ZA974984B - New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them. - Google Patents

New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.

Info

Publication number
ZA974984B
ZA974984B ZA9704984A ZA974984A ZA974984B ZA 974984 B ZA974984 B ZA 974984B ZA 9704984 A ZA9704984 A ZA 9704984A ZA 974984 A ZA974984 A ZA 974984A ZA 974984 B ZA974984 B ZA 974984B
Authority
ZA
South Africa
Prior art keywords
obtaining
processes
pharmaceutical compositions
compositions containing
dione derivatives
Prior art date
Application number
ZA9704984A
Other languages
English (en)
Inventor
Gerard Moinet
Etienne Prugnard
Micheline Kergoat
Gerard Botton
Liliane Doare
Didier Mesangeau
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA974984B publication Critical patent/ZA974984B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9704984A 1996-06-07 1997-06-05 New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them. ZA974984B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9607070A FR2749583B1 (fr) 1996-06-07 1996-06-07 Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant

Publications (1)

Publication Number Publication Date
ZA974984B true ZA974984B (en) 1997-12-30

Family

ID=9492815

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704984A ZA974984B (en) 1996-06-07 1997-06-05 New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.

Country Status (31)

Country Link
US (2) US6437143B2 (de)
EP (1) EP0918759B1 (de)
JP (2) JP3067809B2 (de)
KR (1) KR20000016412A (de)
CN (2) CN1075811C (de)
AR (1) AR008387A1 (de)
AT (1) ATE222897T1 (de)
AU (1) AU726549B2 (de)
BR (1) BR9709654A (de)
CA (1) CA2257275A1 (de)
CZ (1) CZ397598A3 (de)
DE (1) DE69715009T2 (de)
DK (1) DK0918759T3 (de)
EE (1) EE04015B1 (de)
ES (1) ES2180995T3 (de)
FR (1) FR2749583B1 (de)
HK (1) HK1019601A1 (de)
HU (1) HUP0001744A3 (de)
ID (1) ID17810A (de)
IL (1) IL127408A (de)
NO (1) NO312100B1 (de)
NZ (1) NZ333645A (de)
PL (1) PL330363A1 (de)
PT (1) PT918759E (de)
RU (1) RU2169144C2 (de)
SK (1) SK164598A3 (de)
TR (1) TR199802518T2 (de)
TW (1) TW400330B (de)
UA (1) UA57024C2 (de)
WO (1) WO1997047612A1 (de)
ZA (1) ZA974984B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
NZ509172A (en) * 1998-09-21 2004-02-27 Univ Florida Antimalarial agents
HUP0200585A3 (en) * 1999-03-18 2004-07-28 Ono Pharmaceutical Co A process for the preparation of thiazolidine derivatives
WO2001016120A1 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
FR2822069B1 (fr) * 2001-03-19 2003-06-20 Lipha Composition pharmaceutique comprenant un compose stimulant la secretion d'insuline et un derive de thiazolidinedione et son utilisation pour la preparation de medicamments destines a traiter le diabete
FR2826278B1 (fr) * 2001-06-20 2005-03-25 Lipha Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant
ES2400683T3 (es) * 2001-09-26 2013-04-11 Emisphere Technologies, Inc. Método de preparación de ácidos fenoi-alcanoicos y sales de los mismos mediante un producto intermedio de dicarboxilato
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
FR2845003A1 (fr) * 2002-09-30 2004-04-02 Merck Sante Sas Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060263453A1 (en) * 2004-11-01 2006-11-23 Thomas Smith Methods and compositions for modulating glutamate dehydrogenase
DK1866296T3 (en) 2005-04-04 2017-02-13 Univ Florida DESFERRITHIOCINPOLYETHER-ANALOGS
BRPI0809077A2 (pt) * 2007-03-15 2014-09-09 Univ Florida Res Foudantion Inc Análogos de poliéter de desferritiocina
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) * 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
JP5548120B2 (ja) * 2007-04-11 2014-07-16 オメロス コーポレーション 嗜癖の予防および治療のための組成物および方法
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
WO2015042495A2 (en) * 2013-09-22 2015-03-26 Jiva Pharma, Inc. Metformin salts to treat type2 diabetes
EP3071201A4 (de) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin-analoga und verwendungen davon
CA2984250A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
TW268952B (de) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
US5965589A (en) * 1994-08-10 1999-10-12 Takeda Chemical Industries, Ltd. Thiazolidinedione derivatives, their production and use

Also Published As

Publication number Publication date
TR199802518T2 (xx) 1999-04-21
CN1341588A (zh) 2002-03-27
AR008387A1 (es) 2000-01-19
ATE222897T1 (de) 2002-09-15
BR9709654A (pt) 1999-08-10
CA2257275A1 (en) 1997-12-18
CN1221410A (zh) 1999-06-30
ID17810A (id) 1998-01-29
AU726549B2 (en) 2000-11-09
NO985671L (no) 1998-12-04
HUP0001744A1 (hu) 2000-11-28
EE9800426A (et) 1999-06-15
FR2749583A1 (fr) 1997-12-12
KR20000016412A (ko) 2000-03-25
US20010007875A1 (en) 2001-07-12
RU2169144C2 (ru) 2001-06-20
NO985671D0 (no) 1998-12-04
CN1075811C (zh) 2001-12-05
IL127408A0 (en) 1999-10-28
NZ333645A (en) 2000-05-26
SK164598A3 (en) 1999-06-11
CZ397598A3 (cs) 1999-03-17
FR2749583B1 (fr) 1998-08-21
DE69715009T2 (de) 2003-05-08
JP3067809B2 (ja) 2000-07-24
US6437143B2 (en) 2002-08-20
EP0918759B1 (de) 2002-08-28
EE04015B1 (et) 2003-04-15
DE69715009D1 (de) 2002-10-02
US20030100587A1 (en) 2003-05-29
WO1997047612A1 (de) 1997-12-18
HUP0001744A3 (en) 2002-09-30
AU3031797A (en) 1998-01-07
NO312100B1 (no) 2002-03-18
HK1019601A1 (en) 2000-02-18
ES2180995T3 (es) 2003-02-16
JP2000507270A (ja) 2000-06-13
JP2000226379A (ja) 2000-08-15
PL330363A1 (en) 1999-05-10
IL127408A (en) 2002-08-14
UA57024C2 (uk) 2003-06-16
DK0918759T3 (da) 2002-11-25
TW400330B (en) 2000-08-01
PT918759E (pt) 2003-01-31
EP0918759A1 (de) 1999-06-02

Similar Documents

Publication Publication Date Title
ZA974984B (en) New substituted thiazolidine-2,4-dione derivatives, processes for the obtaining thereof, and pharmaceutical compositions containing them.
HUP0001539A3 (en) 2-(1-iminoethylamino)ethyl-homocysteine, process for its preparation and pharmaceutical compositions containing the same
IL113084A0 (en) Thiazolidine and oxazolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
AU7640696A (en) Thiazolidinedione derivatives, method for preparing the derivatives and pharmaceutical compositions containing same
HK1018780A1 (en) 6-Phenylpyridine-2-ylamine derivatives, the composition and use thereof.
IL144501A0 (en) Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
CY2369B1 (en) Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same.
IL138280A0 (en) 20-KETO-11β-ARYLSTERIODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
IL135920A0 (en) 2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
IL108873A0 (en) 2-debenzoyl-2-acyl taxol derivatives, pharmaceutical compositions containing the same, and methods for the preparation thereof
IL112193A0 (en) Phenylpyrazolopyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HK1045693A1 (en) Bicyclic compounds composition and method for stabilizing the same.
HUP0000851A3 (en) Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL139480A0 (en) Epothilone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
ZA965712B (en) New oxazolidinone derivatives, processes for the production thereof and pharmaceutical agents containing these compounds.
HUP9803040A3 (en) Thiazole derivatives, process for the preparation thereof, use thereof and pharmaceutical compositions containing them
IL143577A0 (en) Piperazine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HK1015789A1 (en) Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use.
HK1036974A1 (en) Indole derivatives and medicinal compositions containing the same.
ZA200102589B (en) Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof.
HUP0202520A3 (en) Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them
ZA9810033B (en) Process for the preparation of Thiazolidinedione Derivatives.
HUP0001551A3 (en) Improved method for producing thiazolidinediones, thiazolidinediones and pharmaceutical compositions containing the same
GB9310075D0 (en) New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
HUP9701115A3 (en) N-acetonylbenzamide derivatives, process for the preparation thereof, fungicide compositions containing these compounds and use thereof