DK0857018T3 - Betulinsyrederivater og anvendelser deraf - Google Patents

Betulinsyrederivater og anvendelser deraf

Info

Publication number
DK0857018T3
DK0857018T3 DK96922408T DK96922408T DK0857018T3 DK 0857018 T3 DK0857018 T3 DK 0857018T3 DK 96922408 T DK96922408 T DK 96922408T DK 96922408 T DK96922408 T DK 96922408T DK 0857018 T3 DK0857018 T3 DK 0857018T3
Authority
DK
Denmark
Prior art keywords
betulinic acid
acid derivatives
substd
opt
dotted line
Prior art date
Application number
DK96922408T
Other languages
English (en)
Inventor
Kuo-Hsiung Lee
Fumio Hashimoto
Mark Manak
Yoshiki Kashiwada
Louis Mark Cosentino
Original Assignee
Univ North Carolina
Biotech Res Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Biotech Res Lab filed Critical Univ North Carolina
Application granted granted Critical
Publication of DK0857018T3 publication Critical patent/DK0857018T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK96922408T 1995-06-05 1996-06-05 Betulinsyrederivater og anvendelser deraf DK0857018T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/463,071 US5679828A (en) 1995-06-05 1995-06-05 Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
PCT/US1996/009485 WO1996039033A1 (en) 1995-06-05 1996-06-05 Betulinic acid derivatives and uses therefor

Publications (1)

Publication Number Publication Date
DK0857018T3 true DK0857018T3 (da) 2004-11-29

Family

ID=23838749

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96922408T DK0857018T3 (da) 1995-06-05 1996-06-05 Betulinsyrederivater og anvendelser deraf

Country Status (10)

Country Link
US (1) US5679828A (da)
EP (2) EP1397957A2 (da)
AT (1) ATE275823T1 (da)
AU (1) AU6328896A (da)
CA (1) CA2223513C (da)
DE (1) DE69633398T8 (da)
DK (1) DK0857018T3 (da)
ES (1) ES2231818T3 (da)
PT (1) PT857018E (da)
WO (1) WO1996039033A1 (da)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
EP0902685A1 (de) * 1997-01-24 1999-03-24 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten enthaltend antitumoral, antiviral und antiparasitär wirksame ester von pentacyclischen triterpenen
US5750578A (en) * 1997-02-11 1998-05-12 Regents Of The University Of Minnesota Use of betulin and analogs thereof to treat herpesvirus infection
CA2293502A1 (en) * 1997-06-04 1998-12-10 Cornell Research Foundation, Inc. Betulinol derivatives
US6670345B1 (en) * 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
US6228850B1 (en) * 1997-09-30 2001-05-08 Dabur Research Foundation Antiangiogenic activity of betulinic acid and its derivatives
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this
ES2281960T3 (es) * 1998-03-02 2007-10-01 The University Of North Carolina At Chapel Hill Derivados acilados de betulina y dihidrobetulina, su preparacion y su uso.
US6303589B1 (en) 1998-12-08 2001-10-16 Micro Flo Company Pentacyclic triterpenes
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
US6392070B1 (en) 1999-08-10 2002-05-21 Regents Of The University Of Minnesota Birch bark processing and the isolation of natural products from birch bark
CA2384433C (en) * 1999-09-09 2007-10-23 Dabur Research Foundation Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
EP1476031A1 (en) * 2001-05-11 2004-11-17 University of Ottawa Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
US20040131629A1 (en) * 2002-09-26 2004-07-08 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7365221B2 (en) * 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004069166A2 (en) * 2003-01-29 2004-08-19 Panacos Pharmaceuticals, Inc. Inhibition of hiv-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7537765B2 (en) * 2003-01-29 2009-05-26 Panacos Pharmaceuticals, Inc. Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7026305B2 (en) * 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
CN100591688C (zh) * 2004-03-17 2010-02-24 帕纳克斯医药公司 3-0-(3＇,3＇-二甲基琥珀酰基)桦木酸的药用盐
US20050239748A1 (en) * 2004-03-17 2005-10-27 Panacos Pharmaceuticals, Inc. Pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid
US20060019934A1 (en) * 2004-05-20 2006-01-26 Saxena Brij B Anti-HIV-1 activity of betulinol derivatives
JP2008504808A (ja) * 2004-05-24 2008-02-21 パナコス ファーマシューティカルズ インコーポレーティッド ウイルスキャプシドスペーサーペプチド１タンパク質のプロセシングの破壊によるｈｉｖ−１複製の阻害
US8088757B2 (en) 2004-09-10 2012-01-03 Biorings Llc Betulinol derivatives as anti-cancer agents
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
JP2008535923A (ja) 2005-04-12 2008-09-04 パナコス ファーマシューティカルズ インコーポレーティッド ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸ジ−ｎ−メチル−ｄ−グルカミンの多形
KR20080017334A (ko) * 2005-06-22 2008-02-26 미리어드 제네틱스, 인크. 항바이러스 화합물
ZA200805703B (en) * 2005-12-16 2009-10-28 Panacos Pharmaceuticals Inc Preparation of pharmaceutical salts of 3-0-(3',3'-dimethyl-succinyl) betulinic acid
WO2007114978A2 (en) * 2006-02-09 2007-10-11 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and pa-457
US20070232577A1 (en) * 2006-03-23 2007-10-04 Advanced Life Sciences, Inc. Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
US20090105203A1 (en) * 2006-10-16 2009-04-23 Myriad Genetics, Incorporated Compounds for treating viral infections
US9505800B2 (en) 2006-11-03 2016-11-29 Myrexis, Inc. Extended triterpene derivatives
US20110152229A1 (en) * 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
CN103038245B (zh) 2010-06-04 2015-03-25 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
CN102985438B (zh) 2010-06-04 2016-05-18 百时美施贵宝公司 作为hiv成熟抑制剂的经修饰c-3桦木酸衍生物的c-28酰胺
RU2448115C1 (ru) * 2010-12-20 2012-04-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет (НГУ) Гидрированная бетулоновая кислота и ее амиды как противоопухолевые средства тритерпеновой природы
MY162186A (en) 2011-01-31 2017-05-31 Viiv Healthcare Uk (No 4) Ltd C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
SI2670764T1 (sl) 2011-01-31 2016-03-31 Bristol-Myers Squibb Company C-28 amini derivatov c-3 modificirane betulinske kisline inhibitorjev zorenja hiv
CN103814042B (zh) 2011-09-21 2015-08-19 百时美施贵宝公司 具有抗病毒活性的桦木酸衍生物
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
CN103768078B (zh) 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
AU2014215468B2 (en) 2013-02-06 2017-05-18 VIIV Healthcare UK (No.5) Limited C-19 modified triterpenoids with HIV maturation inhibitory activity
JP6186012B2 (ja) 2013-02-25 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ−３アルキルおよびアルケニル修飾ベツリン酸誘導体
EP3750910A1 (en) 2014-04-11 2020-12-16 VIIV Healthcare UK(No.4) Limited Triterpenoids with hiv maturation inhibitory activity
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2016077569A1 (en) 2014-11-14 2016-05-19 Bristol-Myers Squibb Company C17-aryl substituted betulinic acid analogs
EP3218387A1 (en) 2014-11-14 2017-09-20 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
US20220296610A1 (en) * 2017-04-06 2022-09-22 Derm-Biome Pharmaceuticals Inc. Compositions and methods for treatment of infection and novel cosmeceutical preparations
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
CA3101643C (en) 2018-06-29 2023-02-21 Dfh Therapeutics Triterpene amine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
FR2683531B1 (fr) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5643884A (en) * 1993-08-09 1997-07-01 Glycomed Incorporated Lupane triterpenoid derivatives

Also Published As

Publication number Publication date
WO1996039033A1 (en) 1996-12-12
AU6328896A (en) 1996-12-24
ES2231818T3 (es) 2005-05-16
PT857018E (pt) 2005-01-31
EP0857018A4 (en) 2002-10-23
ATE275823T1 (de) 2004-10-15
EP0857018A1 (en) 1998-08-12
DE69633398T2 (de) 2005-09-22
EP1397957A2 (en) 2004-03-17
DE69633398D1 (de) 2004-10-21
CA2223513A1 (en) 1996-12-12
EP0857018B1 (en) 2004-09-15
US5679828A (en) 1997-10-21
CA2223513C (en) 2009-03-24
DE69633398T8 (de) 2006-01-12

Similar Documents

Publication Publication Date Title
DK0857018T3 (da) Betulinsyrederivater og anvendelser deraf
DK210688D0 (da) 4-demethoxy-4-amino-anthracyclinderivater
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
UA35592C2 (uk) Похідні оцтової кислоти
MY103388A (en) Azithromycin and derivatives as antiprotozoal agents
SE8604089D0 (sv) 2-oxo-1-//(substituerad sulfonyl)amino/karbonyl/-azetidiner
AU6872687A (en) Unsaturated amino acids
DE69014196D1 (de) 3,6-diamino-2,5-pyrazindicarbonitril und ihre herstellung.
ES2146217T3 (es) Agentes quelantes de los acidos aminocarboxilicos con hidroxiarilo.
PT86918A (pt) Process for preparing substituted phenyl compounds
HUP9601525A2 (hu) Trombin- és Xa-faktor-gátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
IT1226143B (it) 1,2 di o acil glicerofosfato l carnitina estere e suoi derivati, procedimento per la sua preparazione e composizioni farmaceutiche che li contengono.
IT1226142B (it) 1,2 di o acil glicerodifosfato di l carnitina estere e suoi derivati, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono.
HUT63387A (en) New indomethacin salts
IT1216684B (it) 2_0_acetil_1,3_bis_difosfato_di_l_carnitina e di esteri della l_carnitina, procedimento per lasua preparazione e formulazioni farmaceutiche che lo contengono.
IT1216683B (it) 2_0_acetil glicerolo_1,3_di fosfato di l_carnitina e degli esteri della l_carnitina, procedimentoperla sua preparazione e formulazionei farmaceutiche che li contengono.
IT1216685B (it) 1,2_di_0_acetil glicero fosfato di l_carnitina e degli esteri della carnitina procedimento per la sua preparazione e formulazioni farmaceutiche che li contengono.
IT1217175B (it) 2-o-acetil-glicero-3-fosfato di l-carnitina e dei suoi esteri,procedimiento per la loro preparazione e formulazione farmaceutiche che li contengono