DK0799819T3 - 1-Dimethylaminomethyl-2-phenylcycloalk-2-enforbindelser med analgesisk virkning - Google Patents

1-Dimethylaminomethyl-2-phenylcycloalk-2-enforbindelser med analgesisk virkning

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Publication number
DK0799819T3
DK0799819T3 DK97102923T DK97102923T DK0799819T3 DK 0799819 T3 DK0799819 T3 DK 0799819T3 DK 97102923 T DK97102923 T DK 97102923T DK 97102923 T DK97102923 T DK 97102923T DK 0799819 T3 DK0799819 T3 DK 0799819T3
Authority
DK
Denmark
Prior art keywords
phenylcycloalk
dimethylaminomethyl
junctions
analgesic action
analgesic
Prior art date
Application number
DK97102923T
Other languages
English (en)
Inventor
Helmut Heinrich Dr Buschmann
Wolfgang Werner A Strassburger
Elmar Josef Dr Friderichs
Babette-Yvonne Dr Koegel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0799819T3 publication Critical patent/DK0799819T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
DK97102923T 1996-03-13 1997-02-22 1-Dimethylaminomethyl-2-phenylcycloalk-2-enforbindelser med analgesisk virkning DK0799819T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19609847A DE19609847A1 (de) 1996-03-13 1996-03-13 Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Publications (1)

Publication Number Publication Date
DK0799819T3 true DK0799819T3 (da) 2002-12-02

Family

ID=7788151

Family Applications (3)

Application Number Title Priority Date Filing Date
DK97102923T DK0799819T3 (da) 1996-03-13 1997-02-22 1-Dimethylaminomethyl-2-phenylcycloalk-2-enforbindelser med analgesisk virkning
DK00116745T DK1069106T3 (da) 1996-03-13 1997-02-22 Dimethyl-(3-aryl-but-3-enyl)-aminforbindelser med analgetisk virkning
DK99119109T DK0983995T3 (da) 1996-03-13 1997-02-22 Dimethyl-(3-aryl-but-3-enyl)-aminforbindelser som farmaceutiske, aktive stoffer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK00116745T DK1069106T3 (da) 1996-03-13 1997-02-22 Dimethyl-(3-aryl-but-3-enyl)-aminforbindelser med analgetisk virkning
DK99119109T DK0983995T3 (da) 1996-03-13 1997-02-22 Dimethyl-(3-aryl-but-3-enyl)-aminforbindelser som farmaceutiske, aktive stoffer

Country Status (28)

Country Link
US (1) US5811582A (da)
EP (4) EP1069106B1 (da)
JP (2) JP4205182B2 (da)
KR (2) KR100538662B1 (da)
CN (1) CN1157366C (da)
AR (1) AR008991A1 (da)
AT (3) ATE263140T1 (da)
AU (1) AU725430B2 (da)
BR (1) BR9700369B1 (da)
CA (1) CA2199679C (da)
CO (1) CO4520279A1 (da)
CZ (1) CZ293971B6 (da)
DE (4) DE19609847A1 (da)
DK (3) DK0799819T3 (da)
ES (3) ES2213526T3 (da)
HK (2) HK1026197A1 (da)
HU (1) HU224819B1 (da)
IL (1) IL120430A (da)
NO (1) NO308294B1 (da)
NZ (1) NZ314384A (da)
PE (1) PE55798A1 (da)
PL (1) PL186050B1 (da)
PT (3) PT983995E (da)
RU (1) RU2167146C2 (da)
SI (3) SI1069106T1 (da)
SK (1) SK284328B6 (da)
UA (1) UA55373C2 (da)
ZA (1) ZA972147B (da)

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DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
DE10000311A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate
DE10025948A1 (de) * 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
ES2265495T3 (es) 2001-03-16 2007-02-16 Dmi Biosciences, Inc. Uso de tramadol para el retardo de la eyaculacion.
DE10132747A1 (de) * 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
DE10224624A1 (de) * 2002-05-30 2003-12-11 Gruenenthal Gmbh Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol
DE10225315A1 (de) * 2002-06-06 2003-12-24 Gruenenthal Gmbh Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
DE10261091A1 (de) * 2002-12-20 2004-07-01 Grünenthal GmbH Gesättigte und ungesättigte Heteroarylcycloalkylmethyl-Amine
DE10326097A1 (de) * 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) * 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005033732B4 (de) * 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
DE102005061429A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxazol-Derivate
TWI448447B (zh) * 2006-07-24 2014-08-11 Gruenenthal Chemie 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
PT2046726E (pt) * 2006-07-24 2010-04-15 Janssen Pharmaceutica Nv Preparação da (2r,3r)-3-(3-metoxifenil)-n,n,2- trimetilpentanamina
CN101948397A (zh) * 2010-09-07 2011-01-19 天津泰普药品科技发展有限公司 镇痛药他喷他多重要中间体的制备方法
EP2619174A4 (en) * 2010-09-20 2014-05-14 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds

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FR2559765B1 (fr) * 1984-02-16 1986-06-13 Rhone Poulenc Sante Nouveaux derives de la phenyl-3 propene-2 amine, leur preparation et les medicaments qui les contiennent
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Also Published As

Publication number Publication date
PT1069106E (pt) 2004-06-30
ATE223888T1 (de) 2002-09-15
JP4205182B2 (ja) 2009-01-07
RU2167146C2 (ru) 2001-05-20
JP4846750B2 (ja) 2011-12-28
CA2199679C (en) 2005-07-05
ES2218924T3 (es) 2004-11-16
NO308294B1 (no) 2000-08-28
DK0983995T3 (da) 2004-05-24
EP1069106A2 (de) 2001-01-17
SK32197A3 (en) 1997-12-10
PT799819E (pt) 2003-01-31
DE59711477D1 (de) 2004-05-06
PL186050B1 (pl) 2003-09-30
SI1069106T1 (en) 2004-04-30
EP0799819A1 (de) 1997-10-08
PL318922A1 (en) 1997-09-15
BR9700369A (pt) 1998-10-27
NZ314384A (en) 1999-06-29
ZA972147B (en) 1997-09-17
EP1069106B1 (de) 2004-01-28
EP1069106A3 (de) 2001-01-24
CA2199679A1 (en) 1997-09-13
EP0983995B1 (de) 2004-03-31
ES2183030T3 (es) 2003-03-16
DK1069106T3 (da) 2004-04-19
CZ293971B6 (cs) 2004-09-15
CN1157366C (zh) 2004-07-14
UA55373C2 (uk) 2003-04-15
JP2008273937A (ja) 2008-11-13
HUP9700574A2 (hu) 1998-10-28
EP0799819B1 (de) 2002-09-11
BR9700369B1 (pt) 2009-01-13
ES2213526T3 (es) 2004-09-01
HUP9700574A3 (en) 2000-01-28
NO971137D0 (no) 1997-03-12
AU725430B2 (en) 2000-10-12
ATE258544T1 (de) 2004-02-15
KR970065504A (ko) 1997-10-13
DE59708160D1 (de) 2002-10-17
HU9700574D0 (en) 1997-04-28
IL120430A (en) 2001-01-28
CO4520279A1 (es) 1997-10-15
KR100538662B1 (ko) 2006-03-28
DE19609847A1 (de) 1997-09-18
EP0983994A2 (de) 2000-03-08
CN1163884A (zh) 1997-11-05
AR008991A1 (es) 2000-03-08
US5811582A (en) 1998-09-22
SI0983995T1 (en) 2004-10-31
EP0983995A2 (de) 2000-03-08
NO971137L (no) 1997-09-15
AU1625197A (en) 1997-09-18
HK1026197A1 (en) 2000-12-08
EP0983995A3 (de) 2001-01-10
MX9701865A (es) 1997-09-30
EP0983994A3 (de) 2001-01-10
SK284328B6 (sk) 2005-01-03
CZ75997A3 (cs) 1998-04-15
HU224819B1 (en) 2006-02-28
KR100602810B1 (ko) 2006-07-20
DE59711267D1 (de) 2004-03-04
JPH107624A (ja) 1998-01-13
ATE263140T1 (de) 2004-04-15
IL120430A0 (en) 1997-07-13
SI0799819T1 (en) 2003-02-28
HK1031864A1 (en) 2001-06-29
PE55798A1 (es) 1998-10-24
PT983995E (pt) 2004-08-31

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