DK0918759T3 - Hidtil ukendte, substituerede thiazolidin-2,4-dionderivater, fremgangsmåder til fremstilling af dem og farmaceutiske præparater, som omfatter dem - Google Patents

Hidtil ukendte, substituerede thiazolidin-2,4-dionderivater, fremgangsmåder til fremstilling af dem og farmaceutiske præparater, som omfatter dem

Info

Publication number
DK0918759T3
DK0918759T3 DK97925034T DK97925034T DK0918759T3 DK 0918759 T3 DK0918759 T3 DK 0918759T3 DK 97925034 T DK97925034 T DK 97925034T DK 97925034 T DK97925034 T DK 97925034T DK 0918759 T3 DK0918759 T3 DK 0918759T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
pharmaceutical compositions
dione derivatives
new substituted
Prior art date
Application number
DK97925034T
Other languages
Danish (da)
English (en)
Inventor
Gerard Moinet
Gerard Botton
Etienne Prugnard
Liliane Doare
Micheline Kergoat
Didier Mesangeau
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0918759T3 publication Critical patent/DK0918759T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97925034T 1996-06-07 1997-06-02 Hidtil ukendte, substituerede thiazolidin-2,4-dionderivater, fremgangsmåder til fremstilling af dem og farmaceutiske præparater, som omfatter dem DK0918759T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9607070A FR2749583B1 (fr) 1996-06-07 1996-06-07 Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
PCT/EP1997/002851 WO1997047612A1 (fr) 1996-06-07 1997-06-02 Nouveaux derives de thiazolidine-2,4-dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant

Publications (1)

Publication Number Publication Date
DK0918759T3 true DK0918759T3 (da) 2002-11-25

Family

ID=9492815

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97925034T DK0918759T3 (da) 1996-06-07 1997-06-02 Hidtil ukendte, substituerede thiazolidin-2,4-dionderivater, fremgangsmåder til fremstilling af dem og farmaceutiske præparater, som omfatter dem

Country Status (30)

Country Link
US (2) US6437143B2 (cs)
EP (1) EP0918759B1 (cs)
JP (2) JP3067809B2 (cs)
KR (1) KR20000016412A (cs)
CN (2) CN1075811C (cs)
AR (1) AR008387A1 (cs)
AT (1) ATE222897T1 (cs)
AU (1) AU726549B2 (cs)
BR (1) BR9709654A (cs)
CA (1) CA2257275A1 (cs)
CZ (1) CZ397598A3 (cs)
DE (1) DE69715009T2 (cs)
DK (1) DK0918759T3 (cs)
EE (1) EE04015B1 (cs)
ES (1) ES2180995T3 (cs)
FR (1) FR2749583B1 (cs)
HU (1) HUP0001744A3 (cs)
ID (1) ID17810A (cs)
IL (1) IL127408A (cs)
NO (1) NO312100B1 (cs)
NZ (1) NZ333645A (cs)
PL (1) PL330363A1 (cs)
PT (1) PT918759E (cs)
RU (1) RU2169144C2 (cs)
SK (1) SK164598A3 (cs)
TR (1) TR199802518T2 (cs)
TW (1) TW400330B (cs)
UA (1) UA57024C2 (cs)
WO (1) WO1997047612A1 (cs)
ZA (1) ZA974984B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
EP1143951A3 (en) * 1998-09-21 2002-02-06 University Of Florida Research Foundation, Inc. Antimalarial agents
HUP0200585A3 (en) * 1999-03-18 2004-07-28 Ono Pharmaceutical Co A process for the preparation of thiazolidine derivatives
PT1206457E (pt) * 1999-08-27 2004-03-31 Lilly Co Eli Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
FR2822069B1 (fr) * 2001-03-19 2003-06-20 Lipha Composition pharmaceutique comprenant un compose stimulant la secretion d'insuline et un derive de thiazolidinedione et son utilisation pour la preparation de medicamments destines a traiter le diabete
FR2826278B1 (fr) * 2001-06-20 2005-03-25 Lipha Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant
CN100516020C (zh) * 2001-09-26 2009-07-22 艾米斯菲尔技术有限公司 通过二羧化物中间体制备苯氧基链烷酸、链烯酸和炔酸及其盐的方法
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
SE0201937D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
FR2845003A1 (fr) * 2002-09-30 2004-04-02 Merck Sante Sas Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060263453A1 (en) * 2004-11-01 2006-11-23 Thomas Smith Methods and compositions for modulating glutamate dehydrogenase
TR201910900T4 (tr) * 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
CN104003955A (zh) * 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) * 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
CN105250285B (zh) * 2007-04-11 2019-09-06 奥默罗斯公司 预防和治疗成瘾的组合物和方法
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
BR112014014544A2 (pt) 2011-12-16 2017-06-13 Univ Florida usos de análogos de 4'-desferritiocina
US9815777B2 (en) 2013-09-22 2017-11-14 Jiva Pharma, Inc. Metformin salts to treat Type2 diabetes
US10010535B2 (en) 2013-11-22 2018-07-03 University Of Florida Research Foundation, Incorporated Desferrithiocin analogs and uses thereof
CA2984250A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
SU1611216A3 (ru) * 1986-12-29 1990-11-30 Пфайзер Инк (Фирма) Способ получени производных тиазолидиндиона или их фармацевтически приемлемых солей с щелочными металлами
TW268952B (cs) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
AU3192195A (en) * 1994-08-10 1996-03-07 Takeda Chemical Industries Ltd. Thiazolidinedione derivatives, their production and use

Also Published As

Publication number Publication date
ATE222897T1 (de) 2002-09-15
FR2749583B1 (fr) 1998-08-21
US20010007875A1 (en) 2001-07-12
US6437143B2 (en) 2002-08-20
HUP0001744A1 (hu) 2000-11-28
ES2180995T3 (es) 2003-02-16
AR008387A1 (es) 2000-01-19
KR20000016412A (ko) 2000-03-25
AU726549B2 (en) 2000-11-09
ID17810A (id) 1998-01-29
TW400330B (en) 2000-08-01
RU2169144C2 (ru) 2001-06-20
TR199802518T2 (xx) 1999-04-21
CN1075811C (zh) 2001-12-05
UA57024C2 (uk) 2003-06-16
CN1221410A (zh) 1999-06-30
EE9800426A (et) 1999-06-15
BR9709654A (pt) 1999-08-10
PT918759E (pt) 2003-01-31
HUP0001744A3 (en) 2002-09-30
NZ333645A (en) 2000-05-26
AU3031797A (en) 1998-01-07
CZ397598A3 (cs) 1999-03-17
EP0918759A1 (fr) 1999-06-02
EE04015B1 (et) 2003-04-15
JP3067809B2 (ja) 2000-07-24
NO312100B1 (no) 2002-03-18
US20030100587A1 (en) 2003-05-29
JP2000507270A (ja) 2000-06-13
JP2000226379A (ja) 2000-08-15
IL127408A (en) 2002-08-14
DE69715009T2 (de) 2003-05-08
DE69715009D1 (de) 2002-10-02
HK1019601A1 (en) 2000-02-18
CN1341588A (zh) 2002-03-27
FR2749583A1 (fr) 1997-12-12
EP0918759B1 (fr) 2002-08-28
CA2257275A1 (en) 1997-12-18
WO1997047612A1 (fr) 1997-12-18
ZA974984B (en) 1997-12-30
NO985671L (no) 1998-12-04
IL127408A0 (en) 1999-10-28
PL330363A1 (en) 1999-05-10
NO985671D0 (no) 1998-12-04
SK164598A3 (en) 1999-06-11

Similar Documents

Publication Publication Date Title
DK0918759T3 (da) Hidtil ukendte, substituerede thiazolidin-2,4-dionderivater, fremgangsmåder til fremstilling af dem og farmaceutiske præparater, som omfatter dem
NO20013242D0 (no) Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem
DK1169313T3 (da) Derivater af 1,4-benzothiazepin-1,1-dioxid substitueret med sukkerradikaler, fremgangsmåder til deres fremstilling, lægemidler som indeholder disse forbindelser og deres anvendelse
NO20041998L (no) Benzoksazin og benzotiazinderivater og farmasoytiske sammensetninger som inneholder dem
DK1086092T3 (da) Benzo(b)thiepin-1,1-dioxidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
NO20016038L (no) Benzenderivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
NO942834D0 (no) 1-benzensulfonyl-1,3-dihydro-indol-2-on-derivater, fremstilling derav, og farmasöytiske blandinger som inneholder dem
NO20015667D0 (no) Tiazoloderivater og farmasöytiske sammensetninger inneholdende dem
DK0676409T3 (da) Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
NO305075B1 (no) Glycinamid-derivater, farmas°ytiske medikamenter som inneholder dem og mellomprodukter for fremstilling av dem
DK0885204T3 (da) Nye arylglycinamidderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende disse forbindelser
DK0991654T3 (da) Hidtil ukendte derivater af 2-(iminomethyl)aminophenyl, deres fremstilling, deres anvendelse til medikamenter og farmaceutiske præparater indeholdende samme
DK1095020T3 (da) 2-Aminopyridinderivater, deres anvendelse som lægemidler og farmaceutiske præparater, der indeholder dem
DK1183256T3 (da) Puridinderivater, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
DK1322158T3 (da) Farmaceutiske præparater med langvarig frigivelse, som indeholder metformin, og fremgangsmåde til fremstilling deraf
NO955320D0 (no) Substituerte 4-fenyltiazolderivater, fremgangsmåte for fremstilling derav og farmasöytiske blandinger som inneholder dem
DK0868911T3 (da) Rapamycinpræparater til oral indgivelse
DK1117642T3 (da) Substituerede 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)-propanolderivater, fremgangsmåder til fremstilling deraf, farmaceutiske præparater indeholdende dem og anvendelse deraf
EE200200022A (et) Aminotiasooli derivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
DK1028960T3 (da) Fremgangsmåde til fremstilling af thiazolidinedion
DK0946531T3 (da) Fremgangsmåde til fremstilling af thiazol-derivater
NO960272D0 (no) Oksatiolaner, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder de samme
DK1210348T3 (da) Naphthyridinderivater, fremgangsmåde til deres fremstilling, deres anvendelse og farmaceutiske præparater omfattende dem
NO20004638L (no) Hypnotisk <beta>- karbolinderivater, fremgangsmÕte til deres fremstilling og deres anvendelse som legemiddelprodukt
DK1037613T3 (da) Fremgangsmåde til fremstilling af farmaceutiske formuleringer, der indeholder en ekstrakt