EE04015B1 - Asendatud 2,4-tiasolidiindiooni derivaadid, nendevalmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Asendatud 2,4-tiasolidiindiooni derivaadid, nendevalmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number
EE04015B1
EE04015B1 EE9800426A EE9800426A EE04015B1 EE 04015 B1 EE04015 B1 EE 04015B1 EE 9800426 A EE9800426 A EE 9800426A EE 9800426 A EE9800426 A EE 9800426A EE 04015 B1 EE04015 B1 EE 04015B1
Authority
EE
Estonia
Prior art keywords
substituted
preparation
methods
pharmaceutical compositions
compositions containing
Prior art date
Application number
EE9800426A
Other languages
English (en)
Estonian (et)
Other versions
EE9800426A (et
Inventor
Moinet G�Rard
Botton G�rard
Prugnard Etienne
Doare Liliane
Kergoat Micheline
Mesangeau Didier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of EE9800426A publication Critical patent/EE9800426A/xx
Publication of EE04015B1 publication Critical patent/EE04015B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EE9800426A 1996-06-07 1997-06-02 Asendatud 2,4-tiasolidiindiooni derivaadid, nendevalmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid EE04015B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9607070A FR2749583B1 (fr) 1996-06-07 1996-06-07 Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
PCT/EP1997/002851 WO1997047612A1 (fr) 1996-06-07 1997-06-02 Nouveaux derives de thiazolidine-2,4-dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant

Publications (2)

Publication Number Publication Date
EE9800426A EE9800426A (et) 1999-06-15
EE04015B1 true EE04015B1 (et) 2003-04-15

Family

ID=9492815

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800426A EE04015B1 (et) 1996-06-07 1997-06-02 Asendatud 2,4-tiasolidiindiooni derivaadid, nendevalmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid

Country Status (30)

Country Link
US (2) US6437143B2 (cs)
EP (1) EP0918759B1 (cs)
JP (2) JP3067809B2 (cs)
KR (1) KR20000016412A (cs)
CN (2) CN1075811C (cs)
AR (1) AR008387A1 (cs)
AT (1) ATE222897T1 (cs)
AU (1) AU726549B2 (cs)
BR (1) BR9709654A (cs)
CA (1) CA2257275A1 (cs)
CZ (1) CZ397598A3 (cs)
DE (1) DE69715009T2 (cs)
DK (1) DK0918759T3 (cs)
EE (1) EE04015B1 (cs)
ES (1) ES2180995T3 (cs)
FR (1) FR2749583B1 (cs)
HU (1) HUP0001744A3 (cs)
ID (1) ID17810A (cs)
IL (1) IL127408A (cs)
NO (1) NO312100B1 (cs)
NZ (1) NZ333645A (cs)
PL (1) PL330363A1 (cs)
PT (1) PT918759E (cs)
RU (1) RU2169144C2 (cs)
SK (1) SK164598A3 (cs)
TR (1) TR199802518T2 (cs)
TW (1) TW400330B (cs)
UA (1) UA57024C2 (cs)
WO (1) WO1997047612A1 (cs)
ZA (1) ZA974984B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
AU774956B2 (en) * 1998-09-21 2004-07-15 Trustees Of Columbia University In The City Of New York, The Antimalarial agents
NZ514177A (en) * 1999-03-18 2003-04-29 Ono Pharmaceutical Co A process for the preparation of thiazolidine derivatives
DE60005973T2 (de) 1999-08-27 2004-05-13 Eli Lilly And Co., Indianapolis Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
FR2822069B1 (fr) * 2001-03-19 2003-06-20 Lipha Composition pharmaceutique comprenant un compose stimulant la secretion d'insuline et un derive de thiazolidinedione et son utilisation pour la preparation de medicamments destines a traiter le diabete
FR2826278B1 (fr) * 2001-06-20 2005-03-25 Lipha Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant
WO2003026582A2 (en) * 2001-09-26 2003-04-03 Emisphere Technologies Inc. Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
SE0201937D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
FR2845003A1 (fr) * 2002-09-30 2004-04-02 Merck Sante Sas Utilisation de derives de thiazolidinedione comme inhibiteurs de l'aldose reductase
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060263453A1 (en) * 2004-11-01 2006-11-23 Thomas Smith Methods and compositions for modulating glutamate dehydrogenase
CN101189216B (zh) 2005-04-04 2011-10-19 佛罗里达大学研究基金会 Desferrithiocin聚醚类似物
WO2008115433A1 (en) 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
CN105250285B (zh) * 2007-04-11 2019-09-06 奥默罗斯公司 预防和治疗成瘾的组合物和方法
US20160331729A9 (en) * 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
DE102007028925A1 (de) * 2007-06-22 2008-12-24 Saltigo Gmbh Verfahren zur Herstellung von 2-Phenoxyacetalen und den daraus korrespondierenden 2-Phenoxycarbaldehyden
EP3620161A1 (en) 2011-12-16 2020-03-11 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
WO2015042495A2 (en) * 2013-09-22 2015-03-26 Jiva Pharma, Inc. Metformin salts to treat type2 diabetes
EP3071201A4 (en) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
SU1611216A3 (ru) * 1986-12-29 1990-11-30 Пфайзер Инк (Фирма) Способ получени производных тиазолидиндиона или их фармацевтически приемлемых солей с щелочными металлами
TW268952B (cs) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
US5965589A (en) * 1994-08-10 1999-10-12 Takeda Chemical Industries, Ltd. Thiazolidinedione derivatives, their production and use

Also Published As

Publication number Publication date
EE9800426A (et) 1999-06-15
JP2000226379A (ja) 2000-08-15
ZA974984B (en) 1997-12-30
AU3031797A (en) 1998-01-07
FR2749583A1 (fr) 1997-12-12
ID17810A (id) 1998-01-29
RU2169144C2 (ru) 2001-06-20
HUP0001744A3 (en) 2002-09-30
BR9709654A (pt) 1999-08-10
AU726549B2 (en) 2000-11-09
CZ397598A3 (cs) 1999-03-17
HK1019601A1 (en) 2000-02-18
NO985671D0 (no) 1998-12-04
FR2749583B1 (fr) 1998-08-21
DE69715009D1 (de) 2002-10-02
PT918759E (pt) 2003-01-31
US6437143B2 (en) 2002-08-20
JP2000507270A (ja) 2000-06-13
SK164598A3 (en) 1999-06-11
US20030100587A1 (en) 2003-05-29
HUP0001744A1 (hu) 2000-11-28
EP0918759A1 (fr) 1999-06-02
ES2180995T3 (es) 2003-02-16
EP0918759B1 (fr) 2002-08-28
UA57024C2 (uk) 2003-06-16
ATE222897T1 (de) 2002-09-15
KR20000016412A (ko) 2000-03-25
TW400330B (en) 2000-08-01
WO1997047612A1 (fr) 1997-12-18
AR008387A1 (es) 2000-01-19
NO985671L (no) 1998-12-04
DE69715009T2 (de) 2003-05-08
CN1075811C (zh) 2001-12-05
CN1221410A (zh) 1999-06-30
JP3067809B2 (ja) 2000-07-24
IL127408A0 (en) 1999-10-28
TR199802518T2 (xx) 1999-04-21
DK0918759T3 (da) 2002-11-25
NO312100B1 (no) 2002-03-18
US20010007875A1 (en) 2001-07-12
CN1341588A (zh) 2002-03-27
IL127408A (en) 2002-08-14
CA2257275A1 (en) 1997-12-18
NZ333645A (en) 2000-05-26
PL330363A1 (en) 1999-05-10

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20040602