DK0831852T3 - Nukleosider med anti-hepatitis B-virusaktivitet - Google Patents
Nukleosider med anti-hepatitis B-virusaktivitetInfo
- Publication number
- DK0831852T3 DK0831852T3 DK96919349T DK96919349T DK0831852T3 DK 0831852 T3 DK0831852 T3 DK 0831852T3 DK 96919349 T DK96919349 T DK 96919349T DK 96919349 T DK96919349 T DK 96919349T DK 0831852 T3 DK0831852 T3 DK 0831852T3
- Authority
- DK
- Denmark
- Prior art keywords
- hepatitis
- nucleosides
- virus activity
- activity
- treatment
- Prior art date
Links
- 208000002672 hepatitis B Diseases 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48571695A | 1995-06-07 | 1995-06-07 | |
PCT/US1996/010026 WO1996040164A1 (fr) | 1995-06-07 | 1996-06-07 | Nucleosides ayant une activite anti-virus de l'hepatite b |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0831852T3 true DK0831852T3 (da) | 2007-03-19 |
Family
ID=23929192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96919349T DK0831852T3 (da) | 1995-06-07 | 1996-06-07 | Nukleosider med anti-hepatitis B-virusaktivitet |
Country Status (11)
Country | Link |
---|---|
US (4) | US6245749B1 (fr) |
EP (2) | EP1655033A1 (fr) |
JP (2) | JP4413996B2 (fr) |
AT (1) | ATE346651T1 (fr) |
AU (1) | AU722214B2 (fr) |
CA (1) | CA2219132C (fr) |
DE (1) | DE69636734T2 (fr) |
DK (1) | DK0831852T3 (fr) |
ES (1) | ES2276404T3 (fr) |
PT (1) | PT831852E (fr) |
WO (1) | WO1996040164A1 (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346627B1 (en) * | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
CA2637774C (fr) | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides avec activite virale anti-hepatite b |
CA2219132C (fr) | 1995-06-07 | 2007-03-06 | Emory University | Nucleosides ayant une activite anti-virus de l'hepatite b |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
EP1754710A3 (fr) * | 1998-02-25 | 2007-12-19 | Emory University | 2'-Fluoronucleosides |
KR100719606B1 (ko) * | 1998-02-25 | 2007-05-17 | 에모리 유니버시티 | 2'-플루오로뉴클레오사이드 |
KR100886653B1 (ko) | 1998-02-25 | 2009-03-04 | 에모리 유니버시티 | 2'-플루오로뉴클레오사이드 |
US6531590B1 (en) * | 1998-04-24 | 2003-03-11 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligonucleotide compounds |
US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
AU5475799A (en) * | 1998-08-10 | 2000-03-06 | Centre National De La Recherche Scientifique | Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis |
US6407077B1 (en) | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
CN1216893C (zh) * | 1998-11-05 | 2005-08-31 | 法国国家科学研究中心 | 具有抗乙型肝炎病毒活性的核苷 |
EP1165080A2 (fr) * | 1999-02-12 | 2002-01-02 | G.D. SEARLE & CO. | Utilisation de composes substitues 1,5-dideoxy-1,5-imino-d-glucitol pour traiter les infections par le virus de l'hepatite |
US6121437A (en) * | 1999-03-16 | 2000-09-19 | Isis Pharmaceuticals, Inc. | Phosphate and thiophosphate protecting groups |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
AU2002228749B2 (en) | 2000-10-18 | 2008-04-24 | Pharmasset Inc | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
EP1387850A2 (fr) | 2001-05-18 | 2004-02-11 | Rakesh Kumar | Nucleosides antiviraux |
US7049303B2 (en) * | 2001-11-07 | 2006-05-23 | Medical Research Council | Inhibition of viruses |
EP1569658A4 (fr) | 2001-12-20 | 2007-05-30 | Pharmassett Ltd | Traitement du virus d'epstein-barr, infection a l'herpesvirus lie au sarcome de kaposi et proliferation cellulaire anormale associee |
SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
TWI244393B (en) | 2002-08-06 | 2005-12-01 | Idenix Pharmaceuticals Inc | Crystalline and amorphous forms of beta-L-2'-deoxythymidine |
CN100536853C (zh) | 2002-09-13 | 2009-09-09 | 艾登尼科斯(开曼)有限公司 | β-L-2′-脱氧核苷用于治疗抗性HBV株以及联合治疗 |
CN1293884C (zh) * | 2002-10-29 | 2007-01-10 | 南京长澳医药科技有限公司 | 6-甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用 |
CA2503730C (fr) * | 2002-10-31 | 2011-10-18 | Metabasis Therapeutics, Inc. | Promedicaments de cytarabine monophosphate |
CN101415719A (zh) | 2003-03-20 | 2009-04-22 | 微生物化学及药品有限公司 | 生产2’-脱氧-β-L-核苷的方法 |
US20040200730A1 (en) * | 2003-04-14 | 2004-10-14 | Kyo Jibiki | Hydrometallurgical copper recovery process |
WO2004096149A2 (fr) | 2003-04-28 | 2004-11-11 | Idenix (Cayman) Limited | Synthese de nucleosides pouvant etre mise a l'echelle industrielle |
US20050059632A1 (en) | 2003-06-30 | 2005-03-17 | Richard Storer | Synthesis of beta-L-2'-deoxy nucleosides |
NO324263B1 (no) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
US20080261913A1 (en) * | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
BR112012024661A2 (pt) | 2010-04-01 | 2015-09-15 | Centre Nat Rech Scient | composto, composição farmacêutica e método de tratamento de um hospedeiro infectado com vírus de hepatite c |
WO2012154321A1 (fr) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Composés et compositions pharmaceutiques pour le traitement d'infections virales |
US9487534B2 (en) | 2011-08-02 | 2016-11-08 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
SI3043803T1 (sl) * | 2013-09-11 | 2022-09-30 | Emory University | Nukleotidne in nukleozidne sestave in njihova uporaba |
CN106061984A (zh) | 2014-02-13 | 2016-10-26 | 配体药物公司 | 前药化合物及其用途 |
EP3164136A4 (fr) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
JOP20170038B1 (ar) * | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
CA3087932A1 (fr) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Composes acetal et leurs utilisations therapeutiques |
US20230233456A1 (en) * | 2021-03-25 | 2023-07-27 | Per Os Biosciences, Llc | Compositions and methods for treating coronavirus |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000137A (en) | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
US4140761A (en) | 1977-04-11 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education & Welfare | Modification of hepatitis B virus infection in chronic carriers of hepatitis B surface antigen |
JPS5668674A (en) | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
US4879277A (en) | 1985-08-26 | 1989-11-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral compositions and methods |
WO1987001284A1 (fr) | 1985-08-26 | 1987-03-12 | United States Of America, Represented By The Unite | Inhibition du caractere infectieux et de l'effet cytopathique du htlv-iii/lav in vitro par la 2',3'-dideoxyinosine, 2',3'-dideoxyguanosine, ou 2',3'-dideoxyadenosine |
EP0217580A3 (fr) | 1985-09-17 | 1990-11-07 | The Wellcome Foundation Limited | Nucléosides thérapeutiques |
US4916122A (en) | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
US4788181A (en) | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
US4963533A (en) | 1986-10-24 | 1990-10-16 | Stichting Rega Vzw (Rega) | Therapeutic application of dideoxycytidinene |
AU613026B2 (en) | 1987-03-24 | 1991-07-25 | Nycomed As | 2',3' dideoxyribofuranoxide derivatives |
US5185437A (en) | 1987-04-09 | 1993-02-09 | Burroughs Wellcome Co. | Therapeutic nucleosides |
SE8701605D0 (sv) | 1987-04-16 | 1987-04-16 | Astra Ab | Novel medicinal compounds |
JPH03501253A (ja) | 1987-09-22 | 1991-03-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | エイズ(aids)治療を目的とするリポソームによるヌクレオシド類似物質 |
NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5270315A (en) | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
US5466806A (en) | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5041449A (en) | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US4900828A (en) | 1988-05-12 | 1990-02-13 | Hoffmann-Laroche Inc. | Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine |
GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
SE8802687D0 (sv) | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
DE68922903T2 (de) | 1988-12-19 | 1995-11-23 | Wellcome Found | Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate. |
UA45942A (uk) | 1989-02-08 | 2002-05-15 | Біокем Фарма, Інк. | 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція |
DK0674634T3 (da) | 1989-02-08 | 2003-08-04 | Iaf Biochem Int | Fremgangsmåde til fremstilling af substituerede 1,3-oxathiolaner med antivirale egenskaber |
NZ233197A (en) | 1989-04-13 | 1991-11-26 | Richard Thomas Walker | Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions |
US5059690A (en) | 1990-03-01 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Purinyl tetrahydrofurans |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
IE904378A1 (en) | 1989-12-20 | 1991-07-03 | Abbott Lab | Analogs of oxetanyl purines and pyrimidines |
US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
AU7872491A (en) | 1990-05-07 | 1991-11-27 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
EP0531452A4 (en) | 1990-05-29 | 1993-06-09 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
EP0533833B1 (fr) | 1990-06-13 | 1995-12-20 | GLAZIER, Arnold | Promedicaments phosphoreux |
FR2663636B1 (fr) | 1990-06-26 | 1992-10-09 | Centre Nat Rech Scient | Procede de fonctionnalisation d'un oligonucleotide. |
SE9003151D0 (sv) | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5587480A (en) | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
CA2095613C (fr) | 1990-11-13 | 2001-01-02 | Bernard Belleau | 1,3-oxathiolanes substituees et 1,3-dithiolanes substituees a proprietes antivirales |
US5444063A (en) | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5248776A (en) | 1990-12-05 | 1993-09-28 | University Of Georgia Research Foundation, Inc. | Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides |
US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
US5179104A (en) | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
WO1992010496A1 (fr) | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | NUCLEOSIDES DE β-L-(-)-1,3-OXATHIOLANE ENANTIOMERIQUEMENT PURS |
IL100502A (en) | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
NZ241625A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers |
GB9104740D0 (en) | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
ATE219366T1 (de) | 1991-03-06 | 2002-07-15 | Univ Emory | Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b |
WO1992018517A1 (fr) | 1991-04-17 | 1992-10-29 | Yale University | Procede de traitement ou de prevention du virus de l'hepatite b |
GB9110874D0 (en) | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9111902D0 (en) | 1991-06-03 | 1991-07-24 | Glaxo Group Ltd | Chemical compounds |
CA2112803A1 (fr) * | 1991-07-12 | 1993-01-21 | Karl Y. Hostetler | Liponucleosides antiviraux: traitement de l'hepatite b |
US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
GB9116601D0 (en) | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
FR2685331A1 (fr) | 1991-12-12 | 1993-06-25 | Centre Nat Rech Scient | Phosphotriesters de la ddu, leur preparation et leur application en therapeutique. |
FR2684996A1 (fr) | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | Derives de 2',3'-didesoxy-3'-aminothymidine, leur preparation et leur application en therapeutique. |
FR2684997A1 (fr) | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | Derives de la 9-(beta-d-xylofurannosyl) adenine et de la 1-(beta-d-xylofurannosyl) cytosine, leur preparation et leur application en therapeutique. |
US5849905A (en) | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
US5770725A (en) | 1992-05-25 | 1998-06-23 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
FR2692265B1 (fr) | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | Composes biologiquement actifs de type phosphotriesters. |
AU4812393A (en) | 1992-09-03 | 1994-03-29 | Biochem Pharma Inc. | Use of rapamycin in the treatment of aids |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
AU701574B2 (en) | 1993-05-12 | 1999-02-04 | Karl Y. Hostetler | Acyclovir derivatives for topical use |
FR2705099B1 (fr) | 1993-05-12 | 1995-08-04 | Centre Nat Rech Scient | Oligonucléotides phosphorothioates triesters et procédé de préparation. |
TW374087B (en) | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
EP0631783A1 (fr) | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Combinaisons antivirales de 2',3'-didéoxy-ribonucléosides avec des dérivés 5-substitués du 6-benzyl-1-éthoxyméthyl-uracile |
CA2637774C (fr) | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides avec activite virale anti-hepatite b |
FR2709754B1 (fr) | 1993-09-10 | 1995-12-01 | Centre Nat Rech Scient | Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale. |
FR2711655A1 (fr) | 1993-10-21 | 1995-05-05 | Centre Nat Rech Scient | Composés 3'-phosphononucléosides et procédé de préparation. |
US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
US5696277A (en) | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
CA2219132C (fr) | 1995-06-07 | 2007-03-06 | Emory University | Nucleosides ayant une activite anti-virus de l'hepatite b |
US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
AU5475799A (en) * | 1998-08-10 | 2000-03-06 | Centre National De La Recherche Scientifique | Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis |
-
1996
- 1996-06-07 CA CA002219132A patent/CA2219132C/fr not_active Expired - Fee Related
- 1996-06-07 EP EP05077806A patent/EP1655033A1/fr not_active Withdrawn
- 1996-06-07 AU AU61707/96A patent/AU722214B2/en not_active Ceased
- 1996-06-07 WO PCT/US1996/010026 patent/WO1996040164A1/fr active IP Right Grant
- 1996-06-07 ES ES96919349T patent/ES2276404T3/es not_active Expired - Lifetime
- 1996-06-07 AT AT96919349T patent/ATE346651T1/de active
- 1996-06-07 DK DK96919349T patent/DK0831852T3/da active
- 1996-06-07 EP EP96919349A patent/EP0831852B1/fr not_active Expired - Lifetime
- 1996-06-07 JP JP50216397A patent/JP4413996B2/ja not_active Expired - Fee Related
- 1996-06-07 DE DE69636734T patent/DE69636734T2/de not_active Expired - Lifetime
- 1996-06-07 PT PT96919349T patent/PT831852E/pt unknown
-
1998
- 1998-07-09 US US09/112,878 patent/US6245749B1/en not_active Expired - Lifetime
-
2001
- 2001-06-12 US US09/879,854 patent/US7468357B2/en not_active Expired - Fee Related
-
2005
- 2005-07-12 US US11/180,964 patent/US20050277616A1/en not_active Abandoned
-
2007
- 2007-03-23 JP JP2007077327A patent/JP2007204485A/ja active Pending
-
2008
- 2008-12-15 US US12/316,627 patent/US20090105185A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007204485A (ja) | 2007-08-16 |
US20020107221A1 (en) | 2002-08-08 |
EP1655033A1 (fr) | 2006-05-10 |
JPH11507381A (ja) | 1999-06-29 |
PT831852E (pt) | 2007-02-28 |
EP0831852B1 (fr) | 2006-11-29 |
EP0831852A4 (fr) | 1999-03-31 |
ES2276404T3 (es) | 2007-06-16 |
WO1996040164A1 (fr) | 1996-12-19 |
EP0831852A1 (fr) | 1998-04-01 |
US20050277616A1 (en) | 2005-12-15 |
CA2219132A1 (fr) | 1996-12-19 |
DE69636734T2 (de) | 2007-10-18 |
ATE346651T1 (de) | 2006-12-15 |
AU722214B2 (en) | 2000-07-27 |
US7468357B2 (en) | 2008-12-23 |
DE69636734D1 (de) | 2007-01-11 |
CA2219132C (fr) | 2007-03-06 |
US6245749B1 (en) | 2001-06-12 |
JP4413996B2 (ja) | 2010-02-10 |
US20090105185A1 (en) | 2009-04-23 |
AU6170796A (en) | 1996-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0831852T3 (da) | Nukleosider med anti-hepatitis B-virusaktivitet | |
DE69232649D1 (de) | Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b | |
ZA97721B (en) | Methods for retreatment of patients afflicted with hepatitis C using consensus interferon. | |
EP1852121A3 (fr) | Analogues de lipides pour traiter des infections virales | |
IL153078A0 (en) | Methods for treating hepatitis delta virus infection with beta-l-2' deoxy nucleosides | |
DK0775007T3 (da) | Blodbehandlingsindretning med forbedret udbytte, og som har en vinklet grænsestyreflade | |
PL366159A1 (en) | Methods and compositions for treating hepatitis c virus | |
ATE481135T1 (de) | Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen | |
DE69823984D1 (de) | Synthese und anti-hiv und anti-hepatitis virus aktivität von 1,3-oxaselenolan nucleosiden | |
DK1284720T3 (da) | L-FMAU til behandling af hepatitis delta-virusinfektion | |
DE68912155T2 (de) | Antivirales Kombinationspräparat. | |
BR9913951A (pt) | Tratamento de infecção de hepatite b com timosina alfa 1 em combinação com lamivudina e flamciclovir | |
NO953473L (no) | Fremgangsmåte for behandling av hepatitt C i individer som er ikke-respondere overfor interferonbehandling | |
DE69718911T2 (de) | Interleukin - 8 als antivirale- und antitumorwirkstoffe | |
WO2004006843A3 (fr) | Polytherapies a base de l-fmau pour le traitement de l'infection par le virus de l'hepatite b | |
EA200300222A1 (ru) | Лечение гепатита c с помощью тимозина, интерферона и рибавирина |