ZA974984B - New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them. - Google Patents

New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.

Info

Publication number
ZA974984B
ZA974984B ZA9704984A ZA974984A ZA974984B ZA 974984 B ZA974984 B ZA 974984B ZA 9704984 A ZA9704984 A ZA 9704984A ZA 974984 A ZA974984 A ZA 974984A ZA 974984 B ZA974984 B ZA 974984B
Authority
ZA
South Africa
Prior art keywords
obtaining
processes
pharmaceutical compositions
compositions containing
dione derivatives
Prior art date
Application number
ZA9704984A
Other languages
English (en)
Inventor
Gerard Moinet
Etienne Prugnard
Micheline Kergoat
Gerard Botton
Liliane Doare
Didier Mesangeau
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA974984B publication Critical patent/ZA974984B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9704984A 1996-06-07 1997-06-05 New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them. ZA974984B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9607070A FR2749583B1 (fr) 1996-06-07 1996-06-07 Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant

Publications (1)

Publication Number Publication Date
ZA974984B true ZA974984B (en) 1997-12-30

Family

ID=9492815

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704984A ZA974984B (en) 1996-06-07 1997-06-05 New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.

Country Status (30)

Country Link
US (2) US6437143B2 (cs)
EP (1) EP0918759B1 (cs)
JP (2) JP3067809B2 (cs)
KR (1) KR20000016412A (cs)
CN (2) CN1075811C (cs)
AR (1) AR008387A1 (cs)
AT (1) ATE222897T1 (cs)
AU (1) AU726549B2 (cs)
BR (1) BR9709654A (cs)
CA (1) CA2257275A1 (cs)
CZ (1) CZ397598A3 (cs)
DE (1) DE69715009T2 (cs)
DK (1) DK0918759T3 (cs)
EE (1) EE04015B1 (cs)
ES (1) ES2180995T3 (cs)
FR (1) FR2749583B1 (cs)
HU (1) HUP0001744A3 (cs)
ID (1) ID17810A (cs)
IL (1) IL127408A (cs)
NO (1) NO312100B1 (cs)
NZ (1) NZ333645A (cs)
PL (1) PL330363A1 (cs)
PT (1) PT918759E (cs)
RU (1) RU2169144C2 (cs)
SK (1) SK164598A3 (cs)
TR (1) TR199802518T2 (cs)
TW (1) TW400330B (cs)
UA (1) UA57024C2 (cs)
WO (1) WO1997047612A1 (cs)
ZA (1) ZA974984B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
NZ526880A (en) * 1998-09-21 2005-05-27 Univ Florida Antimalarial agents
CN1350526A (zh) * 1999-03-18 2002-05-22 小野药品工业株式会社 噻唑烷衍生物的制备方法
DK1206457T3 (da) * 1999-08-27 2004-02-16 Lilly Co Eli Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
FR2822069B1 (fr) * 2001-03-19 2003-06-20 Lipha Composition pharmaceutique comprenant un compose stimulant la secretion d'insuline et un derive de thiazolidinedione et son utilisation pour la preparation de medicamments destines a traiter le diabete
FR2826278B1 (fr) * 2001-06-20 2005-03-25 Lipha Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant
CA2460782C (en) * 2001-09-26 2011-11-08 Emisphere Technologies, Inc. Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
SE0201937D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
FR2845003A1 (fr) * 2002-09-30 2004-04-02 Merck Sante Sas Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060263453A1 (en) * 2004-11-01 2006-11-23 Thomas Smith Methods and compositions for modulating glutamate dehydrogenase
JP5202299B2 (ja) 2005-04-04 2013-06-05 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド デフェリチオシンポリエーテル類似体
AU2008229472B2 (en) 2007-03-15 2013-03-14 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
EP3788877B1 (en) * 2007-04-11 2024-08-07 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
WO2013090750A1 (en) 2011-12-16 2013-06-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
US9815777B2 (en) 2013-09-22 2017-11-14 Jiva Pharma, Inc. Metformin salts to treat Type2 diabetes
JP6838966B2 (ja) 2013-11-22 2021-03-03 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． デスフェリチオシン類似体およびその使用
HK1250216A1 (zh) 2015-04-27 2018-12-07 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
SU1611216A3 (ru) * 1986-12-29 1990-11-30 Пфайзер Инк (Фирма) Способ получени производных тиазолидиндиона или их фармацевтически приемлемых солей с щелочными металлами
TW268952B (cs) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
AU3192195A (en) * 1994-08-10 1996-03-07 Takeda Chemical Industries Ltd. Thiazolidinedione derivatives, their production and use

Also Published As

Publication number Publication date
NO985671D0 (no) 1998-12-04
US20030100587A1 (en) 2003-05-29
JP3067809B2 (ja) 2000-07-24
US6437143B2 (en) 2002-08-20
PT918759E (pt) 2003-01-31
NO312100B1 (no) 2002-03-18
CZ397598A3 (cs) 1999-03-17
ES2180995T3 (es) 2003-02-16
HUP0001744A3 (en) 2002-09-30
AR008387A1 (es) 2000-01-19
PL330363A1 (en) 1999-05-10
NO985671L (no) 1998-12-04
HK1019601A1 (en) 2000-02-18
AU726549B2 (en) 2000-11-09
CN1221410A (zh) 1999-06-30
TW400330B (en) 2000-08-01
FR2749583B1 (fr) 1998-08-21
RU2169144C2 (ru) 2001-06-20
CA2257275A1 (en) 1997-12-18
WO1997047612A1 (fr) 1997-12-18
AU3031797A (en) 1998-01-07
ID17810A (id) 1998-01-29
JP2000226379A (ja) 2000-08-15
TR199802518T2 (xx) 1999-04-21
IL127408A0 (en) 1999-10-28
CN1075811C (zh) 2001-12-05
ATE222897T1 (de) 2002-09-15
DE69715009D1 (de) 2002-10-02
EE04015B1 (et) 2003-04-15
DE69715009T2 (de) 2003-05-08
CN1341588A (zh) 2002-03-27
UA57024C2 (uk) 2003-06-16
BR9709654A (pt) 1999-08-10
FR2749583A1 (fr) 1997-12-12
IL127408A (en) 2002-08-14
NZ333645A (en) 2000-05-26
EP0918759B1 (fr) 2002-08-28
US20010007875A1 (en) 2001-07-12
DK0918759T3 (da) 2002-11-25
HUP0001744A1 (hu) 2000-11-28
KR20000016412A (ko) 2000-03-25
SK164598A3 (en) 1999-06-11
JP2000507270A (ja) 2000-06-13
EP0918759A1 (fr) 1999-06-02
EE9800426A (et) 1999-06-15

Similar Documents

Publication Publication Date Title
ZA974984B (en) New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.
HUP0001539A3 (en) 2-(1-iminoethylamino)ethyl-homocysteine, process for its preparation and pharmaceutical compositions containing the same
AU7640696A (en) Thiazolidinedione derivatives, method for preparing the derivatives and pharmaceutical compositions containing same
IL113084A0 (en) Thiazolidine and oxazolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL144501A0 (en) Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
CY2369B1 (en) Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same.
IL138280A0 (en) 20-KETO-11β-ARYLSTERIODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
HUP9902455A3 (en) 6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them
IL135920A0 (en) 2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
IL108873A0 (en) 2-debenzoyl-2-acyl taxol derivatives, pharmaceutical compositions containing the same, and methods for the preparation thereof
IL141456A0 (en) Rhodanine derivatives and pharmaceutical compositions containing the same
HUP0000851A3 (en) Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL139480A0 (en) Epothilone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL140897A0 (en) Benzocycloheptene derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP9803040A3 (en) Thiazole derivatives, process for the preparation thereof, use thereof and pharmaceutical compositions containing them
ZA965712B (en) New oxazolidinone derivatives, processes for the production thereof and pharmaceutical agents containing these compounds.
ZA200005510B (en) Pharmaceutical composition.
IL143577A0 (en) Piperazine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
ZA200102589B (en) Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof.
HUP0202701A3 (en) Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them
HUP0202893A3 (en) Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them
ZA991590B (en) Indole derivatives and pharmaceutical compositions comprising the same.
AU2231397A (en) Thiazolidine-2,4-dione derivatives
HUP0001093A3 (en) Oxazolidines as 5-ht2a-antagonists, pharmaceutical compositions containing the same and process for their preparation
ZA9810033B (en) Process for the preparation of Thiazolidinedione Derivatives.