DE69715009T2 - Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten - Google Patents

Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten

Info

Publication number
DE69715009T2
DE69715009T2 DE69715009T DE69715009T DE69715009T2 DE 69715009 T2 DE69715009 T2 DE 69715009T2 DE 69715009 T DE69715009 T DE 69715009T DE 69715009 T DE69715009 T DE 69715009T DE 69715009 T2 DE69715009 T2 DE 69715009T2
Authority
DE
Germany
Prior art keywords
production
pharmaceutical compositions
thiazolidinedione derivatives
substituted thiazolidinedione
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715009T
Other languages
English (en)
Other versions
DE69715009D1 (de
Inventor
Gerard Moinet
Gerard Botton
Etienne Prugnard
Liliane Doare
Micheline Kergoat
Didier Mesangeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of DE69715009D1 publication Critical patent/DE69715009D1/de
Application granted granted Critical
Publication of DE69715009T2 publication Critical patent/DE69715009T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69715009T 1996-06-07 1997-06-02 Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten Expired - Fee Related DE69715009T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9607070A FR2749583B1 (fr) 1996-06-07 1996-06-07 Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
PCT/EP1997/002851 WO1997047612A1 (de) 1996-06-07 1997-06-02 Nouveaux derives de thiazolidone-2,4-dione substitues, leurs procedes d'obtension et les compositions pharmaceutiques

Publications (2)

Publication Number Publication Date
DE69715009D1 DE69715009D1 (de) 2002-10-02
DE69715009T2 true DE69715009T2 (de) 2003-05-08

Family

ID=9492815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715009T Expired - Fee Related DE69715009T2 (de) 1996-06-07 1997-06-02 Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten

Country Status (31)

Country Link
US (2) US6437143B2 (de)
EP (1) EP0918759B1 (de)
JP (2) JP3067809B2 (de)
KR (1) KR20000016412A (de)
CN (2) CN1075811C (de)
AR (1) AR008387A1 (de)
AT (1) ATE222897T1 (de)
AU (1) AU726549B2 (de)
BR (1) BR9709654A (de)
CA (1) CA2257275A1 (de)
CZ (1) CZ397598A3 (de)
DE (1) DE69715009T2 (de)
DK (1) DK0918759T3 (de)
EE (1) EE04015B1 (de)
ES (1) ES2180995T3 (de)
FR (1) FR2749583B1 (de)
HK (1) HK1019601A1 (de)
HU (1) HUP0001744A3 (de)
ID (1) ID17810A (de)
IL (1) IL127408A (de)
NO (1) NO312100B1 (de)
NZ (1) NZ333645A (de)
PL (1) PL330363A1 (de)
PT (1) PT918759E (de)
RU (1) RU2169144C2 (de)
SK (1) SK164598A3 (de)
TR (1) TR199802518T2 (de)
TW (1) TW400330B (de)
UA (1) UA57024C2 (de)
WO (1) WO1997047612A1 (de)
ZA (1) ZA974984B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
CA2344913A1 (en) * 1998-09-21 2000-03-30 University Of Florida Research Foundation, Inc. Antimalarial agents
CN1350526A (zh) * 1999-03-18 2002-05-22 小野药品工业株式会社 噻唑烷衍生物的制备方法
DK1206457T3 (da) 1999-08-27 2004-02-16 Lilly Co Eli Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
FR2822069B1 (fr) * 2001-03-19 2003-06-20 Lipha Composition pharmaceutique comprenant un compose stimulant la secretion d'insuline et un derive de thiazolidinedione et son utilisation pour la preparation de medicamments destines a traiter le diabete
FR2826278B1 (fr) * 2001-06-20 2005-03-25 Lipha Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant
CN100516020C (zh) * 2001-09-26 2009-07-22 艾米斯菲尔技术有限公司 通过二羧化物中间体制备苯氧基链烷酸、链烯酸和炔酸及其盐的方法
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
FR2845003A1 (fr) * 2002-09-30 2004-04-02 Merck Sante Sas Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060263453A1 (en) * 2004-11-01 2006-11-23 Thomas Smith Methods and compositions for modulating glutamate dehydrogenase
DK3190106T3 (da) 2005-04-04 2019-07-15 Univ Florida Desferrithiocinpolyether-analoger
NZ579994A (en) * 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
ES2830073T3 (es) * 2007-04-11 2021-06-02 Omeros Corp Composiciones y métodos para la profilaxis y el tratamiento de adicciones
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) * 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
BR112014014544A2 (pt) 2011-12-16 2017-06-13 Univ Florida usos de análogos de 4'-desferritiocina
US9815777B2 (en) 2013-09-22 2017-11-14 Jiva Pharma, Inc. Metformin salts to treat Type2 diabetes
CA2930966A1 (en) 2013-11-22 2015-05-28 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CN107708693A (zh) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
TW268952B (de) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
EP0783496B9 (de) * 1994-08-10 2003-09-03 Takeda Chemical Industries, Ltd. Thiazolidindione derivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
US20010007875A1 (en) 2001-07-12
IL127408A (en) 2002-08-14
EP0918759B1 (de) 2002-08-28
DE69715009D1 (de) 2002-10-02
HK1019601A1 (en) 2000-02-18
CA2257275A1 (en) 1997-12-18
ID17810A (id) 1998-01-29
CN1221410A (zh) 1999-06-30
JP3067809B2 (ja) 2000-07-24
AU3031797A (en) 1998-01-07
IL127408A0 (en) 1999-10-28
BR9709654A (pt) 1999-08-10
UA57024C2 (uk) 2003-06-16
ZA974984B (en) 1997-12-30
NO312100B1 (no) 2002-03-18
EE9800426A (et) 1999-06-15
PL330363A1 (en) 1999-05-10
JP2000226379A (ja) 2000-08-15
AR008387A1 (es) 2000-01-19
JP2000507270A (ja) 2000-06-13
ATE222897T1 (de) 2002-09-15
AU726549B2 (en) 2000-11-09
HUP0001744A3 (en) 2002-09-30
CN1075811C (zh) 2001-12-05
US20030100587A1 (en) 2003-05-29
NO985671L (no) 1998-12-04
KR20000016412A (ko) 2000-03-25
NZ333645A (en) 2000-05-26
NO985671D0 (no) 1998-12-04
TW400330B (en) 2000-08-01
FR2749583B1 (fr) 1998-08-21
RU2169144C2 (ru) 2001-06-20
EE04015B1 (et) 2003-04-15
US6437143B2 (en) 2002-08-20
TR199802518T2 (xx) 1999-04-21
CN1341588A (zh) 2002-03-27
HUP0001744A1 (hu) 2000-11-28
CZ397598A3 (cs) 1999-03-17
PT918759E (pt) 2003-01-31
ES2180995T3 (es) 2003-02-16
FR2749583A1 (fr) 1997-12-12
WO1997047612A1 (de) 1997-12-18
SK164598A3 (en) 1999-06-11
DK0918759T3 (da) 2002-11-25
EP0918759A1 (de) 1999-06-02

Similar Documents

Publication Publication Date Title
DE69715009T2 (de) Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten
DE69730980D1 (de) 6-phenyltetrahydro-1,3-oxazin-2-on derivate und medizinische zusammensetzungen, die sie enthalten
ATE432919T1 (de) Azetidinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE188471T1 (de) Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE69429003T2 (de) Flavonoid und biflavonoid,derivate, pharmazeutische zusammensetzung und ihre anxiolytische wirkung
DE69630145D1 (de) Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
ATE239712T1 (de) Disubstituierte bicyclische heterocyclen, ihre herstellung und ihre verwendung als arzneimittel
ATE239703T1 (de) Azetidinderivate, deren herstellung und sie enthaltende arzneimittel
ATE164843T1 (de) Naphthalinderivate, ihre herstellungsverfahren und zwischenprodukte dafür, und diese enthaltende pharmazeutische zusammensetzungen
DE59905572D1 (de) Substituierte 4-amino-2-aryl-pyrimidine, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
ATE243708T1 (de) Substituierte imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE3877406D1 (de) Benzothiazolinon-derivate, ihre herstellung und pharmazeutische zusammensetzung.
DE69927033T2 (de) 4-aminopyridinderivate, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
DE50003761D1 (de) Indeno-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel
IL145012A0 (en) Fluorine substituted triarylmethane derivatives and pharmaceutical compositions containing the same
DE59814412D1 (de) Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
ATE193533T1 (de) Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE69600601T2 (de) Heterocyclische, aromatische Verbindungen, pharmazeutische und kosmetische Zusammensetzungen,die sie enthalten, und Verwendungen.
DE60006958D1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
DE69706146D1 (de) Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE69517936D1 (de) Substituierte 4-Phenyl-Thiazole Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammenstellungen die sie enthalten
DE69312319D1 (de) Tachyquinin antagonisten, ihre herstellung und ihre verwendung in pharmazeutischen formulierungen
DE69610085D1 (de) Taxol derivate,deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE69942424D1 (de) Neuartige agarofuran derivate, ihre herstellung, pharmazeutische zusammensetzungen, die diese enthalten und ihre verwendung als medizin
DE60005337D1 (de) Spiroimidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee