DK0870761T3 - Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter - Google Patents

Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter

Info

Publication number
DK0870761T3
DK0870761T3 DK98106236T DK98106236T DK0870761T3 DK 0870761 T3 DK0870761 T3 DK 0870761T3 DK 98106236 T DK98106236 T DK 98106236T DK 98106236 T DK98106236 T DK 98106236T DK 0870761 T3 DK0870761 T3 DK 0870761T3
Authority
DK
Denmark
Prior art keywords
muscle relaxant
inflammatory
thiocolchicine derivatives
relaxant activities
thiocolchicine
Prior art date
Application number
DK98106236T
Other languages
Danish (da)
English (en)
Inventor
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK0870761T3 publication Critical patent/DK0870761T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
DK98106236T 1997-04-11 1998-04-06 Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter DK0870761T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000845A IT1291550B1 (it) 1997-04-11 1997-04-11 Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante

Publications (1)

Publication Number Publication Date
DK0870761T3 true DK0870761T3 (da) 2004-06-28

Family

ID=11376857

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98106236T DK0870761T3 (da) 1997-04-11 1998-04-06 Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter

Country Status (16)

Country Link
US (1) US5973204A (xx)
EP (1) EP0870761B1 (xx)
JP (1) JP2916470B2 (xx)
KR (1) KR100559526B1 (xx)
CN (1) CN1089336C (xx)
AT (1) ATE260252T1 (xx)
AU (1) AU738857B2 (xx)
CA (1) CA2234480C (xx)
DE (1) DE69821815T2 (xx)
DK (1) DK0870761T3 (xx)
ES (1) ES2216197T3 (xx)
HK (1) HK1017880A1 (xx)
IT (1) IT1291550B1 (xx)
PT (1) PT870761E (xx)
RU (1) RU2190598C2 (xx)
SI (1) SI0870761T1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) * 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6720323B2 (en) 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
CN100393698C (zh) 2003-06-25 2008-06-11 第一药品(株) 三环衍生物或其药学上可接受的盐、其制备以及包含它们的药物组合物
ITMI20051418A1 (it) * 2005-07-22 2007-01-23 Indena Spa Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
JP5435995B2 (ja) * 2009-01-30 2014-03-05 出光興産株式会社 環状化合物の製造方法
EP2435403A4 (en) * 2009-05-27 2015-04-01 Takeda Pharmaceuticals Usa Inc THIOCOLCHICINE DERIVATIVES AND MANUFACTURING AND USE METHOD THEREFOR
US20110184061A1 (en) * 2010-01-22 2011-07-28 Nielsen Kurt R Thiocolchicine and colchicine analogs, methods of making and methods of use thereof
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
KR20210027408A (ko) * 2018-06-29 2021-03-10 알버타 헬스 서비시즈 콜히친 유도체의 방법 및 용도
RU2740530C1 (ru) * 2020-06-11 2021-01-15 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ профилактики развития постперикардиотомного синдрома и пароксизмов фибрилляции предсердий у кардиохирургических больных

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820029A (en) * 1954-02-10 1958-01-14 U C L A F New thio-derivatives of colchiceine compounds and a process of making same
FR1344474A (fr) * 1962-10-18 1963-11-29 Roussel Uclaf Dérivés de la colchicine et de la thiocolchicine et procédé de préparation
DE68919025T2 (de) * 1988-08-24 1995-03-02 Advance Biofactures Corp 3-Demethylthiocolchicincarbonate und N-Acylanaloge.
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono

Also Published As

Publication number Publication date
AU738857B2 (en) 2001-09-27
AU6073398A (en) 1998-10-15
PT870761E (pt) 2004-05-31
EP0870761B1 (en) 2004-02-25
CN1208033A (zh) 1999-02-17
CA2234480A1 (en) 1998-10-11
EP0870761A1 (en) 1998-10-14
CA2234480C (en) 2006-12-12
DE69821815T2 (de) 2005-01-13
US5973204A (en) 1999-10-26
IT1291550B1 (it) 1999-01-11
CN1089336C (zh) 2002-08-21
KR19980081125A (ko) 1998-11-25
KR100559526B1 (ko) 2006-06-28
SI0870761T1 (en) 2004-06-30
HK1017880A1 (en) 1999-12-03
JPH1121277A (ja) 1999-01-26
JP2916470B2 (ja) 1999-07-05
ES2216197T3 (es) 2004-10-16
RU2190598C2 (ru) 2002-10-10
ATE260252T1 (de) 2004-03-15
ITMI970845A1 (it) 1998-10-11
DE69821815D1 (de) 2004-04-01

Similar Documents

Publication Publication Date Title
HUP0101999A2 (hu) 4-Hidroxi-kinolin-3-karboxamid- és -hidrazid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
DK0731085T3 (da) Stilbenderivater og farmaceutiske sammensætinger indeholdende disse
MXPA02007942A (es) Derivados de pirrolopirimidinona, procesos de preparacion y uso.
DK0539204T3 (da) Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
DK0870761T3 (da) Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter
HU9400352D0 (en) New quinoline- and naphtiridine-carboxylic acid derivatives
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DK1525188T3 (da) Hidtil ukendte derivater af 4,4-dithiobis-(3-aminobutan-1-sulfonater) og sammensætninger, der indeholder dem
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
PT732332E (pt) Benzotienilpiperazinas substituidas sua utilizacao como medicamentos e processos para a sua preparacao
DK0911026T3 (da) Creatinderivater for astma
BR0007183A (pt) Isonipectoamidas para o tratamento de distúrbios mediados por integrina
ATE88176T1 (de) 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
DK0855398T3 (da) Sesquiterpenderivater med antiviral aktivitet
DK164057C (da) Oe5,6aa-cis-1,3-oxathianderivater og fremgangsmaade til deres fremstilling og farmaceutisk middel indeholdende et saadant derivat
DK0677513T3 (da) Octahydro-2-naphthalencarboxylsyrederivat, dets fremstilling og anvendelse
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
DE69819002D1 (de) Polyhydroxyalkylpyrazine derivate,deren herstellung und diese enthaltende arzneimitteln
MY118101A (en) New 17-halogeno-19-nor-steroids, a process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions comprising them
DK0686641T3 (da) 2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem
SE9803280D0 (sv) Novel compounds
NO933199L (no) Heteroarenylpiperaziner, fremgangsmåte for deres fremstilling og anvendelse derav som legemidler
IT9022371A0 (it) Derivati dell'1-arilsolfonil 2-pirrolidone, loro procedimento di preparazione e i nuovi intermedi cosi' ottenuti, il loro impiego come farmaci e le composizioni farmaceutiche che li contengono.
MY135855A (en) "pyrrolopyrimidinone derivatives, process of preparation and use"