DK0970240T3 - Kunstig fejlparringshydridisering - Google Patents

Kunstig fejlparringshydridisering

Info

Publication number
DK0970240T3
DK0970240T3 DK97928870T DK97928870T DK0970240T3 DK 0970240 T3 DK0970240 T3 DK 0970240T3 DK 97928870 T DK97928870 T DK 97928870T DK 97928870 T DK97928870 T DK 97928870T DK 0970240 T3 DK0970240 T3 DK 0970240T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
acid target
mismatch
sequence variation
hydration
Prior art date
Application number
DK97928870T
Other languages
Danish (da)
English (en)
Inventor
Zhen Guo
Lloyd M Smith
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK0970240T3 publication Critical patent/DK0970240T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK97928870T 1996-06-06 1997-06-05 Kunstig fejlparringshydridisering DK0970240T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/659,605 US5780233A (en) 1996-06-06 1996-06-06 Artificial mismatch hybridization

Publications (1)

Publication Number Publication Date
DK0970240T3 true DK0970240T3 (da) 2004-09-20

Family

ID=24646042

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97928870T DK0970240T3 (da) 1996-06-06 1997-06-05 Kunstig fejlparringshydridisering

Country Status (11)

Country Link
US (1) US5780233A (ja)
EP (1) EP0970240B1 (ja)
JP (1) JP3816109B2 (ja)
AT (1) ATE266737T1 (ja)
AU (1) AU710204B2 (ja)
CA (1) CA2254111C (ja)
DE (1) DE69729122T2 (ja)
DK (1) DK0970240T3 (ja)
IL (1) IL126842A (ja)
NZ (1) NZ332753A (ja)
WO (1) WO1997046711A1 (ja)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
AU5152798A (en) 1996-10-29 1998-05-22 University Of Nebraska-Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
FR2766825B1 (fr) * 1997-08-04 2001-04-13 Pasteur Institut Oligonucleotide specifique de l'espece escherichia coli et procede de detection et de visualisation des bacteries de cette espece
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
AU2520799A (en) 1998-02-05 1999-08-23 Bavarian Nordic Research Institute A/S Quantification by inhibition of amplification
US6174680B1 (en) * 1998-12-30 2001-01-16 Dana-Farber Cancer Institute, Inc. Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
CA2367912A1 (en) * 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
CA2365984A1 (en) * 1999-04-08 2000-10-19 Oasis Biosciences, Inc. Antisense oligonucleotides comprising universal and/or degenerate bases
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6579680B2 (en) 2000-02-28 2003-06-17 Corning Incorporated Method for label-free detection of hybridized DNA targets
US20040009514A1 (en) * 2000-02-28 2004-01-15 Frutos Anthony G. Assembly for label-free detection of hybridized nucleic targets
CN1592792B (zh) * 2000-05-19 2010-12-01 伊拉根生物科学公司 检测核酸的材料和方法
AU2002213175B2 (en) 2000-10-14 2007-09-13 Luminex Corporation Solid support assay systems and methods utilizing non-standard bases
CN100385013C (zh) * 2000-10-14 2008-04-30 伊拉根生物科学公司 使用非标准碱基的固相支持体分析系统和方法
EP1383775B1 (en) 2001-04-30 2006-08-02 The Regents of The University of Michigan Isoreticular metal-organic frameworks, process for forming the same, and systematic design of pore size and functionality therein,with application for gas storage
CA2460759C (en) * 2001-09-24 2011-05-31 One Lambda Diagnostic probe detection system
ES2661167T3 (es) * 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
JP2003180397A (ja) * 2001-12-13 2003-07-02 Nisshinbo Ind Inc ミトコンドリアdnaを用いたシロザケのハプロタイプ判定法
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
CA2521999A1 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
CA2513626C (en) 2003-01-17 2013-03-19 Eragen Biosciences, Inc. Nucleic acid amplification using non-standard bases
CA2521127C (en) 2003-04-01 2014-05-27 Eragen Biosciences, Inc. Polymerase inhibitor and method of using same
CA2524572C (en) * 2003-05-01 2018-07-10 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch having enhanced sensitivity to the presence of a mismatch
JP4937749B2 (ja) 2003-05-09 2012-05-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 結晶中に特別なレベルの表面積および気孔率を達成するための方法の実施
AU2004276722B2 (en) 2003-05-19 2009-03-12 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US7745117B2 (en) 2003-06-06 2010-06-29 The Regents Of The University Of Michigan Methods for incorporating non-perfectly matched oligonucleotides into target-specific hybridization sequences
US20060078930A1 (en) * 2004-10-01 2006-04-13 Dynal Biotech Inc. Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20070111213A1 (en) * 2003-10-28 2007-05-17 Lu Wang Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20050130213A1 (en) * 2003-12-10 2005-06-16 Tom Morrison Selective ligation and amplification assay
EP1735097B1 (en) 2004-03-12 2016-11-30 Life Technologies Corporation Nanoliter array loading
GB0406864D0 (en) 2004-03-26 2004-04-28 Qiagen As Nucleic acid sequencing
WO2005118877A2 (en) 2004-06-02 2005-12-15 Vicus Bioscience, Llc Producing, cataloging and classifying sequence tags
EP1766089A1 (en) * 2004-06-30 2007-03-28 Applera Corporation Analog probe complexes
WO2006093526A2 (en) * 2004-07-21 2006-09-08 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
US7892731B2 (en) * 2004-10-01 2011-02-22 Radix Biosolutions, Ltd. System and method for inhibiting the decryption of a nucleic acid probe sequence used for the detection of a specific nucleic acid
US7582798B2 (en) 2004-10-22 2009-09-01 The Regents Of The University Of Michigan Covalently linked organic frameworks and polyhedra
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
KR100682923B1 (ko) * 2005-01-22 2007-02-15 삼성전자주식회사 허들 dna와 인공적인 미스매치가 도입된 프로브를이용한 단일 염기 미스매치에 대한 구별 향상 방법
US7498136B2 (en) 2005-03-18 2009-03-03 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of Neisseria
JP2008535657A (ja) 2005-04-07 2008-09-04 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 開放金属部位を具えた微孔質の金属有機構造体における高いガス吸着
EP2489746B1 (en) * 2005-06-07 2016-02-03 Luminex Corporation Methods for detection and typing of nucleic acids
US7799120B2 (en) 2005-09-26 2010-09-21 The Regents Of The University Of Michigan Metal-organic frameworks with exceptionally high capacity for storage of carbon dioxide at room-temperature
US20070076001A1 (en) * 2005-09-30 2007-04-05 Brand Matthew E Method for selecting a low dimensional model from a set of low dimensional models representing high dimensional data based on the high dimensional data
CN100510105C (zh) * 2006-02-08 2009-07-08 博奥生物有限公司 一种序列特异性寡核苷酸探针及其应用
PL1988996T3 (pl) 2006-02-28 2018-01-31 Univ Michigan Regents Otrzymywanie szkieletów zeolitu z grupami funkcyjnymi
CN1896284B (zh) * 2006-06-30 2013-09-11 博奥生物有限公司 一种鉴别等位基因类型的方法
AU2007293187A1 (en) * 2006-06-30 2008-03-13 Rosetta Genomics Ltd A method for detecting nucleic acids
KR100813263B1 (ko) * 2006-08-17 2008-03-13 삼성전자주식회사 표적 서열 검출용 프로브 설계 방법 및 상기 프로브를이용한 표적 서열 검출 방법
US20090062138A1 (en) * 2007-08-31 2009-03-05 Curry Bo U Array-based method for performing SNP analysis
GB0821457D0 (en) * 2008-11-24 2008-12-31 Trillion Genomics Ltd Oligonucleotides
WO2010085542A2 (en) 2009-01-23 2010-07-29 Novartis Ag Biomarkers related to age-related macular degeneration (amd)
US8686130B2 (en) 2009-10-06 2014-04-01 Riken Artificial fluorescent bases
CN102639712A (zh) * 2009-10-23 2012-08-15 卢米耐克斯公司 用于提高反应特异性的具有非标准碱基的扩增引物
CA2787327C (en) 2010-01-22 2015-09-15 Damon Kittredge Getman Probes for detecting the presence of trichomonas vaginalis in a sample
EP2756101B1 (en) * 2011-09-15 2018-05-23 David A. Shafer Probe: antiprobe compositions for high specificity dna or rna detection
JP5928906B2 (ja) * 2013-08-27 2016-06-01 横河電機株式会社 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置
US10385388B2 (en) 2013-12-06 2019-08-20 Swift Biosciences, Inc. Cleavable competitor polynucleotides
TR201908099T4 (tr) * 2016-01-27 2019-06-21 Devyser Holding Ab Bir hedef sekansta istenilen nükleik asit bölgelerinde seçici amplifikasyon.
WO2019123690A1 (ja) * 2017-12-20 2019-06-27 国立大学法人 富山大学 改良Tmマッピング法
JP7066540B2 (ja) * 2018-06-14 2022-05-13 株式会社日立製作所 デジタルpcrの測定方法および測定装置
JP7487040B2 (ja) 2019-09-27 2024-05-20 東洋鋼鈑株式会社 骨髄増殖性腫瘍に関連する遺伝子変異評価用キット
US20220282314A1 (en) * 2019-08-30 2022-09-08 Toyo Kohan Co., Ltd. Kit for evaluating a gene mutation related to myeloproliferative neoplasms

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside

Also Published As

Publication number Publication date
EP0970240A1 (en) 2000-01-12
NZ332753A (en) 1999-11-29
CA2254111C (en) 2008-02-12
AU3302997A (en) 1998-01-05
DE69729122D1 (de) 2004-06-17
EP0970240B1 (en) 2004-05-12
EP0970240A4 (en) 2001-07-11
DE69729122T2 (de) 2005-04-28
US5780233A (en) 1998-07-14
IL126842A (en) 2004-03-28
JP3816109B2 (ja) 2006-08-30
ATE266737T1 (de) 2004-05-15
AU710204B2 (en) 1999-09-16
WO1997046711A1 (en) 1997-12-11
IL126842A0 (en) 1999-09-22
CA2254111A1 (en) 1997-12-11
JP2000511434A (ja) 2000-09-05

Similar Documents

Publication Publication Date Title
DK0970240T3 (da) Kunstig fejlparringshydridisering
ATE244259T1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
ATE165869T1 (de) Oligonukleotide zur amplifizierung von nukleinsäuresequenzen und zur anknüpfung einer promotersequenz
PT92420A (pt) Metodo e combinacao de reagentes para a determinacao de sequencias de nucleotidos
EA200100402A1 (ru) Способы амплификации и секвенирования нуклеиновых кислот
ATE494394T1 (de) Nukleinsäureliganden, die an dna-polymerasen binden und diese inhibieren
BR0308134A (pt) análise rápida das variações em um genoma
DE69626111D1 (de) Universale primersequenz zur multiplex dna amplifikation
ES2118593T3 (es) Analogos de nucleotidos de pteridina como sondas fluorescentes de adn.
DE69834056D1 (de) De novo oder "universaler" sequenzierungs-array
ATE342356T1 (de) Prostata-spezifisches membranantigen
ES2170145T3 (es) Sustancias y procedimientos de deteccion de micobacterium tuberculosis.
DE69407187D1 (de) Identifizierung von salmonella durch die polymerase-ketten-reaktion
DE69518697D1 (de) Nachweis von Treponema Pallidum und Haemophilus Ducreyi
ATE204331T1 (de) Verfahren und system zur molekularbiologischen diagnose
DE69636917D1 (de) Nucleinsäuresonden und Amplifizierungsoligonukleotide für Neisseria Spezies