BR9915694A - Composições compreendendo cefuroxima axetil - Google Patents
Composições compreendendo cefuroxima axetilInfo
- Publication number
- BR9915694A BR9915694A BR9915694-6A BR9915694A BR9915694A BR 9915694 A BR9915694 A BR 9915694A BR 9915694 A BR9915694 A BR 9915694A BR 9915694 A BR9915694 A BR 9915694A
- Authority
- BR
- Brazil
- Prior art keywords
- cefuroxime axetil
- compositions
- axetil
- production
- cefuroxime
- Prior art date
Links
- KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 title abstract 4
- 229960002620 cefuroxime axetil Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 229950003588 axetil Drugs 0.000 abstract 1
- JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 abstract 1
- 230000009246 food effect Effects 0.000 abstract 1
- 235000021471 food effect Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000007962 solid dispersion Substances 0.000 abstract 1
- 239000006104 solid solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSIçõES COMPREENDENDO CEFUROXIMA AXETIL"<D>. Cefuroxima axetil em uma forma não-gelatinosa em contato com um líquido aquoso, por exemplo na forma de uma solução sólida em um polímero ou na forma de uma dispersão sólida sobre um veículo, por exemplo útil para a produção de composições farmacêuticas compreendendo cefuroxima axetil como ingrediente ativo e o uso de cefuroxima axetil na produção de uma forma de dosagem oral que não apresenta efeito alimentar adverso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0198998A AT413647B (de) | 1998-11-26 | 1998-11-26 | Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten |
PCT/EP1999/009096 WO2000030647A1 (en) | 1998-11-26 | 1999-11-24 | Compositions comprising cefuroxime axetil |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915694A true BR9915694A (pt) | 2001-08-14 |
Family
ID=3525440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915694-6A BR9915694A (pt) | 1998-11-26 | 1999-11-24 | Composições compreendendo cefuroxima axetil |
Country Status (30)
Country | Link |
---|---|
US (1) | US6727243B1 (pt) |
EP (1) | EP1133298B1 (pt) |
JP (1) | JP2002530338A (pt) |
KR (1) | KR20010080566A (pt) |
CN (1) | CN1330546A (pt) |
AR (1) | AR021405A1 (pt) |
AT (3) | AT413647B (pt) |
AU (1) | AU759517B2 (pt) |
BR (1) | BR9915694A (pt) |
CA (1) | CA2348876A1 (pt) |
CO (1) | CO5190668A1 (pt) |
CZ (1) | CZ20011845A3 (pt) |
DE (1) | DE69935609T2 (pt) |
ES (1) | ES2285866T3 (pt) |
HU (1) | HUP0104412A3 (pt) |
ID (1) | ID28615A (pt) |
IL (1) | IL142762A0 (pt) |
MY (1) | MY129564A (pt) |
NO (1) | NO20012526D0 (pt) |
NZ (1) | NZ511588A (pt) |
PE (1) | PE20001326A1 (pt) |
PL (1) | PL348744A1 (pt) |
RU (1) | RU2248794C2 (pt) |
SI (1) | SI1133298T1 (pt) |
SK (1) | SK7162001A3 (pt) |
TR (1) | TR200101417T2 (pt) |
TW (1) | TWI229603B (pt) |
WO (1) | WO2000030647A1 (pt) |
YU (1) | YU34601A (pt) |
ZA (1) | ZA200103927B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100342943B1 (ko) * | 1999-08-04 | 2002-07-02 | 민경윤 | 비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물 |
US7527807B2 (en) * | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
AU2001230490A1 (en) * | 2000-12-01 | 2002-06-11 | Arun Shriniwas Gosavi | Pharmaceutical formulation |
EP1911462A3 (en) * | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
US6524617B1 (en) * | 2001-07-25 | 2003-02-25 | Isp Investments Inc. | Synergistic filler composition |
MY148466A (en) | 2001-10-26 | 2013-04-30 | Merck Frosst Canada Ltd | Granule formulation |
ES2201932B2 (es) * | 2001-11-23 | 2005-03-16 | Glaxo Group Limited | Composicion farmaceutica. |
JP4526247B2 (ja) * | 2002-07-08 | 2010-08-18 | 第一三共株式会社 | 経口用セファロスポリン製剤 |
TW200404550A (en) * | 2002-07-08 | 2004-04-01 | Sankyo Co | Cepharospolin formulation for oral use |
AU2003260803A1 (en) * | 2002-08-30 | 2004-03-19 | Orchid Chemicals And Pharmaceuticals Ltd. | Sustained release pharmaceutical composition |
WO2005002540A2 (en) * | 2003-07-01 | 2005-01-13 | Ranbaxy Laboratories Limited | Dry powder pharmaceutical suspension compositions of cefuroxime axetil |
KR100552567B1 (ko) * | 2003-08-23 | 2006-02-15 | 한국유나이티드제약 주식회사 | 수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법 |
NZ580951A (en) * | 2005-04-29 | 2011-06-30 | Cubist Pharm Inc | Therapeutic compositions |
CN100402035C (zh) * | 2005-07-07 | 2008-07-16 | 石药集团中奇制药技术(石家庄)有限公司 | 一种微囊化头孢呋辛酯的药物组合物 |
CA2800444C (en) | 2010-06-14 | 2018-03-20 | Ratiopharm Gmbh | Ivabradine-containing pharmaceutical composition |
EP2882423A1 (en) * | 2012-08-07 | 2015-06-17 | Sandoz AG | Uncoated tablet comprising granules including a -lactam antibiotic and highly dispersed silicone dioxide |
JP5700740B1 (ja) | 2013-04-25 | 2015-04-15 | 杏林製薬株式会社 | 固形医薬組成物 |
JP5651812B1 (ja) | 2013-04-25 | 2015-01-14 | 杏林製薬株式会社 | 固形医薬組成物 |
US10154993B2 (en) | 2014-10-23 | 2018-12-18 | Kyorin Pharmaceutical Co., Ltd. | Solid pharmaceutical composition |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1572993A (en) * | 1976-02-16 | 1980-08-13 | Glaxo Operations Ltd | Ester derivatives of cefuroxime |
GB1571683A (en) * | 1976-02-16 | 1980-07-16 | Glaxo Operations Ltd | Ester derivatives of cefuroxime |
YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
IL85538A (en) * | 1987-02-27 | 1991-09-16 | Lilly Co Eli | Sustained release matrix tablet formulations containing hydrophilic and enteric polymers |
NL193682C (nl) | 1987-05-14 | 2000-07-04 | Glaxo Group Ltd | Beklede cefuroximaxetilsamenstelling. |
DE3810343A1 (de) * | 1988-03-26 | 1989-10-05 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen retardformen |
DE4139963A1 (de) * | 1991-12-04 | 1993-06-09 | Basf Ag, 6700 Ludwigshafen, De | Redispergierbares dispersionspulver aus n-vinylpyrrolidon-vinylacetat-copolymerisat, dessen herstellung und verwendung |
DE19602757A1 (de) * | 1996-01-26 | 1997-07-31 | Boehringer Mannheim Gmbh | Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung |
US5663258A (en) * | 1996-02-20 | 1997-09-02 | Isp Investments Inc. | Strongly swellable, moderately crosslinked copolymers of vinylpyrrolidone and vinyl acetate |
DE19631085A1 (de) * | 1996-08-01 | 1998-02-05 | Basf Ag | Verwendung von (Meth)acrylsäure-Maleinsäure-Copolymeren zur Verbesserung der Permeabilität der Schleimhaut |
PL191399B1 (pl) * | 1996-10-28 | 2006-05-31 | Gen Mills Inc | Sposób kapsułkowania lub osadzania składnika w osnowie w procesie ciągłym, sposób kapsułkowania i/lub osadzania składników w osnowie opartej na węglowodanach, sposób kapsułkowania i/lub osadzania składników w osnowie oraz kapsułka |
IL119627A (en) * | 1996-11-17 | 2002-03-10 | Yissum Res Dev Co | PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT |
CA2209868C (en) | 1997-08-15 | 2001-08-14 | Bernard Charles Sherman | Pharmaceutical compositions comprising cefuroxime axetil |
CA2322432C (en) * | 1998-03-03 | 2005-12-20 | Daewoong Pharmaceutical Co., Ltd. | Pharmaceutical composition containing cefuroxime axetil stable for moisture absorption |
CA2239331C (en) | 1998-05-29 | 1999-11-30 | Bernard Charles Sherman | Pharmaceutical tablets comprising cefuroxime axetil |
DE19835823A1 (de) | 1998-08-10 | 1999-10-07 | Lindopharm Gmbh | Pharmazeutische Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung sowie aus ihr hergestellte wässerige Suspension |
KR100342943B1 (ko) | 1999-08-04 | 2002-07-02 | 민경윤 | 비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물 |
-
1998
- 1998-11-26 AT AT0198998A patent/AT413647B/de not_active IP Right Cessation
-
1999
- 1999-11-20 TW TW088120315A patent/TWI229603B/zh not_active IP Right Cessation
- 1999-11-24 BR BR9915694-6A patent/BR9915694A/pt not_active IP Right Cessation
- 1999-11-24 ID IDW00200101088A patent/ID28615A/id unknown
- 1999-11-24 WO PCT/EP1999/009096 patent/WO2000030647A1/en active IP Right Grant
- 1999-11-24 YU YU34601A patent/YU34601A/sh unknown
- 1999-11-24 JP JP2000583530A patent/JP2002530338A/ja not_active Withdrawn
- 1999-11-24 KR KR1020017006542A patent/KR20010080566A/ko not_active Application Discontinuation
- 1999-11-24 HU HU0104412A patent/HUP0104412A3/hu unknown
- 1999-11-24 DE DE69935609T patent/DE69935609T2/de not_active Expired - Lifetime
- 1999-11-24 TR TR2001/01417T patent/TR200101417T2/xx unknown
- 1999-11-24 EP EP99959327A patent/EP1133298B1/en not_active Expired - Lifetime
- 1999-11-24 PL PL99348744A patent/PL348744A1/xx unknown
- 1999-11-24 AU AU16544/00A patent/AU759517B2/en not_active Ceased
- 1999-11-24 US US09/445,741 patent/US6727243B1/en not_active Expired - Fee Related
- 1999-11-24 CA CA002348876A patent/CA2348876A1/en not_active Abandoned
- 1999-11-24 CZ CZ20011845A patent/CZ20011845A3/cs unknown
- 1999-11-24 SK SK716-2001A patent/SK7162001A3/sk unknown
- 1999-11-24 ES ES99959327T patent/ES2285866T3/es not_active Expired - Lifetime
- 1999-11-24 IL IL14276299A patent/IL142762A0/xx unknown
- 1999-11-24 CN CN99813759A patent/CN1330546A/zh active Pending
- 1999-11-24 RU RU2001117518/15A patent/RU2248794C2/ru not_active IP Right Cessation
- 1999-11-24 AT AT99959327T patent/ATE357237T1/de active
- 1999-11-24 NZ NZ511588A patent/NZ511588A/en unknown
- 1999-11-24 SI SI9930969T patent/SI1133298T1/sl unknown
- 1999-11-25 AR ARP990106024A patent/AR021405A1/es not_active Application Discontinuation
- 1999-11-25 PE PE1999001186A patent/PE20001326A1/es not_active Application Discontinuation
- 1999-11-26 MY MYPI99005158A patent/MY129564A/en unknown
- 1999-11-26 CO CO99074648A patent/CO5190668A1/es not_active Application Discontinuation
-
2001
- 2001-05-15 ZA ZA200103927A patent/ZA200103927B/en unknown
- 2001-05-23 NO NO20012526A patent/NO20012526D0/no not_active Application Discontinuation
-
2004
- 2004-02-23 AT AT0028104A patent/AT500135A1/de not_active Application Discontinuation
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