DK0941315T3 - Fusionsproteiner indeholdende stressproteiner til induktion af immunreaktioner - Google Patents
Fusionsproteiner indeholdende stressproteiner til induktion af immunreaktionerInfo
- Publication number
- DK0941315T3 DK0941315T3 DK97945684T DK97945684T DK0941315T3 DK 0941315 T3 DK0941315 T3 DK 0941315T3 DK 97945684 T DK97945684 T DK 97945684T DK 97945684 T DK97945684 T DK 97945684T DK 0941315 T3 DK0941315 T3 DK 0941315T3
- Authority
- DK
- Denmark
- Prior art keywords
- antigen
- relates
- vaccines
- induce
- immune responses
- Prior art date
Links
- 102000002812 Heat-Shock Proteins Human genes 0.000 title abstract 7
- 108010004889 Heat-Shock Proteins Proteins 0.000 title abstract 7
- 230000028993 immune response Effects 0.000 title abstract 5
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 7
- 102000036639 antigens Human genes 0.000 abstract 7
- 108091007433 antigens Proteins 0.000 abstract 7
- 229960005486 vaccine Drugs 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000013566 allergen Substances 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000004044 response Effects 0.000 abstract 2
- 241000712461 unidentified influenza virus Species 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75662196A | 1996-11-26 | 1996-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0941315T3 true DK0941315T3 (da) | 2006-05-15 |
Family
ID=25044309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97945684T DK0941315T3 (da) | 1996-11-26 | 1997-11-25 | Fusionsproteiner indeholdende stressproteiner til induktion af immunreaktioner |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0941315B1 (fr) |
| JP (2) | JP4484969B2 (fr) |
| AT (1) | ATE318899T1 (fr) |
| AU (1) | AU736318B2 (fr) |
| CA (1) | CA2272536A1 (fr) |
| DE (1) | DE69735376T2 (fr) |
| DK (1) | DK0941315T3 (fr) |
| ES (1) | ES2258796T3 (fr) |
| HK (1) | HK1022715A1 (fr) |
| PT (1) | PT941315E (fr) |
| WO (1) | WO1998023735A1 (fr) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994029459A1 (fr) | 1993-06-04 | 1994-12-22 | Whitehead Institute For Biomedical Research | Proteines du stress et leurs utilisations |
| IL123219A0 (en) | 1995-08-18 | 1998-09-24 | Sloan Kettering Inst Cancer | Method for treatment of cancer and infectious diseases and compositions useful in same |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6709672B2 (en) | 1997-03-05 | 2004-03-23 | Biotech Tools S.A. | Pharmaceutical or food composition for treating pathologies associated with graft rejection or an allergic or autoimmune reaction |
| BE1011033A6 (fr) * | 1997-03-05 | 1999-04-06 | Univ Bruxelles | Composition pharmaceutique et/ou alimentaire pour le traitement de pathologies liees a un rejet de greffe, une reaction allergique ou auto-immune ou du cancer. |
| JP5132851B2 (ja) | 1997-08-05 | 2013-01-30 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
| EP1002110B2 (fr) | 1997-08-05 | 2009-07-29 | Stressgen Biotechnologies Corporation | Reponses immunitaires contre les antigenes du vph et declenchees par des compositions comprenant un antigene du vph, et proteine du stress ou vecteur d'expression capable d'exprimer ces proteines |
| US7731972B1 (en) | 2000-02-04 | 2010-06-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| AU2337499A (en) * | 1998-01-23 | 1999-08-09 | National Jewish Medical And Research Center | Method for treating inflammatory diseases using heat shock proteins |
| ATE482714T1 (de) | 1998-02-20 | 2010-10-15 | Univ Miami | Modifizierter hitzeschockprotein-antigenpeptid- komplex |
| JP4892132B2 (ja) * | 1998-11-24 | 2012-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | ７０ｋＤ熱ショック蛋白による化合物の細胞内標的輸送 |
| JP2003504074A (ja) | 1999-07-08 | 2003-02-04 | ストレスゲン バイオテクノロジーズ コーポレイション | インビトロでのＴｈ１様応答の誘導 |
| AUPQ233799A0 (en) | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
| US20020039583A1 (en) * | 1999-09-30 | 2002-04-04 | Subjeck John R. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| JP2003510334A (ja) | 1999-09-30 | 2003-03-18 | コリクサ コーポレイション | 癌及び感染症の予防及び治療のためのストレスタンパク質組成物及び方法 |
| US7378096B2 (en) | 1999-09-30 | 2008-05-27 | Health Research, Inc. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| CA2388045C (fr) * | 1999-10-20 | 2014-02-11 | Tzyy-Choou Wu | Compositions immunogeniques a base d'acide nucleique codant la chimere antigene hsp |
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| CA2396384A1 (fr) | 2000-01-14 | 2001-07-19 | Whitehead Institute For Biomedical Research | L'elicitation in vivo des ctl par des proteines de fusion de la proteine de choc thermique correspond a un domaine discret de liaison de l'atp et est independante des cellules cd4+ |
| EE200200709A (et) | 2000-06-26 | 2004-08-16 | Stressgen Biotechnologies Corporation | Liitvalku sisaldava kompositsiooni ning seda liitvalku ja liitpolüpeptiidi kodeeriva nukleiinhappe kasutamine |
| AU2001278117A1 (en) | 2000-08-03 | 2002-02-18 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| GB0028122D0 (en) * | 2000-11-17 | 2001-01-03 | St Georges Entpr Ltd | Method |
| KR20030074787A (ko) | 2001-02-05 | 2003-09-19 | 스트레스젠 바이오테크놀러지스 코포레이션 | Ｂ형 간염 바이러스 치료 |
| EP1536006B1 (fr) | 2002-08-30 | 2011-08-24 | Medinet Co., Ltd. | Antigenes cancereux et leur utilisation |
| GB0226105D0 (en) * | 2002-11-08 | 2002-12-18 | St Georges S Entpr Ltd | Pain relief agents |
| US7420037B2 (en) | 2003-02-13 | 2008-09-02 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| US7309491B2 (en) | 2003-04-11 | 2007-12-18 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| WO2004098526A2 (fr) | 2003-05-05 | 2004-11-18 | Johns Hopkins University | Vaccin a adn anti-cancer faisant appel a des plasmides codant une sequence-signal, un antigene oncoproteine mutant, et une proteine de choc thermique |
| CA2594040A1 (fr) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Interference arn bloquant l'expression de l'immunite potentialisee de proteines pro-apoptotiques induite par adn et des vaccins de cellules dendritiques transfectes |
| CA2594612A1 (fr) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions a motifs moleculaires associes a des agents pathogenes et methodes d'utilisation |
| WO2007066334A1 (fr) | 2005-12-06 | 2007-06-14 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Vaccin ameliore contre la grippe |
| CA2638760A1 (fr) | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions comprenant de l'hemagglutinine, leurs procedes de fabrication et leurs procedes d'utilisation |
| WO2008054535A2 (fr) * | 2006-05-11 | 2008-05-08 | Novavax, Inc. | Nouveaux vaccins contre l'influenza m2 |
| CA2659275C (fr) | 2006-07-27 | 2017-01-10 | Ligocyte Pharmaceuticals, Inc. | Particules de type virus grippal chimerique |
| CA2657955A1 (fr) * | 2006-07-27 | 2008-08-07 | Ligocyte Pharmaceuticals, Inc. | Particules de type virus chimerique |
| EP2129773B1 (fr) * | 2007-02-23 | 2013-02-13 | Baylor Research Institute | Applications thérapeutiques des cellules présentant un antigène humain par l'intermédiaire de la dectine-1 |
| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| CN102014937A (zh) | 2008-03-03 | 2011-04-13 | 迈阿密大学 | 基于异基因癌细胞的免疫治疗 |
| EP2274001A4 (fr) | 2008-03-20 | 2012-08-01 | Univ Miami | Vaccination par protéine de choc thermique gp96 et procédés d'utilisation |
| CN102753582A (zh) | 2009-11-03 | 2012-10-24 | 莱戈赛特医药股份有限公司 | 嵌合RSV-F多肽、和慢病毒或α-反转录病毒GAG基VLP |
| US8685406B2 (en) | 2009-11-13 | 2014-04-01 | The Board Of Regents Of The University Of Texas System | Compositions of and method of using heat shock protein peptides |
| AU2012285710B2 (en) * | 2011-07-21 | 2016-12-15 | Biotech Tools S.A. | Dosage of DnaK |
| WO2016127015A1 (fr) | 2015-02-06 | 2016-08-11 | Heat Biologics, Inc. | Vecteur co-exprimant un vaccin et des molécules co-stimulantes |
| WO2018071405A1 (fr) | 2016-10-11 | 2018-04-19 | University Of Miami | Vecteurs et cellules de vaccin pour immunité contre le virus zika |
| US11548930B2 (en) | 2017-04-04 | 2023-01-10 | Heat Biologics, Inc. | Intratumoral vaccination |
| KR101805430B1 (ko) | 2017-04-26 | 2017-12-06 | (주)넥스젠바이오텍 | 항산화 활성 및 피부 세포 증식 효과가 증가한 열 충격 단백질의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
| CA3230289A1 (fr) * | 2021-08-30 | 2023-03-09 | Japan Eco-Science Co., Ltd. | Formulation immunostimulatrice, et produit cosmetique, alimentaire, additif alimentaire et quasi-medicament contenant ladite formulation immunostimulatrice |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994029459A1 (fr) * | 1993-06-04 | 1994-12-22 | Whitehead Institute For Biomedical Research | Proteines du stress et leurs utilisations |
| IL102687A (en) * | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| IL123219A0 (en) * | 1995-08-18 | 1998-09-24 | Sloan Kettering Inst Cancer | Method for treatment of cancer and infectious diseases and compositions useful in same |
| WO1997026910A2 (fr) * | 1996-01-27 | 1997-07-31 | Max-Delbrück-Centrum für Molekulare Medizin | Vaccin antitumoral pour le traitement immunitaire des tumeurs malignes |
-
1997
- 1997-11-25 PT PT97945684T patent/PT941315E/pt unknown
- 1997-11-25 AU AU51120/98A patent/AU736318B2/en not_active Ceased
- 1997-11-25 WO PCT/CA1997/000897 patent/WO1998023735A1/fr active IP Right Grant
- 1997-11-25 DE DE69735376T patent/DE69735376T2/de not_active Expired - Lifetime
- 1997-11-25 ES ES97945684T patent/ES2258796T3/es not_active Expired - Lifetime
- 1997-11-25 AT AT97945684T patent/ATE318899T1/de not_active IP Right Cessation
- 1997-11-25 JP JP52408198A patent/JP4484969B2/ja not_active Expired - Fee Related
- 1997-11-25 CA CA002272536A patent/CA2272536A1/fr not_active Abandoned
- 1997-11-25 DK DK97945684T patent/DK0941315T3/da active
- 1997-11-25 EP EP97945684A patent/EP0941315B1/fr not_active Expired - Lifetime
-
2000
- 2000-03-10 HK HK00101484A patent/HK1022715A1/xx not_active IP Right Cessation
-
2008
- 2008-05-08 JP JP2008122787A patent/JP2008214360A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2272536A1 (fr) | 1998-06-04 |
| DE69735376D1 (de) | 2006-04-27 |
| EP0941315A1 (fr) | 1999-09-15 |
| EP0941315B1 (fr) | 2006-03-01 |
| AU5112098A (en) | 1998-06-22 |
| WO1998023735A1 (fr) | 1998-06-04 |
| JP2001504702A (ja) | 2001-04-10 |
| ES2258796T3 (es) | 2006-09-01 |
| HK1022715A1 (en) | 2000-08-18 |
| AU736318B2 (en) | 2001-07-26 |
| JP2008214360A (ja) | 2008-09-18 |
| DE69735376T2 (de) | 2006-12-14 |
| JP4484969B2 (ja) | 2010-06-16 |
| ATE318899T1 (de) | 2006-03-15 |
| PT941315E (pt) | 2006-06-30 |
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