DK0932597T3 - Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme - Google Patents

Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme

Info

Publication number
DK0932597T3
DK0932597T3 DK97941921T DK97941921T DK0932597T3 DK 0932597 T3 DK0932597 T3 DK 0932597T3 DK 97941921 T DK97941921 T DK 97941921T DK 97941921 T DK97941921 T DK 97941921T DK 0932597 T3 DK0932597 T3 DK 0932597T3
Authority
DK
Denmark
Prior art keywords
alkyl
treatment
hydroxybutyric acid
alcoholism
gamma
Prior art date
Application number
DK97941921T
Other languages
Danish (da)
English (en)
Inventor
Roberto Cacciaglia
Antonella Loche
Vincenzo Perlini
Lorenza Guano
Original Assignee
Ct Lab Farm Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Lab Farm Srl filed Critical Ct Lab Farm Srl
Application granted granted Critical
Publication of DK0932597T3 publication Critical patent/DK0932597T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
DK97941921T 1996-08-09 1997-08-07 Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme DK0932597T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
PCT/EP1997/004309 WO1998006690A1 (en) 1996-08-09 1997-08-07 USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

Publications (1)

Publication Number Publication Date
DK0932597T3 true DK0932597T3 (da) 2002-06-24

Family

ID=11374795

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97941921T DK0932597T3 (da) 1996-08-09 1997-08-07 Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme

Country Status (13)

Country Link
US (2) US6436998B1 (pt)
EP (1) EP0932597B1 (pt)
JP (1) JP4259615B2 (pt)
AT (1) ATE215065T1 (pt)
AU (1) AU4379097A (pt)
CA (1) CA2263328C (pt)
DE (1) DE69711411T2 (pt)
DK (1) DK0932597T3 (pt)
ES (1) ES2174287T3 (pt)
HU (1) HU228595B1 (pt)
IT (1) IT1283782B1 (pt)
PT (1) PT932597E (pt)
WO (1) WO1998006690A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038672A2 (en) * 1998-12-23 2000-07-06 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
AU2003295393A1 (en) * 2002-11-01 2004-06-07 Baylor Research Institute Ghb treatment methods
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2062875A1 (en) * 2007-11-13 2009-05-27 LABORATORIO FARMACEUTICO C.T. S.r.l. New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
US8778398B2 (en) * 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
BR112012024019B1 (pt) 2010-03-24 2021-10-19 Jazz Phamaceuticals, Inc Forma de dosagem de liberação controlada para administração oral
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
ITUB20152860A1 (it) 2015-08-04 2017-02-04 Laboratorio Farm C T S R L Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
KR20210094513A (ko) 2018-11-19 2021-07-29 재즈 파마슈티칼즈 아일랜드 리미티드 알코올-내성 약물 제형
JP7553453B2 (ja) 2019-03-01 2024-09-18 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
WO2023126076A1 (en) 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940258A (en) * 1971-11-26 1976-02-24 Gaf Corporation Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide
JPS6016432B2 (ja) * 1977-07-26 1985-04-25 グレラン製薬株式会社 複素環式化合物類およびその製造法
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
IT1217783B (it) 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
EP0763016B1 (en) * 1994-06-01 2000-01-26 Axys Pharmaceuticals, Inc. Compositions and methods for treating mast-cell mediated conditions
CZ272296A3 (en) * 1995-09-18 1997-04-16 Sankyo Co Novel derivatives of urea exhibiting acat inhibition activity, their preparation and therapeutic and prophylactic application
ES2237850T3 (es) * 1997-10-14 2005-08-01 Mitsubishi Pharma Corporation Compuestos de piperazina y su uso medicinal.

Also Published As

Publication number Publication date
ES2174287T3 (es) 2002-11-01
WO1998006690A1 (en) 1998-02-19
ITMI961732A1 (it) 1998-02-09
JP2000516225A (ja) 2000-12-05
CA2263328C (en) 2006-07-25
EP0932597B1 (en) 2002-03-27
US6436998B1 (en) 2002-08-20
IT1283782B1 (it) 1998-04-30
AU4379097A (en) 1998-03-06
HUP9902437A3 (en) 2001-07-30
US20020165224A1 (en) 2002-11-07
US6770784B2 (en) 2004-08-03
PT932597E (pt) 2002-09-30
ITMI961732A0 (pt) 1996-08-09
HUP9902437A2 (hu) 1999-12-28
HU228595B1 (en) 2013-04-29
CA2263328A1 (en) 1998-02-19
ATE215065T1 (de) 2002-04-15
DE69711411D1 (de) 2002-05-02
DE69711411T2 (de) 2002-11-07
JP4259615B2 (ja) 2009-04-30
EP0932597A1 (en) 1999-08-04

Similar Documents

Publication Publication Date Title
DK0932597T3 (da) Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme
DK1384710T3 (da) Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe
HU9600963D0 (en) Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
DK0550635T3 (da) Cykliske forbindelser med kondeserede ringe, som er analoger til nitrogenholdige ikke-aromatiske het erocykliske forbindelser
KR100263496B1 (ko) 탁솔 유도체 및 이의 제조방법
IL134635A0 (en) A process for the preparation of acylated cyclic 1,3-dicarbonyl compounds
MY104850A (en) N-phenyloyrazole derivatives
ES2177656T3 (es) Derivados de antraciclinona y su utilizacion en el tratamiento de la amiloidosis.
FI941699A0 (fi) Atsabisyklo-aryyliasetyleeni- ja arylenyynioksiimit kolinenergisina aineina ja hoitomenetelmät
BG103289A (en) Method for yohexene preparation
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
ATE32890T1 (de) 3-aminocarbonylmethoxy-5-phenylpyrazolverbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
BG101671A (en) Diclavunic salt with diaminoether and method for its preparation
AU539177B2 (en) Amino alkoxy pyrazoles
NO870423D0 (no) 5-substituert octahydroindolizin-analgetika-forbindelser og 7-keto-mellomprodukt.
FI860074A (fi) Oktahydroindolizinfoereningar anvaendbara som smaertstillande medel.
ATE228359T1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
ATE47863T1 (de) Makrolide derivate.
IL111246A0 (en) Tricyclic compounds and pharmaceutical compositions containing them
MX9703899A (es) Derivado de arilacrilamida.
WO2001041724A3 (fr) Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle
KR840003777A (ko) 포스포 아미도 티오네이트를 함유한 살균 조성물의 제조방법
IL113677A (en) Diamines and aminoamides and their preparation for use as intermediates for the preparation of 4, 5-dihydro-1h-2,4-aryl fused diazepines and benzodiazocines
DE3664044D1 (de) N,n-dialkylaminoalkyl-hexahydro-5-oxo-1h-pyrrolizine-3-carboxamides