DK0725778T3 - Rekombinant produktion af hidtil ukendte polyketider - Google Patents
Rekombinant produktion af hidtil ukendte polyketiderInfo
- Publication number
- DK0725778T3 DK0725778T3 DK94928169T DK94928169T DK0725778T3 DK 0725778 T3 DK0725778 T3 DK 0725778T3 DK 94928169 T DK94928169 T DK 94928169T DK 94928169 T DK94928169 T DK 94928169T DK 0725778 T3 DK0725778 T3 DK 0725778T3
- Authority
- DK
- Denmark
- Prior art keywords
- polyketides
- novel
- recombinant production
- novel polyketides
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12373293A | 1993-09-20 | 1993-09-20 | |
US16430193A | 1993-12-08 | 1993-12-08 | |
US08/238,811 US5672491A (en) | 1993-09-20 | 1994-05-06 | Recombinant production of novel polyketides |
PCT/US1994/010643 WO1995008548A1 (fr) | 1993-09-20 | 1994-09-20 | Production de nouveaux polycetides par recombinaison |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0725778T3 true DK0725778T3 (da) | 2001-12-17 |
Family
ID=26821834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94928169T DK0725778T3 (da) | 1993-09-20 | 1994-09-20 | Rekombinant produktion af hidtil ukendte polyketider |
Country Status (11)
Country | Link |
---|---|
US (7) | US6022731A (fr) |
EP (1) | EP0725778B1 (fr) |
JP (1) | JPH09505983A (fr) |
AT (2) | ATE206164T1 (fr) |
AU (1) | AU678058B2 (fr) |
CA (1) | CA2171629A1 (fr) |
DE (2) | DE69428451T2 (fr) |
DK (1) | DK0725778T3 (fr) |
ES (2) | ES2164713T3 (fr) |
PT (1) | PT725778E (fr) |
WO (1) | WO1995008548A1 (fr) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
WO1995008548A1 (fr) * | 1993-09-20 | 1995-03-30 | The Leland Stanford Junior University | Production de nouveaux polycetides par recombinaison |
US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US6495348B1 (en) * | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
WO1996034112A1 (fr) * | 1995-04-24 | 1996-10-31 | Chromaxome Corp. | Procedes de generation et de criblage de nouvelles voies metaboliques |
JP3633629B2 (ja) | 1995-07-06 | 2005-03-30 | ザ レランド スタンフォード ジュニア ユニバーシティ | ポリケチドの無細胞合成 |
EP0870053A4 (fr) | 1995-12-19 | 2002-09-11 | Univ Minnesota | Procede metabolique de fabrication de synthases monomeres de polyhydroxyalcanoates |
US5998194A (en) * | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
JP2009213479A (ja) * | 1996-06-08 | 2009-09-24 | Biotica Technology Ltd | ポリケチド類及びそれらの合成 |
US6960453B1 (en) | 1996-07-05 | 2005-11-01 | Biotica Technology Limited | Hybrid polyketide synthases combining heterologous loading and extender modules |
TR199900006T2 (xx) * | 1996-07-05 | 1999-04-21 | Biotica Technology Limited | Eritromisinler ve bunlar�n haz�rlanmas� i�in i�lem. |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
DE69736673T2 (de) * | 1996-08-20 | 2007-09-13 | Novartis Ag | Rifamycin biosynthese genkluster |
US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
US6117659A (en) | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
US6902913B2 (en) | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6969584B2 (en) * | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
WO1999002669A2 (fr) | 1997-07-10 | 1999-01-21 | Kosan Biosciences, Inc. | Production de polyketides dans des plantes |
US6261842B1 (en) | 1997-10-23 | 2001-07-17 | Wisconsin Alumni Research Foundation | Microorganism genomics, compositions and methods related thereto |
US6090601A (en) * | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
US6280999B1 (en) | 1998-01-23 | 2001-08-28 | Kosan Bioscience | Sorangium polyketide synthases and encoding DNA therefor |
US6143526A (en) * | 1998-03-09 | 2000-11-07 | Baltz; Richard H. | Biosynthetic genes for spinosyn insecticide production |
US6265202B1 (en) * | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
GB9814006D0 (en) * | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
US6150513A (en) * | 1998-09-16 | 2000-11-21 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant DNA constructs therefor |
IL142165A0 (en) * | 1998-10-02 | 2002-03-10 | Kosan Biosciences Inc | Polyketide synthase enzymes and recombinant dna constructs therefor |
JP2002528467A (ja) | 1998-10-28 | 2002-09-03 | コーサン バイオサイエンシーズ, インコーポレイテッド | 新規な「不自然な(unnatural)」天然生成物のライブラリ |
WO2000031247A2 (fr) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Matieres et procedes recombinants destines a la production d'epothilone et de derives d'epothilone |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
CA2360011A1 (fr) * | 1999-01-05 | 2000-07-13 | Trustees Of Boston University | Assemblage genetique ordonne |
US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
US20040005673A1 (en) | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
CA2359801A1 (fr) | 1999-02-09 | 2000-08-17 | Rajesh S. Gokhale | Procedes de modulation de l'efficacite de modules de polyketide-synthases |
US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
ES2335385T3 (es) | 1999-10-13 | 2010-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Biosintesis de sustratos de policetido sintasa. |
US6939691B1 (en) | 1999-10-13 | 2005-09-06 | Board Of Trustees Of The Leland Stanford Junior University | E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production |
ATE391789T1 (de) | 1999-12-10 | 2008-04-15 | Invitrogen Corp | Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen |
WO2001060833A2 (fr) | 2000-02-18 | 2001-08-23 | Kosan Biosciences, Inc. | Composes motilides |
DK1278881T3 (da) | 2000-04-13 | 2010-05-10 | Biotica Tech Ltd | Glycosylerede hybrid-produkter og deres fremstilling og anvendelse |
WO2001092991A2 (fr) | 2000-05-30 | 2001-12-06 | Kosan Biosciences, Inc. | Conception de genes de polyketide synthase |
FI111270B (fi) * | 2001-03-19 | 2003-06-30 | Galilaeus Oy | Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten |
US20030194784A1 (en) * | 2001-04-17 | 2003-10-16 | Sherman David H. | DNA encoding methymycin and pikromycin |
WO2002088176A2 (fr) * | 2001-04-26 | 2002-11-07 | Ecopia Biosciences Inc. | Genes et proteines destines a la biosynthese de polyketides |
EP1409686B1 (fr) * | 2001-07-26 | 2006-03-22 | Ecopia Biosciences Inc. | Genes et proteines intervenant dans la biosynthese de rosaramicine |
US20040161839A1 (en) * | 2001-10-05 | 2004-08-19 | Hung-Wen Liu | Method to alter sugar moieties |
GB0125043D0 (en) * | 2001-10-17 | 2001-12-12 | Biotica Tech Ltd | Production, detection and use of transformant cells |
US7189549B2 (en) * | 2002-06-14 | 2007-03-13 | Kosan Biosciences, Inc. | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof |
AU2003213757A1 (en) * | 2002-03-04 | 2003-09-22 | Brown University Research Foundation | Methods to mediate polyketide synthase module effectiveness |
US6989131B2 (en) * | 2002-03-12 | 2006-01-24 | Uop Llc | Catalytic reactor with integral evaporator |
AU2003248694A1 (en) * | 2002-06-13 | 2003-12-31 | Kosan Biosciences, Inc. | Methods and cells for improved production of polyketides |
AU2003253949A1 (en) * | 2002-07-15 | 2004-02-02 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
US20040132055A1 (en) * | 2002-10-24 | 2004-07-08 | Leonard Katz | Recombinant chalcomycin polyketide synthase and modifying genes |
US7067290B2 (en) * | 2002-11-12 | 2006-06-27 | Kosan Biosciences Incorporated | Method for production of polyketides |
US7364877B2 (en) | 2002-12-06 | 2008-04-29 | Kosan Biosciences, Inc. | Polynucleotides encoding disorazole polyketide synthase polypeptides |
US7799904B2 (en) * | 2003-06-13 | 2010-09-21 | University Of Kentucky Research Foundation | Gilvocarcin gene cluster, recombinant production and use thereof |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
KR100549690B1 (ko) | 2003-10-23 | 2006-02-07 | 상하이 지아오통 대학 | 에프알-008 폴리케타이드 합성에 관여하는 유전자 |
US7229814B2 (en) | 2004-05-05 | 2007-06-12 | Regents Of The University Of Minnesota | Nucleic acids and polypeptides involved in the production of cryptophycin |
US7566558B2 (en) | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
US8759031B2 (en) | 2007-04-12 | 2014-06-24 | Wisconsin Alumni Research Foundation | Type I polyketide synthase extender units |
CN102016045A (zh) | 2007-05-02 | 2011-04-13 | 梅瑞尔有限公司 | 具有改善的表达和稳定性的dna质粒 |
BRPI0909839A2 (pt) | 2008-03-28 | 2017-06-13 | Univ California | produção de ácidos dicarboxílicos usando policetídeo sintases |
EP2268828A4 (fr) * | 2008-04-29 | 2012-08-01 | Univ California | Production de biocarburants en utilisant des polykétide synthases |
JP5789190B2 (ja) * | 2008-09-24 | 2015-10-07 | シャンハイ インスティテュート オブ オーガニック ケミストリー,チャイニーズ アカデミー オブ サイエンシズ | 新規の遺伝子クラスター |
US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
AU2012272644B2 (en) | 2011-06-23 | 2017-03-23 | Rho Renewables, Inc. | Recombinant production systems for aromatic molecules |
US8864373B2 (en) * | 2011-09-12 | 2014-10-21 | National Semiconductor Corporation | Small highly accurate battery temperature monitoring circuit |
US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
EP3247378B8 (fr) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Composés macrocycliques participant à une liaison coopérative et leurs utilisations médicales |
CA3000822A1 (fr) | 2015-10-01 | 2017-04-06 | Warp Drive Bio, Inc. | Procedes et reactifs pour l'analyse d'interfaces proteine-proteine |
EP3442599B1 (fr) * | 2016-04-12 | 2022-03-30 | Warp Drive Bio, Inc. | Compositions et procédés pour la production de composés |
CA3031558A1 (fr) | 2016-07-29 | 2018-02-01 | Isomerase Therapeutics Limited | Nouveaux procedes |
CA3042231A1 (fr) | 2016-10-28 | 2018-05-03 | Ginkgo Bioworks, Inc. | Compositions et procedes pour la production de composes |
CN109679969B (zh) * | 2019-01-16 | 2022-09-02 | 河南省商业科学研究所有限责任公司 | 参与调控链霉菌中act产量的细胞被合成基因 |
CN109679980B (zh) * | 2019-01-16 | 2022-09-02 | 河南省商业科学研究所有限责任公司 | 参与调控链霉菌中act产量的氨基酸代谢基因 |
AU2020379734A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
WO2021091967A1 (fr) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Inhibiteurs de ras |
KR20220109407A (ko) | 2019-11-04 | 2022-08-04 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
CN113969255A (zh) | 2020-07-24 | 2022-01-25 | 北京华昊中天生物医药股份有限公司 | 生产脱环氧埃坡霉素b的重组菌及其用途 |
US11690915B2 (en) | 2020-09-15 | 2023-07-04 | Revolution Medicines, Inc. | Ras inhibitors |
EP4106060A1 (fr) | 2021-06-18 | 2022-12-21 | Kemiwatt | Électrolyte aqueux organique à base biologique pour batterie aqueuse organique à flux redox |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0092388B2 (fr) | 1982-04-16 | 1994-10-26 | Eli Lilly And Company | Vecteurs de clonage |
US4935340A (en) * | 1985-06-07 | 1990-06-19 | Eli Lilly And Company | Method of isolating antibiotic biosynthetic genes |
US6063561A (en) | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
US6060234A (en) | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
WO1993013663A1 (fr) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Procede permettant d'effectuer la biosynthese de polycetides specifiques |
US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
WO1995008548A1 (fr) * | 1993-09-20 | 1995-03-30 | The Leland Stanford Junior University | Production de nouveaux polycetides par recombinaison |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
-
1994
- 1994-09-20 WO PCT/US1994/010643 patent/WO1995008548A1/fr not_active Application Discontinuation
- 1994-09-20 EP EP94928169A patent/EP0725778B1/fr not_active Revoked
- 1994-09-20 CA CA002171629A patent/CA2171629A1/fr not_active Abandoned
- 1994-09-20 DE DE69428451T patent/DE69428451T2/de not_active Revoked
- 1994-09-20 DK DK94928169T patent/DK0725778T3/da active
- 1994-09-20 JP JP7509422A patent/JPH09505983A/ja not_active Withdrawn
- 1994-09-20 AU AU77317/94A patent/AU678058B2/en not_active Ceased
- 1994-09-20 ES ES94928169T patent/ES2164713T3/es not_active Expired - Lifetime
- 1994-09-20 PT PT94928169T patent/PT725778E/pt unknown
- 1994-09-20 AT AT94928169T patent/ATE206164T1/de not_active IP Right Cessation
- 1994-09-20 ES ES01104774T patent/ES2240259T3/es not_active Expired - Lifetime
- 1994-09-20 AT AT01104774T patent/ATE297992T1/de not_active IP Right Cessation
- 1994-09-20 DE DE69434408T patent/DE69434408T2/de not_active Expired - Fee Related
-
1997
- 1997-03-31 US US08/828,898 patent/US6022731A/en not_active Expired - Lifetime
- 1997-03-31 US US08/828,887 patent/US5830750A/en not_active Expired - Lifetime
- 1997-03-31 US US08/829,244 patent/US5843718A/en not_active Expired - Lifetime
-
1999
- 1999-03-05 US US09/263,396 patent/US6214573B1/en not_active Expired - Fee Related
- 1999-03-05 US US09/263,184 patent/US6399382B1/en not_active Expired - Fee Related
-
2001
- 2001-08-08 US US09/925,236 patent/US6969611B2/en not_active Expired - Fee Related
-
2005
- 2005-09-15 US US11/227,404 patent/US7312048B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2164713T3 (es) | 2002-03-01 |
DE69434408D1 (de) | 2005-07-21 |
US6214573B1 (en) | 2001-04-10 |
ES2240259T3 (es) | 2005-10-16 |
US20060127986A1 (en) | 2006-06-15 |
US5830750A (en) | 1998-11-03 |
EP0725778A1 (fr) | 1996-08-14 |
US6399382B1 (en) | 2002-06-04 |
US7312048B2 (en) | 2007-12-25 |
AU7731794A (en) | 1995-04-10 |
US6022731A (en) | 2000-02-08 |
CA2171629A1 (fr) | 1995-03-30 |
PT725778E (pt) | 2002-03-28 |
US6969611B2 (en) | 2005-11-29 |
DE69434408T2 (de) | 2006-03-16 |
US5843718A (en) | 1998-12-01 |
WO1995008548A1 (fr) | 1995-03-30 |
JPH09505983A (ja) | 1997-06-17 |
EP0725778B1 (fr) | 2001-09-26 |
DE69428451T2 (de) | 2002-04-18 |
AU678058B2 (en) | 1997-05-15 |
US20020110874A1 (en) | 2002-08-15 |
EP0725778A4 (fr) | 1998-11-11 |
ATE297992T1 (de) | 2005-07-15 |
DE69428451D1 (de) | 2001-10-31 |
ATE206164T1 (de) | 2001-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0725778T3 (da) | Rekombinant produktion af hidtil ukendte polyketider | |
DE69635489D1 (de) | Rekombinante produktion von neuen polyketiden | |
EP1568774A3 (fr) | Production recombinante de polykétides | |
ATE286133T1 (de) | Zellfreie synthese von polyketiden | |
TW326475B (en) | Structural element | |
EP0913466A3 (fr) | Procédé de préparation de L-leucine | |
DE69820038D1 (de) | Prozessueberwachungsvorrichtung | |
MXPA02004666A (es) | Gelatinas recombinantes. | |
ES2187040T3 (es) | Mejoras en capsulas o en relacion con ellas. | |
AU2002354696A1 (en) | Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme | |
IL136667A0 (en) | Methods of producing anti-angiogenic proteins: endostatin, angiostatin or restin, using a pichia yeast expression system | |
DE50111331D1 (de) | Neue verwendung von proteinhydrolysaten | |
DK1346026T3 (da) | Mikroorganisme, der producerer 5'inosinsyre, og fremgangsmåde til produktion af 5'inosinsyre under anvendelse af denne | |
FR2716588B1 (fr) | Système de codage convolutionnel et de décodage de viterbi transparent aux sauts de phase de pi et pi/2, applicable notamment aux transmissions AMRT. | |
DE69821784D1 (de) | Fsk-demodulator mit supralinearem integrator | |
DE69730497D1 (de) | Antibiotika produzierende mikrobe | |
PL341227A1 (en) | Derivatives of ketone peroxides, their production and application | |
ATE318907T1 (de) | Erhöhte herstellung von 2-keto-l-gulonsäure | |
AU1719497A (en) | An enzyme with pectin esterase activity | |
ATE321848T1 (de) | Immobilisierungsträger mit einem porösen medium | |
ATE264394T1 (de) | Klonierung der udp-galaktose-epimerase | |
DE69729010D1 (de) | Produktion des proteins ingap mit hoher expressionsrate | |
DK0934256T3 (da) | Fremgangsmåde til fremstilling af cyanocinnamamider | |
UA41926C2 (uk) | Прокат бульбоподібного профілю та спосіб його виготовлення | |
NL960017I1 (nl) | Expressie van Factor VIII-activiteit in zoogdiercellen. |