DK0820520T3 - Forbedret enzymatisk syntese af oliogosaccharider - Google Patents

Forbedret enzymatisk syntese af oliogosaccharider

Info

Publication number
DK0820520T3
DK0820520T3 DK96911628T DK96911628T DK0820520T3 DK 0820520 T3 DK0820520 T3 DK 0820520T3 DK 96911628 T DK96911628 T DK 96911628T DK 96911628 T DK96911628 T DK 96911628T DK 0820520 T3 DK0820520 T3 DK 0820520T3
Authority
DK
Denmark
Prior art keywords
oliogosaccharides
enzymatic synthesis
enhanced enzymatic
sialyl
enhanced
Prior art date
Application number
DK96911628T
Other languages
Danish (da)
English (en)
Inventor
Shawn Defrees
Robert J Bayer
Murray Ratcliffe
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/419,659 external-priority patent/US5876980A/en
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of DK0820520T3 publication Critical patent/DK0820520T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
DK96911628T 1995-04-11 1996-04-10 Forbedret enzymatisk syntese af oliogosaccharider DK0820520T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/419,659 US5876980A (en) 1995-04-11 1995-04-11 Enzymatic synthesis of oligosaccharides
US103595P 1995-07-11 1995-07-11
PCT/US1996/004790 WO1996032492A1 (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Publications (1)

Publication Number Publication Date
DK0820520T3 true DK0820520T3 (da) 2002-12-02

Family

ID=26668454

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96911628T DK0820520T3 (da) 1995-04-11 1996-04-10 Forbedret enzymatisk syntese af oliogosaccharider

Country Status (8)

Country Link
EP (1) EP0820520B1 (ja)
JP (1) JPH11503328A (ja)
AT (1) ATE222294T1 (ja)
AU (1) AU5445396A (ja)
DE (1) DE69623005T2 (ja)
DK (1) DK0820520T3 (ja)
ES (1) ES2180757T3 (ja)
WO (1) WO1996032492A1 (ja)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5922577A (en) * 1995-04-11 1999-07-13 Cytel Corporation Enzymatic synthesis of glycosidic linkages
WO1997037682A1 (en) * 1996-04-10 1997-10-16 Cytel Corporation Nucleic acids encoding gdp-fucose pyrophosphorylase
IL130964A0 (en) * 1997-01-16 2001-01-28 Cytel Corp Practical in vitro sialylation of recombinant glycoproteins
US6323008B1 (en) 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
US8003782B1 (en) 1999-02-01 2011-08-23 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
EP1541693A4 (en) 2002-07-18 2010-12-15 Yamasa Corp PROCESSES FOR PRODUCING CMP-N-ACETYLNEURAMINIC ACID
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
KR101099403B1 (ko) 2003-09-26 2011-12-27 야마사 쇼유 가부시키가이샤 Ｃｍｐ-ｎ-아세틸뉴라민산의 제조법
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
WO2006050247A2 (en) 2004-10-29 2006-05-11 Neose Technologies, Inc. Remodeling and glycopegylation of fibroblast growth factor (fgf)
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
EP2386571B1 (en) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
ES2516694T3 (es) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
WO2008057683A2 (en) 2006-10-03 2008-05-15 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
BRPI0809670A8 (pt) 2007-04-03 2018-12-18 Biogenerix Ag métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
CN101778859B (zh) 2007-06-12 2014-03-26 诺和诺德公司 改良的用于生产核苷酸糖的方法
CN103497246B (zh) 2008-02-27 2016-08-10 诺沃—诺迪斯克有限公司 缀合的因子viii分子
RU2013106896A (ru) * 2010-07-16 2014-08-27 Глюком А/С Синтез новых производных сиалоолигосахаридов
RU2013146524A (ru) * 2011-03-18 2015-04-27 Глюком А/С Синтез новых фукозо-содержащих производных углеводородов
JP6106160B2 (ja) * 2011-05-13 2017-03-29 グリコム アー／エスＧｌｙｃｏｍ Ａ／Ｓ 人乳オリゴ糖（ｈｍｏ）又はその前駆体の多様化
EP2522232A1 (en) 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
US9234225B2 (en) 2011-05-13 2016-01-12 Glycom A/S Method for generating human milk oligosaccharides (HMOs) or precursors thereof
WO2013190531A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharides, methods for their production and their use in consumable products
WO2013190529A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products
KR101525230B1 (ko) * 2013-05-31 2015-06-01 주식회사 진켐 시알산 유도체의 제조방법
EP3426670A4 (en) 2016-03-07 2019-11-13 Glycom A/S SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH
US20200123184A1 (en) 2017-06-30 2020-04-23 Glycom A/S Purification of oligosaccharides
EP3456836A1 (en) 2017-09-13 2019-03-20 Glycom A/S Separation of sialylated oligosaccharides from fermentation broth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409817A (en) * 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
US5374541A (en) * 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides

Also Published As

Publication number Publication date
WO1996032492A1 (en) 1996-10-17
EP0820520B1 (en) 2002-08-14
EP0820520A1 (en) 1998-01-28
ATE222294T1 (de) 2002-08-15
DE69623005T2 (de) 2003-04-03
ES2180757T3 (es) 2003-02-16
AU5445396A (en) 1996-10-30
JPH11503328A (ja) 1999-03-26
DE69623005D1 (de) 2002-09-19

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