IL127558A0 - Hepatocyte growth factor receptor agonists and uses thereof - Google Patents
Hepatocyte growth factor receptor agonists and uses thereofInfo
- Publication number
- IL127558A0 IL127558A0 IL12755897A IL12755897A IL127558A0 IL 127558 A0 IL127558 A0 IL 127558A0 IL 12755897 A IL12755897 A IL 12755897A IL 12755897 A IL12755897 A IL 12755897A IL 127558 A0 IL127558 A0 IL 127558A0
- Authority
- IL
- Israel
- Prior art keywords
- receptor agonists
- growth factor
- hepatocyte growth
- factor receptor
- hgf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2121596P | 1996-07-03 | 1996-07-03 | |
PCT/US1997/010688 WO1998000543A1 (en) | 1996-07-03 | 1997-06-20 | Hepatocyte growth factor receptor agonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL127558A0 true IL127558A0 (en) | 1999-10-28 |
Family
ID=21803007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12755897A IL127558A0 (en) | 1996-07-03 | 1997-06-20 | Hepatocyte growth factor receptor agonists and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US6099841A (da) |
EP (1) | EP0922102B1 (da) |
JP (1) | JP2000515735A (da) |
AT (1) | ATE465257T1 (da) |
AU (1) | AU729029B2 (da) |
CA (1) | CA2258153C (da) |
DE (1) | DE69739856D1 (da) |
DK (1) | DK0922102T3 (da) |
IL (1) | IL127558A0 (da) |
WO (1) | WO1998000543A1 (da) |
ZA (1) | ZA975851B (da) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
DK1053256T3 (da) * | 1998-01-26 | 2011-10-03 | Genentech Inc | Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf |
WO2001005955A2 (en) * | 1999-07-14 | 2001-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Animals comprising human hepatocellular tissue |
CA2356701C (en) * | 1999-10-29 | 2011-02-15 | Ryuichi Morishita | Gene therapy for diabetic ischemic disease |
US20080241835A1 (en) * | 1999-11-01 | 2008-10-02 | Genentech, Inc. | Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same |
AU2001277854B2 (en) * | 2000-06-29 | 2007-03-01 | North Shore-Long Island Jewish Health System | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
WO2003057155A2 (en) * | 2001-12-27 | 2003-07-17 | Van Andel Research Institute | Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor |
EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
BRPI0407446A (pt) * | 2003-02-13 | 2006-01-31 | Pharmacia Corp | Anticorpos para c-met para o tratamento de cânceres |
US7407660B2 (en) * | 2003-04-16 | 2008-08-05 | Genentech, Inc. | Methods and compositions for selective modulation of vascularization |
US20040208876A1 (en) * | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
ITMI20031127A1 (it) * | 2003-06-05 | 2004-12-06 | Uni Degli Studi Del Piemont E Orientale Am | Anticorpi anti-hgf-r e loro uso |
HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
AU2004290070A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
WO2005108424A1 (en) * | 2004-05-06 | 2005-11-17 | Genentech, Inc. | Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use |
US20060003931A1 (en) * | 2004-05-06 | 2006-01-05 | Genentech, Inc. | Crystal structure of the hepatocyte growth factor and methods of use |
EP1810037B1 (en) * | 2004-10-20 | 2010-07-21 | PEAS Institut AB | Assessment of biological activity of hepatocyte growth factor (hgf) |
WO2006074397A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Cripto binding molecules |
WO2006077675A1 (ja) * | 2005-01-24 | 2006-07-27 | Kringle Pharma Inc. | 移植臓器の線維化抑制剤 |
CN101151046A (zh) * | 2005-03-02 | 2008-03-26 | 三菱制药株式会社 | 抗病毒剂 |
BRPI0612169A2 (pt) * | 2005-03-25 | 2010-10-19 | Genentech Inc | métodos prognósticos, métodos de detecção, de distinção, de identificação, de determinação e de monitoramento relacionados com cáncer de pulmão, métodos para amplificação de um ácido nucléico que codifica c-met humano , biomarcadores de cáncer de pulmão, agentes de imagem de cáncer de pulmão, polinucleotìdeos, agente s de ligação de antìgeno, conjuntos, meios legìveis em computador e kits e/ou artigos de fabricação |
RU2404193C2 (ru) * | 2005-03-25 | 2010-11-20 | Дженентек, Инк. | Способ лечения опухоли у субъекта |
WO2006105511A1 (en) | 2005-03-31 | 2006-10-05 | The General Hospital Corporation | Monitoring and modulating hgf/hgfr activity |
JP2008545753A (ja) * | 2005-06-02 | 2008-12-18 | ギャラクシー バイオテック, エルエルシー | 抗体で脳腫瘍を処置する方法 |
CA2646620C (en) * | 2006-03-20 | 2015-07-14 | Seikagaku Corporation | Therapeutic agent for rheumatoid arthritis |
CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
US20100150863A1 (en) | 2006-12-20 | 2010-06-17 | Bayer Pharmaceuticals Corporation | Hydroxy methyl phenyl pyrazolyl urea compound useful in treatment of cancer |
US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
WO2009111644A2 (en) * | 2008-03-05 | 2009-09-11 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
ES2712732T3 (es) | 2009-02-17 | 2019-05-14 | Cornell Res Foundation Inc | Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico |
JP2013511969A (ja) | 2009-11-25 | 2013-04-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 確定的内胚葉細胞の肝分化のための方法 |
CA2782333C (en) | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
AU2011274423B2 (en) | 2010-07-09 | 2016-02-11 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
EP2635602B1 (en) | 2010-11-03 | 2016-09-07 | Argen-X Nv | Anti c-met antibodies |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
EP2773660A2 (en) | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
NZ626620A (en) | 2012-01-10 | 2016-07-29 | Biogen Ma Inc | Enhancement of transport of therapeutic molecules across the blood brain barrier |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
EP2968498A4 (en) | 2013-03-15 | 2016-09-07 | Biogen Ma Inc | PREPARATIONS CONTAINING FACTOR IX POLYPEPTIDE |
EP3059244B1 (en) * | 2013-10-15 | 2020-08-26 | The University of Tokyo | C-met protein agonist |
EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
CA2961323C (en) | 2014-09-16 | 2021-11-30 | Symphogen A/S | Anti-met antibodies and compositions |
MX2017010066A (es) | 2015-02-04 | 2017-11-01 | Hoffmann La Roche | Oligomeros antisentido de tau y usos de los mismos. |
CN115181778A (zh) | 2015-02-04 | 2022-10-14 | 百时美施贵宝公司 | 选择治疗性分子的方法 |
AU2016304764C1 (en) | 2015-08-07 | 2023-06-01 | Imaginab, Inc. | Antigen binding constructs to target molecules |
GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
CN113727757A (zh) | 2019-02-21 | 2021-11-30 | 瑞泽恩制药公司 | 使用结合met的抗-met抗体和双特异性抗原结合分子治疗眼癌的方法 |
EP4003003A4 (en) * | 2019-07-26 | 2023-07-26 | Ambys Medicines, Inc. | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF HEPATOCYTES |
AU2020349462A1 (en) | 2019-09-16 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging |
US20240084041A1 (en) | 2022-09-01 | 2024-03-14 | Regeneron Pharmaceuticals, Inc. | Methods of treating non-small cell lung cancer using mesenchymal epithelial transition factor (met)-targeted agents |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5648273A (en) * | 1989-12-27 | 1997-07-15 | The United States Of America, As Represented By The Department Of Health And Human Services | Hepatic growth factor receptor is the MET proto-oncogene |
US5362716A (en) * | 1989-12-27 | 1994-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines |
JP2750372B2 (ja) * | 1990-06-19 | 1998-05-13 | 敏一 中村 | 賢疾患治療剤 |
US6566098B1 (en) * | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
EP0520158A1 (en) * | 1991-05-10 | 1992-12-30 | PHARMACIA S.p.A. | Truncated forms of the hepatocyte growth factor (HGF) receptor |
US5227158A (en) * | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
AU675929B2 (en) * | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
US5328837A (en) * | 1992-05-18 | 1994-07-12 | Genentech, Inc. | Hepatocyte growth factor protease domain variants |
US5316921A (en) * | 1992-05-18 | 1994-05-31 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
CA2134773A1 (en) * | 1992-06-04 | 1993-12-09 | Robert J. Debs | Methods and compositions for in vivo gene therapy |
CA2144081C (en) * | 1992-09-16 | 2004-11-30 | Filip Roos | Protection against liver damage by hgf |
AU5416694A (en) | 1992-10-28 | 1994-05-24 | Jorg Meyer | Metal-plastic composite, process for producing it and apparatus for carrying out the process |
RU2139092C1 (ru) | 1993-06-03 | 1999-10-10 | Терапьютик Антибодиз Инк. | Фрагменты антител в терапии |
US5464815A (en) * | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
US8200624B2 (en) | 2010-07-20 | 2012-06-12 | Sybase, Inc. | Membership tracking and data eviction in mobile middleware scenarios |
-
1997
- 1997-06-20 AU AU34949/97A patent/AU729029B2/en not_active Expired
- 1997-06-20 EP EP97931275A patent/EP0922102B1/en not_active Expired - Lifetime
- 1997-06-20 WO PCT/US1997/010688 patent/WO1998000543A1/en active Application Filing
- 1997-06-20 JP JP10504193A patent/JP2000515735A/ja not_active Ceased
- 1997-06-20 CA CA002258153A patent/CA2258153C/en not_active Expired - Lifetime
- 1997-06-20 DE DE69739856T patent/DE69739856D1/de not_active Expired - Lifetime
- 1997-06-20 DK DK97931275.8T patent/DK0922102T3/da active
- 1997-06-20 AT AT97931275T patent/ATE465257T1/de not_active IP Right Cessation
- 1997-06-20 IL IL12755897A patent/IL127558A0/xx unknown
- 1997-06-27 US US08/884,669 patent/US6099841A/en not_active Expired - Lifetime
- 1997-07-01 ZA ZA975851A patent/ZA975851B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA975851B (en) | 1999-01-04 |
CA2258153C (en) | 2004-08-17 |
CA2258153A1 (en) | 1998-01-08 |
EP0922102A1 (en) | 1999-06-16 |
US6099841A (en) | 2000-08-08 |
EP0922102B1 (en) | 2010-04-21 |
DE69739856D1 (de) | 2010-06-02 |
JP2000515735A (ja) | 2000-11-28 |
AU3494997A (en) | 1998-01-21 |
AU729029B2 (en) | 2001-01-25 |
WO1998000543A1 (en) | 1998-01-08 |
DK0922102T3 (da) | 2010-08-16 |
ATE465257T1 (de) | 2010-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL127558A0 (en) | Hepatocyte growth factor receptor agonists and uses thereof | |
HK1033582A1 (en) | Antibodies to death receptor 4 (dr4) and uses thereof | |
EP1746160A3 (en) | Hepatocyte growth factor receptor antagonists and uses thereof | |
IL146448A0 (en) | Dr4 antibodies and uses thereof | |
WO2003066661A3 (en) | Human dr4 antibodies and uses thereof | |
HK1142093A1 (en) | Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process | |
MXPA02011656A (es) | Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos. | |
WO2000053761A3 (en) | Human cytokine as ligand of the zalpha receptor and uses thereof | |
BR9910251A (pt) | Estimulação hematopoiética | |
WO1999045098A3 (en) | Delivery or proteins into eukaryotic cells with recombinant yersinia | |
NO971341D0 (no) | Promoter for reseptor tyrosinkinase TIE | |
TW200640944A (en) | VGF polypeptides and methods of treating VGF-related disorders | |
RS20100249A (en) | CONJUGATES AND PROCEDURES FOR THEIR PRODUCTION, AND THEIR USE FOR THE TRANSPORT OF MOLECULES THROUGH BIOLOGICAL MEMBRANE | |
DE69120287D1 (en) | Aminosulfonylharnstoff-acat-inhibitoren | |
NO983177L (no) | Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft | |
TR200001102T2 (tr) | İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları. | |
NZ514691A (en) | Method to type prion proteins | |
NZ514027A (en) | Cloning and expression of haemophilus somnus transferrin-binding proteins | |
GB9723824D0 (en) | Cytostatic agents | |
FI971879A0 (fi) | Allogeenisten ja ksenogeenisten proteiinien vasta-aineet, niiden käyttö diagnoosissa ja hoidossa ja menetelmät niiden määrittämiseksi | |
ZA200203880B (en) | Placental human neurokinin B precursor. | |
CA2200846A1 (en) | Promoter for the receptor tyrosine kinase, tie |