DK0757685T3 - Hidtil ukendte, acycliske og cycliske amider som midler til forögelse af frigivelsen af neurotransmitter - Google Patents
Hidtil ukendte, acycliske og cycliske amider som midler til forögelse af frigivelsen af neurotransmitterInfo
- Publication number
- DK0757685T3 DK0757685T3 DK95910708T DK95910708T DK0757685T3 DK 0757685 T3 DK0757685 T3 DK 0757685T3 DK 95910708 T DK95910708 T DK 95910708T DK 95910708 T DK95910708 T DK 95910708T DK 0757685 T3 DK0757685 T3 DK 0757685T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- acyclic
- agents
- novel
- neurotransmitter release
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23674394A | 1994-04-29 | 1994-04-29 | |
PCT/IB1995/000189 WO1995029909A1 (fr) | 1994-04-29 | 1995-03-20 | Nouveaux amides acycliques et cycliques utilises comme stimulateurs de la liberation des neurotransmetteurs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0757685T3 true DK0757685T3 (da) | 2004-10-25 |
Family
ID=22890767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95910708T DK0757685T3 (da) | 1994-04-29 | 1995-03-20 | Hidtil ukendte, acycliske og cycliske amider som midler til forögelse af frigivelsen af neurotransmitter |
Country Status (14)
Country | Link |
---|---|
US (1) | US5854232A (fr) |
EP (1) | EP0757685B1 (fr) |
JP (4) | JP3004728B2 (fr) |
AT (1) | ATE271553T1 (fr) |
AU (1) | AU1884595A (fr) |
CA (1) | CA2188427C (fr) |
DE (1) | DE69533284T2 (fr) |
DK (1) | DK0757685T3 (fr) |
ES (1) | ES2223049T3 (fr) |
FI (1) | FI964340A0 (fr) |
IL (1) | IL113436A0 (fr) |
MX (1) | MX9605218A (fr) |
PT (1) | PT757685E (fr) |
WO (1) | WO1995029909A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09183725A (ja) * | 1995-09-01 | 1997-07-15 | Pfizer Inc | ガン治療用治療剤 |
JPH11512750A (ja) * | 1996-06-27 | 1999-11-02 | ファイザー インク. | 2―(2―オキソ―エチリデン)―イミダゾリジン―4―オンの誘導体およびファルネシル蛋白質トランスフェラーゼ阻害物質としてのそれらの使用法 |
PT870757E (pt) * | 1997-04-10 | 2002-09-30 | Pfizer | Derivados de adamantano substituidos por fluoro |
GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
DE69716492T2 (de) | 1997-11-25 | 2003-06-26 | Bratkova, Ljubov | Licht konvertierendes material und zusammensetzung zu dessen herstellung |
US6262081B1 (en) | 1998-07-10 | 2001-07-17 | Dupont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
ATE396722T1 (de) * | 1999-07-21 | 2008-06-15 | Boehringer Ingelheim Pharma | Kleine moleküle zur behandlung von endzündlichen erkrankungen |
US20050074487A1 (en) * | 1999-12-16 | 2005-04-07 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
DE60127595T2 (de) * | 2000-05-31 | 2008-01-10 | Santen Pharmaceutical Co., Ltd | Inhibitoren der TNF-Alpha Bildung zur Behandlung von Autoimmunerkrankungen |
US7585523B2 (en) * | 2002-08-27 | 2009-09-08 | Targeted Medical Pharma | Composition and method to augment and sustain neurotransmitter production |
JP2006519225A (ja) * | 2003-02-27 | 2006-08-24 | 社団法人芝蘭会 | 依存症治療用医薬組成物 |
ES2319539T3 (es) | 2003-09-17 | 2009-05-08 | Janssen Pharmaceutica Nv | Compuestos heterociclicos condensados como moduladores del receptor de serotonina. |
ATE539753T1 (de) * | 2005-08-04 | 2012-01-15 | Janssen Pharmaceutica Nv | Pyrimidin-verbindungen als serotonin-rezeptor- modulatoren |
US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
EP2077261A4 (fr) * | 2006-09-27 | 2010-04-14 | Nissan Chemical Ind Ltd | Procédé servant à produire un composé succinimide |
EP2322505A4 (fr) | 2008-08-29 | 2011-10-19 | Kowa Co | Dérivé 1-adamantylazétidine-2-one et préparation pharmaceutique comprenant ce dérivé |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
EP2919788A4 (fr) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Méthodes et compositions pour le traitement de la schizophrénie |
CN108610292B (zh) * | 2018-06-12 | 2020-11-10 | 清华大学 | 一类3,5-二取代乙内酰脲类化合物及其制备方法与应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4216318A (en) * | 1975-12-29 | 1980-08-05 | Smith Kline & French Laboratories Limited | Heterocyclic alkyl 4-pyrimidones |
US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
CA2018438C (fr) * | 1989-06-14 | 2000-08-08 | Joseph Alan Finkelstein | Acides imidazolyl-alkenoiques |
US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
DE69218795T2 (de) * | 1992-01-16 | 1997-07-10 | Du Pont Merck Pharma | Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen |
US5278162A (en) * | 1992-09-18 | 1994-01-11 | The Du Pont Merck Pharmaceutical Company | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man |
TW370529B (en) * | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
JP2895961B2 (ja) * | 1992-12-17 | 1999-05-31 | フアイザー・インコーポレイテツド | Crfアンタゴニストとしてのピロロピリミジン |
WO1995010506A1 (fr) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyle-n-arylpyrimidinamines et leurs derives |
TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
-
1995
- 1995-03-20 ES ES95910708T patent/ES2223049T3/es not_active Expired - Lifetime
- 1995-03-20 EP EP95910708A patent/EP0757685B1/fr not_active Expired - Lifetime
- 1995-03-20 MX MX9605218A patent/MX9605218A/es not_active IP Right Cessation
- 1995-03-20 US US08/737,376 patent/US5854232A/en not_active Expired - Fee Related
- 1995-03-20 WO PCT/IB1995/000189 patent/WO1995029909A1/fr active IP Right Grant
- 1995-03-20 DE DE69533284T patent/DE69533284T2/de not_active Expired - Fee Related
- 1995-03-20 AT AT95910708T patent/ATE271553T1/de not_active IP Right Cessation
- 1995-03-20 AU AU18845/95A patent/AU1884595A/en not_active Abandoned
- 1995-03-20 JP JP7528089A patent/JP3004728B2/ja not_active Expired - Fee Related
- 1995-03-20 CA CA002188427A patent/CA2188427C/fr not_active Expired - Fee Related
- 1995-03-20 PT PT95910708T patent/PT757685E/pt unknown
- 1995-03-20 DK DK95910708T patent/DK0757685T3/da active
- 1995-04-20 IL IL11343695A patent/IL113436A0/xx unknown
-
1996
- 1996-10-28 FI FI964340A patent/FI964340A0/fi not_active IP Right Cessation
-
1998
- 1998-10-13 JP JP29066498A patent/JP3432753B2/ja not_active Expired - Fee Related
- 1998-10-13 JP JP29068298A patent/JP3158103B2/ja not_active Expired - Fee Related
- 1998-10-13 JP JP29063698A patent/JP3281320B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2188427A1 (fr) | 1995-11-09 |
DE69533284T2 (de) | 2005-07-21 |
PT757685E (pt) | 2004-10-29 |
JP3432753B2 (ja) | 2003-08-04 |
MX9605218A (es) | 1997-10-31 |
JP3158103B2 (ja) | 2001-04-23 |
FI964340A (fi) | 1996-10-28 |
EP0757685B1 (fr) | 2004-07-21 |
EP0757685A1 (fr) | 1997-02-12 |
CA2188427C (fr) | 2000-06-27 |
WO1995029909A1 (fr) | 1995-11-09 |
FI964340A0 (fi) | 1996-10-28 |
JPH11209374A (ja) | 1999-08-03 |
DE69533284D1 (de) | 2004-08-26 |
US5854232A (en) | 1998-12-29 |
JPH11193273A (ja) | 1999-07-21 |
ES2223049T3 (es) | 2005-02-16 |
ATE271553T1 (de) | 2004-08-15 |
AU1884595A (en) | 1995-11-29 |
IL113436A0 (en) | 1995-07-31 |
JP3004728B2 (ja) | 2000-01-31 |
JPH11217371A (ja) | 1999-08-10 |
JP3281320B2 (ja) | 2002-05-13 |
JPH09506371A (ja) | 1997-06-24 |
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