
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