ATE468127T1 - Ii-key/antigene epitop-hybrid-peptid-vakzine - Google Patents

Ii-key/antigene epitop-hybrid-peptid-vakzine

Info

Publication number
ATE468127T1
ATE468127T1 AT03789700T AT03789700T ATE468127T1 AT E468127 T1 ATE468127 T1 AT E468127T1 AT 03789700 T AT03789700 T AT 03789700T AT 03789700 T AT03789700 T AT 03789700T AT E468127 T1 ATE468127 T1 AT E468127T1
Authority
AT
Austria
Prior art keywords
mhc class
terminal
interest
nucleic acid
polypeptide
Prior art date
Application number
AT03789700T
Other languages
English (en)
Inventor
Robert Humphreys
Minzhen Xu
Original Assignee
Antigen Express Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/245,871 external-priority patent/US20030235594A1/en
Application filed by Antigen Express Inc filed Critical Antigen Express Inc
Priority claimed from PCT/US2003/028574 external-priority patent/WO2004030616A2/en
Application granted granted Critical
Publication of ATE468127T1 publication Critical patent/ATE468127T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03789700T 2002-09-17 2003-09-12 Ii-key/antigene epitop-hybrid-peptid-vakzine ATE468127T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/245,871 US20030235594A1 (en) 1999-09-14 2002-09-17 Ii-Key/antigenic epitope hybrid peptide vaccines
US10/253,286 US7179645B2 (en) 2002-09-24 2002-09-24 Ii-Key/antigenic epitope hybrid peptide vaccines
PCT/US2003/028574 WO2004030616A2 (en) 2002-09-17 2003-09-12 Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES

Publications (1)

Publication Number Publication Date
ATE468127T1 true ATE468127T1 (de) 2010-06-15

Family

ID=31993142

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789700T ATE468127T1 (de) 2002-09-17 2003-09-12 Ii-key/antigene epitop-hybrid-peptid-vakzine

Country Status (3)

Country Link
US (2) US7179645B2 (de)
AT (1) ATE468127T1 (de)
DE (1) DE60332645D1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
WO2006098769A2 (en) * 2004-09-24 2006-09-21 Afg Biosolutions, Inc. Multipathogen and monopathogen protection against the bacterial and viral infections associated with biological warfare, cardiac diseases, and cancers
JP5116150B2 (ja) * 2005-09-07 2013-01-09 日本電気株式会社 Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
CA2812794C (en) * 2005-09-08 2020-02-11 Henry M. Jackson Foundation For The Advancement Of Military Medicine, C. Targeted identification of immunogenic peptides
US8945573B2 (en) * 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
CA2523032A1 (en) * 2005-10-07 2007-04-07 Immunovaccine Technologies Inc. Vaccines for cancer therapy
PT1957528E (pt) * 2005-11-30 2013-01-09 Univ Copenhagen Uma vacina de nucleótido
US9202184B2 (en) * 2006-09-07 2015-12-01 International Business Machines Corporation Optimizing the selection, verification, and deployment of expert resources in a time of chaos
US7809660B2 (en) * 2006-10-03 2010-10-05 International Business Machines Corporation System and method to optimize control cohorts using clustering algorithms
US20080294459A1 (en) * 2006-10-03 2008-11-27 International Business Machines Corporation Health Care Derivatives as a Result of Real Time Patient Analytics
US8145582B2 (en) * 2006-10-03 2012-03-27 International Business Machines Corporation Synthetic events for real time patient analysis
US8055603B2 (en) * 2006-10-03 2011-11-08 International Business Machines Corporation Automatic generation of new rules for processing synthetic events using computer-based learning processes
WO2008092041A2 (en) * 2007-01-24 2008-07-31 Carnegie Mellon University Optical biosensors
US7970759B2 (en) 2007-02-26 2011-06-28 International Business Machines Corporation System and method for deriving a hierarchical event based database optimized for pharmaceutical analysis
US7792774B2 (en) 2007-02-26 2010-09-07 International Business Machines Corporation System and method for deriving a hierarchical event based database optimized for analysis of chaotic events
US7788203B2 (en) * 2007-02-26 2010-08-31 International Business Machines Corporation System and method of accident investigation for complex situations involving numerous known and unknown factors along with their probabilistic weightings
US7853611B2 (en) * 2007-02-26 2010-12-14 International Business Machines Corporation System and method for deriving a hierarchical event based database having action triggers based on inferred probabilities
US20080294361A1 (en) * 2007-05-24 2008-11-27 Popp Shane M Intelligent execution system for the monitoring and execution of vaccine manufacturing
CN106310293A (zh) 2007-09-27 2017-01-11 免疫疫苗技术有限公司 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
US7930262B2 (en) * 2007-10-18 2011-04-19 International Business Machines Corporation System and method for the longitudinal analysis of education outcomes using cohort life cycles, cluster analytics-based cohort analysis, and probabilistic data schemas
US8426153B2 (en) * 2007-12-03 2013-04-23 Carnegie Mellon University Linked peptides fluorogenic biosensors
US7779051B2 (en) * 2008-01-02 2010-08-17 International Business Machines Corporation System and method for optimizing federated and ETL'd databases with considerations of specialized data structures within an environment having multidimensional constraints
KR101588736B1 (ko) * 2008-01-10 2016-01-26 리서치 디벨롭먼트 파운데이션 얼리키아 샤피엔시스에 대한 백신 및 진단제
AU2009253780B2 (en) 2008-06-05 2014-08-14 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
CA2731444A1 (en) * 2008-09-02 2010-03-11 Antigen Express, Inc. Human papillomavirus / li-key hybrids and methods of use
PL2865387T3 (pl) * 2008-11-21 2019-12-31 Københavns Universitet (University Of Copenhagen) Pobudzenie odpowiedzi odpornościowej
CA2750922A1 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-key hybrid peptides that modulate the immune response to influenza
US8187611B2 (en) * 2009-10-29 2012-05-29 Albert Einstein College Of Medicine Of Yeshiva University Anti-peptide antibodies that cross react with protective antigen of Bacillus anthracis and uses thereof
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
US10318877B2 (en) 2010-10-19 2019-06-11 International Business Machines Corporation Cohort-based prediction of a future event
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
PL3262932T3 (pl) * 2011-10-28 2019-10-31 Regeneron Pharma Genetycznie zmodyfikowany główny układ zgodności tkankowej myszy
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
US11096994B2 (en) 2012-10-30 2021-08-24 Aravax Pty Ltd Immunotherapeutic molecules and uses thereof
EP2848937A1 (de) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Verfahren zur Identifizierung neuartiger HIV-1-Immunogene
RU2689552C2 (ru) * 2013-09-25 2019-05-28 Аравакс Пти Лтд Новая иммунотерапевтическая композиция и ее применения
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CN105753989A (zh) * 2014-12-15 2016-07-13 牛津疫苗医学生物科技（英国）有限公司 人工多抗原融合蛋白及其制备和应用
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
WO2016183500A1 (en) * 2015-05-14 2016-11-17 La Jolla Institute For Allergy And Immunology Novel antigens and t cell epitopes from cockroach and methods of making and using same
GB201704417D0 (en) 2017-03-20 2017-05-03 Univ Copenhagen Improved li vaccine adjuvant
CN114010777B (zh) * 2021-08-31 2022-07-22 王树毅 一种多佐剂制备多组分疫苗的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247080A (en) * 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4650764A (en) * 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
CA1255586A (en) * 1984-07-24 1989-06-13 Hendrik M. Geysen Method of determining mimotopes
US4797368A (en) * 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US6133029A (en) * 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US5194425A (en) * 1988-06-23 1993-03-16 Anergen, Inc. Mhc-mediated toxic conjugates useful in ameliorating autoimmunity
CA2047191A1 (en) * 1989-02-17 1990-08-18 Hendrik M. Geysen Method for the use and synthesis of peptides
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5126132A (en) * 1989-08-21 1992-06-30 The United States Of America As Represented By The Department Of Health And Human Services Tumor infiltrating lymphocytes as a treatment modality for human cancer
DE69033911D1 (de) * 1989-10-24 2002-03-14 Chiron Corp System zur freisetzung von infektiösen proteinen
US6120769A (en) 1989-11-03 2000-09-19 Immulogic Pharmaceutical Corporation Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
CA2090860C (en) * 1990-11-21 2003-09-16 Richard A. Houghten Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US6419931B1 (en) * 1991-08-26 2002-07-16 Epimmune Inc. Compositions and methods for eliciting CTL immunity
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
AU671971B2 (en) * 1991-11-29 1996-09-19 Chiron Corporation Anti-cancer immunotherapeutic vector constructs
US5679527A (en) * 1992-03-25 1997-10-21 Antigen Express, Inc. Modification of polypeptide structure
EP0671926B1 (de) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunmodulierende peptide
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US5559028A (en) * 1993-05-19 1996-09-24 Antigen Express, Inc. Methods of enhancing or antigen presentation to T cells inhibiting
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US5910300A (en) 1995-11-01 1999-06-08 Bracco Research S.A. Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
AU3307497A (en) 1996-06-26 1998-01-14 Antigen Express, Inc. Immunotherapy by modulation of antigen presentation
US6432409B1 (en) 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response

Also Published As

Publication number Publication date
US20080305122A1 (en) 2008-12-11
DE60332645D1 (de) 2010-07-01
US20040058881A1 (en) 2004-03-25
US7179645B2 (en) 2007-02-20

Similar Documents

Publication Publication Date Title
ATE468127T1 (de) Ii-key/antigene epitop-hybrid-peptid-vakzine
GB2439474A (en) LI-Key/Antigenic epitope hybrid peptide vaccines
CA2289912A1 (en) Human receptor proteins; related reagents and methods
HUP0004639A2 (hu) Chlamydia fehérje, génszekvencia és ezek alkalmazása
NO995002D0 (no) Modifiserte TNF-<alfa>-molekyler, DNA som koder for slike modifiserte TNF-<alfa>-molekyler og vaksiner omfattende slike TNF-<alfa>-molekyler og DNA
NZ333999A (en) GnRH-leukotoxin chimeric proteins for use in vaccines
EP0784059A4 (de) Antigenes polypeptid aus chlamydia pneumoniae
ATE366313T1 (de) Antigene peptide aus neisseria
SE9402089D0 (sv) Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments
ATE298798T1 (de) Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin
ATE378590T1 (de) Verfahren zum auffinden von peptiden zur verwendung in der immuntherapie
CA2542104A1 (en) Method for the identification of epitopes related to immunogenicity in biopharmaceuticals
CA2514303A1 (en) Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
JPH05506247A (ja) ヒトγインターフェロンのアンタゴニスト
JPS6470498A (en) Synthetic peptide and antibody thereto
ATE327251T1 (de) Methode zur reduzierung der immunogenizität von staphylokinase durch entfernen von t-zell epitopen
Krikorian et al. A peptide carrier with a built-in vaccine adjuvant: construction of immunogenic conjugates
ATE357526T1 (de) Modifizierte hcv peptid-impfstoffe
NO20005081L (no) Et polypeptid som omfatter aminosyren fra et N-terminalt kolinbindende protein A trunkat, vaksine avledet derav og anvendelser derav
Patel et al. A cyclic peptide analogue of the loop III region of platelet‐derived growth factor‐BB is a synthetic antigen for the native protein
PE20010239A1 (es) Gen derivado de lawsonia y polipeptidos, peptidos y proteinas de hemolisina relacionados y sus usos
Verdoliva et al. Antigenicity of topochemically related peptides
WO2004056316A8 (en) Vaccines against hiv-1 tat protein to generate neutralizing antibodies
KR940005665A (ko) 분리된 폴리펩티드, 이를 암호하는 핵산 분자, 상기 폴리펩티드를 포함하는 조성물 및 이를 사용하는 방법
MX2024001179A (es) Proteinas de union a antigenos que se unen especificamente a ct45.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties