DK0929516T3 - Benzamidinderivater og disses anvendelse som lægemidler med LTB4-antagonistisk virkning - Google Patents
Benzamidinderivater og disses anvendelse som lægemidler med LTB4-antagonistisk virkningInfo
- Publication number
- DK0929516T3 DK0929516T3 DK97942007T DK97942007T DK0929516T3 DK 0929516 T3 DK0929516 T3 DK 0929516T3 DK 97942007 T DK97942007 T DK 97942007T DK 97942007 T DK97942007 T DK 97942007T DK 0929516 T3 DK0929516 T3 DK 0929516T3
- Authority
- DK
- Denmark
- Prior art keywords
- drugs
- antagonistic effect
- benzamidine derivatives
- ltb4
- ltb4 antagonistic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19636689A DE19636689A1 (de) | 1996-09-10 | 1996-09-10 | Neue Benzamidinderivate |
| PCT/EP1997/004921 WO1998011062A1 (de) | 1996-09-10 | 1997-09-09 | Benzamidinderivate und ihre verwendung als arzneimittel mit ltb4-antagonistischer wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0929516T3 true DK0929516T3 (da) | 2003-01-13 |
Family
ID=7805125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97942007T DK0929516T3 (da) | 1996-09-10 | 1997-09-09 | Benzamidinderivater og disses anvendelse som lægemidler med LTB4-antagonistisk virkning |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6197824B1 (ru) |
| EP (2) | EP0929516B1 (ru) |
| JP (2) | JP4150427B2 (ru) |
| KR (1) | KR20000036005A (ru) |
| CN (1) | CN1104412C (ru) |
| AR (1) | AR009741A1 (ru) |
| AT (2) | ATE266630T1 (ru) |
| AU (1) | AU727900B2 (ru) |
| BG (1) | BG63938B1 (ru) |
| BR (1) | BR9712816A (ru) |
| CA (1) | CA2262566C (ru) |
| CO (1) | CO4900032A1 (ru) |
| CZ (1) | CZ297252B6 (ru) |
| DE (3) | DE19636689A1 (ru) |
| DK (1) | DK0929516T3 (ru) |
| EA (1) | EA003245B1 (ru) |
| EE (1) | EE04431B1 (ru) |
| ES (1) | ES2184131T3 (ru) |
| HK (1) | HK1020564A1 (ru) |
| HU (1) | HUP9904367A3 (ru) |
| IL (1) | IL128144A (ru) |
| NO (1) | NO312239B1 (ru) |
| NZ (1) | NZ334895A (ru) |
| PL (1) | PL188012B1 (ru) |
| PT (1) | PT929516E (ru) |
| SK (1) | SK282432B6 (ru) |
| TR (1) | TR199900501T2 (ru) |
| TW (1) | TW378200B (ru) |
| UA (1) | UA60315C2 (ru) |
| WO (1) | WO1998011062A1 (ru) |
| ZA (1) | ZA978045B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID29066A (id) | 1998-12-14 | 2001-07-26 | Hoffmann La Roche | Turunan fenilglisina |
| US6291531B1 (en) * | 1999-10-07 | 2001-09-18 | Boehringer Ingelheim Pharma Kg | LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition |
| DE19948428A1 (de) * | 1999-10-07 | 2001-04-12 | Boehringer Ingelheim Pharma | Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel |
| DE10052658A1 (de) * | 2000-10-24 | 2002-05-02 | Boehringer Ingelheim Pharma | Neue Pyranosidderivate |
| DE10052333A1 (de) * | 2000-10-24 | 2002-05-02 | Boehringer Ingelheim Pharma | Neue Sulfooxybenzamide |
| US6489359B2 (en) | 2000-10-24 | 2002-12-03 | Boehringer Ingelheim Pharma Kg | Sulphoxybenzamides |
| US6528491B2 (en) | 2000-10-24 | 2003-03-04 | Boehringer Ingelheim Pharma Kg | Pyranoside derivatives |
| US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
| US6608054B2 (en) * | 2001-03-20 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and endothelin antagonists |
| AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
| US20030119901A1 (en) * | 2001-07-14 | 2003-06-26 | Boehringer Ingelheim Pharma Kg | Pharmaceutical formulation containing an LTB4 antagonist |
| NZ530973A (en) * | 2001-07-14 | 2006-07-28 | Boehringer Ingelheim Pharma | Pharmaceutical formulation containing an LTB4 antagonist |
| CN1658852A (zh) * | 2001-08-31 | 2005-08-24 | 神经化学（国际）有限公司 | 用于治疗淀粉样变性的脒衍生物 |
| DE10213350A1 (de) * | 2002-03-26 | 2003-10-16 | Boehringer Ingelheim Pharma | Verwendung von LTB¶4¶Antagonisten in der Tiermedizin |
| US6921752B2 (en) * | 2002-03-26 | 2005-07-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of LTB4 antagonists in veterinary medicine |
| RS20050390A (en) * | 2002-11-26 | 2008-04-04 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg., | Pharmaceutical composition comprising a ltb4 antagonist and a cox-2 inhibitor or a combined cox 1/2 inhibitor |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| CN1997367B (zh) * | 2004-07-05 | 2010-11-24 | 同和药品株式会社 | 预防和治疗过敏性炎症的组合物 |
| KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| US8679288B2 (en) * | 2008-06-09 | 2014-03-25 | Lam Research Corporation | Showerhead electrode assemblies for plasma processing apparatuses |
| CN106831611B (zh) * | 2017-01-23 | 2019-06-21 | 北京化工大学 | 一种偕胺肟类化合物及其在制备抑制癌细胞增殖药的应用 |
| EP3623368A4 (en) | 2017-05-12 | 2021-04-07 | Riken | CLASS A GPCR BINDING COMPOUND MODIFIER |
| WO2020061688A1 (en) * | 2018-09-24 | 2020-04-02 | The University Of British Columbia | Modulation of granzyme k activity in the treatment of skin conditions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5246965A (en) | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| PT902013E (pt) | 1992-02-05 | 2002-06-28 | Boehringer Ingelheim Pharma | Novos derivados amidina sua preparacao e utilizacao como medicamento com actividade antagonista de ltb4 |
| DE4219158A1 (de) * | 1992-06-11 | 1993-12-16 | Thomae Gmbh Dr K | Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| DE4424714A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff |
| DE19546452A1 (de) * | 1995-12-13 | 1997-06-19 | Boehringer Ingelheim Kg | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
-
1996
- 1996-09-10 DE DE19636689A patent/DE19636689A1/de not_active Withdrawn
-
1997
- 1997-09-08 ZA ZA9708045A patent/ZA978045B/xx unknown
- 1997-09-09 ES ES97942007T patent/ES2184131T3/es not_active Expired - Lifetime
- 1997-09-09 PL PL33213697A patent/PL188012B1/pl not_active IP Right Cessation
- 1997-09-09 DK DK97942007T patent/DK0929516T3/da active
- 1997-09-09 CA CA002262566A patent/CA2262566C/en not_active Expired - Fee Related
- 1997-09-09 KR KR1019997001964A patent/KR20000036005A/ko not_active Application Discontinuation
- 1997-09-09 WO PCT/EP1997/004921 patent/WO1998011062A1/de active IP Right Grant
- 1997-09-09 EA EA199900279A patent/EA003245B1/ru not_active IP Right Cessation
- 1997-09-09 EP EP97942007A patent/EP0929516B1/de not_active Expired - Lifetime
- 1997-09-09 HU HU9904367A patent/HUP9904367A3/hu unknown
- 1997-09-09 BR BR9712816-3A patent/BR9712816A/pt not_active IP Right Cessation
- 1997-09-09 US US09/242,389 patent/US6197824B1/en not_active Expired - Lifetime
- 1997-09-09 NZ NZ334895A patent/NZ334895A/xx not_active IP Right Cessation
- 1997-09-09 AT AT02003690T patent/ATE266630T1/de not_active IP Right Cessation
- 1997-09-09 CO CO97052335A patent/CO4900032A1/es unknown
- 1997-09-09 UA UA99042008A patent/UA60315C2/ru unknown
- 1997-09-09 AT AT97942007T patent/ATE224363T1/de active
- 1997-09-09 EP EP02003690A patent/EP1203764B1/de not_active Expired - Lifetime
- 1997-09-09 TW TW086113036A patent/TW378200B/zh not_active IP Right Cessation
- 1997-09-09 SK SK296-99A patent/SK282432B6/sk not_active IP Right Cessation
- 1997-09-09 EE EEP199900086A patent/EE04431B1/xx not_active IP Right Cessation
- 1997-09-09 PT PT97942007T patent/PT929516E/pt unknown
- 1997-09-09 AU AU43838/97A patent/AU727900B2/en not_active Ceased
- 1997-09-09 DE DE59711625T patent/DE59711625D1/de not_active Expired - Lifetime
- 1997-09-09 JP JP51324398A patent/JP4150427B2/ja not_active Expired - Fee Related
- 1997-09-09 IL IL12814497A patent/IL128144A/en not_active IP Right Cessation
- 1997-09-09 CN CN97197748A patent/CN1104412C/zh not_active Expired - Fee Related
- 1997-09-09 DE DE59708278T patent/DE59708278D1/de not_active Expired - Lifetime
- 1997-09-09 TR TR1999/00501T patent/TR199900501T2/xx unknown
- 1997-09-09 CZ CZ0082299A patent/CZ297252B6/cs not_active IP Right Cessation
- 1997-09-10 AR ARP970104148A patent/AR009741A1/es active IP Right Grant
-
1999
- 1999-03-01 BG BG103219A patent/BG63938B1/bg active Active
- 1999-03-09 NO NO19991131A patent/NO312239B1/no not_active IP Right Cessation
- 1999-12-02 HK HK99105613A patent/HK1020564A1/xx not_active IP Right Cessation
-
2000
- 2000-12-01 US US09/728,856 patent/US6265612B1/en not_active Expired - Lifetime
-
2008
- 2008-04-16 JP JP2008107036A patent/JP4288299B2/ja not_active Expired - Fee Related
Also Published As
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