DK0937041T3 - Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel - Google Patents
Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddelInfo
- Publication number
- DK0937041T3 DK0937041T3 DK97911049T DK97911049T DK0937041T3 DK 0937041 T3 DK0937041 T3 DK 0937041T3 DK 97911049 T DK97911049 T DK 97911049T DK 97911049 T DK97911049 T DK 97911049T DK 0937041 T3 DK0937041 T3 DK 0937041T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxyphenylacetyl
- pyrrolidinium
- oxyl
- cyclopentyl
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT197396 | 1996-11-11 | ||
PCT/AT1997/000245 WO1998021183A1 (de) | 1996-11-11 | 1997-11-11 | Enantiomerenreine, basische aryl-cycloalkyl-hydroxycarbonsäureester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0937041T3 true DK0937041T3 (da) | 2003-08-11 |
Family
ID=3525062
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97911049T DK0937041T3 (da) | 1996-11-11 | 1997-11-11 | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
DK03005232.8T DK1371645T3 (da) | 1996-11-11 | 1997-11-11 | Anvendelse af (3S,2'R)-glycopyrronium som lægemiddel |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03005232.8T DK1371645T3 (da) | 1996-11-11 | 1997-11-11 | Anvendelse af (3S,2'R)-glycopyrronium som lægemiddel |
Country Status (19)
Country | Link |
---|---|
US (1) | US6307060B1 (pt) |
EP (3) | EP0937041B1 (pt) |
JP (1) | JP2001504459A (pt) |
CN (1) | CN100391942C (pt) |
AT (1) | ATE238280T1 (pt) |
AU (1) | AU745331B2 (pt) |
CA (1) | CA2271276C (pt) |
DE (1) | DE59709927D1 (pt) |
DK (2) | DK0937041T3 (pt) |
ES (2) | ES2407135T3 (pt) |
HK (1) | HK1061023A1 (pt) |
HU (1) | HU228273B1 (pt) |
NO (1) | NO314354B1 (pt) |
NZ (1) | NZ336202A (pt) |
PL (1) | PL195520B1 (pt) |
PT (2) | PT1371645E (pt) |
RU (1) | RU2238936C2 (pt) |
SI (2) | SI1371645T1 (pt) |
WO (1) | WO1998021183A1 (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613795B2 (en) | 1996-11-11 | 2003-09-02 | Christian Noe | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments |
DK0937041T3 (da) * | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
EP1302458A4 (en) | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | ESTERDERIVATE |
ES2206021B1 (es) | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
AT412088B (de) * | 2002-12-18 | 2004-09-27 | Pharmacon Forschung & Beratung Gmbh | Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere |
AU2002347552A1 (en) * | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
DE60313898T2 (de) * | 2003-04-10 | 2008-01-17 | Ranbaxy Laboratories, Ltd. | Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten |
PE20050231A1 (es) * | 2003-06-24 | 2005-05-20 | Novartis Ag | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 |
SI1718336T1 (sl) | 2004-02-06 | 2008-10-31 | Meda Pharma Gmbh & Co Kg | Nova kombinacija antiholinergika in beta mimetikov za zdravljenje respiratornih bolezni |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
JP2008504341A (ja) * | 2004-06-29 | 2008-02-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ステロイドと抗コリン作用剤とを含む吸入用薬剤 |
EP1616567A1 (en) * | 2004-07-16 | 2006-01-18 | Boehringer Ingelheim Pharma GmbH & Co.KG | Medicaments for inhalation comprising PDE IV inhibitors and glycopyrrolate salts |
EP1781607A2 (en) * | 2004-08-19 | 2007-05-09 | Ranbaxy Laboratories Limited | Pyrrolidine derivatives as muscarinic receptor antagonists |
GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
GB0504463D0 (en) * | 2005-03-03 | 2005-04-13 | Arakis Ltd | Method of crystallisation and purification |
SI1863476T1 (sl) * | 2005-03-16 | 2016-05-31 | Meda Pharma Gmbh & Co. Kg | Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni |
TW200722418A (en) * | 2005-04-20 | 2007-06-16 | Astrazeneca Ab | Novel compounds |
WO2006114379A1 (de) * | 2005-04-23 | 2006-11-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombination für die inhalation enthaltend neben einem anticholinergikum ein betamimetikum und ein steroid |
CA2632780C (en) * | 2005-12-21 | 2013-11-12 | Meda Pharma Gmbh & Co. Kg | Combination of r,r-glycopyrrolate, rolipram, and budesonide for the treatment of inflammatory diseases |
GB0613161D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
AU2010253776B2 (en) * | 2009-05-29 | 2015-01-22 | Pearl Therapeutics, Inc. | Compositions for pulmonary delivery of long-acting muscarinic antagonists and long-acting B2 adrenergic receptor agonists and associated methods and systems |
KR101781237B1 (ko) | 2010-01-28 | 2017-09-22 | 테론 파마슈티칼즈, 인크. | 7-아조니아바이시클로〔2.2.1〕헵탄 유도체, 제조 방법, 및 그의 제약적 용도 |
AR081889A1 (es) * | 2010-06-14 | 2012-10-24 | Chiesi Farma Spa | Forma cristalina de cloruro de glicopirronio |
BR112012029824A2 (pt) * | 2010-06-14 | 2016-08-09 | Chiesi Farma Spa | métodos para o preparo de cloreto de glicopirrônio, cloreto de glicopirrônio, composição farmacêutica e uso de cloreto de glicopirrônio |
JOP20120023B1 (ar) | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
CN102627595A (zh) * | 2012-03-09 | 2012-08-08 | 徐奎 | 一种制备格隆溴铵的方法 |
US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
KR20150119468A (ko) | 2013-02-28 | 2015-10-23 | 더미라, 인코포레이티드 | 글리코피롤레이트 염 |
US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
AU2014229361B2 (en) | 2013-03-14 | 2016-08-04 | Novartis Ag | Deamorphization of spray-dried formulations via spray-blending |
CN104586841A (zh) * | 2013-10-30 | 2015-05-06 | 中国药科大学 | (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途 |
US9926270B2 (en) | 2014-08-20 | 2018-03-27 | Dermira, Inc. | Process for production of glycopyrronium tosylate |
ES2700597T3 (es) * | 2014-12-24 | 2019-02-18 | Lesvi Laboratorios Sl | Proceso para la preparación de (3RS) -3 - [(2SR) - (2-ciclopentil-2-hidroxi-2-fenilacetil) oxi] -1,1-dimetilpirrolidinio |
CN107304178B (zh) * | 2016-04-21 | 2020-03-27 | 辽宁药联制药有限公司 | 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法 |
JP7161466B2 (ja) | 2016-08-02 | 2022-10-26 | ジャーニー メディカル コーポレーション | グリコピロニウム化合物を作製するための方法及び使用する方法 |
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US3157671A (en) * | 1964-11-17 | Ljl-diethyl-a-hydroxypyrrolidimum | ||
CA625276A (en) * | 1961-08-08 | D. Lunsford Carl | Esters of amino alcohols | |
US2882276A (en) * | 1959-04-14 | Certain esters of amino alcohols | ||
US2980693A (en) * | 1961-04-18 | Methods for producing same | ||
CA629039A (en) * | 1961-10-10 | A.H. Robins Company | 1-substituted-3-pyrrolidyl benzilates | |
GB821436A (en) * | 1956-02-22 | 1959-10-07 | Parke Davis & Co | 3-pyrrolidinyl benzilates |
US2958028A (en) * | 1957-11-01 | 1960-10-25 | Collins Radio Co | Remote control system |
US2956062A (en) * | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
US3185702A (en) * | 1959-03-16 | 1965-05-25 | Lunsford Carl Dalton | Basic esters of 3-aryl-3-pyrrolidinols |
GB885430A (en) * | 1960-08-17 | 1961-12-28 | Loewe Opta Ag | Arrangement for receiving stereophonic transmissions |
GB1170831A (en) * | 1967-02-01 | 1969-11-19 | Robins Co Inc A H | O-Substituted Pyrrolidinols and S-Substituted Thiopyrrolidinols and Processes for their Preparation |
US3691198A (en) * | 1970-12-21 | 1972-09-12 | Cpc International Inc | Synthesis of 1-substituted-3-halopyrrolidines |
FI49713C (fi) * | 1974-05-15 | 1975-09-10 | Medica Pharma Co Ltd | Terapeuttisesti tehokkaan erytro-1-metyyli-3-pyrrolidinyyli-alfa-syklo -pentyylimandelaattimetobromidin valmistusmenetelmä. |
US4208423A (en) * | 1978-11-24 | 1980-06-17 | Syntex Inc. | Anticholinergic bronchodilators |
US4228171A (en) * | 1979-03-05 | 1980-10-14 | Syntex (U.S.A.) Inc. | Antichlorinergic bronchodilators |
US4721722A (en) * | 1985-07-12 | 1988-01-26 | United Pharmaceuticals, Inc. | Anti-spasmodic agents containing quaternary nitrogen |
KR19990008109A (ko) * | 1995-04-28 | 1999-01-25 | 나가사까 겐지로 | 1,4-이치환 피페리딘 유도체 |
WO1998000133A1 (en) | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (s,s)-glycopyrrolate |
EP0909172A4 (en) | 1996-07-01 | 1999-06-09 | Sepracor Inc | METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE WITH ENANTIOMERIC ENRICHED (R, s) -GLYCOPYRROLATE |
DK0937041T3 (da) * | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
US6603808B1 (en) | 1999-07-22 | 2003-08-05 | Compaq Information Technologies Group, L.P. | Dual mode phone line networking modem utilizing conventional telephone wiring |
-
1997
- 1997-11-11 DK DK97911049T patent/DK0937041T3/da active
- 1997-11-11 ES ES03005232T patent/ES2407135T3/es not_active Expired - Lifetime
- 1997-11-11 JP JP52194298A patent/JP2001504459A/ja active Pending
- 1997-11-11 CA CA002271276A patent/CA2271276C/en not_active Expired - Fee Related
- 1997-11-11 ES ES97911049T patent/ES2195121T3/es not_active Expired - Lifetime
- 1997-11-11 HU HU9903791A patent/HU228273B1/hu not_active IP Right Cessation
- 1997-11-11 CN CNB971996210A patent/CN100391942C/zh not_active Expired - Fee Related
- 1997-11-11 EP EP97911049A patent/EP0937041B1/de not_active Expired - Lifetime
- 1997-11-11 NZ NZ336202A patent/NZ336202A/xx not_active IP Right Cessation
- 1997-11-11 PT PT3005232T patent/PT1371645E/pt unknown
- 1997-11-11 SI SI9730800T patent/SI1371645T1/sl unknown
- 1997-11-11 PT PT97911049T patent/PT937041E/pt unknown
- 1997-11-11 AU AU48560/97A patent/AU745331B2/en not_active Ceased
- 1997-11-11 AT AT97911049T patent/ATE238280T1/de active
- 1997-11-11 DK DK03005232.8T patent/DK1371645T3/da active
- 1997-11-11 RU RU99112115/04A patent/RU2238936C2/ru not_active IP Right Cessation
- 1997-11-11 SI SI9730556T patent/SI0937041T1/xx unknown
- 1997-11-11 EP EP03005232A patent/EP1371645B1/de not_active Expired - Lifetime
- 1997-11-11 DE DE59709927T patent/DE59709927D1/de not_active Expired - Lifetime
- 1997-11-11 WO PCT/AT1997/000245 patent/WO1998021183A1/de active IP Right Grant
- 1997-11-11 EP EP03005233A patent/EP1369414A1/de not_active Withdrawn
- 1997-11-11 PL PL97332595A patent/PL195520B1/pl unknown
-
1999
- 1999-03-03 NO NO19991056A patent/NO314354B1/no not_active IP Right Cessation
- 1999-05-11 US US09/309,960 patent/US6307060B1/en not_active Expired - Lifetime
-
2004
- 2004-06-03 HK HK04104008.8A patent/HK1061023A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6307060B1 (en) | 2001-10-23 |
CA2271276C (en) | 2009-01-13 |
SI1371645T1 (sl) | 2013-07-31 |
HUP9903791A2 (hu) | 2000-03-28 |
DE59709927D1 (de) | 2003-05-28 |
NO991056D0 (no) | 1999-03-03 |
RU2238936C2 (ru) | 2004-10-27 |
PT937041E (pt) | 2003-09-30 |
HU228273B1 (en) | 2013-02-28 |
NZ336202A (en) | 2000-10-27 |
SI0937041T1 (en) | 2003-10-31 |
DK1371645T3 (da) | 2013-06-03 |
AU745331B2 (en) | 2002-03-21 |
HK1061023A1 (pt) | 2004-09-03 |
PT1371645E (pt) | 2013-05-21 |
NO991056L (no) | 1999-05-11 |
EP1371645A1 (de) | 2003-12-17 |
HUP9903791A3 (en) | 2001-10-29 |
ES2195121T3 (es) | 2003-12-01 |
CN100391942C (zh) | 2008-06-04 |
EP1369414A1 (de) | 2003-12-10 |
AU4856097A (en) | 1998-06-03 |
PL195520B1 (pl) | 2007-09-28 |
CA2271276A1 (en) | 1998-05-22 |
EP1371645B1 (de) | 2013-02-20 |
CN1237159A (zh) | 1999-12-01 |
JP2001504459A (ja) | 2001-04-03 |
WO1998021183A1 (de) | 1998-05-22 |
PL332595A1 (en) | 1999-09-27 |
NO314354B1 (no) | 2003-03-10 |
ES2407135T3 (es) | 2013-06-11 |
EP0937041B1 (de) | 2003-04-23 |
ATE238280T1 (de) | 2003-05-15 |
EP0937041A1 (de) | 1999-08-25 |
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