DK0902789T3 - Androstenderivater - Google Patents

Androstenderivater

Info

Publication number
DK0902789T3
DK0902789T3 DK97921345T DK97921345T DK0902789T3 DK 0902789 T3 DK0902789 T3 DK 0902789T3 DK 97921345 T DK97921345 T DK 97921345T DK 97921345 T DK97921345 T DK 97921345T DK 0902789 T3 DK0902789 T3 DK 0902789T3
Authority
DK
Denmark
Prior art keywords
beta
androstene
hydroxyandrosta
androstenes
dichloroacetoxy
Prior art date
Application number
DK97921345T
Other languages
Danish (da)
English (en)
Inventor
Nicholas S Bodor
Original Assignee
Soft Drugs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21780726&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0902789(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Soft Drugs Inc filed Critical Soft Drugs Inc
Application granted granted Critical
Publication of DK0902789T3 publication Critical patent/DK0902789T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97921345T 1996-05-09 1997-05-01 Androstenderivater DK0902789T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1710296P 1996-05-09 1996-05-09
PCT/US1997/006812 WO1997042214A1 (en) 1996-05-09 1997-05-01 Androstene derivatives

Publications (1)

Publication Number Publication Date
DK0902789T3 true DK0902789T3 (da) 2002-05-06

Family

ID=21780726

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97921345T DK0902789T3 (da) 1996-05-09 1997-05-01 Androstenderivater

Country Status (19)

Country Link
US (1) US5981517A (cs)
EP (1) EP0902789B1 (cs)
JP (1) JP3328938B2 (cs)
CN (1) CN1144812C (cs)
AT (1) ATE212351T1 (cs)
AU (1) AU721622B2 (cs)
BR (1) BR9709062A (cs)
CA (1) CA2254079C (cs)
CZ (1) CZ292860B6 (cs)
DE (1) DE69710065T2 (cs)
DK (1) DK0902789T3 (cs)
ES (1) ES2171933T3 (cs)
HU (1) HUP9902449A3 (cs)
NO (2) NO311646B1 (cs)
NZ (1) NZ332608A (cs)
PL (1) PL186637B1 (cs)
PT (1) PT902789E (cs)
RU (1) RU2194053C2 (cs)
WO (1) WO1997042214A1 (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001241045A1 (en) * 2000-03-09 2001-09-17 Kissei Pharmaceutical Co. Ltd. Preventive or therapeutic drugs for eye diseases
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
CA2417825C (en) * 2000-08-05 2008-07-22 Glaxo Group Limited 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyl)oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
AU2002210768B2 (en) * 2000-11-03 2008-01-10 The University Of Manchester Selective glucocorticoid receptor agonists
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
MY137522A (en) * 2001-04-30 2009-02-27 Glaxo Group Ltd Novel anti-inflammatory androstane derivatives.
WO2002100879A1 (en) * 2001-06-12 2002-12-19 Glaxo Group Limited Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
DE602004008083T2 (de) * 2003-06-19 2008-04-24 Nicholas S. Gainsville Bodor Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroiden
EP1653974B1 (en) * 2003-06-19 2010-01-06 BODOR, Nicholas S. Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application
EP1684767A1 (en) * 2003-11-03 2006-08-02 Norton Healthcare Limited Soft steroid compositions for use in dry powder inhalers
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
JP2020523357A (ja) * 2017-06-13 2020-08-06 ボドール ラボラトリーズ， インコーポレイテッド 強力な抗炎症ソフトコルチコステロイド化合物およびその使用
CN111100176A (zh) * 2019-12-20 2020-05-05 重庆华邦胜凯制药有限公司 一种化合物的制备方法
CN120344544A (zh) * 2023-01-10 2025-07-18 四川科伦博泰生物医药股份有限公司 糖皮质激素受体激动剂及其偶联物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE135476C (cs) *
US3258473A (en) * 1963-10-04 1966-06-28 Syntex Corp 17-dihaloacetate esters of 17alpha-hydroxy-21-desoxypregnane derivatives
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
GB2014579B (en) * 1978-02-08 1982-08-25 Glaxo Group Ltd Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
CA1201114A (en) * 1980-02-15 1986-02-25 Gordon H. Phillipps Androstane carbothioates
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
FR2551069B1 (fr) * 1983-08-26 1986-07-25 Jouveinal Sa 17-oxo-21-thioesters d'hydrocortisone, leur preparation et leurs applications comme medicament
JPS617291A (ja) * 1984-06-20 1986-01-13 Mitsubishi Chem Ind Ltd 新規なコルチコイド誘導体およびその製法
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
US5223493A (en) * 1984-12-28 1993-06-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US5026639A (en) * 1988-01-14 1991-06-25 Nippon Mining Company, Limited Method to improve mRNA translation and use thereof for production of platelet factor-4
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0902789A1 (en) 1999-03-24
US5981517A (en) 1999-11-09
WO1997042214A1 (en) 1997-11-13
ATE212351T1 (de) 2002-02-15
NO20015790L (no) 1998-05-04
CA2254079A1 (en) 1997-11-13
PL329802A1 (en) 1999-04-12
CZ292860B6 (cs) 2003-12-17
NO20015790D0 (no) 2001-11-27
HUP9902449A3 (en) 2000-03-28
EP0902789A4 (cs) 1999-04-14
BR9709062A (pt) 2000-01-04
RU2194053C2 (ru) 2002-12-10
CZ361698A3 (cs) 1999-03-17
AU721622B2 (en) 2000-07-13
NO315425B1 (no) 2003-09-01
NO311646B1 (no) 2001-12-27
DE69710065T2 (de) 2002-08-29
ES2171933T3 (es) 2002-09-16
AU2740797A (en) 1997-11-26
NO985232D0 (no) 1998-11-09
JP3328938B2 (ja) 2002-09-30
EP0902789B1 (en) 2002-01-23
CA2254079C (en) 2004-09-14
NO985232L (no) 1998-12-04
PL186637B1 (pl) 2004-02-27
HK1021539A1 (en) 2000-06-16
CN1224429A (zh) 1999-07-28
CN1144812C (zh) 2004-04-07
DE69710065D1 (de) 2002-03-14
NZ332608A (en) 2000-01-28
JP2000509716A (ja) 2000-08-02
HUP9902449A2 (hu) 1999-11-29
PT902789E (pt) 2002-07-31

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