PT941315E - Proteinas de stress contendo proteinas de fusao para induzir respostas imunitarias - Google Patents
Proteinas de stress contendo proteinas de fusao para induzir respostas imunitariasInfo
- Publication number
- PT941315E PT941315E PT97945684T PT97945684T PT941315E PT 941315 E PT941315 E PT 941315E PT 97945684 T PT97945684 T PT 97945684T PT 97945684 T PT97945684 T PT 97945684T PT 941315 E PT941315 E PT 941315E
- Authority
- PT
- Portugal
- Prior art keywords
- antigen
- immune response
- proteins
- stress
- relates
- Prior art date
Links
- 102000002812 Heat-Shock Proteins Human genes 0.000 title abstract 7
- 108010004889 Heat-Shock Proteins Proteins 0.000 title abstract 7
- 230000028993 immune response Effects 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 7
- 102000036639 antigens Human genes 0.000 abstract 7
- 108091007433 antigens Proteins 0.000 abstract 7
- 229960005486 vaccine Drugs 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000013566 allergen Substances 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000004044 response Effects 0.000 abstract 2
- 241000712461 unidentified influenza virus Species 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75662196A | 1996-11-26 | 1996-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT941315E true PT941315E (pt) | 2006-06-30 |
Family
ID=25044309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97945684T PT941315E (pt) | 1996-11-26 | 1997-11-25 | Proteinas de stress contendo proteinas de fusao para induzir respostas imunitarias |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0941315B1 (pt) |
| JP (2) | JP4484969B2 (pt) |
| AT (1) | ATE318899T1 (pt) |
| AU (1) | AU736318B2 (pt) |
| CA (1) | CA2272536A1 (pt) |
| DE (1) | DE69735376T2 (pt) |
| DK (1) | DK0941315T3 (pt) |
| ES (1) | ES2258796T3 (pt) |
| HK (1) | HK1022715A1 (pt) |
| PT (1) | PT941315E (pt) |
| WO (1) | WO1998023735A1 (pt) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT700445E (pt) | 1993-06-04 | 2002-07-31 | Whitehead Biomedical Inst | Proteinas de stress e suas utilizacoes |
| EP0888053A4 (en) | 1995-08-18 | 2002-07-31 | Sloan Kettering Inst Cancer | METHOD FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASES AND COMPOSITIONS USEFUL FOR THE TREATMENT |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6709672B2 (en) | 1997-03-05 | 2004-03-23 | Biotech Tools S.A. | Pharmaceutical or food composition for treating pathologies associated with graft rejection or an allergic or autoimmune reaction |
| BE1011033A6 (fr) * | 1997-03-05 | 1999-04-06 | Univ Bruxelles | Composition pharmaceutique et/ou alimentaire pour le traitement de pathologies liees a un rejet de greffe, une reaction allergique ou auto-immune ou du cancer. |
| US7731972B1 (en) | 2000-02-04 | 2010-06-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| ATE327259T1 (de) | 1997-08-05 | 2006-06-15 | Stressgen Biotechnologies Corp | Immunantwort gegen hpv antigene hervorgerufen von zusammensetzungen die ein hpv antigen und ein stressprotein enthalten oder einem expressionsvektor fähig zur expression dieser proteine |
| JP5132851B2 (ja) | 1997-08-05 | 2013-01-30 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
| US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| IL137404A0 (en) * | 1998-01-23 | 2001-07-24 | Nat Jewish Med & Res Center | Method for treating inflammatory diseases using heat shock proteins |
| ATE359084T1 (de) | 1998-02-20 | 2007-05-15 | Univ Miami | Modifizierter hitzeschockprotein/peptidantigen komplex |
| JP4892132B2 (ja) * | 1998-11-24 | 2012-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | ７０ｋＤ熱ショック蛋白による化合物の細胞内標的輸送 |
| CA2378097A1 (en) | 1999-07-08 | 2001-01-18 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
| AUPQ233799A0 (en) | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
| JP2003510334A (ja) * | 1999-09-30 | 2003-03-18 | コリクサ コーポレイション | 癌及び感染症の予防及び治療のためのストレスタンパク質組成物及び方法 |
| US7378096B2 (en) | 1999-09-30 | 2008-05-27 | Health Research, Inc. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| US20020039583A1 (en) * | 1999-09-30 | 2002-04-04 | Subjeck John R. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| EP1222289B1 (en) * | 1999-10-20 | 2008-04-16 | The Johns Hopkins University School Of Medicine | Chimeric immunogenic compositions and nucleic acids encoding them |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| JP2003519668A (ja) | 2000-01-14 | 2003-06-24 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | 熱ショックタンパク質融合タンパク質による、ｃｄ４＋ｔ細胞非依存性のインビボｃｔｌ惹起による個別ａｔｐ結合ドメインのマッピング |
| NZ523408A (en) | 2000-06-26 | 2006-02-24 | Stressgen Biotechnologies Corp | Human papilloma virus treatment |
| CA2417214C (en) | 2000-08-03 | 2016-06-21 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| GB0028122D0 (en) * | 2000-11-17 | 2001-01-03 | St Georges Entpr Ltd | Method |
| RU2295536C2 (ru) | 2001-02-05 | 2007-03-20 | Стрессджен Байотекнолоджиз Корп. | Композиции на основе белка вируса гепатита в и стрессового белка и их применение |
| ATE521702T1 (de) | 2002-08-30 | 2011-09-15 | Medinet Co Ltd | Krebsantigene und deren nutzung |
| GB0226105D0 (en) * | 2002-11-08 | 2002-12-18 | St Georges S Entpr Ltd | Pain relief agents |
| US7420037B2 (en) | 2003-02-13 | 2008-09-02 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| US7309491B2 (en) | 2003-04-11 | 2007-12-18 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| WO2004098526A2 (en) | 2003-05-05 | 2004-11-18 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| WO2006073970A2 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
| MY157941A (en) | 2005-01-19 | 2016-08-15 | Vaxinnate Corp | Compositions of pathogen-associated molecular patterns and methods of use |
| EP1968632B1 (en) | 2005-12-06 | 2012-04-11 | Yeda Research And Development Co., Ltd. | Improved influenza vaccine |
| EP1991264B1 (en) | 2006-03-07 | 2015-01-07 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| EP1998814A4 (en) * | 2006-05-11 | 2010-06-16 | Novavax Inc | NEW VACCINES AGAINST INFLUENZA M2 |
| AU2007345682B2 (en) * | 2006-07-27 | 2013-07-18 | Ligocyte Pharmaceuticals, Inc. | Chimeric virus-like particles |
| CA2659275C (en) | 2006-07-27 | 2017-01-10 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| NZ603245A (en) * | 2007-02-23 | 2014-04-30 | Baylor Res Inst | Therapeutic applications of activation of human antigen-presenting cells through dectin-1 |
| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| AU2009223838B2 (en) | 2008-03-03 | 2012-07-26 | The University Of Miami | Allogeneic cancer cell-based immunotherapy |
| CA2718884C (en) | 2008-03-20 | 2016-11-22 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| EP2496609A4 (en) | 2009-11-03 | 2013-05-08 | Ligocyte Pharmaceuticals Inc | CHIMERIC RSV-F POLYPEPTIDE AND VLPS ON LENTIVIREN OR ALPHA RETROVIRUS GAG BASE |
| US8685406B2 (en) | 2009-11-13 | 2014-04-01 | The Board Of Regents Of The University Of Texas System | Compositions of and method of using heat shock protein peptides |
| AU2012285710B2 (en) * | 2011-07-21 | 2016-12-15 | Biotech Tools S.A. | Dosage of DnaK |
| RU2714157C2 (ru) | 2015-02-06 | 2020-02-12 | Хит Байолоджикс, Инк. | Вектор, коэкспрессирующий молекулы для вакцинации и костимулирующие молекулы |
| WO2018071405A1 (en) | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| CA3058938A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
| KR101805430B1 (ko) | 2017-04-26 | 2017-12-06 | (주)넥스젠바이오텍 | 항산화 활성 및 피부 세포 증식 효과가 증가한 열 충격 단백질의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
| CA3230289A1 (en) * | 2021-08-30 | 2023-03-09 | Japan Eco-Science Co., Ltd. | Immunostimulatory preparation and cosmetic, food, feed additive, and quasi-pharmaceutical product containing the immunostimulatory preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL102687A (en) * | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| PT700445E (pt) * | 1993-06-04 | 2002-07-31 | Whitehead Biomedical Inst | Proteinas de stress e suas utilizacoes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| EP0888053A4 (en) * | 1995-08-18 | 2002-07-31 | Sloan Kettering Inst Cancer | METHOD FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASES AND COMPOSITIONS USEFUL FOR THE TREATMENT |
| WO1997026910A2 (de) * | 1996-01-27 | 1997-07-31 | Max-Delbrück-Centrum für Molekulare Medizin | Tumorimpfstoff für die immuntherapie von malignen tumoren |
-
1997
- 1997-11-25 AU AU51120/98A patent/AU736318B2/en not_active Ceased
- 1997-11-25 EP EP97945684A patent/EP0941315B1/en not_active Expired - Lifetime
- 1997-11-25 AT AT97945684T patent/ATE318899T1/de not_active IP Right Cessation
- 1997-11-25 ES ES97945684T patent/ES2258796T3/es not_active Expired - Lifetime
- 1997-11-25 PT PT97945684T patent/PT941315E/pt unknown
- 1997-11-25 JP JP52408198A patent/JP4484969B2/ja not_active Expired - Fee Related
- 1997-11-25 DE DE69735376T patent/DE69735376T2/de not_active Expired - Lifetime
- 1997-11-25 DK DK97945684T patent/DK0941315T3/da active
- 1997-11-25 WO PCT/CA1997/000897 patent/WO1998023735A1/en active IP Right Grant
- 1997-11-25 CA CA002272536A patent/CA2272536A1/en not_active Abandoned
-
2000
- 2000-03-10 HK HK00101484A patent/HK1022715A1/xx not_active IP Right Cessation
-
2008
- 2008-05-08 JP JP2008122787A patent/JP2008214360A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0941315A1 (en) | 1999-09-15 |
| DK0941315T3 (da) | 2006-05-15 |
| WO1998023735A1 (en) | 1998-06-04 |
| JP2001504702A (ja) | 2001-04-10 |
| DE69735376T2 (de) | 2006-12-14 |
| EP0941315B1 (en) | 2006-03-01 |
| HK1022715A1 (en) | 2000-08-18 |
| CA2272536A1 (en) | 1998-06-04 |
| DE69735376D1 (de) | 2006-04-27 |
| JP4484969B2 (ja) | 2010-06-16 |
| AU736318B2 (en) | 2001-07-26 |
| ES2258796T3 (es) | 2006-09-01 |
| ATE318899T1 (de) | 2006-03-15 |
| AU5112098A (en) | 1998-06-22 |
| JP2008214360A (ja) | 2008-09-18 |
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