ES2164713T3 - Produccion recombinante de nuevos poliquetidos. - Google Patents
Produccion recombinante de nuevos poliquetidos.Info
- Publication number
- ES2164713T3 ES2164713T3 ES94928169T ES94928169T ES2164713T3 ES 2164713 T3 ES2164713 T3 ES 2164713T3 ES 94928169 T ES94928169 T ES 94928169T ES 94928169 T ES94928169 T ES 94928169T ES 2164713 T3 ES2164713 T3 ES 2164713T3
- Authority
- ES
- Spain
- Prior art keywords
- new
- polychetides
- recombinant production
- polyketides
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PRESENTAN NUEVOS POLIKETIDOS Y NUEVOS METODOS PARA PRODUCIR EFICIENTEMENTE POLICETIDOS TANTO NUEVOS COMO CONOCIDOS, UTILIZANDO TECNOLOGIA RECOMBINANTE. EN PARTICULAR, SE DESCRIBE UN NUEVO SISTEMA DE ANFITRION-VECTOR QUE SE UTILIZA PARA PRODUCIR SINTASAS DE POLIKETIDOS QUE A SU VEZ CATALIZAN LA PRODUCCION DE UNA VARIEDAD DE POLIKETIDOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12373293A | 1993-09-20 | 1993-09-20 | |
US16430193A | 1993-12-08 | 1993-12-08 | |
US08/238,811 US5672491A (en) | 1993-09-20 | 1994-05-06 | Recombinant production of novel polyketides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164713T3 true ES2164713T3 (es) | 2002-03-01 |
Family
ID=26821834
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01104774T Expired - Lifetime ES2240259T3 (es) | 1993-09-20 | 1994-09-20 | Produccion recombinante de poliquetidos aromaticos. |
ES94928169T Expired - Lifetime ES2164713T3 (es) | 1993-09-20 | 1994-09-20 | Produccion recombinante de nuevos poliquetidos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01104774T Expired - Lifetime ES2240259T3 (es) | 1993-09-20 | 1994-09-20 | Produccion recombinante de poliquetidos aromaticos. |
Country Status (11)
Country | Link |
---|---|
US (7) | US5830750A (es) |
EP (1) | EP0725778B1 (es) |
JP (1) | JPH09505983A (es) |
AT (2) | ATE206164T1 (es) |
AU (1) | AU678058B2 (es) |
CA (1) | CA2171629A1 (es) |
DE (2) | DE69434408T2 (es) |
DK (1) | DK0725778T3 (es) |
ES (2) | ES2240259T3 (es) |
PT (1) | PT725778E (es) |
WO (1) | WO1995008548A1 (es) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE206164T1 (de) * | 1993-09-20 | 2001-10-15 | Univ Leland Stanford Junior | Rekombinante herstellung von neuen polyketiden |
US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
US6495348B1 (en) * | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
KR20040041639A (ko) * | 1995-04-24 | 2004-05-17 | 크로막솜 코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
JP3633629B2 (ja) | 1995-07-06 | 2005-03-30 | ザ レランド スタンフォード ジュニア ユニバーシティ | ポリケチドの無細胞合成 |
EP0870053A4 (en) | 1995-12-19 | 2002-09-11 | Univ Minnesota | METABOLIC PROCESS FOR THE MANUFACTURE OF POLYHYDROXYALCANOATE MONOMER SYNTHASES |
US5998194A (en) * | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
JP2009213479A (ja) * | 1996-06-08 | 2009-09-24 | Biotica Technology Ltd | ポリケチド類及びそれらの合成 |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
SK182498A3 (en) * | 1996-07-05 | 2000-05-16 | Biotica Tech Ltd | Erythromycins and process for their preparation |
US6960453B1 (en) | 1996-07-05 | 2005-11-01 | Biotica Technology Limited | Hybrid polyketide synthases combining heterologous loading and extender modules |
DE69736673T2 (de) | 1996-08-20 | 2007-09-13 | Novartis Ag | Rifamycin biosynthese genkluster |
US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
US6399789B1 (en) | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
US6117659A (en) | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6902913B2 (en) | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6969584B2 (en) * | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
US6262340B1 (en) | 1997-07-10 | 2001-07-17 | Kosan Biosciences, Inc. | Production of polyketides in plants |
US6261842B1 (en) | 1997-10-23 | 2001-07-17 | Wisconsin Alumni Research Foundation | Microorganism genomics, compositions and methods related thereto |
US6090601A (en) * | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
US6280999B1 (en) | 1998-01-23 | 2001-08-28 | Kosan Bioscience | Sorangium polyketide synthases and encoding DNA therefor |
US6143526A (en) * | 1998-03-09 | 2000-11-07 | Baltz; Richard H. | Biosynthetic genes for spinosyn insecticide production |
US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
GB9814006D0 (en) | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
US6150513A (en) * | 1998-09-16 | 2000-11-21 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant DNA constructs therefor |
US6503737B1 (en) * | 1998-10-02 | 2003-01-07 | Kosan Biosciences, Inc. | Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster |
CA2347128A1 (en) | 1998-10-28 | 2000-05-04 | Kosan Biosciences, Inc. | Library of novel "unnatural" natural products |
EP1135470A2 (en) * | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
US20040005673A1 (en) | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
EP1141275B1 (en) * | 1999-01-05 | 2009-08-12 | Trustees Of Boston University | Improved nucleic acid cloning |
US7001748B2 (en) | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
EP1153124A2 (en) | 1999-02-09 | 2001-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to mediate polyketide synthase module effectiveness |
US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
US6939691B1 (en) | 1999-10-13 | 2005-09-06 | Board Of Trustees Of The Leland Stanford Junior University | E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production |
NZ517557A (en) * | 1999-10-13 | 2004-05-28 | Univ Leland Stanford Junior | E. coli host cells that synthesize methylmalonyl CoA |
WO2001042509A1 (en) | 1999-12-10 | 2001-06-14 | Invitrogen Corporation | Use of multiple recombination sites with unique specificity in recombinational cloning |
AU2001238476A1 (en) | 2000-02-18 | 2001-08-27 | Kosan Biosciences, Inc. | Motocide compounds |
AU2001248588B2 (en) | 2000-04-13 | 2006-02-02 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
AU2001275012A1 (en) | 2000-05-30 | 2001-12-11 | Kosan Biosciences, Inc. | Design of polyketide synthase genes |
FI111270B (fi) * | 2001-03-19 | 2003-06-30 | Galilaeus Oy | Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten |
US20030194784A1 (en) * | 2001-04-17 | 2003-10-16 | Sherman David H. | DNA encoding methymycin and pikromycin |
WO2002088176A2 (en) * | 2001-04-26 | 2002-11-07 | Ecopia Biosciences Inc. | Genes and proteins for the biosynthesis of polyketides |
EP1409686B1 (en) * | 2001-07-26 | 2006-03-22 | Ecopia Biosciences Inc. | Genes and proteins for the biosynthesis of rosaramicin |
US20040161839A1 (en) * | 2001-10-05 | 2004-08-19 | Hung-Wen Liu | Method to alter sugar moieties |
GB0125043D0 (en) * | 2001-10-17 | 2001-12-12 | Biotica Tech Ltd | Production, detection and use of transformant cells |
US7189549B2 (en) * | 2002-06-14 | 2007-03-13 | Kosan Biosciences, Inc. | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof |
US20060110789A1 (en) * | 2002-03-04 | 2006-05-25 | Gokhale Rajesh S | Methods to mediate polyketide synthase module effectiveness |
US6989131B2 (en) * | 2002-03-12 | 2006-01-24 | Uop Llc | Catalytic reactor with integral evaporator |
US20040087003A1 (en) * | 2002-06-13 | 2004-05-06 | Zhihao Hu | Methods and cells for improved production of polyketides |
WO2004007688A2 (en) * | 2002-07-15 | 2004-01-22 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
US20040132055A1 (en) * | 2002-10-24 | 2004-07-08 | Leonard Katz | Recombinant chalcomycin polyketide synthase and modifying genes |
US7067290B2 (en) * | 2002-11-12 | 2006-06-27 | Kosan Biosciences Incorporated | Method for production of polyketides |
AU2003298864A1 (en) | 2002-12-06 | 2004-06-30 | Kosan Biosciences, Inc. | Disorazole polyketide synthase encoding polynucleotides |
US7799904B2 (en) * | 2003-06-13 | 2010-09-21 | University Of Kentucky Research Foundation | Gilvocarcin gene cluster, recombinant production and use thereof |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
KR100549690B1 (ko) | 2003-10-23 | 2006-02-07 | 상하이 지아오통 대학 | 에프알-008 폴리케타이드 합성에 관여하는 유전자 |
EP1751279A4 (en) | 2004-05-05 | 2008-03-19 | Univ Minnesota | NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN |
US7566558B2 (en) | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
US8759031B2 (en) | 2007-04-12 | 2014-06-24 | Wisconsin Alumni Research Foundation | Type I polyketide synthase extender units |
SI2147105T1 (sl) | 2007-05-02 | 2013-08-30 | Merial Limited | DNA-plazmidi z izboljšano ekspresijo in stabilnostjo |
EP2254995A4 (en) | 2008-03-28 | 2011-05-25 | Univ California | PRODUCTION OF DICARBOXYLIC ACIDS USING SYNTHASE POLYCTICIDES |
BRPI0909059A2 (pt) * | 2008-04-29 | 2019-09-24 | Univ California | produção de biocombustíveis usando sintases de policetídeo. |
WO2010034243A1 (en) * | 2008-09-24 | 2010-04-01 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
CA2839570C (en) | 2011-06-23 | 2020-04-07 | Rho Renewables, Inc. | Recombinant production systems for decarboxylated aromatic molecules |
US8864373B2 (en) * | 2011-09-12 | 2014-10-21 | National Semiconductor Corporation | Small highly accurate battery temperature monitoring circuit |
US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
EP4085933A3 (en) * | 2016-04-12 | 2023-01-11 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
US11781128B2 (en) | 2016-07-29 | 2023-10-10 | Isomerase Therapeutics Limited | Methods for producing hybrid polyketide synthase genes and polyketides |
AU2017350900A1 (en) | 2016-10-28 | 2019-06-13 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
CN109679969B (zh) * | 2019-01-16 | 2022-09-02 | 河南省商业科学研究所有限责任公司 | 参与调控链霉菌中act产量的细胞被合成基因 |
CN109679980B (zh) * | 2019-01-16 | 2022-09-02 | 河南省商业科学研究所有限责任公司 | 参与调控链霉菌中act产量的氨基酸代谢基因 |
TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ras抑制劑 |
WO2021091967A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
KR20220109407A (ko) | 2019-11-04 | 2022-08-04 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
CN113969255A (zh) | 2020-07-24 | 2022-01-25 | 北京华昊中天生物医药股份有限公司 | 生产脱环氧埃坡霉素b的重组菌及其用途 |
CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
EP4106060A1 (en) | 2021-06-18 | 2022-12-21 | Kemiwatt | Biobased aqueous organic electrolyte for aqueous organic redox flow battery |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0092388B2 (en) | 1982-04-16 | 1994-10-26 | Eli Lilly And Company | Cloning vectors |
US4935340A (en) * | 1985-06-07 | 1990-06-19 | Eli Lilly And Company | Method of isolating antibiotic biosynthetic genes |
WO1993013663A1 (en) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
US6063561A (en) | 1991-01-17 | 2000-05-16 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
US6060234A (en) | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
ATE206164T1 (de) * | 1993-09-20 | 2001-10-15 | Univ Leland Stanford Junior | Rekombinante herstellung von neuen polyketiden |
US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
-
1994
- 1994-09-20 AT AT94928169T patent/ATE206164T1/de not_active IP Right Cessation
- 1994-09-20 PT PT94928169T patent/PT725778E/pt unknown
- 1994-09-20 CA CA002171629A patent/CA2171629A1/en not_active Abandoned
- 1994-09-20 WO PCT/US1994/010643 patent/WO1995008548A1/en not_active Application Discontinuation
- 1994-09-20 AU AU77317/94A patent/AU678058B2/en not_active Ceased
- 1994-09-20 JP JP7509422A patent/JPH09505983A/ja not_active Withdrawn
- 1994-09-20 EP EP94928169A patent/EP0725778B1/en not_active Revoked
- 1994-09-20 ES ES01104774T patent/ES2240259T3/es not_active Expired - Lifetime
- 1994-09-20 DE DE69434408T patent/DE69434408T2/de not_active Expired - Fee Related
- 1994-09-20 DK DK94928169T patent/DK0725778T3/da active
- 1994-09-20 ES ES94928169T patent/ES2164713T3/es not_active Expired - Lifetime
- 1994-09-20 DE DE69428451T patent/DE69428451T2/de not_active Revoked
- 1994-09-20 AT AT01104774T patent/ATE297992T1/de not_active IP Right Cessation
-
1997
- 1997-03-31 US US08/828,887 patent/US5830750A/en not_active Expired - Lifetime
- 1997-03-31 US US08/829,244 patent/US5843718A/en not_active Expired - Lifetime
- 1997-03-31 US US08/828,898 patent/US6022731A/en not_active Expired - Lifetime
-
1999
- 1999-03-05 US US09/263,396 patent/US6214573B1/en not_active Expired - Fee Related
- 1999-03-05 US US09/263,184 patent/US6399382B1/en not_active Expired - Fee Related
-
2001
- 2001-08-08 US US09/925,236 patent/US6969611B2/en not_active Expired - Fee Related
-
2005
- 2005-09-15 US US11/227,404 patent/US7312048B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU7731794A (en) | 1995-04-10 |
US6969611B2 (en) | 2005-11-29 |
US5843718A (en) | 1998-12-01 |
US5830750A (en) | 1998-11-03 |
US6214573B1 (en) | 2001-04-10 |
US20060127986A1 (en) | 2006-06-15 |
US6399382B1 (en) | 2002-06-04 |
AU678058B2 (en) | 1997-05-15 |
DK0725778T3 (da) | 2001-12-17 |
EP0725778A1 (en) | 1996-08-14 |
DE69434408D1 (de) | 2005-07-21 |
CA2171629A1 (en) | 1995-03-30 |
US20020110874A1 (en) | 2002-08-15 |
PT725778E (pt) | 2002-03-28 |
EP0725778A4 (en) | 1998-11-11 |
ATE297992T1 (de) | 2005-07-15 |
DE69428451D1 (de) | 2001-10-31 |
EP0725778B1 (en) | 2001-09-26 |
DE69434408T2 (de) | 2006-03-16 |
US6022731A (en) | 2000-02-08 |
DE69428451T2 (de) | 2002-04-18 |
ATE206164T1 (de) | 2001-10-15 |
WO1995008548A1 (en) | 1995-03-30 |
JPH09505983A (ja) | 1997-06-17 |
US7312048B2 (en) | 2007-12-25 |
ES2240259T3 (es) | 2005-10-16 |
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