BR9811972A - Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada - Google Patents

Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada

Info

Publication number
BR9811972A
BR9811972A BR9811972-9A BR9811972A BR9811972A BR 9811972 A BR9811972 A BR 9811972A BR 9811972 A BR9811972 A BR 9811972A BR 9811972 A BR9811972 A BR 9811972A
Authority
BR
Brazil
Prior art keywords
particulate
dosage forms
pharmaceutical dosage
solid
dispersion
Prior art date
Application number
BR9811972-9A
Other languages
English (en)
Inventor
Isaac Ghebre-Sellassie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9811972A publication Critical patent/BR9811972A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Patente de Invenção: <B>"FORMAS SóLIDAS DE DOSAGEM FARMACêUTICA EM FORMA DE UMA DISPERSãO PARTICULADA"<D>. Esta invenção refere-se a dispersões particuladas de agentes farmacêuticos em uma matriz de um polímero solúvel em água que exibe bom aumento de biodisponibilidade em dissolução aquosa. O método desta invenção utiliza polímeros solúveis em água tais como polivinilpirrolidona, hidroxipropil celulose ou hidroxipropil metilcelulose como veículos. A invenção proporciona mistura ou extrusão dos ingredientes ativos em forma sólida particulada com o veículo polimérico a uma temperatura em que o polímero amolece, ou mesmo funde, mas a droga permenece sólida ou cristalina. As partículas de droga tornam-se assim revestidas e produzem um produto que é revestido em forma de matriz, isto é, uma dispersão particulada.
BR9811972-9A 1997-08-21 1998-07-29 Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada BR9811972A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5619597P 1997-08-21 1997-08-21
PCT/US1998/015693 WO1999008660A1 (en) 1997-08-21 1998-07-29 Solid pharmaceutical dosage forms in form of a particulate dispersion

Publications (1)

Publication Number Publication Date
BR9811972A true BR9811972A (pt) 2000-08-15

Family

ID=22002810

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811972-9A BR9811972A (pt) 1997-08-21 1998-07-29 Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada

Country Status (17)

Country Link
US (1) US20010048946A1 (pt)
EP (1) EP1011640A1 (pt)
JP (1) JP2001515029A (pt)
KR (1) KR20010023085A (pt)
AR (1) AR018252A1 (pt)
AU (1) AU8600098A (pt)
BR (1) BR9811972A (pt)
CA (1) CA2292586C (pt)
CO (1) CO4960652A1 (pt)
GT (1) GT199800136A (pt)
HN (1) HN1998000115A (pt)
NZ (1) NZ502869A (pt)
PA (1) PA8458101A1 (pt)
PE (1) PE109599A1 (pt)
SV (1) SV1998000104A (pt)
WO (1) WO1999008660A1 (pt)
ZA (1) ZA987551B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE159426T1 (de) * 1991-04-16 1997-11-15 Nippon Shinyaku Co Ltd Verfahren zur herstellung einer festen dispersion
DE69214956T2 (de) * 1991-08-02 1997-04-10 Wilcom Tufting Pty. Ltd., Chippendale, Neusuedwales Verfahren und system zum tuften
US20030153607A1 (en) * 1998-11-12 2003-08-14 Smithkline Beecham P.L.C. Novel composition and use
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
GEP20053427B (en) 1999-12-23 2005-01-25 Pfizer Prod Inc Pharmaceutical Compositions Providing Enhanced Drug Concentrations
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
JP4997683B2 (ja) * 2000-09-25 2012-08-08 日本新薬株式会社 医薬固体分散体の製法
DE60110192T2 (de) * 2000-12-07 2006-03-09 Warner-Lambert Company Llc Verfahren und System zur gleichmäßigen Arzneistoffabgabe
DE60233874D1 (de) 2001-06-22 2009-11-12 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
GB0127805D0 (en) * 2001-11-20 2002-01-09 Smithkline Beecham Plc Pharmaceutical composition
BR0307344A (pt) 2002-02-01 2004-12-14 Pfizer Prod Inc Composições farmacêuticas de dispersões amorfas de fármacos e materiais formadores de microfase lipofìlica
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
RU2005103625A (ru) * 2002-08-12 2005-08-20 Пфайзер Продактс Инк. (Us) Фармацевтические композиции полуупорядоченных лекарств и полимеров
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
US20050100608A1 (en) * 2003-02-21 2005-05-12 Watson Pharmaceuticals, Inc. Testosterone oral dosage formulations and associated methods
US8273371B2 (en) * 2003-06-27 2012-09-25 Johan Adriaan Martens Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
GB0315012D0 (en) * 2003-06-27 2003-07-30 Leuven K U Res & Dev Zeotiles
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2005011635A2 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CA2554271A1 (en) * 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
US20050202079A1 (en) * 2004-03-15 2005-09-15 Mylan Pharmaceuticals Inc. Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2598204C (en) * 2004-11-09 2015-01-13 Board Of Regents, The University Of Texas System Stabilized hme composition with small drug particles
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
US20060147518A1 (en) * 2004-12-30 2006-07-06 Pierre Fabre Medicament Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it
FR2880274B1 (fr) * 2004-12-30 2007-04-13 Pierre Fabre Medicament Sa Dispersion solide stable d'un derive d'alcaloides de vinca et son procede de fabrication
NZ554793A (en) * 2004-12-30 2010-04-30 Pf Medicament Stable solid dispersion of a derivative of a vinca alkaloid such as vinorelbine ditartrate in polyethylene glycol
NZ585116A (en) * 2005-05-10 2011-12-22 Novartis Ag Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride
GB0612695D0 (en) * 2006-06-27 2006-08-09 Univ Gent Process for preparing a solid dosage form
WO2008074097A1 (en) * 2006-12-21 2008-06-26 Alphapharm Pty Ltd Pharmaceutical compound and composition
PT2309987E (pt) * 2008-07-03 2012-12-13 Novartis Ag Processo para granulação por fusão
WO2010136604A1 (en) * 2009-05-29 2010-12-02 Dsm Ip Assets B.V. Transfer matrix for transferring a bioactive agent to body tissue
EP2675434A1 (en) 2011-02-17 2013-12-25 F.Hoffmann-La Roche Ag A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion
MX356105B (es) * 2011-09-14 2018-05-14 Celgene Corp Formulaciones de ácido ciclopropancarboxílico de {2-[(1s)-1-(3-etoxi-4-metoxi-fenil)-2-metansulfonil-etil]-3-oxo-2 ,3-dihidro-1h-isoindol-4-il}-amida.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038322A (ja) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
JPH054919A (ja) * 1990-07-25 1993-01-14 Sankyo Co Ltd チアゾリジン誘導体の固体分散体
ATE159426T1 (de) * 1991-04-16 1997-11-15 Nippon Shinyaku Co Ltd Verfahren zur herstellung einer festen dispersion
EP0617612B1 (en) * 1991-12-18 1997-09-10 Warner-Lambert Company A process for the preparation of a solid dispersion
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
DE4226753A1 (de) * 1992-08-13 1994-02-17 Basf Ag Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
JPH07324086A (ja) * 1994-05-31 1995-12-12 Sankyo Co Ltd チアゾリジン誘導体の固体分散体または固体分散体製剤
DE19515972A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
PA8458101A1 (es) 2001-12-14
SV1998000104A (es) 1999-07-02
AU8600098A (en) 1999-03-08
CA2292586A1 (en) 1999-02-25
WO1999008660A1 (en) 1999-02-25
ZA987551B (en) 1999-02-23
AR018252A1 (es) 2001-11-14
NZ502869A (en) 2002-10-25
JP2001515029A (ja) 2001-09-18
CA2292586C (en) 2006-02-14
GT199800136A (es) 2000-02-11
EP1011640A1 (en) 2000-06-28
PE109599A1 (es) 1999-12-19
US20010048946A1 (en) 2001-12-06
CO4960652A1 (es) 2000-09-25
HN1998000115A (es) 1999-06-02
KR20010023085A (ko) 2001-03-26

Similar Documents

Publication Publication Date Title
BR9811972A (pt) Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada
ATE235889T1 (de) Mikropartikel aus chitosan-gelatin a
IT1317358B1 (it) Derivati cross-linkati dell&#39;acido ialuronico.
WO2004032862A3 (en) Cyclodextrin-based materials, compositions and uses related thereto
BR0215460A (pt) Processo para revestir uma superfìcie de um veìculo automotor, e composição para o mesmo
KR940005266A (ko) 미립자 제제 및 그의 제조법
IT1243390B (it) Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
WO2003024455A8 (en) Stent coated with a sustained-release drug delivery and method for use thereof
IL111647A (en) Pharmaceutical compositions comprising microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles and their preparation
BRPI0410956A (pt) pelìculas com base em óxido de polietileno e sistemas de liberação de droga feitos delas
ATE206441T1 (de) Block- und pfropfcopolymere und dazu gehöriges verfahren
PT1059915E (pt) Amido de ligacaocruzada com alto teor em amilose tendo grupos funcionais como matriz para a libertacao lenta de agentes farmaceuticos
DE69816778D1 (de) Beschichtete teilchen, methode zu ihrer herstellung und verwendung
BR9811478A (pt) Composições de polìmero-ácido tânico para a liberação controlada de agentes farmacêuticos particularmente na cavidade oral
WO2004039428A3 (en) Transdermal delivery system for dried particulate or lyophilized medications
BR9812590B1 (pt) processo para preparaÇço de composiÇÕes farmacÊuticas de sabor mascarado.
HRP20010463B1 (en) Controlled release galantamine composition
BR9910178A (pt) Sistema de distribuição antimicrobiano, processos de aplicação de um agente antimicrobiano, e de formação de um sistema de distribuição antimicrobiano
BR9915694A (pt) Composições compreendendo cefuroxima axetil
ES2168855T3 (es) Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion.
GB2305606A (en) Drug delivery composition for the nasal administration of antiviral agents
BR9916760A (pt) Composição condicionadora de cabelos compreendendo
BR9811985A (pt) Dispositivo de dosagem
BR9802915A (pt) Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um)
BR0009173A (pt) Utilização de um agente anti-lixiviação

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.