DK0939628T3 - Thiolsulfon-metalloproteaseinhibitorer - Google Patents
Thiolsulfon-metalloproteaseinhibitorerInfo
- Publication number
- DK0939628T3 DK0939628T3 DK97936169T DK97936169T DK0939628T3 DK 0939628 T3 DK0939628 T3 DK 0939628T3 DK 97936169 T DK97936169 T DK 97936169T DK 97936169 T DK97936169 T DK 97936169T DK 0939628 T3 DK0939628 T3 DK 0939628T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- proteinase
- thiolsulfon
- metalloprotease inhibitors
- mmp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Lubricants (AREA)
- Enzymes And Modification Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2204396P | 1996-07-22 | 1996-07-22 | |
| PCT/US1997/012874 WO1998003164A1 (fr) | 1996-07-22 | 1997-07-22 | Composes a base de sulfone de thiol servant d'inhibiteurs des metalloproteases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0939628T3 true DK0939628T3 (da) | 2003-07-07 |
Family
ID=21807522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97936169T DK0939628T3 (da) | 1996-07-22 | 1997-07-22 | Thiolsulfon-metalloproteaseinhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6013649A (fr) |
| EP (1) | EP0939628B1 (fr) |
| JP (1) | JP2001505869A (fr) |
| KR (1) | KR20000067963A (fr) |
| CN (1) | CN1230884A (fr) |
| AT (1) | ATE233552T1 (fr) |
| AU (1) | AU714687B2 (fr) |
| BR (1) | BR9710758A (fr) |
| CA (1) | CA2260859A1 (fr) |
| CZ (1) | CZ16799A3 (fr) |
| DE (1) | DE69719538T2 (fr) |
| DK (1) | DK0939628T3 (fr) |
| ES (1) | ES2194209T3 (fr) |
| IL (1) | IL128079A0 (fr) |
| NO (1) | NO990262L (fr) |
| NZ (1) | NZ333824A (fr) |
| PL (1) | PL331369A1 (fr) |
| PT (1) | PT939628E (fr) |
| RU (1) | RU2221781C2 (fr) |
| WO (1) | WO1998003164A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) * | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| RU2250105C2 (ru) * | 1997-11-14 | 2005-04-20 | Дж.Д.Сёрл ЛЛС | Ароматическая сульфонгидроксамовая кислота в качестве ингибитора металлопротеаз |
| EP1132379A4 (fr) | 1998-09-21 | 2005-02-16 | Takeda Pharmaceutical | Nouveaux derives de thiol, leur procede de production et leur utilisation |
| US6288261B1 (en) * | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| DE60015079T2 (de) * | 1999-01-27 | 2005-03-03 | Wyeth Holdings Corp. | Acetylenische sulfonamid-thiol-tace-inhibitoren |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6583299B1 (en) * | 1999-05-20 | 2003-06-24 | G.D. Searle & Co. | α-amino-β-sulfonyl hydroxamic acid compounds |
| US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| EA200301116A1 (ru) * | 2001-05-11 | 2004-06-24 | Фармация Корпорейшн | Гидроксаматы ароматических сульфонов и их применение в качестве ингибиторов протеаз |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) * | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| JP2003081838A (ja) * | 2001-09-11 | 2003-03-19 | Rohto Pharmaceut Co Ltd | グルコサミン製剤 |
| DE10201392A1 (de) * | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| JP2005537228A (ja) * | 2002-04-25 | 2005-12-08 | ファルマシア・コーポレーション | ピペリジニル−及びピペラジニル−スルホニルメチルヒドロキサム酸並びにプロテアーゼ阻害剤としてのその使用 |
| BR0312036A (pt) * | 2002-06-25 | 2005-04-05 | Pharmacia Corp | ácido arilsulfonilhidroxâmico e derivados de amida bem como composição farmacêutica contendo os mesmos e uso dos mesmos |
| BR0317715A (pt) * | 2002-12-27 | 2005-11-22 | Angiotech Int Ag | Composições e processos de uso de collajolie |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| JP5208510B2 (ja) | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP5155171B2 (ja) * | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
| CA2698928A1 (fr) * | 2007-09-28 | 2009-04-09 | Absolute Science, Inc. | Composes et procedes permettant de traiter des maladies dependant de metalloproteases a zinc matricielles |
| US20110190285A1 (en) * | 2008-09-19 | 2011-08-04 | Absolute Science, Inc. | Methods of treating a botulinum toxin related condition in a subject |
| PL2442647T3 (pl) | 2009-06-15 | 2016-09-30 | Związki ditiolowe, pochodne i ich zastosowania | |
| FR2950890B1 (fr) * | 2009-10-06 | 2011-12-30 | Tetrahedron | Procede de synthese de la 2-thiohistidine et analogues |
| GB201313238D0 (en) * | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| AU2018229277A1 (en) | 2017-02-28 | 2019-10-10 | Immunogen, Inc. | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| WO1993001169A2 (fr) * | 1991-07-05 | 1993-01-21 | Merck Sharp & Dohme Limited | Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5376664A (en) * | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| ATE197146T1 (de) * | 1993-08-10 | 2000-11-15 | Black James Foundation | Gastrin-und cck-rezeptorligande |
| DE69420859T2 (de) * | 1993-11-04 | 2000-01-05 | The Liposome Co.,Inc. | Multilamellare liposomformulierungen, die einen arachidsäuremetaboliten enthalten |
| GB9323162D0 (en) * | 1993-11-10 | 1994-01-05 | British Bio Technology | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| DE69509401T2 (de) * | 1994-10-05 | 1999-08-19 | Darwin Discovery Ltd. | Peptidische verbindungen und deren therapeutische verwendung als metalloproteinase-inhibitoren |
| KR19990036271A (ko) * | 1995-08-08 | 1999-05-25 | 토마스 네프 | 콜라겐 과다생산과 연관된 질환의 치료에 이용되는 ｃ-프로테나제 저해물질 |
| TR199800990T2 (xx) * | 1995-12-08 | 1998-07-21 | Agouron Pharmaceuticals, Inc. | Metaloproteinaz inhibit�rleri, bunlar� i�eren farmas�tik bile�imler, bunlar�n farmas�tik kullan�mlar� ve bunlar�n �retiminde kullan�labilecek y�ntemler ve ara �r�nler. |
-
1997
- 1997-07-22 IL IL12807997A patent/IL128079A0/xx unknown
- 1997-07-22 CN CN97198098A patent/CN1230884A/zh active Pending
- 1997-07-22 CZ CZ99167A patent/CZ16799A3/cs unknown
- 1997-07-22 PT PT97936169T patent/PT939628E/pt unknown
- 1997-07-22 AT AT97936169T patent/ATE233552T1/de not_active IP Right Cessation
- 1997-07-22 WO PCT/US1997/012874 patent/WO1998003164A1/fr not_active Application Discontinuation
- 1997-07-22 ES ES97936169T patent/ES2194209T3/es not_active Expired - Lifetime
- 1997-07-22 EP EP97936169A patent/EP0939628B1/fr not_active Expired - Lifetime
- 1997-07-22 KR KR1019997000465A patent/KR20000067963A/ko not_active Application Discontinuation
- 1997-07-22 DK DK97936169T patent/DK0939628T3/da active
- 1997-07-22 NZ NZ333824A patent/NZ333824A/xx unknown
- 1997-07-22 AU AU38904/97A patent/AU714687B2/en not_active Ceased
- 1997-07-22 JP JP50719698A patent/JP2001505869A/ja not_active Abandoned
- 1997-07-22 RU RU99103642/04A patent/RU2221781C2/ru not_active IP Right Cessation
- 1997-07-22 US US08/900,028 patent/US6013649A/en not_active Expired - Fee Related
- 1997-07-22 PL PL97331369A patent/PL331369A1/xx unknown
- 1997-07-22 CA CA002260859A patent/CA2260859A1/fr not_active Abandoned
- 1997-07-22 DE DE69719538T patent/DE69719538T2/de not_active Expired - Fee Related
- 1997-07-22 BR BR9710758A patent/BR9710758A/pt not_active IP Right Cessation
-
1999
- 1999-01-21 NO NO990262A patent/NO990262L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU714687B2 (en) | 2000-01-06 |
| NZ333824A (en) | 2000-08-25 |
| US6013649A (en) | 2000-01-11 |
| JP2001505869A (ja) | 2001-05-08 |
| CN1230884A (zh) | 1999-10-06 |
| AU3890497A (en) | 1998-02-10 |
| DE69719538D1 (en) | 2003-04-10 |
| NO990262D0 (no) | 1999-01-21 |
| IL128079A0 (en) | 1999-11-30 |
| CA2260859A1 (fr) | 1998-01-29 |
| BR9710758A (pt) | 1999-08-17 |
| DE69719538T2 (de) | 2004-02-19 |
| PL331369A1 (en) | 1999-07-05 |
| EP0939628A1 (fr) | 1999-09-08 |
| EP0939628B1 (fr) | 2003-03-05 |
| ATE233552T1 (de) | 2003-03-15 |
| CZ16799A3 (cs) | 1999-06-16 |
| ES2194209T3 (es) | 2003-11-16 |
| KR20000067963A (ko) | 2000-11-25 |
| EP0939628A4 (fr) | 1999-12-22 |
| WO1998003164A1 (fr) | 1998-01-29 |
| PT939628E (pt) | 2003-07-31 |
| RU2221781C2 (ru) | 2004-01-20 |
| NO990262L (no) | 1999-03-17 |
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