DK0952822T3 - Mikropartikler af chitosan-gelatine A - Google Patents

Mikropartikler af chitosan-gelatine A

Info

Publication number
DK0952822T3
DK0952822T3 DK98900600T DK98900600T DK0952822T3 DK 0952822 T3 DK0952822 T3 DK 0952822T3 DK 98900600 T DK98900600 T DK 98900600T DK 98900600 T DK98900600 T DK 98900600T DK 0952822 T3 DK0952822 T3 DK 0952822T3
Authority
DK
Denmark
Prior art keywords
chitosan
bioadhesive
microspheres
gelatin
polymeric material
Prior art date
Application number
DK98900600T
Other languages
Danish (da)
English (en)
Inventor
Peter James Watts
Lisbeth Illum
Original Assignee
West Pharm Serv Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharm Serv Drug Res Ltd filed Critical West Pharm Serv Drug Res Ltd
Application granted granted Critical
Publication of DK0952822T3 publication Critical patent/DK0952822T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98900600T 1997-01-14 1998-01-14 Mikropartikler af chitosan-gelatine A DK0952822T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9700624.1A GB9700624D0 (en) 1997-01-14 1997-01-14 Drug delivery composition
PCT/GB1998/000108 WO1998030207A1 (en) 1997-01-14 1998-01-14 Chitosan-gelatin a microparticles

Publications (1)

Publication Number Publication Date
DK0952822T3 true DK0952822T3 (da) 2003-07-21

Family

ID=10805925

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98900600T DK0952822T3 (da) 1997-01-14 1998-01-14 Mikropartikler af chitosan-gelatine A

Country Status (15)

Country Link
US (1) US6465626B1 (de)
EP (1) EP0952822B1 (de)
JP (1) JP2001508061A (de)
AT (1) ATE235889T1 (de)
AU (1) AU725460B2 (de)
CA (1) CA2275717C (de)
DE (1) DE69812887T2 (de)
DK (1) DK0952822T3 (de)
ES (1) ES2200306T3 (de)
GB (2) GB9700624D0 (de)
NO (1) NO993195D0 (de)
NZ (1) NZ335815A (de)
PT (1) PT952822E (de)
WO (1) WO1998030207A1 (de)
ZA (1) ZA98273B (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP1067910B1 (de) * 1998-04-03 2004-05-26 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
WO2000004876A2 (en) * 1998-07-23 2000-02-03 Johns Hopkins University School Of Medicine Controlled release of bioactive substances
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
DE59908471D1 (de) * 1999-07-02 2004-03-11 Cognis Iberia Sl Mikrokapseln - II
GB9924797D0 (en) * 1999-10-20 1999-12-22 West Pharm Serv Drug Res Ltd Compound
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7527807B2 (en) 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
BR0112393A (pt) * 2000-06-21 2003-07-08 Internat Health Man Associates Composições e processos para aperfeiçoamento de absorção oral de agentes antimicrobiais
IT1318618B1 (it) * 2000-07-10 2003-08-27 A C R Applied Coating Res S A Microsfere bioadesive a rilascio rapido per la somministrazionesublinguale di principi attivi.
ITMI20010347A1 (it) 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
CN1543338B (zh) 2001-08-16 2010-06-16 Cmp医疗有限公司 壳多糖微粒及其医疗用途
EP1443944A1 (de) * 2001-11-12 2004-08-11 Johannes Reinmüller Pharmazeutische anwendungen von hyaluronsäure-präparaten
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
US6830556B2 (en) 2002-01-08 2004-12-14 Zimmer Orthopaedic Surgical Products, Inc. Debridement extension providing irrigation and mechanical scrubbing for removal of dead, devitalized, or contaminated tissue from a wound
AU2003207508A1 (en) * 2002-01-10 2003-07-30 Northeastern University Hybrid immobilized catalytic system with controlled permeability
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
EP1607117A4 (de) 2003-03-27 2007-10-24 Bioactis Ltd Applikator für pulvermedikation in der nasenhöhle
AU2004235744A1 (en) * 2003-05-01 2004-11-18 Archimedes Development Limited Nasal administration of the LH-RH analog leuprolide
WO2005002510A2 (en) * 2003-06-16 2005-01-13 Loma Linda University Medical Center Deployable multifunctional hemostatic agent
US20050118238A1 (en) * 2003-06-16 2005-06-02 Zhu Yong H. Deployable hemostatic agent
CN100381110C (zh) * 2003-06-16 2008-04-16 洛马林达大学医学中心 可展开的止血剂
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
DE10332160A1 (de) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
GB0328186D0 (en) 2003-12-05 2004-01-07 West Pharm Serv Drug Res Ltd Intranasal compositions
GB0329918D0 (en) 2003-12-24 2004-01-28 West Pharm Serv Drug Res Ltd Intranasal compositions
US20050175679A1 (en) * 2004-02-10 2005-08-11 Michael Moshman Controlled release formulations
JP4694214B2 (ja) * 2004-02-20 2011-06-08 ローム株式会社 比較器、ａｄ変換回路、半導体装置、および撮像装置
WO2005081866A2 (en) 2004-02-23 2005-09-09 Loma Linda University Medical Center Hemostatic agent for topical and internal use
EP1727525A4 (de) * 2004-03-23 2009-12-09 Lytone Enterprise Inc In chitosan eingebettete oder verkapselte kapsel
US7740883B2 (en) * 2004-03-28 2010-06-22 University Of Debrecen Nanoparticles from chitosan
WO2005107710A2 (en) * 2004-05-06 2005-11-17 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
EP1758633B1 (de) * 2004-05-13 2015-03-18 Medtronic Vascular, Inc. Verfahren für das compoundieren eines therapeutikums an die adventitia eines gefässes
GB0416328D0 (en) * 2004-07-21 2004-08-25 Univ Cardiff Use of dry powder compositions for pulmonary delivery
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
DE102004059792A1 (de) 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
EP1824459A1 (de) * 2004-12-17 2007-08-29 Medipol S.A. Hydrophile teilchen auf basis von kationischen chitosan-derivaten
US20090136505A1 (en) 2005-02-23 2009-05-28 Johanna Bentz Intranasal Administration of Active Agents to the Central Nervous System
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8303972B2 (en) * 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
AU2006242535B2 (en) * 2005-04-29 2012-08-09 Merck Sharp & Dohme Corp. Therapeutic compositions
JP2007006849A (ja) * 2005-07-04 2007-01-18 Japan Science & Technology Agency ６−アミノ−６−デオキシキトサン誘導体から成る核酸導入剤
WO2008020318A2 (en) * 2006-03-30 2008-02-21 Engene, Inc. Non-viral compositions and methods for transfecting gut cells in vivo
EP2035338B1 (de) 2006-06-02 2020-10-07 Synedgen, Inc. Verfahren zur herstellung von chitosan-arginin-verbindungen
EP2026820A1 (de) 2006-06-20 2009-02-25 CMP Therapeutics Limited Zusammensetzungen mit chitin-mikroteilchen und ihre medizinische anwendung
US20080248508A1 (en) * 2006-08-17 2008-10-09 Shenda Baker Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
JP5415769B2 (ja) * 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
EP2112923A1 (de) 2007-01-22 2009-11-04 Targacept Inc. Intranasale, orale und sublinguale verabreichung von metanikotin-analogen
GB0716907D0 (en) 2007-08-31 2007-10-10 Archimedes Dev Ltd Pharmaceutical powder compositions
GB0722507D0 (en) * 2007-11-19 2007-12-27 Zhao Xiaobin Hyaluronic acid personal lubricant
DE102008059857A1 (de) * 2008-12-01 2010-06-02 Forschungsinstitut für Leder und Kunststoffbahnen gGmbH Mit Kohlenhydrat-Derivaten additivierte Gelatinezusammensetzungen
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
CN102844053B (zh) 2009-11-25 2015-08-05 洛马林达大学医学中心 基于壳聚糖的止血织物
GB201006218D0 (en) 2010-04-14 2010-06-02 Ayanda As Composition
EP2696846B1 (de) * 2011-04-11 2018-01-17 Vitux Group AS Orale pharmazeutische dispersionszusammensetzungen
US8968790B2 (en) * 2011-12-09 2015-03-03 Shaker A. Mousa Nanoformulation of vitamin D derivatives and/or vitamin D metabolites
FR2991172A1 (fr) * 2012-06-01 2013-12-06 Galderma Res & Dev Compositions pharmaceutiques topiques comprenant des microcapsules
US9878000B2 (en) 2012-06-20 2018-01-30 University Of Waterloo Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof
US20140005379A1 (en) 2012-06-20 2014-01-02 Frank GU Nanoparticle delivery system and components thereof
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
EP3562486B1 (de) 2016-12-31 2024-03-13 Bioxcel Therapeutics, Inc. Verwendung von sublingualem dexmedetomidin zur behandlung von unruhe
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
JP7282735B2 (ja) * 2018-02-26 2023-05-29 株式会社新日本科学 粉末製剤、カートリッジ、及びデバイス
BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
CA3145388A1 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN112370437B (zh) * 2020-10-20 2022-10-21 好医生药业集团有限公司 一种阿莫西林胶囊及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226849A (en) 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
JPS6034925B2 (ja) 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
CA1219201A (en) 1983-03-07 1987-03-17 Albert E. Chu Microorganism detection test
GB8712176D0 (en) 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
CA2004270A1 (en) * 1988-12-29 1990-06-29 William R. Michael Perfume microcapsules for use in granular detergent compositions
GB8904370D0 (en) 1989-02-25 1989-04-12 Cosmas Damian Ltd Liquid delivery compositions
BE1003677A3 (nl) 1990-01-29 1992-05-19 Schacht Etienne Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen.
EP0454444A1 (de) 1990-04-24 1991-10-30 Nissan Chemical Industries Ltd. Glutarimidderivate und Herbizide
CA2042529C (en) * 1990-08-10 2002-07-30 Chokyun Rha Polysaccharide article and uses therefor
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
GB9414966D0 (en) * 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
GB9419979D0 (en) 1994-10-04 1994-11-16 Medeva Holdings Bv Vaccine compositions
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon

Also Published As

Publication number Publication date
ZA98273B (en) 1999-07-13
JP2001508061A (ja) 2001-06-19
CA2275717A1 (en) 1998-07-16
WO1998030207A1 (en) 1998-07-16
GB2335357A (en) 1999-09-22
NO993195L (no) 1999-06-28
DE69812887T2 (de) 2003-12-18
AU725460B2 (en) 2000-10-12
US6465626B1 (en) 2002-10-15
NO993195D0 (no) 1999-06-28
EP0952822B1 (de) 2003-04-02
NZ335815A (en) 2001-03-30
GB2335357B (en) 2000-12-13
CA2275717C (en) 2007-09-11
ES2200306T3 (es) 2004-03-01
GB9916018D0 (en) 1999-09-08
GB9700624D0 (en) 1997-03-05
PT952822E (pt) 2003-08-29
EP0952822A1 (de) 1999-11-03
DE69812887D1 (de) 2003-05-08
AU5568998A (en) 1998-08-03
ATE235889T1 (de) 2003-04-15

Similar Documents

Publication Publication Date Title
DK0952822T3 (da) Mikropartikler af chitosan-gelatine A
GB2305606A (en) Drug delivery composition for the nasal administration of antiviral agents
BR9811972A (pt) Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada
DE69028710T2 (de) Arzneiabgabesystem, verfahren zu dessen herstellung sowie dessen verwendung
HUP9904174A2 (hu) Bőrön át történő adagoláshoz szánt gyógyszerkészítmények
ATE245450T1 (de) Haftende mikrokügelchen umfassende zusammensetzung zur arzneimittelgabe
HUP0002935A2 (hu) Gyomorban visszatartott, szabályozott hatóanyag kibocsátású mikrogömböcskék javított gyógyszeradagolás elősegítésére
KR880000088A (ko) 지속적인 방출 제제
DE69710757D1 (de) Milnacipranhaltige darreichungsform mit verzögerter wirkstoffabgabe
EP0871435A4 (de) Drei verschiedene polymertypen enthaltende formulierung mit verzögerter freigabe
DE69505949T2 (de) Arzneimittel, impfstoffe und hormone in polylaktidbeschichteten mikropartikel
DE69803940T2 (de) Ophthalmische zusammensetzungen mit verlängerte freisetzung enthaltend im wasser lösliche arzneistoffe
CA2312710A1 (en) Sustained release formulation containing three different types of polymers and tablet formed therefrom
NO995313L (no) Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen
GR3030732T3 (en) Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent.
PT1003477E (pt) Sistema terapeutico transdermico (tts), contendo polimeros de (met)acrilato com grupos amonio para administracao de levonorgestrel
SE9704401D0 (sv) Matrix pellets for greasy, oily or sticky drug substances
ATE119389T1 (de) Orale arzneiform und überzugsmittel, enthaltend ein im colon abbaubares polysaccharid.
WO2003053413A3 (en) Sustained-release compositions
ATE158172T1 (de) Pulverförmige pharmazeutische zusammensetzung
ATE256134T1 (de) Sulfatierte phosphatidylinositole, ihre herstellung und verwendung
FR2751967B1 (fr) Agents antipaludeens et antibabesioses et compositions pharmaceutiques les contenant
TH27939B (th) สูตรส่วนผสมทางเภสัช
HUP9902681A2 (hu) Térhálósított amilózt és hidroxi-propil-metil-cellulózt tartalmazó hordozóval készült szabályozott felszabadulású tabletta gyógyszerkészítmény