DK0922102T3 - Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf - Google Patents

Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf

Info

Publication number
DK0922102T3
DK0922102T3 DK97931275.8T DK97931275T DK0922102T3 DK 0922102 T3 DK0922102 T3 DK 0922102T3 DK 97931275 T DK97931275 T DK 97931275T DK 0922102 T3 DK0922102 T3 DK 0922102T3
Authority
DK
Denmark
Prior art keywords
receptor agonists
growth factor
hepatocyte growth
applications
factor receptor
Prior art date
Application number
DK97931275.8T
Other languages
English (en)
Inventor
Kenneth J Hillan
Ralph H Schwall
Kelly H Tabor
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0922102T3 publication Critical patent/DK0922102T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/4753Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK97931275.8T 1996-07-03 1997-06-20 Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf DK0922102T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2121596P 1996-07-03 1996-07-03
PCT/US1997/010688 WO1998000543A1 (en) 1996-07-03 1997-06-20 Hepatocyte growth factor receptor agonists and uses thereof

Publications (1)

Publication Number Publication Date
DK0922102T3 true DK0922102T3 (da) 2010-08-16

Family

ID=21803007

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97931275.8T DK0922102T3 (da) 1996-07-03 1997-06-20 Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf

Country Status (11)

Country Link
US (1) US6099841A (da)
EP (1) EP0922102B1 (da)
JP (1) JP2000515735A (da)
AT (1) ATE465257T1 (da)
AU (1) AU729029B2 (da)
CA (1) CA2258153C (da)
DE (1) DE69739856D1 (da)
DK (1) DK0922102T3 (da)
IL (1) IL127558A0 (da)
WO (1) WO1998000543A1 (da)
ZA (1) ZA975851B (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
ES2368823T3 (es) * 1998-01-26 2011-11-22 Genentech, Inc. Anticuerpos del receptor 4 de muerte (dr4) y usos de los mismos.
WO2001005955A2 (en) * 1999-07-14 2001-01-25 The Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
EP1142590B8 (en) * 1999-10-29 2008-11-26 AnGes MG, Inc. Gene therapy for diabetic ischemic disease
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
CA2452445C (en) * 2000-06-29 2011-02-15 North Shore-Long Island Jewish Health System Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
EP1516185A4 (en) * 2001-12-27 2007-06-20 Van Andel Res Inst PRESENTATION OF MONOCLONAL ANTIBODIES AND TREATMENT OF TUMORS EXPRESSING MET AND BINDING THE HEPATOCYTIC GROWTH FACTOR
EP2075256A2 (en) 2002-01-14 2009-07-01 William Herman Multispecific binding molecules
US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
WO2004072117A2 (en) * 2003-02-13 2004-08-26 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
WO2004093892A2 (en) * 2003-04-16 2004-11-04 Genentech, Inc. Stanniocalcin-1, variant or antagonists thereof for selective modulation of vascularization
US20040208876A1 (en) * 2003-04-18 2004-10-21 Kim Kyung Jin Monoclonal antibodies to hepatocyte growth factor
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ITMI20031127A1 (it) 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
EP2385069A3 (en) 2003-11-12 2012-05-30 Biogen Idec MA Inc. Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
WO2005108424A1 (en) * 2004-05-06 2005-11-17 Genentech, Inc. Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use
US20060003931A1 (en) * 2004-05-06 2006-01-05 Genentech, Inc. Crystal structure of the hepatocyte growth factor and methods of use
DE602005022474D1 (de) * 2004-10-20 2010-09-02 Peas Inst Ab Beurteilung der biologischen aktivität von hgf (hepatocyte growth factor)
NZ556788A (en) 2005-01-05 2011-03-31 Biogen Idec Inc Humanized CRIPTO binding molecules with CDRs from murine B3F6
CN101102788A (zh) * 2005-01-24 2008-01-09 克霖固鲁制药股份有限公司 移植器官纤维化抑制剂
WO2006093211A1 (ja) * 2005-03-02 2006-09-08 Mitsubishi Pharma Corporation 抗ウイルス剤
RU2404193C2 (ru) * 2005-03-25 2010-11-20 Дженентек, Инк. Способ лечения опухоли у субъекта
JP2008533991A (ja) * 2005-03-25 2008-08-28 ジェネンテック・インコーポレーテッド 肺癌におけるc−met突然変異
EP1863519B1 (en) 2005-03-31 2013-09-25 The General Hospital Corporation Modulating hgf/hgfr activity for treating lymphodema
JP2008545753A (ja) * 2005-06-02 2008-12-18 ギャラクシー バイオテック, エルエルシー 抗体で脳腫瘍を処置する方法
JP5137818B2 (ja) 2006-03-20 2013-02-06 生化学工業株式会社 関節リウマチの処置剤
EP1996716B1 (en) 2006-03-20 2011-05-11 The Regents of the University of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
AR059922A1 (es) * 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
CA2698343C (en) 2007-09-04 2018-06-12 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
WO2009111644A2 (en) * 2008-03-05 2009-09-11 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
ES2712732T3 (es) 2009-02-17 2019-05-14 Cornell Res Foundation Inc Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico
EP2504424A1 (en) 2009-11-25 2012-10-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for hepatic differentiation of definitive endoderm cells
RU2673908C2 (ru) 2009-12-02 2018-12-03 Имэджинэб, Инк. Мини-антитела j591 и цис-диатела для направленной доставки простата-специфичного мембранного антигена (psma) человека и способы их применения
JP2013532627A (ja) 2010-07-01 2013-08-19 武田薬品工業株式会社 cMET阻害剤とHGFおよび/またはcMETに対する抗体との組み合わせ
DK2591099T3 (da) 2010-07-09 2021-02-15 Bioverativ Therapeutics Inc Kimære koagulationsfaktorer
WO2012059562A1 (en) 2010-11-03 2012-05-10 Argen-X-Bv C-met antibody combinations
US9738707B2 (en) 2011-07-15 2017-08-22 Biogen Ma Inc. Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
EP2773660A2 (en) 2011-11-03 2014-09-10 Argen-X B.V. Chimeric human-camel antigens and their use
CA2860579A1 (en) 2012-01-10 2013-07-18 Biogen Idec Ma Inc. Enhancement of transport of therapeutic molecules across the blood brain barrier
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
EP2968498A4 (en) 2013-03-15 2016-09-07 Biogen Ma Inc PREPARATIONS CONTAINING FACTOR IX POLYPEPTIDE
WO2015056713A1 (ja) * 2013-10-15 2015-04-23 国立大学法人東京大学 c-Metタンパク質アゴニスト
BR112016021383A2 (pt) 2014-03-24 2017-10-03 Genentech Inc Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
IL250902B (en) 2014-09-16 2022-08-01 Symphogen As Anti-met antibodies and preparations
EP3954993A1 (en) 2015-02-04 2022-02-16 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules
EP3253875B1 (en) 2015-02-04 2020-01-08 H. Hoffnabb-La Roche Ag Tau antisense oligomers and uses thereof
CA2994951A1 (en) 2015-08-07 2017-02-16 Imaginab, Inc. Antigen binding constructs to target molecules
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
IT201800000535A1 (it) 2018-01-03 2019-07-03 Procedimenti per la cura del cancro.
AU2020224136A1 (en) 2019-02-21 2021-09-02 Regeneron Pharmaceuticals, Inc. Methods of treating ocular cancer using anti-MET antibodies and bispecific antigen binding molecules that bind MET
JP2022541850A (ja) * 2019-07-26 2022-09-27 アンビス メディスンズ,インク. 肝細胞を産生するための方法および組成物
CA3146933A1 (en) 2019-09-16 2021-03-25 Marcus KELLY Radiolabeled met binding proteins for immuno-pet imaging
WO2024050466A1 (en) 2022-09-01 2024-03-07 Regeneron Pharmaceuticals, Inc. Methods of treating non-small cell lung cancer using mesenchymal epithelial transition factor (met)-targeted agents

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5362716A (en) * 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
US5648273A (en) * 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
JP2750372B2 (ja) * 1990-06-19 1998-05-13 敏一 中村 賢疾患治療剤
US6566098B1 (en) * 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
EP0584125B1 (en) * 1991-05-10 1997-07-16 PHARMACIA & UPJOHN S.p.A. Truncated forms of the hepatocyte growth factor (hgf) receptor
US5227158A (en) * 1991-06-10 1993-07-13 Genentech, Inc. Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
DE69333807T2 (de) * 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
US5316921A (en) * 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
AU4528493A (en) * 1992-06-04 1994-01-04 Regents Of The University Of California, The In vivo gene therapy with intron-free sequence of interest
DE69310525T2 (de) * 1992-09-16 1997-10-02 Genentech Inc Schutz gegen leberschäden mit hgf
WO1994009969A1 (de) 1992-10-28 1994-05-11 Max Born Inst Fuer Nichtlinear Metall/kunststoff-verbundkörper, verfahren zu dessen herstellung und vorrichtung zur ausführung des verfahrens
RU2139092C1 (ru) 1993-06-03 1999-10-10 Терапьютик Антибодиз Инк. Фрагменты антител в терапии
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US8200624B2 (en) 2010-07-20 2012-06-12 Sybase, Inc. Membership tracking and data eviction in mobile middleware scenarios

Also Published As

Publication number Publication date
CA2258153C (en) 2004-08-17
ATE465257T1 (de) 2010-05-15
IL127558A0 (en) 1999-10-28
AU729029B2 (en) 2001-01-25
CA2258153A1 (en) 1998-01-08
EP0922102B1 (en) 2010-04-21
AU3494997A (en) 1998-01-21
WO1998000543A1 (en) 1998-01-08
DE69739856D1 (de) 2010-06-02
JP2000515735A (ja) 2000-11-28
ZA975851B (en) 1999-01-04
US6099841A (en) 2000-08-08
EP0922102A1 (en) 1999-06-16

Similar Documents

Publication Publication Date Title
DK0922102T3 (da) Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
EP1746160A3 (en) Hepatocyte growth factor receptor antagonists and uses thereof
DK1181319T3 (da) Kimære DR4-antistoffer og anvendelser deraf
DE69838147D1 (de) Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität
IL159527A0 (en) Human dr4 antibodies and uses thereof
TR199902818T2 (xx) Be�eri kullan�m i�in antikorlar ve be�eri kullan�m i�in antikorlar olu�turmak i�in y�ntemler.
PT1526172E (pt) Processo para a replicação de vírus influenza em cultura celular e os vírus influenza que podem ser obtidos pelo processo
BR0206985A (pt) Anticorpos modificados e métodos de uso
TR200000927T2 (tr) Prostaglandin agonistleri ve kemik bozukluklarının tedavisi
ATE405650T1 (de) Produktion von ganzen antikörpern in prokaryontischen zellen
WO1999045098A3 (en) Delivery or proteins into eukaryotic cells with recombinant yersinia
ES2177316T3 (es) Anticuerpos humanos antifacotores ix/ixa.
NO971341D0 (no) Promoter for reseptor tyrosinkinase TIE
DE69120287T2 (de) Aminosulfonylharnstoff-acat-inhibitoren
DK1196442T3 (da) VGF-polypeptider og fremgangsmåder til behandling af VGF-relaterede lidelser
EA200000875A1 (ru) Белки, взаимодействующие с каспазой-8
DK1196188T3 (da) VGF-selektive monoklonale antistoffer og deres anvendelse til behandling af VGF-relaterede lidelser
DK1159426T3 (da) Kloning og udtryk af Haemophilus somnus transferrin-bindende proteiner
UA30435A (uk) Спосіб визначення онкологічного маркеру в сироватці крові
DK293790D0 (da) Fremgangsmaade og sammensaetninger til behandling af pattedyrsinfektioner under anvendelse af praeparater omfattende gift fra hymenoptera, proteinagtige komponenter eller polypeptidkomponenter heraf eller analoger til disse proteinagtige komponenter eller polypeptidkomponenter