DK0789575T3 - Perifer-nerve-system-specifikke natriumkanaler, DNA kodende derfor, screening af lægemidler og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents
Perifer-nerve-system-specifikke natriumkanaler, DNA kodende derfor, screening af lægemidler og fremgangsmåder til fremstilling og anvendelse derafInfo
- Publication number
- DK0789575T3 DK0789575T3 DK95939723T DK95939723T DK0789575T3 DK 0789575 T3 DK0789575 T3 DK 0789575T3 DK 95939723 T DK95939723 T DK 95939723T DK 95939723 T DK95939723 T DK 95939723T DK 0789575 T3 DK0789575 T3 DK 0789575T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- preparation
- peripheral nerve
- drug screening
- pns
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33402994A | 1994-11-02 | 1994-11-02 | |
US48240195A | 1995-06-07 | 1995-06-07 | |
PCT/US1995/014251 WO1996014077A1 (fr) | 1994-11-02 | 1995-11-02 | Canaux sodium specifiques du systeme nerveux peripherique, adn les codant, cristallisation, diffraction par les rayons x, modelisation moleculaire informatique, composition medicamenteuse rationnelle, criblage medicamenteux et procede de fabrication et d'utilisation de ces canaux |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0789575T3 true DK0789575T3 (da) | 2009-01-12 |
Family
ID=26989015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95939723T DK0789575T3 (da) | 1994-11-02 | 1995-11-02 | Perifer-nerve-system-specifikke natriumkanaler, DNA kodende derfor, screening af lægemidler og fremgangsmåder til fremstilling og anvendelse deraf |
Country Status (13)
Country | Link |
---|---|
US (5) | US6110672A (fr) |
EP (2) | EP1985703A3 (fr) |
JP (5) | JP2000503521A (fr) |
AT (1) | ATE407207T1 (fr) |
AU (1) | AU697465B2 (fr) |
CA (1) | CA2204355C (fr) |
DE (1) | DE69535830D1 (fr) |
DK (1) | DK0789575T3 (fr) |
ES (1) | ES2314978T3 (fr) |
MX (1) | MX9703187A (fr) |
NZ (1) | NZ296748A (fr) |
PT (1) | PT789575E (fr) |
WO (1) | WO1996014077A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU697465B2 (en) | 1994-11-02 | 1998-10-08 | Research Foundation Of The State University Of New York, The | Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof |
US6184349B1 (en) | 1995-10-11 | 2001-02-06 | Syntex (Usa) Inc. | Cloned peripheral nerve, tetrodotoxin-resistant sodium channel α-subunit |
US6030810A (en) * | 1997-02-26 | 2000-02-29 | Delgado; Stephen Gregory | Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof |
EP0875570A3 (fr) * | 1997-05-01 | 1999-12-22 | Smithkline Beecham Plc | Polypeptides neurodégénératives HHPDZ65 |
CH693031A5 (de) * | 1997-11-20 | 2003-01-31 | Hoffmann La Roche | Nucleinsäure, die einen Nervengewebe-Natriumkanal kodiert. |
JP2002539832A (ja) * | 1999-03-26 | 2002-11-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 48個のヒト分泌タンパク質 |
US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
AU1846501A (en) | 1999-11-26 | 2001-06-04 | Bionomics Limited | Loci for idiopathic generalized epilepsy, mutations thereof and method using same to assess, diagnose, prognose or treat epilepsy |
AU2001273888A1 (en) | 2000-07-05 | 2002-01-14 | Neurosearch A/S | New sodium channel (rnav1.5a) and use thereof |
GB0021617D0 (en) * | 2000-09-02 | 2000-10-18 | Imp College Innovations Ltd | Diagnosis and treatment of cancer |
AU2001294141A1 (en) * | 2000-09-19 | 2002-04-02 | Gbf Gesellschaft Fur Biotechnologische Forschung Mbh | Crystalline fgf9 dimer and methods of use |
DE10054878A1 (de) * | 2000-11-06 | 2002-05-08 | Boehringer Ingelheim Int | Natriumkanäle vom Typus der peripheren Nerven |
SV2003000753A (es) * | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
US20060088827A1 (en) * | 2002-01-17 | 2006-04-27 | Rainer Hipfel | Diagnostic and therapeutic use of a voltage-gated ion channel scn2a for neurodegenerative diseases |
US7659082B2 (en) | 2002-02-19 | 2010-02-09 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
US9278088B2 (en) | 2002-02-19 | 2016-03-08 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
WO2003072751A2 (fr) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Systeme d'expression pour canal sodique dependant d'un potentiel d'action specifique au cerveau humain de type 1 |
AU2003297693A1 (en) * | 2002-12-04 | 2004-06-23 | Euro-Celtique S.A. | Splice variant of human sodium iii channel (hnaiii18) |
EP1638581A2 (fr) | 2003-03-31 | 2006-03-29 | The Brigham And Women's Hospital, Inc. | Immunomodulateurs zwitterioniques destines au traitement de l'asthme et des allergies |
WO2005069969A2 (fr) * | 2004-01-21 | 2005-08-04 | University Of Utah Research Foundation | Canal sodique nav1.7 mutant et procedes associes |
WO2005076981A2 (fr) * | 2004-02-05 | 2005-08-25 | Board Of Regents, The University Of Texas System | Procedes et compositions lies a la differenciation neuronale |
US7485468B2 (en) | 2004-10-15 | 2009-02-03 | Galapagos Bv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
WO2007092451A2 (fr) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Polysaccharides zwitterioniques pour favoriser la maturation du système immunitaire et la santé |
JP2010529173A (ja) * | 2007-06-14 | 2010-08-26 | ハマースミス・イメイネット・リミテッド | 神経活性の測定 |
US20120283116A1 (en) | 2009-09-11 | 2012-11-08 | Leppert Mark F | Mutant Sodium Channel Nav1.7 and Methods Related Thereto |
US9539281B2 (en) | 2011-07-12 | 2017-01-10 | The Brigham And Women's Hospital, Inc. | Lipid-containing PSA compositions, methods of isolation and methods of use thereof |
CN108135167B (zh) | 2015-08-19 | 2021-07-09 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
WO2018014012A1 (fr) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Compositions de glycolipide et procédés d'utilisation |
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NL137318C (fr) | 1964-06-09 | |||
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4500530A (en) * | 1980-11-26 | 1985-02-19 | Boucher John H | Method of treating horses to inhibit or reduce increases in crenated red blood cells during exercise |
US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (fr) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Récepteurs chimériques par liaison et expression de l'ADN |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
US4921794A (en) | 1987-01-14 | 1990-05-01 | President And Fellows Of Harvard College | T7 DNA polymerase |
US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
US5091310A (en) | 1988-09-23 | 1992-02-25 | Cetus Corporation | Structure-independent dna amplification by the polymerase chain reaction |
US5142033A (en) | 1988-09-23 | 1992-08-25 | Hoffmann-La Roche Inc. | Structure-independent DNA amplification by the polymerase chain reaction |
US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
US4994370A (en) | 1989-01-03 | 1991-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | DNA amplification technique |
JPH04503306A (ja) | 1989-02-01 | 1992-06-18 | ザ・ジェネラル・ホスピタル・コーポレーション | 単純ヘルペスウイルス1型発現ベクター |
US5380836A (en) * | 1989-02-13 | 1995-01-10 | Arch Development Corporation | Nucleic acid encoding sodium channel protein |
WO1990009391A1 (fr) * | 1989-02-13 | 1990-08-23 | Arch Development Corporation | Acide nucleique codant une proteine de canaux de sodium |
EP0445749B1 (fr) * | 1990-03-08 | 1996-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Cyclopentènylamines N-monosubstituées, procédé pour leur préparation et leur emploi comme médicament |
IE911869A1 (en) | 1990-06-01 | 1991-12-04 | Regeneron Pharma | A family of map2 protein kinases |
DK0550687T3 (da) | 1990-09-28 | 1999-12-13 | Hoffmann La Roche | 5' til 3'-exonukleasemutationer af termostabile DNA-polymeraser |
WO1992006693A1 (fr) | 1990-10-22 | 1992-04-30 | Fox Chase Cancer Center | Produit de recombinaison d'adn destine a la therapie par l'arn |
WO1993003743A1 (fr) | 1991-08-16 | 1993-03-04 | The General Hospital Corporation | Procede d'apport de gene a des cellules post-mitotiques |
US5356777A (en) * | 1992-10-01 | 1994-10-18 | University Of Pittsburgh | Methods of detecting periodic paralysis in horses |
US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
US5340728A (en) | 1992-12-09 | 1994-08-23 | E. I. Du Pont De Nemours And Company | Method for amplification of targeted segments of nucleic acid using nested polymerase chain reaction |
WO1994014978A1 (fr) | 1992-12-18 | 1994-07-07 | Strack Hans B | Production amelioree de produits de la pcr en presence d'une proteine se fixant sur un seul brin de l'adn, et preparation de celle-ci a partir de thermus flavus |
AU697465B2 (en) | 1994-11-02 | 1998-10-08 | Research Foundation Of The State University Of New York, The | Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof |
-
1995
- 1995-11-02 AU AU41434/96A patent/AU697465B2/en not_active Ceased
- 1995-11-02 DK DK95939723T patent/DK0789575T3/da active
- 1995-11-02 CA CA002204355A patent/CA2204355C/fr not_active Expired - Fee Related
- 1995-11-02 PT PT95939723T patent/PT789575E/pt unknown
- 1995-11-02 WO PCT/US1995/014251 patent/WO1996014077A1/fr active Application Filing
- 1995-11-02 NZ NZ296748A patent/NZ296748A/xx not_active IP Right Cessation
- 1995-11-02 MX MX9703187A patent/MX9703187A/es unknown
- 1995-11-02 EP EP08102871A patent/EP1985703A3/fr not_active Withdrawn
- 1995-11-02 US US08/836,325 patent/US6110672A/en not_active Expired - Lifetime
- 1995-11-02 ES ES95939723T patent/ES2314978T3/es not_active Expired - Lifetime
- 1995-11-02 JP JP8515424A patent/JP2000503521A/ja not_active Withdrawn
- 1995-11-02 EP EP95939723A patent/EP0789575B8/fr not_active Revoked
- 1995-11-02 DE DE69535830T patent/DE69535830D1/de not_active Expired - Lifetime
- 1995-11-02 AT AT95939723T patent/ATE407207T1/de active
-
1999
- 1999-12-09 US US09/457,571 patent/US6703486B2/en not_active Expired - Fee Related
-
2002
- 2002-05-17 JP JP2002143880A patent/JP2003047484A/ja active Pending
-
2004
- 2004-01-29 US US10/768,798 patent/US20040229792A1/en not_active Abandoned
-
2006
- 2006-12-29 JP JP2006356815A patent/JP2007169286A/ja active Pending
-
2007
- 2007-06-06 US US11/810,919 patent/US8012748B2/en not_active Expired - Fee Related
- 2007-06-06 US US11/810,882 patent/US20090029415A1/en not_active Abandoned
-
2008
- 2008-10-31 JP JP2008282154A patent/JP2009055921A/ja active Pending
- 2008-10-31 JP JP2008282171A patent/JP2009118844A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ296748A (en) | 1999-11-29 |
EP0789575A1 (fr) | 1997-08-20 |
JP2000503521A (ja) | 2000-03-28 |
US20030092645A1 (en) | 2003-05-15 |
PT789575E (pt) | 2008-12-15 |
EP0789575B8 (fr) | 2009-01-14 |
AU697465B2 (en) | 1998-10-08 |
EP1985703A3 (fr) | 2009-04-08 |
MX9703187A (es) | 1998-02-28 |
JP2007169286A (ja) | 2007-07-05 |
US20090203122A1 (en) | 2009-08-13 |
US6110672A (en) | 2000-08-29 |
AU4143496A (en) | 1996-05-31 |
CA2204355C (fr) | 2001-01-16 |
EP0789575B1 (fr) | 2008-09-03 |
US8012748B2 (en) | 2011-09-06 |
US20040229792A1 (en) | 2004-11-18 |
EP0789575A4 (fr) | 2000-11-08 |
US20090029415A1 (en) | 2009-01-29 |
EP1985703A2 (fr) | 2008-10-29 |
US6703486B2 (en) | 2004-03-09 |
DE69535830D1 (de) | 2008-10-16 |
JP2009055921A (ja) | 2009-03-19 |
CA2204355A1 (fr) | 1996-05-17 |
WO1996014077A1 (fr) | 1996-05-17 |
ES2314978T3 (es) | 2009-03-16 |
JP2009118844A (ja) | 2009-06-04 |
JP2003047484A (ja) | 2003-02-18 |
ATE407207T1 (de) | 2008-09-15 |
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