DK0741737T3 - Vandopløslige antifugale azoler - Google Patents

Vandopløslige antifugale azoler

Info

Publication number
DK0741737T3
DK0741737T3 DK95906968T DK95906968T DK0741737T3 DK 0741737 T3 DK0741737 T3 DK 0741737T3 DK 95906968 T DK95906968 T DK 95906968T DK 95906968 T DK95906968 T DK 95906968T DK 0741737 T3 DK0741737 T3 DK 0741737T3
Authority
DK
Denmark
Prior art keywords
hydrogen
6alkyl
pct
image
antifugal
Prior art date
Application number
DK95906968T
Other languages
Danish (da)
English (en)
Inventor
Jan Heeres
Jean Louis Mesens
Leo Jacobus Jozef Backx
Der Eycken Luc Alfons Leo Van
Frank Christopher Odds
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0741737T3 publication Critical patent/DK0741737T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • External Artificial Organs (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK95906968T 1994-01-24 1995-01-17 Vandopløslige antifugale azoler DK0741737T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18535294A 1994-01-24 1994-01-24
PCT/EP1995/000174 WO1995019983A1 (en) 1994-01-24 1995-01-17 Watersoluble azole antifungals

Publications (1)

Publication Number Publication Date
DK0741737T3 true DK0741737T3 (da) 2000-05-22

Family

ID=22680644

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95906968T DK0741737T3 (da) 1994-01-24 1995-01-17 Vandopløslige antifugale azoler

Country Status (31)

Country Link
US (1) US5707977A (no)
EP (1) EP0741737B1 (no)
JP (1) JP3764750B2 (no)
KR (1) KR100352147B1 (no)
CN (1) CN1078210C (no)
AT (1) ATE186540T1 (no)
AU (1) AU688455B2 (no)
CA (1) CA2179640C (no)
CY (1) CY2176B1 (no)
CZ (1) CZ288544B6 (no)
DE (1) DE69513279T2 (no)
DK (1) DK0741737T3 (no)
ES (1) ES2141329T3 (no)
FI (1) FI116057B (no)
GR (1) GR3032550T3 (no)
HU (1) HU227281B1 (no)
IL (1) IL112413A (no)
LV (1) LV12634B (no)
MY (1) MY111814A (no)
NO (1) NO308412B1 (no)
NZ (1) NZ278882A (no)
PH (1) PH31664A (no)
PL (1) PL181947B1 (no)
PT (1) PT741737E (no)
RU (1) RU2156764C2 (no)
SG (1) SG48386A1 (no)
SI (1) SI0741737T1 (no)
SK (1) SK282059B6 (no)
TW (1) TW376385B (no)
WO (1) WO1995019983A1 (no)
ZA (1) ZA95521B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW457240B (en) 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
CA2197672C (en) * 1995-06-02 2011-05-17 Anil K. Saksena Tetrahydrofuran antifungals
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
AU6257396A (en) * 1995-06-19 1997-01-15 Schering Corporation Tetrahydrofuran antifungals
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
JP2001504465A (ja) 1996-11-12 2001-04-03 セプラコール,インク. 2r,4s,s,s―および2s,4r,s,s―ヒドロキシイトラコナゾール
JP2001504466A (ja) * 1996-11-12 2001-04-03 セプラコール,インク. 2r,4s,r,r―および2s,4r,r,r―ヒドロキシイトラコナゾール
CA2269617A1 (en) * 1996-11-12 1998-05-22 Chris H. Senanayake 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
EP0942907A1 (en) * 1996-11-12 1999-09-22 Sepracor, Inc. 2r, 4s, s, r- and 2s, 4r, s, r-hydroxyitraconazole
US6262052B1 (en) * 1997-02-11 2001-07-17 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
TW593312B (en) * 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
JP4473350B2 (ja) * 1997-07-11 2010-06-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 2,4,4−三置換−1,3−ジオキソラン抗菌・抗カビ剤
DE69822859T2 (de) * 1997-10-07 2005-01-27 Schering Corp. Krytallinischer fungizider polymorph
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6265584B1 (en) * 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
WO2000030655A1 (en) * 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
JO2691B1 (en) 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2343980A4 (en) * 2008-09-08 2012-06-06 Nian Wu ANTIFUNGAL AGENTS BASED ON TRIAZOLE
RU2563811C1 (ru) * 2014-08-08 2015-09-20 Федеральное государственное бюджетное учреждение науки Институт химической физики им. Н.Н. Семенова Российской академии наук (ИХФ РАН) Фармацевтическая композиция для лечения грибковых заболеваний
CN106243087B (zh) * 2016-09-12 2018-10-09 三峡大学 一种三唑吡咯烷酮类杀菌剂,合成方法及其应用
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
ES2159623T3 (es) * 1993-12-21 2001-10-16 Schering Corp Antifungicos de tetrahidrofurano.

Also Published As

Publication number Publication date
GR3032550T3 (en) 2000-05-31
SK282059B6 (sk) 2001-10-08
NO963073D0 (no) 1996-07-23
FI962947A0 (fi) 1996-07-23
IL112413A (en) 1999-11-30
NZ278882A (en) 1997-06-24
CN1078210C (zh) 2002-01-23
IL112413A0 (en) 1995-03-30
CA2179640C (en) 2005-11-15
ATE186540T1 (de) 1999-11-15
ES2141329T3 (es) 2000-03-16
US5707977A (en) 1998-01-13
CZ288544B6 (cs) 2001-07-11
JPH09508360A (ja) 1997-08-26
EP0741737B1 (en) 1999-11-10
HUT75943A (en) 1997-05-28
FI962947A (fi) 1996-07-23
MY111814A (en) 2001-01-31
NO963073L (no) 1996-07-23
CZ195696A3 (en) 1997-02-12
NO308412B1 (no) 2000-09-11
KR100352147B1 (ko) 2002-11-11
PL315558A1 (en) 1996-11-12
RU2156764C2 (ru) 2000-09-27
DE69513279T2 (de) 2000-07-13
HU9602008D0 (en) 1996-09-30
EP0741737A1 (en) 1996-11-13
PL181947B1 (en) 2001-10-31
LV12634A (lv) 2001-03-20
SK89696A3 (en) 1998-02-04
CA2179640A1 (en) 1995-07-27
ZA95521B (en) 1996-07-23
WO1995019983A1 (en) 1995-07-27
DE69513279D1 (de) 1999-12-16
TW376385B (en) 1999-12-11
AU688455B2 (en) 1998-03-12
LV12634B (en) 2001-07-20
FI116057B (fi) 2005-09-15
SG48386A1 (en) 1998-04-17
JP3764750B2 (ja) 2006-04-12
CY2176B1 (en) 2002-08-23
PH31664A (en) 1999-01-12
AU1535595A (en) 1995-08-08
CN1138862A (zh) 1996-12-25
PT741737E (pt) 2000-04-28
SI0741737T1 (en) 2000-02-29
HU227281B1 (en) 2011-01-28

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